• The Transactions of the Korean Institute of Electrical Engineers P
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• v.64 no.3
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• pp.143-145
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• 2015

One of the many problems besetting the converter designer is being able to design a switching power supply that can operate in the range of very wide input voltage. Specially, in an emergency diesel generator system, the AVR(Automatic Voltage Regulator) is a regulator which regulates the output voltage of the generator at a nominal constant voltage level. In addition, the AVR must be operated in very wide input voltage. Therefore, a power supply for the AVR must be operated at the very wide input voltage range. In this paper, a quasi-resonant flyback power supply with very wide input voltage range is proposed. Also, the performance of the proposed power supply is demonstrated through experiments.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.101-101
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• 1997

As part of a drug discovery program to develope more effective platinum-based anticancer drugs, a series of platinum complexes trans -diaminocyclohexane platinum bi sdiphenylphosphino -ethane (KHPC-002) cis-diaminocyclohexane platinum bisdiphenylphosphino-ethane (KHPC-006) has been evaluated in vitro against 4 human carcinoma cell lines with those of cisplatin using a tetrazolium-based colorimetric assay (MTT assay). The cell lines were two human bladder carcinoma cell lines, HT-1197 and HT-1376, human colon carcinoma cell line, HCT-116, and prostate cancer cell line DU-145.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.111-111
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• 1997

As part of a drug discovery program to develope more effective platinum-based anticancer drugs, a series of platinum complexes trans-diaminocyclohexane platinum bi sdiphenylphosphino - ethane ( KHPC- 002) cis-diaminocyclohexane platinum bi sdiphenylphosphino - ethane ( KHPC- 006) has been evaluated in vitro against 4 human carcinoma cell lines with those of cisplatin using a tetrazolium-based colorimetric assay (MTT assay). The cell lines were two human bladder carcinoma cell lines, HT-1197 and HT-1376, human colon carcinoma cell line, HCT-116, and prostate cancer cell line DU-145. in vitro cytotoxic potential of each platinum complex was expressed as the cytotoxicity index (Cl, %).

• Journal of Applied Biological Chemistry
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• v.48 no.4
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• pp.198-201
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• 2005

Two known isoquinoline alkaloids, (+)-chelidonine (1) and (-)-stylopine (2), were isolated from $CHCl_3$-soluble fraction of whole plants of Chelidonium majus L. var. asiaticum, and their structures were identified by spectroscopic methods and X-ray crystallographic analysis. Two isolates (1 and 2) were examined for their in vitro cytotoxic activities against five human cancer cell lines including DU-145 (prostate), MCF (breast), A549 (lung), HePG2 (liver), and HT-29 (colon) by sulphorhodamine B (SRB) assay.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.165-165
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• 2004

• Preventive Nutrition and Food Science
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• v.11 no.4
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• pp.278-284
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• 2006

The beneficial effects of digested onion extracts have been assessed by antimutagenic and anticancer activities by Ames test and SRB test. The total phenolic acids and flavonoids in onion extracts were determined. Red and yellow onions contain more phenolic acids and flavonoids than those in the white onion. Digested, extracts showed antimutagenic activity and anticancer activity, and it appears that the antimutagenic activity of digested extracts of onion against mutagens and anticancer activities were related to their phenols and flavonoids contents. Moreover, the extracts inhibited the proliferation of four human tumorigenic cell lines such as HT-29 (colon), MCF-7 (breast), DU-145 (prostate) and HepG2 (liver), in a dose-dependent manner. Phenolic acids and flavonoids caused oxidative damage to the cancer cell lines and induced apoptosis. Generally, red onion extracts showed effective antimutagenic and anticancer activity, and the digested red onion extracts elicited stronger antimutagenic activity than those of the onion extracts without digestion.

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.08a
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• pp.144-145
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• 2005

• Journal of The Korean Society of Clinical Toxicology
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• v.6 no.2
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• pp.142-145
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• 2008

Lamotrigine is a newer anti-epileptic drug for adjunctive treatment of refractory epilepsy, partial seizures, generalized tonic-clonic seizures, and bipolar disorder. Lamotrigine overdose causes serious central nervous and cardiovascular problems, but reports are uncommon. Few lamotrigine overdoses have been described because anti-epileptic drug use is limited and usually used with combination of other anti-epileptic drugs. In addition, most patients visit emergency departments with multi-drug overdoses, so few cases of lamotrigine poisoning alone exist. We had a female patient visit our emergency department a couple of hours after a lamotrigine overdose treated with intravenous hydration and urine alkalization by NaHCO3. She recovered successfully without any evidence of renal injury. However, she developed profound rhabdomyolysis, a previously unreported complication of this medication. We suggest that serial creatine kinase levels should be measured after lamotrigine poisoning.

• Journal of the Korean Chemical Society
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• v.63 no.2
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• pp.85-93
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• 2019

A panel of chalcone-sulphonamide hybrids has been designed by tethering appropriate sulphonamide scaffold with substituted chalcones as a multi-target drug for anticancer screening. Chalcones were prepared by Claisen-Schmidt condensation reaction of a substituted aldehyde with para aminoacetophenone. All the synthesized compounds were evaluated against selected five cancer cell lines, MCF-7 (Breast cancer), DU-145 (Human prostate Carcinoma), HCT-15 (Colon cancer), NCIH-522 (stage 2, adenocarcinoma; non-small cell lung cancer) and HT-3 (Human cervical cancer). Most of the synthesized chalcone-sulphonamide hybrids showed amended cytotoxic activity against various cancer cell lines which may be attributed to the linkage of sulphonamide with chalcone skeleton. The synthesized compounds were characterized by FT-IR, $^1H$ NMR, $^{13}C$ NMR and HR-LCMS and spectral study assert the structures of synthesized sulphonamide-chalcone hybrids.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2020.11a
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• pp.145-146
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• 2020

현재 IMO에서는 자율운항선박의 상용화를 위해 국제표준 규정 개발을 위한 논의 중이며, 이러한 규정을 개발하기 위한 사전작업으로서 기존 협약을 자율운항선박에 적용하였을 때 발생하는 조치를 식별하기 위한 RSE 작업을 수행하고 있다. RSE 작업은 해사안전위원회(MSC), 법률위원회(LEG) 그리고 간소화위원회(FAL) 별로 각 위원회에서 담당하고 있는 협약들을 대상으로 수행하고 있다. 본 논문에서는 각 위원회별로 수행한 RSE 작업 결과를 기반으로 자율운항선박의 상용화를 위한 국제표준 규정 개발 단계에서 향후 추가적인 논의 및 검토가 필요한 잠재격차 및 주제들을 종합적으로 분석하여 제시하였다.