• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2815-2819
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• 2014

Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydan Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.

• 대한전자공학회논문지SP
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• 제41권6호
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• pp.9-18
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• 2004

본 논문에서 우리는 시차공간영상 (disparity space image)을 이용한 새로운 스테레오 정합 방법을 제안한다. 본 논문에서는 실측 제어점 대신 영상 안에서 특징점을 추출하여 정합영역을 설정하였고, 간단한 비용행렬을 정의하였다. 그리고 정합 속도를 증가시키기 위해 화소 단위의 정합을 이용하였다. 화소 단위의 정합은 정합 속도는 향상시키지만, 주변 영역을 이용하지 않기 때문에 정합의 정확성이 낮아진다. 이러한 단점을 보완하기 위해 시차공간영상의 특성을 이용하여 정합경로를 확대시켜서 주변 영역을 최대한 이용하였다. 또한, 현재 위치에서 이전과 이후의 시차공간영상을 체적화하여 전후의 시차공간영상을 이용함으로써 정합의 정확도를 더욱 향상시키는 정합 보정 모듈을 추가하였다. 본 논문에서 제안된 알고리즘은 다양한 영상에 적용하여 실험하였고, 그 결과 제안된 방법의 우수한 성능을 확인할 수 있었다.

• 한국수산과학회지
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• 제40권3호
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• pp.167-177
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• 2007

We measured the salinity, pH, and concentrations of $^{222}Rn$ and nutrients in groundwater in the southeastern coastal aquifer off Busan from March to September 2005 to evaluate its submarine discharge and geochemical characteristics. Salinity in coastal groundwater increased sharply at 20 m depth and exceeded 25 ppt below 40 m during the study period, indicating that a strong transition zone between fresh groundwater and seawater developed between 20 and 40 m depths. Fresh groundwater in the upper layer of this transition zone was characterized by high pH, $^{222}Rn$, dissolved inorganic nitrogen (DIN), and dissolved inorganic phosphorus (DIP) and low dissolved inorganic silicate (DSi) relative to seawater in the lower layer. In addition, the vertical profiles of the $^{222}Rn$, DIN, and DIP concentrations imply that a strong advective groundwater flow occurs along the interface of fresh groundwater and seawater near 20 m depth. The geochemical constituents in coastal groundwater also showed strong seasonal variation, with the highest concentrations in summer (June 2005) due to the changes of groundwater recharge and sea level. This implies that the input of terrestrial chemical species into the coastal ocean through submarine groundwater discharge (SGD) could change seasonally. To ascertain the seasonal variation of SGD and SGD-driven chemical species fluxes, and associated ecological responses in the coastal ocean, more extensive studies are necessary using various SGD tracers or seepage meters in the future.

• 한국보육지원학회지
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• 제7권3호
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• pp.125-141
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• 2011

본격적인 청소년기로 진입하는 중학교 청소년의 건강한 자아분화 지원에 도움을 주고자, 중학교 청소년의 자아분화에 미치는 부모간 갈등과 특질불안의 영향을 특질불안의 매개 효과를 통해 살펴보았다. 이를 위해 대구 경북지역 중학교에 재학중인 중 3 남녀 청소년 252명을 대상으로 Skowron과 Fiedlander(1998)의 자아분화(DSI-R) 척도를 기초로 정경연(2007)이 개발한 자아분화 척도, Spielberger(1973)의 특질불안 척도(STAIC) 척도, 권영옥과 이정덕(1997)이 개발한 아동이 지각한 부모갈등 척도를 사용하여 자료수집 하였다. 수집된 자료는 SPSS 19.0 프로그램의 Pearson의 적률상관관계, 단순 및 중회귀분석을 통해 유의수준은 .05 미만에서 통계적 유의성을 검증하였다. 연구결과 첫째, 중학교 청소년의 자아분화는 부모간 갈등에 의해 부적으로 영향 받는 것으로 나타났다. 부모간 갈등이 높을수록 중학교 청소년의 자아분화는 낮게 나타났다. 둘째, 중학교 청소년의 특질불안은 부모간 갈등에 의해 정적으로 영향 받는 것으로 나타났다. 부모간 갈등이 높을수록 중학교 청소년의 특질불안은 높게 나타났다. 셋째, 중학교 청소년의 자아분화에 미치는 부모간 갈등의 부적인 영향력은 청소년 자신의 특질불안이 통제될 때 상당히 떨어지는 것으로 나타났다. 이는 중학교 청소년의 자아분화에 미치는 부모간 갈등의 부적인 영향력이 중학교 청소년 자신의 특질불안에 의해 부분매개 됨을 시사하는 것이다.

