• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.399-409
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• 2021

1,2-Diacetylbenzene (DAB) is a metabolite of 1,2-diethylbenzene, which is commonly used in the manufacture of plastics and gasoline. We examined the neurotoxic effects of DAB in young and old rats, particularly its effects on hippocampus. Previously, we reported DAB impairs hippocampal neurogenesis but that the underlying mechanism remained unclear. In this study, we evaluate the toxicities exhibited by DAB in the hippocampi of 6-month-old (young) and 20-month-old (old) male SD rats by treating animals intraperitoneally with DAB at 3 mg/kg/day for 1 week. Hippocampal areas were dissected from brains and RNA was extracted and subjected to RNA-seq analysis. RNA results showed animals exhibited age-dependent sensitivity to the neurotoxic effects of DAB. We observed that inflammatory pathways were up-regulated in old rats but that metabolism- and detoxification-related pathways were up-regulated in young rats. This result in old rats, especially upregulation of the TREM1 signaling pathway (an inflammatory response involved in Alzheimer's disease (AD)) was confirmed by RT-PCR. Our study results provide a better understanding of age-dependent responses to DAB and new insight into the association between DAB and AD.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.115-120
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• 2004

A bulk liquid membrane system was introduced for selective separation of an amino acid mixture. We confirmed p-diamethylaminobenzaldehyde (DAB), sulfosalicylic acid (SSA) and 1-naphtol were very useful carriers for selective separation of an amino acid mixture. As a result, Ala, Leu, Val, Phe and Ile were successfully separated by SSA, 1-naphtol in basic condition, 1-naphtol in weak acidic condition, DAB in strong acidic condition and DAB in strong basic condition. The separation mechanism was proposed by ion pair mechanism in the case of SSA and 1-naphtol and Imine bond formation mechanism was also introduced for DAB.

• Journal of the Institute of Convergence Signal Processing
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• v.4 no.2
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• pp.7-11
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• 2003

Nowadays, as digital technologies are rapidly developed and requirements for the various types of broadband multimedia services increases, the radio broadcasting is moving to digitalization. DAB(Digital Audio Broadcasting), as an alternation of existing analog radio broadcasting, is a new type of multimedia broadcasting system. DAB supports not only high-quality audio broadcasting but also various types of multimedia data services. In this paper, we investigate the performance optimization method of MOT Protocol, as the standard for additional services, to support the multimedia services in the DAB network. Because the performance of the MOT protocol is dependent on various parameters such as segment size, segment repetition and so on, we find those by simulation for performance optimization. According to simulation results, the suitable segment size is about 2Kbyte and segment repetition is 4 times for performance optimization.

• Journal of Broadcast Engineering
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• v.8 no.1
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• pp.72-79
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• 2003

The Eureka-147 Digital Audio Broadcasting(DAB) system is the new international standard for mobile broadcasting services including high-quality audio, program associated data and other multimedia data. In this paper, we design the transport frame structures for the mobile multimedia services by using the configuration of the Eureka-147 DAB multiplex and MPEG system specifications, and then compare their performances in terms of functionality and overhead. Especially, we suggest and analyze the effective transport structures, which are improved in the efficiency of media multiplexing architecture, by removing the functionally overlapped parts between DAB and MPEG systems. In addition, we evaluate the transmission environments of various DAB data channels and demonstrate the transmission error effects on the low bit rate video stream.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.792-795
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• 2004

This paper is an interference analysis from S-DAB(Satellite-Digital Audio Broadcasting) into terrestrial IMT-2000 systems intending to use the band 2630-2 655 MHz and that could be used to determine the impact of S­DAB on terrestrial IMT-2000 in the context of co-frequency sharing through the development of pfd masks.

• KSBB Journal
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• v.14 no.6
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• pp.665-671
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• 1999

In this study, enhanced production of 10-deacetylbaccatin III(10-DAB), a precursor of taxol in semisynthesis, was investigated in Taxus cuspidata cell suspension cultures. The effects of initial inoculum size and sugar concentration were examined to prove the relationship between the production of 10-DAB and cell growth. The cell growth was found to be stimulated in Schenk and Hildebrandt(SH) medium. The lower the inoculum size as well as initial sugar concentration, the faster the cell growth rate. When the initial sugar concentration was dept low, the production of 10-DAB into medium was increased. By using perfusion culture, continuous cell growth was possible until the end of culture and more than 34.67 g/L of cell concentration could by obtained. This is about 2.5 times higher level than that of control batch culture.

