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Cytotoxic Isoquinoline Alkaloids from Chelidonium majus var. asiaticum  

Lee, Jun (Department of Enviro-Biotechnology, Gyeongsang National University)
Shon, Mi-Yae (Department of Food Science, Jinju National University)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Ha, Tae-Joung (Yeongnam Agricultural Research Institute, NICS, RDA)
Hwang, Seon-Woo (Department of Enviro-Biotechnology, Gyeongsang National University)
Nam, Sang-Hae (Department of Food Science, Jinju National University)
Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University)
Park, Ki-Hun (Department of Enviro-Biotechnology, Gyeongsang National University)
Yang, Min-Suk (Department of Enviro-Biotechnology, Gyeongsang National University)
Publication Information
Journal of Applied Biological Chemistry / v.48, no.4, 2005 , pp. 198-201 More about this Journal
Abstract
Two known isoquinoline alkaloids, (+)-chelidonine (1) and (-)-stylopine (2), were isolated from $CHCl_3$-soluble fraction of whole plants of Chelidonium majus L. var. asiaticum, and their structures were identified by spectroscopic methods and X-ray crystallographic analysis. Two isolates (1 and 2) were examined for their in vitro cytotoxic activities against five human cancer cell lines including DU-145 (prostate), MCF (breast), A549 (lung), HePG2 (liver), and HT-29 (colon) by sulphorhodamine B (SRB) assay.
Keywords
Chelidonium majus var. asiaticum; Chelidonine; Stylopine; X-ray analysis; Cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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