• 한국수산과학회지
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• 제45권6호
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• pp.704-715
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• 2012

To examine temporal and spatial variation in salinity and nutrients in the shallow pore water of intertidal sandflats, we measured salinity and nutrient concentrations (dissolved inorganic nitrogen [DIN], phosphorus [DIP], and silicate [DSi]) in pore water of the intertidal zone along the coastline of Jeju Island at two and/or three month intervals from May 2009 to December 2010. Geochemical parameters (grain size, ignition loss [IL], chemical oxygen demand [COD], and acid volatile sulfur [AVS]) in sediment were also investigated. The surface sediments in intertidal sandflats of Jeju Island were mainly composed of sand, slightly gravelly sand and gravelly sand, with a range of mean grain size from 0.5 to 2.5 ${\O}$. Concentrations of IL and COD in sediment were higher along the eastern coast, as compared to the western coast, due to differences in biogenic sediment composition. Salinity and nutrient concentrations in pore water were markedly different across time and space during rainy seasons, whereas concentrations were temporally and spatially more stable during dry seasons. These results suggest that salinity and nutrient concentrations in pore water depend on the advective flow of fresh groundwater. We also observed an imbalance of the DIN/DIP ratio in pore water due to the influence of contaminated sources of DIN. In particular, nutrient concentrations during rainy and dry seasons were characterized by high DIN/DIP ratios (mean-127) and low DIN/DIP ratios (mean-10), respectively, relative to the Redfield ratio (16) in offshore seawater. Such an imbalance of DIN/DIP ratios in pore water can affect the coastal ecosystem and appears to cause outbreaks of benthic seaweed along the coastline of Jeju Island.

• ALGAE
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• 제23권4호
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• pp.277-288
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• 2008

The relationship between nutrients and phytoplankton dynamics was investigated daily from 12 April to 22 July 2003 in Sagami Bay, Japan. According to multidimensional scaling (MDS) and cluster analysis, phytoplankton community was divided into four distinct groups. The first group was consisted of centric diatom species, such as Guinardia spp., Detonula spp., Letocylindrus danicus, Skeletonema costatum, Eucampia zodiacus and Chaetoceros spp.. The second and third clusters comprised mainly diatoms and dinoflagellates, respectively. The other cluster was restricted to the samples collected during the last sampling period when the rainfall and river discharge was frequently recorded. Canonical correspondence analysis (CCA) was applied to analyze four groups respectively, which focused on the effects of nutrients concentration and ratio on phytoplankton variations. Based on CCA analysis, most species of centric diatom were negatively correlated with DSi concentrations and Si/N ratio. Nutrients were strongly limited phytoplankton growth during the summer when the rainfall was not observed, whereas river discharge by rainfall and counterclockwise coastal currents (although the surface circulation pattern is often altered by Kuroshio Current, the counterclockwise coastal currents are generally dominant) has brought phytoplankton population accumulation and triggered the micoalgae growth in western part of the bay. Phosphorous (P) was strongly limited after significantly increases in the phytoplankton abundances. However, silicate (Si) was not a major limiting factor for phytoplankton production, since Si/DIN and Si/P ratio did not create any potential stoichiometric limitation. This indicates that high Si availability contributes favorably to the maintenance of diatom ecosystems in Sagami Bay.

• Journal of Ecology and Environment
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• 제37권1호
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• pp.1-11
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• 2014

To understand the effects of fluctuations in dam discharge due to river environments and phytoplankton communities, we monitored such environments and phytoplankton communities biweekly, from February 2001 to February 2002 and from February 2004 to February 2005, in the lower Han River (LHR), South Korea. The phytoplankton abundance during the dry season was approximately two times higher than that during the rainy season. In particular, fluctuations in diatom assemblages, which constituted over 70% of the total phytoplankton abundance, were affected severely by the changes in the discharge. When a large quantity of water in a dam was discharged into the LHR, the conductivity and the concentrations of total nitrogen (TN), total phosphorus (TP), and dissolved inorganic phosphorus (DIP) decreased rapidly, whereas the concentrations of suspended solids (SS), dissolved inorganic nitrogen (DIN), and dissolved silica (DSi) increased immediately. Time-delayed relationship also revealed that the dam discharge had an immediately significant negative relationship with phytoplankton abundance. On the whole, fluctuations in phytoplankton communities in the LHR were influenced much more by hydrodynamics such as dam discharge than by the availability of nutrients. Thus, the variability in these concentrations usually parallels the strength of river flow that is associated with summer rainfall, with higher values during periods of high river discharge.

