• The Korean Journal of Physiology and Pharmacology
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• v.12 no.6
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• pp.337-342
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• 2008

Human bone marrow mesenchymal stem cells (hBM-MSCs) represent a potentially valuable cell type for clinical therapeutic applications. The present study was designed to evaluate the effect of long-term culturing (up to $10^{th}$ passages) of hBM-MSCs from eight individual amyotrophic lateral sclerosis (ALS) patients, focusing on functional ion channels. All hBM-MSCs contain several MSCs markers with no significant differences, whereas the distribution of functional ion channels was shown to be different between cells. Four types of $K^+$ currents, including noise-like $Ca^{+2}$-activated $K^+$ current ($IK_{Ca}$), a transient outward $K^+$ current ($I_{to}$), a delayed rectifier $K^+$ current ($IK_{DR}$), and an inward-rectifier $K^+$ current ($K_{ir}$) were heterogeneously present in these cells, and a TTX-sensitive $Na^+$ current ($I_{Na,TTX}$) was also recorded. In the RT-PCR analysis, Kv1.1,, heag1, Kv4.2, Kir2.1, MaxiK, and hNE-Na were detected. In particular, ($I_{Na,TTX}$) showed a significant passage-dependent increase. This is the first report showing that functional ion channel profiling depend on the cellular passage of hBM-MSCs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.6
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• pp.558-571
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• 1992

In this paper, we propose an improved method of state exploration called the extended circular exploration (ECE) for the efficiency of state exploration and the reduction of explosively growing state. The ECE does not need to explore all the reachable global states, and It can be applied to JV($\boxDr$$\geq$ 2) -party protocol with alternative routes, i.e., it is applicable to the protocol In which adaptiverouting mechanism can be performed. The ECE eliminates a restriction of topology of the conventional circular exploration(CE) by exploring only those global states which are reachable, provided that the participant processes of any group of transitions proceed at the same speed, and that they can be formed as a cycle. Thus the state space explored if not exhaustive. The algorithm presented can detect deadlock error and unspecified reception error It requires storage space and /or execution time much less than those of the conventional perturbation(CP) . It might be used for a solution of the N-process collision and the interference mechanism.

• Development and Reproduction
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• v.18 no.4
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• pp.213-224
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• 2014

Previously we have shown that human abdominal adipose derived-stem cells (ADSCs) could aggregate during the high-density culture in the presence of human serum (HS). In the present study, we observed that human cord blood serum (CBS) and follicular fluid (HFF) also induced aggregation. Similarly, porcine serum could induce aggregation whereas bovine and sheep sera induced little aggregation. qRT-PCR analyses demonstrated that, compared to FBS-cultured ADSCs, HS-cultured cells exhibited higher level of mRNA expression of CLDN3, -6, -7, -15, and -16 genes among the tight junction proteins. ADSCs examined at the time of aggregation by culture with HS, BSA, HFF, CBS, or porcine serum showed significantly higher level of mRNA expression of JAM2 among JAM family members. In contrast, cells cultured in FBS, bovine serum or sheep serum, showed lower level of JAM2 expression. Immunocytochemical analyses demonstrated that the aggregates of HS-cultured cells (HS-Agg) showed intense staining against the anti-JAM2 antibody whereas neither non-aggregated cells (HS-Ex) nor FBS-cultured cells exhibited weak staining. Western blot results showed that HS-Agg expressed JAM2 protein more prominently than HS-Ex and FBS-cultured cells, both of latter reveled weaker intensity. These results suggest that the aggregation property of ADSCs during high-density culture would be dependent on the specific components of serum, and that JAM2 molecule could play a role in the animal sera-induced aggregation in vitro.

• Journal of the Korean Society of Food Culture
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• v.33 no.2
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• pp.186-198
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• 2018

