• Polymer(Korea)
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• v.38 no.4
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• pp.434-440
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• 2014

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres$^{(R)}$). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.39 no.1
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• pp.9-13
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• 2013

Objectives: Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect of BP. To date, there have been no specific reports on the incidence of BRONJ among Koreans. This study investigated the preliminary results from a nationwide survey of BRONJ in the Departments of Oral and Maxillofacial Surgery (OMFS) at individual training hospitals. Materials and Methods: A total of 15 OMFS departments (10 from dental schools, 4 from medical schools, and 1 from a dental hospital) participated in a multi-centric survey. This study assessed every BRONJ case diagnosed between January 2010 and December 2010. The patient age and BP type were evaluated. Results: A total of 254 BRONJ cases were collected. The majority of BRONJ cases were associated with oral BP therapy, while 21.8% of the cases were associated with intravenous administration. Alendronate was the drug most frequently related to BRONJ (59.2% of cases), followed by risedronate (14.3%) and zolendronate (17.0%). The average age of BRONJ patients was $70.0{\pm}10.1$ years, with a range of 38-88 years of age. With the number of BP patients in Korea reported to be around 600,000 in 2008, the estimated incidence of BRONJ is at least 0.04% or 1 per 2,300 BP patients. Conclusion: The results suggest that the estimated incidence of BRONJ in Korea is higher than the incidence of other countries. Future prospective studies should be carried out to investigate the exact epidemiological characteristics of BRONJ in Korea.

• Journal of the Korean Arthroscopy Society
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• v.12 no.1
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• pp.53-57
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• 2008

Purpose: We analyzed the clinical results after arthroscopic treatment in acute pyogenic arthritis of the knee. Materials and Methods: From July 2000 to January 2005, we reviewed 16 cases(15 patients) of acute pyogenic arthritis of the knee on which arthroscopic treatment was done. The mean age was 61.9 years and the mean follow-up period was 30.5 months. There were 8 cases with diabetes or degenerative osteoarthritis and 14 cases with acupuncture or intraarticular injection history. Results: Causative organisms were identified in 7 cases. The average postoperative antibiotics were used intravenously for 25.5 days and per orally for 22.5 days. There were 11 complications; 5 cases of partial ankylosis, 2 cases of secondary arthritis, 1 case of chronic osteomyelitis and 3 cases of death. Patients with over 3 week immobilization had higher rate of stiffness of knee joint(p=0.032) but there was no significant difference between the symptom to treatment duration and the incidence rate of complications(p=0.293). The cases of which the causative organism was detected had higher incidences of complications(p=0.034). Conclusion: The incidence of joint stiffness was higher in the patients of longer immobilization. More complications were detected in the cases of which the causative organism is detected.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.19 no.2 s.72
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• pp.195-202
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• 2006

Thin-walled structures are efficiently utilized an automobiles, aircraft, satellite and ship as well as needed light weight simultaneously. This paper presents new shape of automobile hood reinforcement that rotating parts as engine, transmission are protected by thin-walled structures. The automobile hood is concerned about the resonance occurs due to the frequency of the rotating parts. The hood must be designed by supporting the stiffness of design loads and considering the natural frequencies. Hence, it is sustained the stiffness and considered the vibration by resonance. It is deep related to ride. Therefore, the topology, shape and size optimization methods are used to design the automobile hood. Topology technique is applied to determine the layout of a structural component optimum size with maximized natural frequency by volume reduction. In this research, The optimal structure layout of an inner reinforcement of an automobile hood for the natural frequency of a designated mode is obtained by using topology optimization method. The optimum size and the optimum shape are determined by PLBA(Pshenichny-Lim-Belegundu-Arora) algorithm.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.369-372
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• 2008

