• The Korean Journal of Physiology and Pharmacology
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• 제12권6호
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• pp.337-342
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• 2008

Human bone marrow mesenchymal stem cells (hBM-MSCs) represent a potentially valuable cell type for clinical therapeutic applications. The present study was designed to evaluate the effect of long-term culturing (up to $10^{th}$ passages) of hBM-MSCs from eight individual amyotrophic lateral sclerosis (ALS) patients, focusing on functional ion channels. All hBM-MSCs contain several MSCs markers with no significant differences, whereas the distribution of functional ion channels was shown to be different between cells. Four types of $K^+$ currents, including noise-like $Ca^{+2}$-activated $K^+$ current ($IK_{Ca}$), a transient outward $K^+$ current ($I_{to}$), a delayed rectifier $K^+$ current ($IK_{DR}$), and an inward-rectifier $K^+$ current ($K_{ir}$) were heterogeneously present in these cells, and a TTX-sensitive $Na^+$ current ($I_{Na,TTX}$) was also recorded. In the RT-PCR analysis, Kv1.1,, heag1, Kv4.2, Kir2.1, MaxiK, and hNE-Na were detected. In particular, ($I_{Na,TTX}$) showed a significant passage-dependent increase. This is the first report showing that functional ion channel profiling depend on the cellular passage of hBM-MSCs.

• 한국통신학회논문지
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• 제17권6호
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• pp.558-571
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• 1992

본 논문에서는 프로토콜 검증을 위한 상태 탐색시에 발생하는 상태의 무한정한 증가를 방지하고 상태 탐색의 효율성을 높이기위하여 화장된 선형 탐색이라고 불리우는 상태탐색 방법을 제안하였다. 본 논문에서 제안된 확장된 선형 탐색방법은 모든 전달가능한 상태를 탐색할 필요가 없으며 한 프로세스에서 다른 프로세스의 통신노선이 하나이상이 존재하고 상호통신중인 프로세스의 상태변이가 같은 속도로 진행되며 메세지의 통신형태가 하나의 사이클을 구성할수 있다면 2개 이상의 프로세스 사이에서리 통신 프로토콜을 검증할수가 있다. 본 논문에서 제시된 방식에의하여 종전에 제시되었던 선형탐색 방식에 의한 프로세스간통신 형태에 대한 제약을 제거할수있다. 또한 본 논문에서 제시된 알고리즘은 되도록 에러및 규정되지않은 리셉숀 에러들을 검출 할 수가 있으며 종전의 perturbation방식보다 훨씬 적은 기억용량에서도 수행가능하고 또한 그 수행속도도 매우 빠르다. 따라서 본 논문에서 제시된 방식은 N개의 프로세스 사이의 충돌 및 상호 교란에대한 하나의 해답을 제시하고있다.

• 한국발생생물학회지:발생과생식
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• 제18권4호
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• pp.213-224
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• 2014

Previously we have shown that human abdominal adipose derived-stem cells (ADSCs) could aggregate during the high-density culture in the presence of human serum (HS). In the present study, we observed that human cord blood serum (CBS) and follicular fluid (HFF) also induced aggregation. Similarly, porcine serum could induce aggregation whereas bovine and sheep sera induced little aggregation. qRT-PCR analyses demonstrated that, compared to FBS-cultured ADSCs, HS-cultured cells exhibited higher level of mRNA expression of CLDN3, -6, -7, -15, and -16 genes among the tight junction proteins. ADSCs examined at the time of aggregation by culture with HS, BSA, HFF, CBS, or porcine serum showed significantly higher level of mRNA expression of JAM2 among JAM family members. In contrast, cells cultured in FBS, bovine serum or sheep serum, showed lower level of JAM2 expression. Immunocytochemical analyses demonstrated that the aggregates of HS-cultured cells (HS-Agg) showed intense staining against the anti-JAM2 antibody whereas neither non-aggregated cells (HS-Ex) nor FBS-cultured cells exhibited weak staining. Western blot results showed that HS-Agg expressed JAM2 protein more prominently than HS-Ex and FBS-cultured cells, both of latter reveled weaker intensity. These results suggest that the aggregation property of ADSCs during high-density culture would be dependent on the specific components of serum, and that JAM2 molecule could play a role in the animal sera-induced aggregation in vitro.

