• Earthquakes and Structures
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• 제8권6호
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• pp.1499-1528
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• 2015

The yielding mechanisms of reinforced concrete (RC) structures are the main cause of the collapse of RC buildings during earthquake excitation. Nowadays, the application of earthquake energy dissipation devices, such as viscous dampers (VDs), is being widely considered to protect RC structures which are designed to withstand severe seismic loads. However, the effect of VDs on the formation of plastic hinges and the yielding criteria of RC members has not been investigated extensively, due to the lack of an analytical model and a numerical means to evaluate the seismic response of structures. Therefore, this paper offers a comprehensive investigation of how damper devices influence the yielding mechanisms of RC buildings subjected to seismic excitation. For this purpose, adapting the Newmark method, a finite element algorithm was developed for the nonlinear dynamic analysis of reinforced concrete buildings equipped with VDs that are subjected to earthquake. A special finite element computer program was codified based on the developed algorithm. Finally, a parametric study was conducted for a three-story RC building equipped with supplementary VD devices, performing a nonlinear analysis in order to evaluate its effect on seismic damage and on the response of the structure. The results of this study showed that implementing VDs substantially changes the mechanism and formation of plastic hinges in RC buildings.

• 소성∙가공
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• 제26권5호
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• pp.293-299
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• 2017

In this paper, finite element stamping analysis was carried out for the front lower arm to examine the applicability of solid element with damage theory to predict shear fracture phenomena induced by sheared edge as well as deformation mechanisms. Mechanical properties related to deformation and damage theory were determined from tensile test. Shear fracture was predicted by normalized Cockcroft-Latham model with initial imposition of the damage value along the sheared edge. Simulation results illustrated that the analysis with solid element and damage theory predicted edge profile, strain distribution, and forming load more accurately than the analysis with shell element. Simulation with solid element can also predict the shear fracture more exactly comparing to analysis with shell element and forming limit curve.

• Journal of Applied Biological Chemistry
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• 제56권1호
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• pp.37-42
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• 2013

In eukaryotes, most of the genome are transcribed, however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are processed through coordinated mechanisms of protein sensors, transducers, and effectors including RNAs. During recent years, small RNAs have been increasingly studied and gradually considered as key regulators in various aspects of biology. Upon DNA damage, small RNAs including diRNAs (DSB induced RNA) are generated in both plant and human cell lines. Inhibition of their biogenesis has severe influence on DSB repair system.

• 한국안전학회지
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• 제14권1호
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• pp.41-48
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• 1999

The fatigue life tests were performed in strain control with triangular and hole-time wave-forms at $650^{\circ}C$. The fatigue lifes were investigated according to waveform examining damage mechanisms, which could be used to predict the fatigue life and estimate the remaining life. The results obtained are as follows; The fatigue lifes were in order of the fast-fast>the fast-slow>the slow-fast in the triangular waveforms, and the fatigue lifes in slow-fast waveforms got shorter in the hold-time waveforms. The damage mechanisms of the fracture surfaces were transgranular fracture in the fast-fast, the fast-slow waveforms and intergranular fracture in the slow-fast waveform.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.381-388
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• 2020

Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely abused drugs worldwide. The continuous use of METH eventually leads to drug addiction and causes serious health complications, including attention deficit, memory loss and cognitive decline. These neurological complications are strongly associated with METH-induced neurotoxicity and neuroinflammation, which leads to neuronal cell death. The current review investigates the molecular mechanisms underlying METH-mediated neuronal damages. Our analysis demonstrates that the process of neuronal impairment by METH is closely related to oxidative stress, transcription factor activation, DNA damage, excitatory toxicity and various apoptosis pathways. Thus, we reach the conclusion here that METH-induced neuronal damages are attributed to the neurotoxic and neuroinflammatory effect of the drug. This review provides an insight into the mechanisms of METH addiction and contributes to the discovery of therapeutic targets on neurological impairment by METH abuse.

