• Title/Summary/Keyword: DU

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HYBRID LIGHT DUTY VEHICLES EVALUATION PROGRAM

  • Trigui, R.;Badin, F.;Jeanneret, B.;Harel, F.;Coquery, G.;Lallemand, R.;Ousten, JP.;Castagne, M.;Debest, M.;Gittard, E.;Vangraefshepe, F.;Morel, V.;Baghli, L.;Rezzoug, A.;Labbe, J.;Biscalia, S.
    • International Journal of Automotive Technology
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    • v.4 no.2
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    • pp.65-75
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    • 2003
  • A HEV evaluation program, funded by ADEME, was carried out by a group of Laboratories of different specialties in order to evaluate and compare consumption, emission and component technologies of the three first HEVs put on the market (Toyota Prius, Nissan Tino and Honda Insight). This paper presents the results obtained until now. These results show good consumption and emission performance of the tested vehicles compared to conventional ones. The energy management seems to be globally the same for the three vehicles excepting for cold stans where the Insight allows a very earlier stop of the engine compared to the Tino and especially to the Prius. A mapping of the engine consumption of the Prius and the Insight was performed in order to furnish data for the simulation models. The Permanent Magnet motors of the Prius and Tino have different number of pair poles and then different emf at a given speed. The low emf values of the Prius allow operation at high speed with less field weakening control than for the Tino. The inverters of the Prius and the Tino, controlled by a PWM at respectively 5 kHz and 7 kHz switching frequency, are made of IGBTs with high commutation performances.

A Study on the Costume of Ksitigarbha Bodhisattvas Buddist Drawing in the Koryo Dynasty (高麗時代 地藏菩薩圖의 服飾에 관한 硏究)

  • 전혜숙;김진희
    • The Research Journal of the Costume Culture
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    • v.7 no.1
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    • pp.177-195
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    • 1999
  • In this study, I tried to find out the diffusion and the receptive process of new culture with examining the costume of Ksitigrbha Bodhisattva Buddist drawings, which were drawn by our people in the Koryo dynasty. I classified each part of the costume of Ksitigarbha Bodhisattvas and found out overall characteristics and analyzed their meaning. The results are as follows ; First, because there were several ‘du-gun’ of peculiar types, Ksitigarbha Bodhisattvas were supposed to have ‘du-gun’ before Buddhism was diffused throughout China through the West. The type of ‘du-gun’ was deveoloed more and more through the West and appeared as the type of ‘du-gun’ of Ksitigarbha Bodhisattvas in ‘Ji-Jang Do’ in the Koryo dynasty. And the pecuilar type of du-gun was supposed to have been under the influence of the costume of Taoism in those days. Second, I think that the Buddhist defication of the costume in Ksitigarbha Bodhisattvas was a phenomenon in the process that belief in Ksitigarbha was united with popular belief and widely diffused and became to have its important meaning of its own. Third, the feminine tendency of the costume in Ksitigarbha meaning of the early goddess remained partly in the costume even though Ksitigarbha Bodhisattva was god in India. Fourth, Several found shape designs are supposed to be affected by the diplomatic relationship with the West. As mentioned above the costume ‘Ji-Jang Do’ in the Koryo dynasty was affected by china\`s, world-wide in that ga-sa was Gandira style based on Hellenistic art. Therefore, the reception if new culture was selective on the basis of the country\`s need and this new culture was changed into something peculiar to affect other countries simultaneously with reception.

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Fermentation Characteristics of Exopolysaccharide-Producing Lactic Acid Bacteria from Sourdough and Assessment of the Isolates for Industrial Potential