• 한국식생활문화학회지
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• 제33권2호
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• pp.186-198
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• 2018

The Sasang constitution typology was analyzed through SCAT2 and a specialist to examine the correlation between the Sasang constitution and dietary pattern, and the difference in BMI and food preference according to Sasang constitution was determined. The Sasang constitution typology of the subjects was classified by SCAT2 and a specialist. Seventy-four subjects were screened by SCAT2 (SC), and 18 of them were judged by the specialist (SP). The results of SCAT2 and the specialist were consistent in 13 subjects (SS). BMI and food preference among these groups were compared. The concordance rate of SCAT2 and the specialist classification was 72.2%. The BMI in SC was significantly lower in the order of Taeeumin, Soyangin, and Soeumin, but no significant difference was observed between Taeeumin and Soyangin in SP and SS. To analyze the preference of food and the constitutional suitability, the 'Yin-Yang food preference index' was developed and compared with the data classified by constitutional food according to existing ideological medical theory. As a result, there were 33 food items that matched in the SP-SS, which was more than that in the SC-SP (4 items), SC-SS (6 items), and SC-SP-SS (4 items). Twenty-four of the 33 matched food items were consistent with the existing constitutional food data. In conclusion, SCAT2 is a very useful tool for Sasang constitutional research, but for more objective research, it is recommended that subjects who show consistent results by different methods be targeted.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2009년도 한국우주과학회보 제18권2호
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• pp.34.4-35
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• 2009

We have studied the radial g-r color gradients of early-type galaxies in the Sloan Digital Sky Survey (SDSS) DR6 in the redshift range 0.00 < z < 0.06. The color profiles of ~30 per cent of the galaxies in this sample show positive color gradients (centers being bluer). These positive gradient galaxies often show strong $H\beta$ absorption line strengths or emission line ratios that are consistent with star-forming populations. Combining the optical data with Galaxy Evolution Explorer (GALEX) UV photometry, we find that all positive gradient galaxies show blue UV-optical colors. They also exhibit a tendency of having a lower stellar velocity dispersion. Positive gradient galaxies tend to live in lower density regions than negative gradient galaxies and are likely to have a late-type companion galaxy. On the other hand, massive early-type galaxies show negative color gradients. A simplistic population analysis shows that these positive color gradients are visible only for half a billion years after a star burst. Although the effective radius decreases and mean surface brightness increases due to this centrally concentrated star formation, the positions of the positive gradient galaxies on the fundamental plane cannot be reproduced by any amount of recent star formation. Instead it required a lower velocity dispersion.

• 천문학회보
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• 제38권1호
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• pp.39-39
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• 2013

We present a study of correlations between the elemental abundances and galaxy morphologies of 91 blue compact galaxies (BCGs) at z=0.20-0.35 with Sloan Digital Sky Survey (SDSS) DR7 data. We classify the morphologies of the galaxies as either 'disturbed' or 'undisturbed', by visual inspection of the SDSS images, and using the Gini coefficient and M20. We derive oxygen and nitrogen abundances using the Te method. We find that a substantial fraction of BCGs with disturbed morphologies, indicative of merger remnants, show relatively high N/O and low O/H abundance ratios. The majority of the disturbed BCGs exhibit higher N/O values at a given O/H value compared to the morphologically undisturbed galaxies, implying more efficient nitrogen enrichment in disturbed BCGs. We detect Wolf-Rayet (WR) features in only a handful of the disturbed BCGs, which appears to contradict the idea that WR stars are responsible for high nitrogen abundance. Combining these results with Galaxy Evolution Explorer (GALEX) GR6 ultraviolet (UV) data, we find that the majority of the disturbed BCGs show systematically lower values of the $H{\alpha}$ to near-UV star formation rate ratio. The equivalent width of the $H{\beta}$ emission line is also systematically lower in the disturbed BCGs. Based on these results, we infer that disturbed BCGs have undergone star formation over relatively longer time scales, resulting in a more continuous enrichment of nitrogen. We suggest that this correlation between morphology and chemical abundances in BCGs is due to a difference in their recent star formation histories.

• Imaging Science in Dentistry
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• 제42권4호
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• pp.237-242
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• 2012

Purpose: The objectives of this study were to survey the radiographic exposure parameters, to measure the patient doses for intraoral dental radiography nationwide, and thus to establish the diagnostic reference levels (DRLs) in intraoral dental X-ray examination in Korea. Materials and Methods: One hundred two intraoral dental radiographic machines from all regions of South Korea were selected for this study. Radiographic exposure parameters, size of hospital, type of image receptor system, installation duration of machine, and type of dental X-ray machine were documented. Patient entrance doses (PED) and dose-area products (DAP) were measured three times at the end of the exit cone of the X-ray unit with a DAP meter (DIAMENTOR M4-KDK, PTW, Freiburg, Germany) for adult mandibular molar intraoral dental radiography, and corrections were made for room temperature and pressure. Measured PED and DAP were averaged and compared according to the size of hospital, type of image receptor system, installation duration, and type of dental X-ray machine. Results: The mean exposure parameters were 62.6 kVp, 7.9 mA, and 0.5 second for adult mandibular molar intraoral dental radiography. The mean patient dose was 2.11 mGy (PED) and 59.4 $mGycm^2$ (DAP) and the third quartile one 3.07 mGy (PED) and 87.4 $mGycm^2$ (DAP). Doses at university dental hospitals were lower than those at dental clinics (p<0.05). Doses of digital radiography (DR) type were lower than those of film-based type (p<0.05). Conclusion: We recommend 3.1 mGy (PED), 87.4 $mGycm^2$ (DAP) as the DRLs in adult mandibular molar intraoral dental radiography in Korea.

