• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.1028-1040
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• 2019

The current study was performed to investigate the magnitude of exercise-induced muscle damage (EIMD) after downhill running (DR) of different intensities and to examine the availability of muscle echo intensity as biomarkers to detect regional damage within quadriceps muscle group (QG) following DR. Healthy college-age men (n=11) were experienced twice DR sessions [$50%HR_{max}$ DR, LDR; $70%HR_{max}$ DR, HDR] separated by a 2-week wash-out period with the random order. After DR, severity of EIMD according to exercise intensity were determined by serum creatine kinase (CK) activity, muscle tenderness, and neuromuscular function indicators such as a maximal voluntary isometric contraction (MVIC) and range of motion (ROM). Transvaginal B-mode imaging had been employed to evaluate regional muscle echo intensity within QG [rectus femoris, RF; vastus lateralis, VL; vastus medialis, VM; vastus intermedius, VI]. After both DR sessions, changes in serum CK activity and muscle tenderness have tended to more increase in HDR compared to those of LDR. There was a significant interaction effect between exercise intensity during DR and the time course of serum CK activity(p<.05). However, there were no statistical differences between sessions in muscle tenderness. The time course of changes in the neuromuscular functions after DR were similar to those of regional muscle echo intensity regardless exercise intensity. Although neuromuscular function showed to decline in HDR more than those of LDR after DR, no statistical differences between sessions. In contrast, there were significant interaction effects between sessions and time course of changes in RF and VL muscle echo intensity(p<.01), but not shown in those of VI and VM. These results indicated that each muscles within the QG show different response profiles for EIMD during DR, exercise intensity influences on these responses as well. In particular, current findings suggested that muscle echo intensity derived from ultrasound imaging is capable of detecting regional muscle damage in QG following DR.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.4
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• pp.21-29
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• 1998

As silicon geometry shrinks into deep submicron and the operating speed icreases, higher accuracy is required in the analysis of the propagation delays of the gates and interconnects in an ASIC. In this paper, the driving characteristics of a CMOS gate is represented by a gatedriver model, consisting of a linear resistor $R_{dr}$ and an independent ramp voltage source $V_{dr}$ . We drivered $R_{dr}$ and $V_{dr}$ as the functions of the timing data representing gate driving capability and an effective capacitance $C_{eff}$ reflecting resistance shielding effect by interconnet circuits. Through iterative applications of these equations and AWE algorithm, $R_{dr}$ , $V_{dr}$ and $C_{eff}$ are comuted simulataneously. then, the gate delay is decided by $C_{eff}$ and the interconnect circuit delay is determined by $R_{dr}$ and $V_{dr}$ . this process has been implemented as an ASIC timing analysis program written in C language and four real circuits were analyzed. In all cases, we found less than 5% of errors for both of gate andinterconnect circuit delays with a speedup factor ranging from a few tens to a few hundreds, compared to SPICE.SPICE.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7817-7819
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• 2014

Childhood cancers are relatively uncommon in comparison to adult cancers. There is no literature available to shed light on clinic-pathological types and patterns of care for childhood cancers in our population in North-East India. In this analysis we therefore tried to determine the common childhood cancers diagnosed in our institute, clinical profile of the patients, types of treatment and compliance, and median survival estimates. Leukemia was most common, followed by retinoblastoma, central nervous system tumours and lymphomas. Ascertaining the clinic-pathological profile of childhood cancers in our population is essential for allocation and management of resources for this small but important group of patients.

• Journal of Acupuncture Research
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• v.30 no.1
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• pp.43-55
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• 2013

I investigated whether snake venom toxin(SVT) from Vipera lebetina turanica enhances the apoptosis ability of tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) in cancer cells. TRAIL inhibited HCT116 cell growth in a dose-dependent manner. Consistent with cell growth inhibition, the expression of TRAIL receptors; DR4 and DR5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, 8, 9 and Bax. However, the expression of survival proteins(eg, cFLIP, survivin, XIAP and Bcl2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the reactive oxygen species(ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the apoptosis related protein such as caspase-3 and-9 as well as cell growth inhibitory effects. The collective results suggest that SVT facilitates TRAIL-induced apoptosis in human colorectal cancer HCT116 cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS pathway signals.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.2
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• pp.213-222
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• 1995