  • Jung, Seung-Won;Kim, Wang-June;Lee, Kwang-Geun;Kim, Cheol-Woo;Noh, Wan-Seob
    • Journal of Microbiology and Biotechnology
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    • v.18 no.7
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    • pp.1266-1273
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    • 2008
  • Lactic acid bacteria (LAB) with antimicrobial activity and high exopolysaccharide (EPS) production ability isolated from sourdough were studied for their fermentation characteristics as potential new starter cultures. The values of pH, titratable acidity, and viable cell counts were $4.06{\pm}0.009-4.50{\pm}0.015,\;0.787{\pm}0.020%-1.172{\pm}0.018%,\;and\;8.78{\pm}0.08-8.98{\pm}0.06$ log CFU/ml, respectively. In order to select probiotics with a high survival rate in the gut, isolates were tested to assess resistance against the artificial gastric acid and bile juice. Viable LAB counts were significantly (p<0.05) affected by the acidity. At pH 2.0, the total declines in the initial bacterial counts were 4.52$\pm$0.07 log for S. thermophilus St-Body-1, >7.98$\pm$0.03 log for E. flavescens DU-10, >7.95$\pm$0.05 log for E. faecium DU-12, and 3.15$\pm$0.06 log for L. amylovorus DU-21. Among the strains, L. amylovorus DU-21 was the only strain that had bile tolerance under simulated gastrointestinal conditions. In order to improve EPS production by L. amylovorus DU-21, the influence of carbon source was studied. When glucose was used as a carbon source, EPS production dramatically increased to 17.19$\pm$0.28 g/l (p<0.05). The maximum cell growth (10.012$\pm$>0.012 log CFU/ml) and EPS production (18.71$\pm$0.19 g/l) were achieved when 15 g/l of glucose was employed as the carbon source.

Trifolium pratense induces apoptosis through caspase pathway in FaDu human hypopharynx squamous carcinoma cells

  • Lee, Seul Ah;Park, Bo-Ram;Kim, Chun Sung
    • International Journal of Oral Biology
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    • v.44 no.3
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    • pp.81-88
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    • 2019
  • Trifolium pratense leaves (red clover) has been used in Oriental and European folk medicine for the treatment of whooping cough, asthma, and eczema, and is now being used to treat and alleviate the symptoms, such as hot flushes, cardiovascular health effects that occur in postmenopausal women. However, relatively little scientific data is available on the physiological activity of this plant. Therefore, in this study, we investigated the anti-cancer activity of T. pratense leaves using methanol extract of T. pratense leaves (MeTP) on human FaDu hypopharyngeal squamous carcinoma cells. MeTP inhibited the viability of FaDu cells by inducing apoptosis through the cleavage of procaspase-3, -7, and -9 and poly (adenosine diphosphate ribose-ribose) polymerase (PARP), downregulation of Bcl-2, and upregulation of Bax, as determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, Live & dead assay, 4'6-diamidino-2-phenylindole stain, fluorescence-activated cell sorting analysis, and Western blot analysis. In addition, colony formation was slightly inhibited when FaDu cells were treated with a non-cytotoxic concentration (0.125 mg/mL) of MeTP and almost completely inhibited when cells were treated with 0.25 mg/mL MeTP. Collectively, these results indicate that MeTP induced cell apoptosis via caspase- and mitochondrial-dependent apoptotic pathways, and inhibited colony formation of cancer cells in FaDu human hypopharyngeal squamous carcinoma cells. These findings suggest MeTP should be considered for clinical development as a chemotherapeutic option in oral cancer.

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer

  • He, Shan;Lyu, Fangqiao;Lou, Lixia;Liu, Lu;Li, Songlin;Jakowitsch, Johannes;Ma, Yan
    • Journal of Ginseng Research
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    • v.45 no.2
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    • pp.273-286
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    • 2021
  • Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells

  • Kang, Kyeong-Rok;Kim, Jae-Sung;Lim, HyangI;Seo, Jeong-Yeon;Park, Jong-Hyun;Chun, Hong Sung;Yu, Sun-Kyoung;Kim, Heung-Joong;Kim, Chun Sung;Kim, Do Kyung
    • The Korean Journal of Physiology and Pharmacology
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    • v.26 no.6
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    • pp.447-456
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    • 2022
  • The present study was carried out to investigate the effect of Arctigenin on cell growth and the mechanism of cell death elicited by Arctigenin were examined in FaDu human pharyngeal carcinoma cells. To determine the apoptotic activity of Arctigenin in FaDu human pharyngeal carcinoma cells, cell viability assay, DAPI staining, caspase activation analysis, and immunoblotting were performed. Arctigenin inhibited the growth of cells in a dose-dependent manner and induced nuclear condensation and fragmentation. Arctigenin-treated cells showed caspase-3/7 activation and increased apoptosis versus control cells. FasL, a death ligand associated with extrinsic apoptotic signaling pathways, was up-regulated by Arctigenin treatment. Moreover, caspase-8, a part of the extrinsic apoptotic pathway, was activated by Arctigenin treatments. Expressions of anti-apoptotic factors such as Bcl-2 and Bcl-xL, components of the mitochondria-dependent intrinsic apoptosis pathway, significantly decreased following Arctigenin treatment. The expressions of pro-apoptotic factors such as BAX, BAD and caspase-9, and tumor suppressor -53 increased by Arctigenin treatments. In addition, Arctigenin activated caspase-3 and poly (ADP-ribose) polymerase (PARP) induced cell death. Arctigenin also inhibited the proliferation of FaDu cells by the suppression of p38, NF-κB, and Akt signaling pathways. These results suggest that Arctigenin may inhibit cell proliferation and induce apoptotic cell death in FaDu human pharyngeal carcinoma cells through both the mitochondria-mediated intrinsic pathway and the death receptor-mediated extrinsic pathway.

Dating Sun's Locations at Equinoxes Inscribed on Cheonsang Yeolcha Bunyajido

  • Sang-Hyeon Ahn
    • Journal of The Korean Astronomical Society
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    • v.56 no.2
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    • pp.201-212
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    • 2023
  • The inscription of Cheonsang Yeolcha Bunyajido (天象列次分野之圖) has the sun's locations at the equinoxes, which must have been copied from the astronomical treatises in Chinese historical annals, Songshu (宋書) and Jinshu (晉書). According to the treatises, an astronomer Wang Fan (王蕃, 228-266 CE) referred those values from a calendrical system called Qianxiangli (乾象曆, 223 CE), from which it is confirmed that it adopted the sun's location at the winter solstice of the $(21{\frac{1}{4}})^{th}$ du of the 8th lunar lodge Dou (斗) as the reference direction for equatorial lodge angles. This indicates that the sun's locations at equinoxes and solstices in the calendrical system are the same as those in Jingchuli (景初曆, 237 CE). Hence, we propose that the sun's location at the autumnal equinox in Cheonsang Yeolcha Bunyajido should be corrected from 'wu du shao ruo' (五度少弱), meaning the $(5{\frac{1}{6}})^{th}$ du, to 'wu du ruo' (五度弱), meaning the $(4{\frac{11}{12}})^{th}$ du, of the first lunar lodge Jiao (角), as seen in Jingchuli. We reconstruct the polar coordinate system used in circular star charts, assuming that the mean motion rule was applied and its reference direction was the sun's location at the winter solstice. Considering the precession, we determined the observational epoch of the sun's location at the winter solstice to be to = -18.3 ± 43.0 adopting the observational error of the so-called archaic determinatives (古度). It is noteworthy that the sun's locations at equinoxes inscribed in Cheonsang Yeolcha Bunyajido originated from Houhan Sifenli (後漢 四分曆) of the Latter Han dynasty (85 CE), while the coordinate origin in the star chart is related to Taichuli (太初曆) of the Former Han dynasty (104 BCE).

The Variations of Stratospheric Ozone over the Korean Peninsula 1985~2009 (한반도 상공의 오존층 변화 1985~2009)