In this research experimentally analyzes the flow characteristics of a combined High flowing Self-Compacting Concrete of which the viscosity agent and defoaming agent addition amount are changed, to make the combined High flowing Self-Compacting Concrete that can secure the required flow performance and air amount. As a result of the experiment, the slump flow of the combined High flowing Self-Compacting Concrete added with viscosity agent increases when the viscosity agent addition amount is 0.2%(${\times}$W %). When viscosity agent addition amount increases, viscosity agent shows that it largely deviates from the regulation value in the flow time of V-funnel, which is presented in the JSCE standards (grade 2). Also, all mixtures, except for mixtures added with viscosity agent, defoaming agent, and AE agent, do not meet a target air amount $4.5{\pm}1.5%$. High flowing Self-Compacting Concrete mixtureadded with defoaming agent shows that although time passes after its first mixture, its air amount reduces a little. Based on the experiment, we can know an optimal polymer amount to obtain the required flow performance

• Journal of Acupuncture Research
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• v.24 no.4
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• pp.55-68
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• 2007

Objectives : This research was performed to investigate the effect of herbal acupuncture(Crataegus pinnatifida) at WI-SU($BL_{21}$) on weight gain, food intake, food efficiency, serum of lipid concentrations, liver function and cardiovascular risk of rats fed high fat diet for 8weeks. Methods : Experimental groups were divided into high fat diet group(Control), high fat diet and saline in $BL_{21}$ treated group(Saline), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-1, 0.08mg/ml/g), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-2, 0.04mg/ml/g), high fat diet and Crataegus pinnatifida-herbal acupuncture in $BL_{21}$ treated group(HA-3, 0.016mg/ml/g), Herbal acupuncture was bilaterally treated at Crataegus pinnatifida-herbal acupuncture in both $BL_{21}$ 1time (0.2cc) per 4days, total 14 times in 56days. Results : Body weight was decreased in HA-1 and food efficiency was decreased in HA-1, HA-3. Feed intake was increased in HA-3. The level of serum total cholesterol was decreased in Saline, HA-1, HA-2, HA-3. The level of serum HDL-cholesterol was increased in HA-1, but LDL-cholesterol was not significant. The level of serum triglyceride was decreased in HA-1, HA-2, HA-3. and the level of serum Total Bilirubin was decreased in HA-1. The level of serum Atherogenic index was decreased in HA-1, HA-2, HA-3. and the level of serum HTR was increased in HA-3. The evel of serum AST, ALT were increased in saline, and the level of serum r-GTP was not significant. Conclusions : Crataegus pinnatifida acupuncture in Wi-Su($BL_{21}$) can control the body weight, feed intake and feed efficiency ratio, total cholesterol, HDL-cholesterol, triglyceride, total bilirubin, and prevention cardiovascular risk. And Crataegus pinnatifida acupuncture is not injurious on liver function.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.11a
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• pp.66-66
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• 2008

본 연구에서는 ITO/Ag/ITO 다층 박막을 유기발광소자와 플렉시블 광전소자의 전극으로 적용하기 위하여 선형 대항 타겟 스퍼터(Linear facing target sputter) 시스템을 이용하여 성막하였고, ITO/Ag/ITO 다층박막의 전기적, 광학적, 구조적 특성을 분석하였다. 선형 대항 타겟 스퍼터 시스템은 강한 일방항의 자계와 타겟에 걸린 음극에 의해 전자의 회전, 왕복 운동이 가능해 마주보는 두 ITO 타겟 사이에 고밀도의 플라즈마를 구속 시켜 플라즈마 데미지 없이 산화물 박막을 성막시킬 수 있는 장치이다. 대항 타겟 스퍼터 시스템을 이용하여 성막한 ITO 전극을 DC power, working pressure, Ar/O2 ratio 에 따른 특성을 각각 분석하였다. glass 기판위에 최적화된 ITO 전극을 bottom layer로 두고, bottom ITO layer 위에 thermal evaporation 을 이용하여 Ag 박막을 6~20nm의 조건에 따라 두께를 다르게 성막하고, Ag 박막을 성막한 후에 다시 bottom ITO 전극과 같은 조건으로 ITO 전극을 top layer로 성막 하였다. 두 비정질의 ITO 전극 사이에 매우 앓은 Ag 박막을 성막 함으로 해서 glass 기판위에 ITO/Ag/ITO 다층 박막전극은 매우 낮은 저항과 높은 투과도를 나타낸다. ITO/Ag/ITO 박막의 전기적 광학적 특성을 보기 위해 hall measurement와 UV/visible spectrometer 분석을 각각 진행하였다. ITO/Ag/ITO 다층 박막 전극이 매우 얇은 두께임에도 불구하고 $4\Omega$/sq.의 낮은 면저항과 85%의 높은 투과도를 나타내는 이유는 ITO/Ag/ITO 전극 사이에 있는 Ag층의 표면 플라즈몬 공명 (SPR) 현상으로 설명할 수 있다. ITO/Ag/ITO 전극의 Ag의 거동을 분석 하기위해 FESEM분석과 synchrotron x-ray scattering 분석을 하였다. ITO/Ag/ITO 전극의 Ag층이 islands의 모양에서 연속적으로 연결되는 변화과정 중에 SPR현상이 일어남을 알 수 있다. 여기서, 대항 타겟 스퍼터 시스템을 이용하여 성막한 ITO/Ag/ITO 다층박막을 OLED 또는 inverted OLEDs의 top 전극으로의 적용 가능성을 보이고 있다.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.9 s.351
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• pp.149-157
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• 2006