To increase the night use level, this study was analyzed perception of users about the public safety, and extracted main variables which were influencing public safety. The public safety was evaluated by the actual (on site) and nonactual users (off site) and the Delphi method. The night users of female and the elders were relatively more than male and the young respectively as compared with day. Walking was predominant in approaching means. In public safety ratings, $\boxDr$vuknerability to violence$\boxUl$varied accoding to sex, income, education, marriage, job, age. $\boxDr$crowding, $\boxDr$noise$\boxUl$ were important variables in satisfying users at night. $\boxDr$Lack of surveillance, $\boxDr$harassment of other person$\boxUl$, $\boxDr$rowdy behavior in poorer visibility$\boxUl$, $\boxDr$fear in lower intensity of light$\boxUl$ and $\boxDr$vulnerability to violence$\boxUl$stood high , so it is required guarantee of security guard to enhance the park use at night Although the ratings between field and indoor evaluation were somewhat different the variables had so similiar rant.

• Journal of Advanced Navigation Technology
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• v.7 no.1
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• pp.1-5
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• 2003

In this paper, the output power level and phase noise property of nine conventional push-push FET DROs (Dielectric Resonator Oscillator) have been experimentally investigated by adding one more identical DR at the drain port. The nine oscillators designed to generate 20 GHz from 10 GHz fundamental frequency, have been tested for each of three different power combiners at the output port. It has been observed that the output power level of the push-push FET DROs can be improved by placing the DR while maintaining their phase noise characteristics were approximately the same as before adding the DR.

• BMB Reports
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• v.56 no.10
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• pp.537-544
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• 2023

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

• The Journal of the Korean dental association
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• v.50 no.8
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• pp.482-506
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• 2012

Dentists have been striving to find ways to relieve patients' pain and discomfort. The prestige of dentists is made up of dentists' self-sacrifice, academic research and pursuit of patients' well being. However, nowadays the dentists' prestige has been lost and practice on humanity has merely existed. At this time, it is meaningful to shed new light on life of a pioneer in Korean dentistry and take some time for self-examination. Today, we are going to look into life of Dr. Jong-Suh Ahn and his achievements in Korean dentistry. In 1925, Dr. Ahn Jong Suh graduated from KyungSung Dental school as a first graduating class. Then, he learned advanced dentistry at Severance Hospital and in April of 1932 as a young dentist with full of potentials, he opened his dental clinic in Tianjin, China. As an awakening Korean, in 1925 he organized an association of Korean dentists, called HanSung Dental Association and worked as a secretary to manage general affairs. Han Sung Dental Association later became today's Korean Dental Association. On December 9th, 1945, he founded ChoSun Dental Association. He accomplished great deals during his five consecutive terms as a chairman and held other important positions with prestige to lead and expand the scope Korean dental association. There were three other successors to Dr. Ahn as the presidents of Dental Association. Dr. Yong-Jin Kim had a great interest in internal affairs and dental materials. Dr. Myung-Jin Park was active in scientific affairs and Dr. Dong-Chan Han focused on smooth operation of the association. From 1945 to 1963, Dr. Ahn submitted important agendas such as dentist's qualification, scientific and academic affairs, general affairs, dental materials, public oral health, and dental administration to Dental Association's general meeting and central committee. Dr. Ahn overcame hardships of Japanese imperialism, celebrated independence of Korea, experienced 6.25 Korean War and lived through evolving Korean dentistry in 1960s. Dr. Jong-Suh Ahn, who showed the prestige of dentist and expanded the scope of dental association, is exemplary to all dentists.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2409-2412
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• 2015

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2879-2881
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• 2015

There is paucity of data on non Hodgkin's lymphoma (NHL) from our population in North-East India. In this retrospective study, patients were consecutively followed-up to see the clinic-pathological pattern of NHL, various responses, and pattern of relapses to first line treatment with chemotherapy. All patients in the present study received standard regimen of cyclophosphamde, doxorubicin, vincristine, prednisolone (CHOP) with or without rituximab (R-CHOP) as per our institutional protocol as first line therapy. Our study has shown that, in our adult population, the majority of NHL cases present with stage II and stage III disease and extra nodal involvement, B-cell lymphomas and diffuse large cell lymphomas being the most common subtypes. International prognostic index was a significant factor for varied responses to treatment. The majority of relapses after complete remission occurred in the first year.