Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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A novel cis/trans-diaminocyclohexane platinum coordination complexes possessing in vitro and in vivo antitumor activity

  • Jung, Jee-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Chang, Sung-Goo (Department of Urology, School of Medicine, Kyung Hee University) ;
  • Lee, Kyung-Tae (College of Pharmacy, Kyung Hee University) ;
  • Park, Young-Soo (College of Pharmacy, Kyung Hee University) ;
  • Lee, Joo-Han (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.) ;
  • Lee, Kyou-Heung (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.) ;
  • Kim, Sang-Lin (Boryung Central Research Institute, Boryung Pharmaceutical Co., LTD.)
  • Published : 1997.04.01
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Abstract

As part of a drug discovery program to develope more effective platinum-based anticancer drugs, a series of platinum complexes trans -diaminocyclohexane platinum bi sdiphenylphosphino -ethane (KHPC-002) cis-diaminocyclohexane platinum bisdiphenylphosphino-ethane (KHPC-006) has been evaluated in vitro against 4 human carcinoma cell lines with those of cisplatin using a tetrazolium-based colorimetric assay (MTT assay). The cell lines were two human bladder carcinoma cell lines, HT-1197 and HT-1376, human colon carcinoma cell line, HCT-116, and prostate cancer cell line DU-145.

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