• Journal of Ginseng Research
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• v.23 no.2 s.54
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• pp.105-114
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• 1999

To investigate the effects of korean ginseng on the expression of transferrin receptor (TfR) in the liver cell membrane, we had carried out the experiments of $[^{3}H]thymidine$ uptake, $^{125}I-transferrin$ binding, and TfR mRNA expression in the liver after partial hepatectomy of normal and 3'-methyl-4-dimethylaminoa-zobenzene (3'-Me-DAB) treated rat with or without treatment of korean gingseng. $[^3H]thymidine$ uptake was not changed in the liver of 3'-Me-DAB or ginseng treated rat compared to that of control rat, but increased in that of partial hepatectomy of normal or 3'-Me-DAB treated rat. And this increased $[^{3}H]thymidine$ uptake was lowered slightly by the treatment of ginseng. Transferrin binding sites in the liver plasma membrane of ginseng treated rat with or without partial hepatectomy were similar, but increased in that of 3'-Me-DAB treated rat with or without partial hepatectomy compared to those of each control rat and these increased binding sites were reduced by ginseng treatment. Transferrin binding affinity (l/kd) was not changed by ginseng treatment, but tended to decrease in the liver of 3'-Me-DAB treated rat or in those after partial hepatectomy of all groups and reverse by ginseng treatment in 3'-Me-DAB treated rat. The expression of TfR mRNA was increased in the liver of 3'-Me-DAB treated rat with partial hepatectomy (peak at 24 hours), but lowered by ginseng treatment in this rat. From these results, it is suggested that korean ginseng has no effect on the increased expression of TfR with decreased affinity in the cell membrane of regenerated liver after partial hepatectomy of rat, but could inhibt that of 3'-Me-DAB treated rat through the regulation of DNA synthesis or TfR mRNA in partial.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.10.1-10.11
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• 2018

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta ($ER{\beta}$) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2/DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse $ER{\beta}$-enhanced BCa cell growth and invasion. Further mechanism dissection found that $ER{\beta}$ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The $ER{\beta}$ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3' UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified $ER{\beta}$/miR-92a/DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this $ER{\beta}$-mediated signal pathway to better suppress BCa progression.

• Proceedings of the KIPE Conference
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• 2018.07a
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• pp.310-311
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• 2018

본 논문은 배터리팩 테스터에 적용되는 3상 전류원 기반의 Dual Active Converter(DAB)의 효율 향상 기법에 대해 제안한다. 기존의 1, 2차 측 스위치의 위상차를 통해 컨버터의 출력을 제어하는 경우, 변압기 1, 2차 측 전압 차이에 의해 스위치에 순환 전류가 커지고 도통 손실이 증가하는 문제가 있다. 본 논문에서는 3상 전류원 기반의 DAB 컨버터의 1, 2차 측 스위치의 위상과 시비율을 동시에 제어함으로써 스위치 도통 손실을 저감할 수 있는 방식을 제안한다. 제안하는 제어방법은 시뮬레이션 및 실험을 통해 검증하였다.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2002.11a
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• pp.207-211
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• 2002

DAB(Digital Audio Broadcasting)는 고품질의 오디오뿐만 아니라 멀티미디어 데이터 서비스를 제공할 수 있는 새로운 국제표준이다. 본 논문에서는 Eureka-147 DAB를 통해 멀티미디어 데이터를 효율적으로 전송하기 위한 방안으로 DAB의 다중화 구조와 MPEG-2와 MPEG-4 시스템 규격을 이용하여 미디어들 간의 동기화와 다중화 기능을 제공할 수 있는 전송프레임 구조를 제안하고, 실험을 통하여 각 프레임 구조에 대한 성능을 비교·평가하였다. 특히 DAB의 다중화와 중복되는 MPEG 시스템의 기능을 제거하여 다중화 프레임 구조의 효율성을 향상시키는 방안들을 제시하고, 이를 비교·분석하였다. 또한 구현한 시스템을 이용하여 멀티미디어데이터를 다양한 환경의 채널을 통해 전송할 때 전송 오류의 영향을 측정하고 평가하였다.