  • Park, Sang Seo;Kim, Jhoon;Cho, Nayeong;Lee, Yun Gon;Cho, Hi Ku
    • Atmosphere
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    • v.21 no.4
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    • pp.349-359
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    • 2011
  • The climatology in stratospheric ozone over the Korean Peninsula, presented in previous studies (e.g., Cho et al., 2003; Kim et al., 2005), is updated by using daily and monthly data from satellite and ground-based data through December 2009. In addition, long-term satellite data [Total Ozone Mapping Spectrometer (TOMS), Ozone Monitoring Instrument (OMI), 1979~2009] have been also analyzed in order to deduce the spatial distributions and temporal variations of the global total ozone. The global average of total ozone (1979~2009) is 298 DU which shows a minimum of about 244 DU in equatorial latitudes and increases poleward in both hemispheres to a maximum of about 391 DU in Okhotsk region. The recent period, from 2006 to 2009, shows reduction in total ozone by 6% relative to the values for the pre-1980s (1979~1982). The long-term trends were estimated by using a multiple linear regression model (e.g., WMO, 1999; Cho et al., 2003) including explanatory variables for the seasonal variation, Quasi-Biennial Oscillation (QBO) and solar cycle over three different time intervals: a whole interval from 1979 to 2009, the former interval from 1979 to 1992, and the later interval from 1993 to 2009 with a turnaround point of deep minimum in 1993 is related to the effect of Mt. Pinatubo eruption. The global trend shows -0.93% $decade^{-1}$ for the whole interval, whereas the former and the later interval trends amount to -2.59% $decade^{-1}$ and +0.95% $decade^{-1}$, respectively. Therefore, the long-term total ozone variations indicate that there are positive trends showing a recovery sign of the ozone layer in both North/South hemispheres since around 1993. Annual mean total ozone (1985~2009) is distributed from 298 DU for Jeju ($33.52^{\circ}N$) to 352 DU for Unggi ($42.32^{\circ}N$) in almost zonally symmetric pattern over the Korean Peninsula, with the latitudinal gradient of 6 DU $degree^{-1}$. It is apparent that seasonal variability of total ozone increases from Jeju toward Unggi. The annual mean total ozone for Seoul shows 323 DU, with the maximum of 359 DU in March and the minimum of 291 DU in October. It is found that the day to day variability in total ozone exhibits annual mean of 5.7% in increase and -5.2% in decrease. The variability as large as 38.4% in increase and 30.3% in decrease has been observed, respectively. The long-term trend analysis (e.g., WMO, 1999) of monthly total ozone data (1985~2009) merged by satellite and ground-based measurements over the Korean Peninsula shows increase of 1.27% $decade^{-1}$ to 0.80% $decade^{-1}$ from Jeju to Unggi, respectively, showing systematic decrease of the trend magnitude with latitude. This study also presents a new analysis of ozone density and trends in the vertical distribution of ozone for Seoul with data up to the end of 2009. The mean vertical distributions of ozone show that the maximum value of the ozone density is 16.5 DU $km^{-1}$ in the middle stratospheric layer between 24 km and 28 km. About 90.0% and 71.5% of total ozone are found in the troposphere and in the stratosphere between 15 and 33 km, respectively. The trend analysis reconfirms the previous results of significant positive ozone trend, of up to 5% $decade^{-1}$, in the troposphere and the lower stratosphere (0~24 km), with negative trend, of up to -5% $decade^{-1}$, in the stratosphere (24~38 km). In addition, the Umkehr data show a positive trend of about 3% $decade^{-1}$ in the upper stratosphere (38~48 km).

Le Lien de Causalit$\acute{e}$ et la Prescription Extinctive en Mati$\acute{e}$re de Responsabilit$\acute{e}$ M$\acute{e}$dicale en Droit Français (프랑스법상 의사책임분야(醫事責任分野)에서의 인과관계와 소멸시효론에 관한 소고)

