• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.575-576
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• 2021

프로토타이핑은 게임의 방향성을 정하고 향후 완성된 게임의 모습을 예상케 해 제작 프로세스를 줄이고 제작 비용을 최소화 시키는 가장 효과적인 방법이다. 본 연구에서는 게임 제작 프로젝트에서 프로토타입을 개발 방법론을 기본으로 하여 게임기획, 게임 QA, 게임 사용자의 피드백을 파이프라인으로 연결하여 게임성을 향상 시키는 개발 방법에 대하여 살펴본다. 게임 개발에 있어 위 3가지 단계는 게임을 개발하는데 있어 게임성을 확보하기 위한 효율적인 방법임을 확인한다.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.65 no.4
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• pp.457-467
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• 2020

Legumes are one of the largest families of crop plants and are widely consumed and produced for their nutritional and commercial benefits. Mung bean (Vigna radiata L.) is a legume crop that contains various functional compounds ; moreover, it has strong antioxidant properties and is becoming an increasingly important food crop. However, most previous studies on mung beans have focused on their primary metabolites. In this study, we investigated the composition and contents of phenolic compounds, fatty acids, soyasapogenol and tocopherol in mung beans cultivated in different regions and cultivated at different seeding dates. Material analysis was conducted using the following methods: LC-MS/MS, GC-FID and HPLC-ELSD. In total, 57 different samples were analyzed. Thirteen phenolic compounds were detected in mung beans. Of these, vitexin and isovitexin were the most abundant compounds, accounting for approximately 99% of phenolic compounds. The difference in phenol compounds according to the seeding dates of mung bean was not statistically significant. The total fatty acid content in beans was the highest in Pyeongchang. Significant differences in total fatty acid content were found according to the cultivation regions. Crops grown in Sohyeon and Dahyeon showed the highest soyasapogenol B content in the Suwon region, and these were the lowest in Jeonju. The total tocopherol content of beans cultivated in Dahyeon and Sohyeon was the lowest and highest in Pyeongchang. Soyasapogenol B and total tocopherol content were not significantly different according to seeding dates. This study was conducted to obtain basic data for the cultivation of mung beans with a high content of various functional materials in terms of regional specialization and optimal seeding time.

• BMB Reports
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• v.51 no.5
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• pp.249-254
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• 2018

Natural pterocarpan Medicarpin (Med) has been shown to have various beneficial biological roles, including inhibition of osteoclastogenesis, stimulation of bone regeneration and induction of apoptosis. However, the effect of the Med on lipolysis in adipocytes has not been reported. Here, we show the effect of Med on lipolysis in different mouse adipocytes and elucidate the underlying mechanism. We observed that Med treatment promoted release of glycerol in the media. Differentiated mouse brown adipose tissue cells were treated with Med. RNA-Seq analysis was performed to elucidate the effect of med and subsequently was confirmed by qRT-PCR and western blotting analyses. Med treatment increased both protein and gene expression levels of hormone-sensitive lipase (Hsl) and adipose triglyceride lipase (Atgl), which are two critical enzymes necessary for lipolysis. Mechanistic study showed that Med activates Protein Kinase A (PKA) and phosphorylates Hsl at PKA target position at $Serine^{660}$. Silencing of PKA gene by short interfering RNA attenuated the Med-induced increase in glycerol release and Hsl phosphorylation. The results unveil that Med boosts lipolysis via a PKA-dependent pathway in adipocytes and may provide a possible avenue of further research of Med mediated reduction of body fat.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.10-11
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• 2015

최근 자율 주행 분야의 연구에서 LIDAR를 활용한 분류 기법들이 연구되고 있다. 그러나 2D 영상 처리와 비교하여, 대량의 3D 포인트를 사용하는 분류 알고리즘의 성능을 평가하기 위한 지상 검증자료를 쉽게 획득하기 어렵다. 본 연구는 LIDAR를 가상 공간에서 시뮬레이션 함으로써 감지한 물체의 정보를 기록함으로써 3D 포인트 클라우드를 사용하는 다양한 분류 알고리즘의 검증을 위한 지상검증자료를 생성하는 기법을 설명한다. 본 기법은 실제 LIDAR를 사용하는 것보다 적은 비용으로 다양한 환경에서의 분류 알고리즘 성능 검증을 가능하게 한다.

• Journal of Korea Society of Industrial Information Systems
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• v.27 no.2
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• pp.115-128
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• 2022

The purpose of this study is to conduct keyword trend analysis using articles data on the impact of Covid-19 in the aviation in dustry. In this study, related articles were extracted centering on the keyword "Airline" by dividing the period of 6months before and after Covid-19 occurrence. After that, Topic modeling(LDA) was performed. Through this, The main topic was extracted in the event of an epidemic such as Covid-19, It is expected to be used as primary data to predict the aviation industry's impact when occurrence like Covid-19.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.3
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• pp.814-836
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• 2021

Wildlife ecologists and biologists recapture deer to collect tracking data from deer collars or wait for a drop-off of a deer collar construction that is automatically detached and disconnected. The research teams need to manage a base camp with medical trailers, helicopters, and airplanes to capture deer or wait for several months until the deer collar drops off of the deer's neck. We propose an intelligent robust base-station research with a low-cost and time saving method to obtain recording sensor data from their collars to a listener node, and readings are obtained without opening the weatherproof deer collar. We successfully designed the and implemented a robust base station system for automatically collecting data of the collars and listener motes in harsh wilderness environments. Intelligent solutions were also analyzed for improved data collections and pattern predictions with drone-based detection and tracking algorithms.