• Imaging Science in Dentistry
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• 제40권4호
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• pp.165-169
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• 2010

Purpose : To survey the radiographic examination protocol for lateral cephalometric radiographic examinations and to measure their patient doses in Korea and to compare the dose according to the size of hospital, the type of image receptor system, and the installation duration. Materials and Methods : The radiographic examination protocols (kVp, mA, and exposure time) for lateral cephalometric radiography were surveyed with 61 cephalometric radiographic equipments and their patient dose-area product (DAP) measured with a DAP meter (DIAMENTOR M4-KDK, PTW, Freiburg, Germany) for 51 cephalometric radiographic equipments. The radiographic examination protocols and patient doses were compared according to the size of hospital (university dental hospital, dental hospital, and dental clinic), the type of image receptor system (film-based, DR and CR type) and the installation duration, respectively. SPSS 12.0.1 for Windows (SPSS Inc., Chicago, USA) was used for independent t-test and ANOVA test. Results : The average protocols were 77.0 kVp, 12.7 mA, 6.2 second for cephalometric radiography. The average patient dose (DAP) was $128.0mGy\;cm^2$ and 3rd quartile dose (DAP) $161.1mGy\;cm^2$ for cephalometric radiography for adult male. There was no statistically significant difference at average patient DAP according to the size of hospital, the type of image receptor system, and the installation duration, repectively. Conclusion : The average patient dose was $128.0mGy\;cm^2$ and the third quartile patient dose $161.1mGy\;cm^2$ for lateral cephalometric radiography for adult male in Korea.

• Journal of Gastric Cancer
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• 제17권3호
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• pp.255-266
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• 2017

Purpose: Although Roux-en-Y (R-Y) reconstruction after distal gastrectomy has several advantages, such as prevention of bile reflux into the remnant stomach, it is rarely used because of the technical difficulty. This prospective randomized clinical trial aimed to show the efficacy of a novel method of R-Y reconstruction involving the use of 2 circular staplers by comparing this novel method to Billroth-I (B-I) reconstruction. Materials and Methods: A total of 118 patients were randomly allocated into the R-Y (59 patients) and B-I reconstruction (59 patients) groups. R-Y anastomosis was performed using two circular staplers and no hand sewing. The primary end-point of this clinical trial was the reflux of bile into the remnant stomach evaluated using endoscopic and histological findings at 6 months after surgery. Results: No significant differences in clinicopathological findings were observed between the 2 groups. Although anastomosis time was significantly longer for the patients of the R-Y group (P<0.001), no difference was detected between the 2 groups in terms of the total surgery duration (P=0.112). Endoscopic findings showed a significant reduction of bile reflux in the remnant stomach in the R-Y group (P<0.001), and the histological findings showed that reflux gastritis was more significant in the B-I group than in the R-Y group (P=0.026). Conclusions: The results of this randomized controlled clinical trial showed that compared with B-I reconstruction, R-Y reconstruction using circular staplers is a safe and feasible procedure. This clinical trial study was registered at www.ClinicalTrials.gov (registration No. NCT01142271).

• 한국정보통신학회논문지
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• 제8권6호
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• pp.1250-1256
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• 2004

현재 및 과거 위치 질의를 위해 연속적으로 변경되는 위치의 이동은 저장되고 색인화 되어야 한다. 기존의 R-트리에 시간을 다른 차원으로 추가하여 간단하게 확장한 3차원 R-트리는 현재 위치 질의를 다루지 않고 있으며, 색인 노드들의 많은 중첩으로 인하여 공간 활용도가 낮다는 문제점이 있다. 이 논문에서는 분할된 노드의 공간 활용도를 높이기 위하여 향상된 3차원 R-트리의 동적 분할 정책을 제안한다. 또한, 이동체들의 현재 및 과거 위치를 질의하기 위해 새로운 태그 색인 구조를 소개함으로서 기존의 3차원 R-트리를 확장하였다. 현재 및 과거 위치 질의에서 제안하는 태그 동적 3차원 R-트리는 기존의 3차원 R-트리와 TB-트리 보다 성능이 우수하였다.