Turbo code, a kind of error correction coding technique, has been used in the field of digital mobile communication system. As the number of iterations increases, it can achieves remarkable BER performance over AWGN channel environment. However, if the number of iterations is increased in the several channel environments, any further iteration results in very little improvement, and requires much delay and computation in proportion to the number of iterations. To solve this problems, it is necessary to device an efficient criterion to stop the iteration process and prevent unnecessary delay and computation. In this paper, it proposes an efficient and simple criterion for stopping the iteration process in turbo decoding. By using variance values of LLR in turbo decoder, the proposed algerian can largely reduce the average number of iterations without BER performance degradation in all SNR regions. As a result of simulation, the average number of iterations in the upper SNR region is reduced by about $34.66%{\sim}41.33%$ compared to method using variance values of extrinsic information. the average number of iterations in the lower SNR region is reduced by about $13.93%{\sim}14.45%$ compared to CE algorithm and about $13.23%{\sim}14.26%$ compared to SDR algorithm.

• BMB Reports
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• v.53 no.11
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• pp.582-587
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• 2020

It is well known that oxidative stress participates in neuronal cell death caused production of reactive oxygen species (ROS). The increased ROS is a major contributor to the development of ischemic injury. Indoleamine 2,3-dioxygenase 1 (IDO-1) is involved in the kynurenine pathway in tryptophan metabolism and plays a role as an anti-oxidant. However, whether IDO-1 would inhibit hippocampal cell death is poorly known. Therefore, we explored the effects of cell permeable Tat-IDO-1 protein against oxidative stress-induced HT-22 cells and in a cerebral ischemia/reperfusion injury model. Transduced Tat-IDO-1 reduced cell death, ROS production, and DNA fragmentation and inhibited mitogen-activated protein kinases (MAPKs) activation in H₂O₂ exposed HT-22 cells. In the cerebral ischemia/reperfusion injury model, Tat-IDO-1 transduced into the brain and passing by means of the blood-brain barrier (BBB) significantly prevented hippocampal neuronal cell death. These results suggest that Tat-IDO-1 may present an alternative strategy to improve from the ischemic injury.

• BMB Reports
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• v.48 no.11
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• pp.618-623
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• 2015

FK506 binding protein 12 (FK506BP) is a small peptide with a single FK506BP domain that is involved in suppression of immune response and reactive oxygen species. FK506BP has emerged as a potential drug target for several inflammatory diseases. Here, we examined the protective effects of directly applied cell permeable FK506BP (PEP-1-FK506BP) on corneal alkali burn injury (CAI). In the cornea, there was a significant decrease in the number of cells expressing pro-inflammation, apoptotic, and angiogenic factors such as TNF-α, COX-2, and VEGF. Both corneal opacity and corneal neovascularization (CNV) were significantly decreased in the PEP-1-FK506BP treated group. Our results showed that PEP-1-FK506BP can significantly inhibit alkali burn-induced corneal inflammation in rats, possibly by accelerating corneal wound healing and by reducing the production of angiogenic factors and inflammatory cytokines. These results suggest that PEP-1-FK506BP may be a potential therapeutic agent for CAI.