The Sasang constitution typology was analyzed through SCAT2 and a specialist to examine the correlation between the Sasang constitution and dietary pattern, and the difference in BMI and food preference according to Sasang constitution was determined. The Sasang constitution typology of the subjects was classified by SCAT2 and a specialist. Seventy-four subjects were screened by SCAT2 (SC), and 18 of them were judged by the specialist (SP). The results of SCAT2 and the specialist were consistent in 13 subjects (SS). BMI and food preference among these groups were compared. The concordance rate of SCAT2 and the specialist classification was 72.2%. The BMI in SC was significantly lower in the order of Taeeumin, Soyangin, and Soeumin, but no significant difference was observed between Taeeumin and Soyangin in SP and SS. To analyze the preference of food and the constitutional suitability, the 'Yin-Yang food preference index' was developed and compared with the data classified by constitutional food according to existing ideological medical theory. As a result, there were 33 food items that matched in the SP-SS, which was more than that in the SC-SP (4 items), SC-SS (6 items), and SC-SP-SS (4 items). Twenty-four of the 33 matched food items were consistent with the existing constitutional food data. In conclusion, SCAT2 is a very useful tool for Sasang constitutional research, but for more objective research, it is recommended that subjects who show consistent results by different methods be targeted.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.34.4-35
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• 2009

We have studied the radial g-r color gradients of early-type galaxies in the Sloan Digital Sky Survey (SDSS) DR6 in the redshift range 0.00 < z < 0.06. The color profiles of ~30 per cent of the galaxies in this sample show positive color gradients (centers being bluer). These positive gradient galaxies often show strong $H\beta$ absorption line strengths or emission line ratios that are consistent with star-forming populations. Combining the optical data with Galaxy Evolution Explorer (GALEX) UV photometry, we find that all positive gradient galaxies show blue UV-optical colors. They also exhibit a tendency of having a lower stellar velocity dispersion. Positive gradient galaxies tend to live in lower density regions than negative gradient galaxies and are likely to have a late-type companion galaxy. On the other hand, massive early-type galaxies show negative color gradients. A simplistic population analysis shows that these positive color gradients are visible only for half a billion years after a star burst. Although the effective radius decreases and mean surface brightness increases due to this centrally concentrated star formation, the positions of the positive gradient galaxies on the fundamental plane cannot be reproduced by any amount of recent star formation. Instead it required a lower velocity dispersion.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.1
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• pp.39-39
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• 2013

We present a study of correlations between the elemental abundances and galaxy morphologies of 91 blue compact galaxies (BCGs) at z=0.20-0.35 with Sloan Digital Sky Survey (SDSS) DR7 data. We classify the morphologies of the galaxies as either 'disturbed' or 'undisturbed', by visual inspection of the SDSS images, and using the Gini coefficient and M20. We derive oxygen and nitrogen abundances using the Te method. We find that a substantial fraction of BCGs with disturbed morphologies, indicative of merger remnants, show relatively high N/O and low O/H abundance ratios. The majority of the disturbed BCGs exhibit higher N/O values at a given O/H value compared to the morphologically undisturbed galaxies, implying more efficient nitrogen enrichment in disturbed BCGs. We detect Wolf-Rayet (WR) features in only a handful of the disturbed BCGs, which appears to contradict the idea that WR stars are responsible for high nitrogen abundance. Combining these results with Galaxy Evolution Explorer (GALEX) GR6 ultraviolet (UV) data, we find that the majority of the disturbed BCGs show systematically lower values of the $H{\alpha}$ to near-UV star formation rate ratio. The equivalent width of the $H{\beta}$ emission line is also systematically lower in the disturbed BCGs. Based on these results, we infer that disturbed BCGs have undergone star formation over relatively longer time scales, resulting in a more continuous enrichment of nitrogen. We suggest that this correlation between morphology and chemical abundances in BCGs is due to a difference in their recent star formation histories.

• Imaging Science in Dentistry
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• v.42 no.4
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• pp.237-242
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• 2012

Purpose: The objectives of this study were to survey the radiographic exposure parameters, to measure the patient doses for intraoral dental radiography nationwide, and thus to establish the diagnostic reference levels (DRLs) in intraoral dental X-ray examination in Korea. Materials and Methods: One hundred two intraoral dental radiographic machines from all regions of South Korea were selected for this study. Radiographic exposure parameters, size of hospital, type of image receptor system, installation duration of machine, and type of dental X-ray machine were documented. Patient entrance doses (PED) and dose-area products (DAP) were measured three times at the end of the exit cone of the X-ray unit with a DAP meter (DIAMENTOR M4-KDK, PTW, Freiburg, Germany) for adult mandibular molar intraoral dental radiography, and corrections were made for room temperature and pressure. Measured PED and DAP were averaged and compared according to the size of hospital, type of image receptor system, installation duration, and type of dental X-ray machine. Results: The mean exposure parameters were 62.6 kVp, 7.9 mA, and 0.5 second for adult mandibular molar intraoral dental radiography. The mean patient dose was 2.11 mGy (PED) and 59.4 $mGycm^2$ (DAP) and the third quartile one 3.07 mGy (PED) and 87.4 $mGycm^2$ (DAP). Doses at university dental hospitals were lower than those at dental clinics (p<0.05). Doses of digital radiography (DR) type were lower than those of film-based type (p<0.05). Conclusion: We recommend 3.1 mGy (PED), 87.4 $mGycm^2$ (DAP) as the DRLs in adult mandibular molar intraoral dental radiography in Korea.