• Archives of Pharmacal Research
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• 제29권7호
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• pp.577-581
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• 2006

Oxidative mechanisms are thought to have a major role in cataract formation and diabetic complications. Antioxidant enzymes play an essential role in the antioxidant system of the cells that work to maintain low steady-state concentrations of the reactive oxygen species. When HLE-B3 cells, a human lens cell line were exposed to 50-100 mM glucose for 3 days, decrease of viability, inactivation of antioxidant enzymes, and modulation of cellular redox status were observed. Significant increase of cellular oxidative damage reflected by lipid peroxidation and DNA damage were also found. The glycation-mediated inactivation of antioxidant enzymes may result in the perturbation of cellular antioxidant defense mechanisms and subsequently lead to a pro-oxidant condition and may contribute to various pathologies associated with the long term complications of diabetes.

• 한국정밀공학회지
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• 제23권6호
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• pp.119-127
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• 2006

A non-destructive time domain approach to examine structural damage using parameterized partial differential equations and Galerkin approximation techniques is presented. The time domain analysis for damage detection is independent of modal parameters and analytical models unlike frequency domain methods which generally rely on analytical models. The time history of the vibration response of the structure was used to identify the presence of damage. Damage in a structure causes changes in the physical coefficients of mass density, elastic modulus and damping coefficients. This is a part of our ongoing effort on the general problem of modeling and parameter estimation for internal damping mechanisms in a composite beam. Namely, in detecting damage through time-domain or frequency-domain data from smart sensors, the common damages are changed in modal properties such as natural frequencies, mode shapes, and mode shape curvature. This paper examines the use of beam-like structures with piezoceramic sensors and actuators to perform identification of those physical parameters, and detect the damage. Experimental results are presented from tests on cantilevered composite beams damaged at different locations and different dimensions. It is demonstrated that the method can sense the presence of damage and obtain the position of a damage.

• 대한기계학회논문집A
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• 제26권5호
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• pp.835-842
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• 2002

In this paper, static and fatigue bending strengths and failure mechanisms of CFRP (carbon fiber reinforced plastics) laminates having impact damages have been evaluated. Composite laminates used for this experiment are CF/EPOXY orthotropy laminated plates, which have two-interfaces $[0^0_ 4/90^0_4]_{ sym}$. A steel ball launched by the air gun collides against CFRP laminates to generate impact damages. The damage growth during bending fatigue test is observed by the scanning acoustic microscope (SAM) and also, the fracture surfaces were observed by using the SEM (scanning electron microscope). In the case of impacted-side compression, fracture is propagated from the transverse crack generated near impact point. On the other hand, fracture is developed toward the impact point from the edge of interface-B delamination in the case of impacted-side tension. Eventually, failure mechanisms have been confirmed based on the observed delamination areas and fracture surfaces.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4879-4881
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• 2012

Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage induced by ionizing radiation, and non-homologous end joining is the predominant pathway for repair of radiation-induced DSBs. Some cell signaling pathways that respond to normal growth factors are abnormally activated in human cancer. These pathways also invoke the cell survival mechanisms that lead to resistance to radiation. The molecular connection between the EGFR and its control over DNA repair capacity appears to be mediated by one or more signaling pathways downstream of this receptor. The purpose of this mini-review was not only to highlight the relation of the EGFR signal as a regulatory mechanism to DNA repair and radiation resistance, but also to provide clues to improving existing radiation resistance through novel therapies based on the above-mentioned mechanism.

• Advances in Computational Design
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• 제8권2호
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• pp.97-112
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• 2023

The Finite Element (FE) modeling of Reinforced Concrete (RC) under seismic loading has a sensitive impact in terms of getting good contribution compared to experimental results. Several idealized model types for simulating the nonlinear response have been developed based on the plasticity distribution alone the model. The Continuum Models are the most used category of modeling, to understand the seismic behavior of structural elements in terms of their components, cracking patterns, hysteretic response, and failure mechanisms. However, the material modeling, contact and nonlinear analysis strategy are highly complex due to the joint operation of concrete and steel. This paper presents a numerical simulation of a chosen RC column under monotonic and cyclic loading using the FE Abaqus, to assessthe hysteretic response and failure mechanisms in the RC columns, where the perfect bonding option is used for the contact between concrete and steel. While results of the numerical study under cyclic loading compared to experimental tests might be unsuccessful due to the lack of bond-slip modeling. The monotonic loading shows a good estimation of the envelope response and deformation components. In addition, this work further demonstrates the advantage and efficiency of the damage distributions since the obtained damage distributions fit the expected results.