• 혜화의학회지
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• 제8권1호
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• pp.793-825
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• 1999

For the development of drugs for alzheimer,s disease, the study was done to review the oriental pathology, clinical data, recent trends for research and strategy for future study. The results were as follows: 1. The medical term Chi-dsi implying alzheimer,s disease was referred for the first time in a medical book, Hwatasheneubijeon written by Hwa-Ta and its differentiation and treatment were studied more in Ming or Ching dynasties. Chi-dai can be differentated as weak(虛) syndrome and Shi(實) syndrome. This can be caused by deficiencies of renal Yin, renal Yang, cardiac Yin and hepatic blood, while that by deficiencies of pathological fluid(痰飮) and clotted blood(瘀血). 2. Dementia can be roughly classified as alzheimer's disease and multi-infarct disease. Its causes were known to be cholinergic transmitter, C-peptide, amyloid-${\beta}$, apolipoprotein, APP(amyloid precursor protein), TGF, MMP-9 and free radical. 3. In Korea experimental studies were chiefly done for the elimataion of C-peptide, amyloid-${\beta}$, apolipoprotein, APP for alzheimer's disease, for the development of drug inhibiting degerative change following CVA and loss of memory and also administrative measure was done by support of government. 4. Drugs of dimentia developed so far were Chi-Dai dan, extracts from aloe, mushroom, green tea, Ganoderma and also folic acid, vitamin C, DHEA and silk amino acid were reported to be effective in dimenta. 5. Future strategic research had better be done on dementia-inducing factors such as acetylcholine, C-peptide, amyloid-${\beta}$, apolipoprotein, APP, TGF, MMP-9 and free radical, development of animal model for dimentia, clinical study, epidemiology, nursing and administrative studies and also consortium for dimentia research should be formed so that repeated investment be avoided.

• 정보처리학회논문지B
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• 제15B권1호
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• pp.9-16
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• 2008

본 논문에서는 스테레오 영상으로부터 중간 시점 영상을 생성하는 알고리즘을 제안한다. 사람이 3차원 영상을 자연스럽게 인지하기 위해서는 다시점의 영상이 필요하다. 이를 위해 많은 수의 카메라를 이용하면 시스템이 복잡하고 커지며 전송량도 문제가 된다. 따라서 송신측에서 스테레오 영상만을 촬영하여 송신하고, 수신측에서 여러 장의 중간 시점 영상을 생성하는 방법을 생각할 수 있다. 제안하는 방법은 스테레오 영상간의 시차에 따른 화소의 차로 표현되는 시차공간영상을 생성한다. 시차공간영상을 이용하여 최적의 시차 경로를 탐색하여 시차 지도를 만든다. 최종적으로 정합이 이루어지지 않은 가려짐 영역을 처리한 후에 중간 시점의 영상을 생성한다. 제안한 방법으로 생성한 영상은 30 dB PSNR 이상의 결과를 얻었다.

• 약학회지
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• 제42권1호
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• pp.5-11
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• 1998

5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized as new colon-specific prodrugs of 5-aminosalicylic acid (5-ASA), their apparent partition coefficients, and the extent of conversion in the homogenates of tissue and contents of various G.I. Tract segments of rats were evaluated. These prodrugs were stable in the homogenate of tissue and contents of stomach, proximal small intestine (PSI) or distal small intestine (DSI). Release of 5-ASA from 5-ASA-Asp after incubation with the cecal and colonic contents for 8hrs at $37^{\circ}C$ was 18%, and 8%, respectively. No significant conversion of prodrug was observed in the cecal and colonic contents of rats pretreated with kanamycin sulfate, which indicated that microbial enzymes were responsible for the cleavage of these prodrugs.