• Molecules and Cells
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• v.45 no.9
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• pp.603-609
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• 2022

Cells can communicate in a variety of ways, such as by contacting each other or by secreting certain factors. Recently, extracellular vesicles (EVs) have been proposed to be mediators of cell communication. EVs are small vesicles with a lipid bilayer membrane that are secreted by cells and contain DNA, RNAs, lipids, and proteins. These EVs are secreted from various cell types and can migrate and be internalized by recipient cells that are the same or different than those that secrete them. EVs harboring various components are involved in regulating gene expression in recipient cells. These EVs may also play important roles in the senescence of cells and the accumulation of senescent cells in the body. Studies on the function of EVs in senescent cells and the mechanisms through which nonsenescent and senescent cells communicate through EVs are being actively conducted. Here, we summarize studies suggesting that EVs secreted from senescent cells can promote the senescence of other cells and that EVs secreted from nonsenescent cells can rejuvenate senescent cells. In addition, we discuss the functional components (proteins, RNAs, and other molecules) enclosed in EVs that enter recipient cells.

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4499-4513
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• 2022

Spent fuel behavior of dry storage was simulated in a continuous state from steady-state operation by modifying FRAPCON-4.0 to incorporate spent fuel-specific fuel behavior models. Spent fuel behavior of a typical PWR was compared with that of NuScale Power Module (NPM^TM). Current PWR discharge burnup (60 MWd/kgU) gives a sufficient margin to the hoop stress limit of 90 MPa. Most hydrogen precipitation occurs in the first 50 years of dry storage, thereby no extra phenomenological safety factor is identified for extended dry storage up to 100 years. Regulation for spent fuel management can be significantly alleviated for LWR-based SMRs. Hydride embrittlement safety criterion is irrelevant to NuScale spent fuels; they have sufficiently lower plenum pressure and hydrogen contents compared to those of PWRs. Cladding creep out during dry storage reduces the subchannel area with burnup. The most deformed cladding outer diameter after 100 years of dry storage is found to be 9.64 mm for discharge burnup of 70 MWd/kgU. It may deteriorate heat transfer of dry storage by increasing flow resistance and decreasing the view factor of radiative heat transfer. Self-regulated by decreasing rod internal pressure with opening gap, cladding creep out closely reaches the saturated point after ~50 years of dry storage.

• Journal of Integrative Natural Science
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• v.17 no.1
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• pp.31-41
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• 2024

Calcium ions play an important role in development and intracellular signaling. Dictyostelium discoideum has 14 genes encoding calcium -binding proteins (CBPs), but the function of most CBPs during development has not yet been studied. In this study, we investigated the specific functions of CBP7, one of 14 CBPs, in development using RNA interference cell lines of CBP7, cell lines overexpressing CBP7, cell lines with point mutations in the EF-hand domain, and cell lines expressing fragment proteins. was intended to reveal. CBP7 consists of 169 amino acids and contains 4EF-hand domains. The CBP7-overexpressing cells showed complete loss of developmental process. These cells remained in the single-cell growth stage under development -inducing conditions, while wild-type cells formed aggregations within 6-8h of development and eventually formed fruiting bodies. The experiments using point-mutated CBP7 protein showed that all EF-hand domains of CBP7 were important for CBP7 to function during developmental process. These results suggest that CBP7 plays an important role in developmental processes across all EF-hand domains.

• BMB Reports
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• v.53 no.3
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• pp.142-147
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• 2020

Lipid accumulation in white adipose tissue is the key contributor to the obesity and orchestrates numerous metabolic health problems such as type 2 diabetes, hypertension, atherosclerosis, and cancer. Nonetheless, the prevention and treatment of obesity are still inadequate. Recently, scientists found that brown adipose tissue (BAT) in adult humans has functions that are diametrically opposite to those of white adipose tissue and that BAT holds promise for a new strategy to counteract obesity. In this study, we evaluated the potential of sinapic acid (SA) to promote the thermogenic program and lipolysis in BAT. SA treatment of brown adipocytes induced the expression of brown-adipocyte activation-related genes such as Ucp1, Pgc-1α, and Prdm16. Furthermore, structural analysis and western blot revealed that SA upregulates protein kinase A (PKA) phosphorylation with competitive inhibition by a pan-PKA inhibitor, H89. SA binds to the adenosine triphosphate (ATP) site on the PKA catalytic subunit where H89 binds specifically. PKA-cat-α1 gene-silencing experiments confirmed that SA activates the thermogenic program via a mechanism involving PKA and cyclic AMP response element-binding protein (CREB) signaling. Moreover, SA treatment promoted lipolysis via a PKA/p38-mediated pathway. Our findings may allow us to open a new avenue of strategies against obesity and need further investigation.