• Imaging Science in Dentistry
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• v.40 no.4
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• pp.165-169
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• 2010

Purpose : To survey the radiographic examination protocol for lateral cephalometric radiographic examinations and to measure their patient doses in Korea and to compare the dose according to the size of hospital, the type of image receptor system, and the installation duration. Materials and Methods : The radiographic examination protocols (kVp, mA, and exposure time) for lateral cephalometric radiography were surveyed with 61 cephalometric radiographic equipments and their patient dose-area product (DAP) measured with a DAP meter (DIAMENTOR M4-KDK, PTW, Freiburg, Germany) for 51 cephalometric radiographic equipments. The radiographic examination protocols and patient doses were compared according to the size of hospital (university dental hospital, dental hospital, and dental clinic), the type of image receptor system (film-based, DR and CR type) and the installation duration, respectively. SPSS 12.0.1 for Windows (SPSS Inc., Chicago, USA) was used for independent t-test and ANOVA test. Results : The average protocols were 77.0 kVp, 12.7 mA, 6.2 second for cephalometric radiography. The average patient dose (DAP) was $128.0mGy\;cm^2$ and 3rd quartile dose (DAP) $161.1mGy\;cm^2$ for cephalometric radiography for adult male. There was no statistically significant difference at average patient DAP according to the size of hospital, the type of image receptor system, and the installation duration, repectively. Conclusion : The average patient dose was $128.0mGy\;cm^2$ and the third quartile patient dose $161.1mGy\;cm^2$ for lateral cephalometric radiography for adult male in Korea.

• Journal of Gastric Cancer
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• v.17 no.3
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• pp.255-266
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• 2017

Purpose: Although Roux-en-Y (R-Y) reconstruction after distal gastrectomy has several advantages, such as prevention of bile reflux into the remnant stomach, it is rarely used because of the technical difficulty. This prospective randomized clinical trial aimed to show the efficacy of a novel method of R-Y reconstruction involving the use of 2 circular staplers by comparing this novel method to Billroth-I (B-I) reconstruction. Materials and Methods: A total of 118 patients were randomly allocated into the R-Y (59 patients) and B-I reconstruction (59 patients) groups. R-Y anastomosis was performed using two circular staplers and no hand sewing. The primary end-point of this clinical trial was the reflux of bile into the remnant stomach evaluated using endoscopic and histological findings at 6 months after surgery. Results: No significant differences in clinicopathological findings were observed between the 2 groups. Although anastomosis time was significantly longer for the patients of the R-Y group (P<0.001), no difference was detected between the 2 groups in terms of the total surgery duration (P=0.112). Endoscopic findings showed a significant reduction of bile reflux in the remnant stomach in the R-Y group (P<0.001), and the histological findings showed that reflux gastritis was more significant in the B-I group than in the R-Y group (P=0.026). Conclusions: The results of this randomized controlled clinical trial showed that compared with B-I reconstruction, R-Y reconstruction using circular staplers is a safe and feasible procedure. This clinical trial study was registered at www.ClinicalTrials.gov (registration No. NCT01142271).

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.6
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• pp.1250-1256
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• 2004

The movement of continuously changing positions should be stored and indexed for querying current and past positions. A simple extension of the original R-tree to add time as another dimension, called 3D R-tree, does not handle current position queries and does not address the problem of low space utilization due to high overlap of index nodes. In this paper, 1 propose the dynamic splitting policy for improving the 3D R-tree in order to improve space utilization of split nodes. 1 also extend the original 3D R-tree by introducing a new tagged index structure for being able to query the current and past positions of moving objects. 1 found out that my extension of the original R-tree, called the tagged dynamic 3DR-tree, outperforms both the 3D R-tree and 75-tree when querying current and past position.