Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Cytotoxic Isoquinoline Alkaloids from Chelidonium majus var. asiaticum

  • Lee, Jun (Department of Enviro-Biotechnology, Gyeongsang National University) ;
  • Shon, Mi-Yae (Department of Food Science, Jinju National University) ;
  • Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Ha, Tae-Joung (Yeongnam Agricultural Research Institute, NICS, RDA) ;
  • Hwang, Seon-Woo (Department of Enviro-Biotechnology, Gyeongsang National University) ;
  • Nam, Sang-Hae (Department of Food Science, Jinju National University) ;
  • Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University) ;
  • Park, Ki-Hun (Department of Enviro-Biotechnology, Gyeongsang National University) ;
  • Yang, Min-Suk (Department of Enviro-Biotechnology, Gyeongsang National University)
  • Published : 2005.12.31
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Abstract

Two known isoquinoline alkaloids, (+)-chelidonine (1) and (-)-stylopine (2), were isolated from $CHCl_3$-soluble fraction of whole plants of Chelidonium majus L. var. asiaticum, and their structures were identified by spectroscopic methods and X-ray crystallographic analysis. Two isolates (1 and 2) were examined for their in vitro cytotoxic activities against five human cancer cell lines including DU-145 (prostate), MCF (breast), A549 (lung), HePG2 (liver), and HT-29 (colon) by sulphorhodamine B (SRB) assay.

Keywords

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