  • Park, Soo-Gon
    • The Korean Society of Law and Medicine
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    • v.15 no.2
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    • pp.367-397
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    • 2014
  • Dans le contentieux m$\acute{e}$dical, il est difficile de prouver l'existence d'un lien de causalit$\acute{e}$ entre la faute m$\acute{e}$dicale et les pr$\acute{e}$judices subis par la victime. R$\acute{e}$partir bien de façon raisonnable la charge de la preuve du lien causal est alors une des questions pr$\acute{e}$occup$\acute{e}$es par la doctrine cor$\acute{e}$enne. La Cour supr$\hat{e}$me cor$\acute{e}$enne semble toutefois facilliter l'indemnisation des victimes dans les cas o$\grave{u}$ la responsabilit$\acute{e}$ du m$\acute{e}$decin a ${\acute{e}}t{\acute{e}}$ mise en cause, et cela en admettant des fois une solution op$\acute{e}$rant un renversement de la charge de la preuve du lien causal. Une telle attitude a ${\acute{e}}t{\acute{e}}$ m$\hat{e}$me affirm$\acute{e}$e dans un arr$\hat{e}$t rendu r$\acute{e}$cemment en cas de dommage caus$\acute{e}$ par le fait du produit de sant$\acute{e}$, notamment pour le cas de contamination virale par voie de transfusion. La Cour a $\acute{e}$galement reconnu que l'action se pr$\acute{e}$scrit $\grave{a}$ partir du moment de la consolidation du pr$\acute{e}$judice. Aux termes de cette $\acute{e}$tude, on pourra constater que le juge français reconna$\hat{i}$t aussi l'assouplissement de la charge de la preuve du lien de causalit$\acute{e}$ en mati$\acute{e}$re d'action m$\acute{e}$dicale. Il faudra toutefois souligner que le ph$\acute{e}$nom$\acute{e}$ne ne soit pas g$\acute{e}$n$\acute{e}$ralis$\acute{e}$ en droit français, d'autant plus que la pr$\acute{e}$somption de l'existence de la causalit$\acute{e}$ en la mati$\grave{e}$re a $\acute{e}$t$\acute{e}$ admise de mani$\grave{e}$re restrictive par la l$\acute{e}$gislation sp$\acute{e}$cifique. Tel $\acute{e}$tait notamment le cas pour les accidents de la contamination par le virus du sida ou de l'h$\acute{e}$patite C survenus apr$\grave{e}$s la transfusion. En d$\acute{e}$finitive, on peut dire qu'en droit français, le principe est maintenu en cas de manquement $\grave{a}$ une obligation de r$\acute{e}$sultat n$\acute{e}$e du contrat m$\acute{e}$dical, tandis que la Cour de cassation admet parfois en mati$\grave{e}$re de droit commun de la responsabilit$\acute{e}$ contractuelle la pr$\acute{e}$somption de causalit$\acute{e}$ en cas d'inex$\acute{e}$cution des obligations de r$\acute{e}$sultat. En fait, la pr$\acute{e}$somption de causalit$\acute{e}$ dans le contentieux m$\acute{e}$dical pourra mener les m$\acute{e}$decins $\grave{a}$ se diriger vers les traitements d$\acute{e}$fensifs. Cette situation peut m$\hat{e}$me conduire $\grave{a}$ emp$\hat{e}$cher le d$\acute{e}$veloppement de la science m$\acute{e}$dicale, enfin $\grave{a}$ une situation d$\acute{e}$savantageuse aux patients. Il y a alors lieu de se m$\acute{e}$fier des int$\acute{e}$r$\hat{e}$ts d$\acute{e}$s$\acute{e}$quilibr$\acute{e}$s entre le m$\acute{e}$decin et le patient. De ce point de vue, on peut estimer que le droit français donne des suggestions aux juristes cor$\acute{e}$ens dans la recherche des solutions plus ad$\acute{e}$quates en ce qui concerne la charge de la preuve du lien causal en mati$\acute{e}$re de responsabilit$\acute{e}$ m$\acute{e}$dicale.

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Performance Analysis of the Reed-Soomon Codes (Reed-Solomon 부호의 성능분석)

  • 정제홍;박진수
    • The Journal of the Acoustical Society of Korea
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    • v.12 no.1
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    • pp.20-26
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    • 1993
  • 본 논문은 Reed-Solomon부호의 복호가능어 가중치 분포에 대한 명시적 식과 근사식을 구하여 이를 복호기 오류확률 PE(u)에 적용하고, 복호기 오류확률의 상한식을 구하고 분석하였다. t+1개 이상의 오류가 발생했을 때 복호기 오류확률의 추정치 Q와 Q'를 개선하여 식 Q를 제안하고, 컴퓨터 시뮬레이션을 수행한 결과 가중치 u가 커질 때 복호기 오류확률은 추정치 Q와 Q'에는 접근하였으나, 본 논문에서 제안한 Q와는 일치됨을 확인하였다. 그리고, 가중치 u가 부호의 길이 n에 접근할 때, 복호가능어의 명시적 식 Du와 근사식 Du'가 서로 일치하고, 복호기 오류확률 Pe(u)와 근사오류확률 Pe(u')가 일치함을 보였다. 또하 t+1개 이상의 오류가 발생했을 때 복호기 오류확률은 1/t!보다 작으며, 가중치분포 Au에 Vn(t)를 곱한 결과는 근사복호가능어 Du'와 일치함도 확인하였다.

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