• Archives of Plastic Surgery
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• 제48권4호
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• pp.462-466
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• 2021

• 한국응용과학기술학회지
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• 제36권3호
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• pp.1028-1040
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• 2019

본 연구는 내리막 달리기(downhill running, DR) 후 초음파 영상분석을 이용해 대퇴사두근 무리(quadriceps group, QG) 내 근손상의 국소화 여부를 검증하고, DR 동안 운동 강도가 운동유발성 근손상(exercise-induced muscle damage, EIMD) 및 근육 반향세기 변화에 미치는 영향을 규명하려는 목적으로 수행되었다. 규칙적인 신체활동이 없는 건강한 남성 11명이 무작위 교차설계에 따라 서로 다른 강도[low-intensity DR session($50%HR_{max}$), LDR; high-intensity DR session($70%HR_{max}$), HDR]의 DR 운동을 수행하였다. DR 후 EIMD의 심각성은 혈청크레아틴 키나아제(creatine kinase, CK) 활성 수준 변화와 함께 신경근 기능 지수로서 무릎 신전근의 최대 수의적 등척성 수축(maximal voluntary isometric contraction, MVIC) 및 관절가동범위(range of motion, ROM) 변화를 통해 결정되었다. 회색조 분석을 적용한 근육 반향세기 평가는 DR에 따른 QG 내 국소 근육별(rectus femoris, RF; vastus lateralis, VL; vastus medialis, VM; vastus intermedius, VI) 손상 양상을 탐지하기 위해 활용되었다. 모든 세션에서 혈청 CK 활성 수준과 VL 및 VM의 근통증 정도는 운동 후 24시간째(RF의 경우 각각 LDR 24시간째와 HDR 48시간째) 최대에 이르렀으며, 혈청 CK 수준에서 운동 강도에 따른 유의한 차이(p<.05)가 나타난 반면 근통증에서 세션 간 통계적 차이는 없었다. 무릎 관절을 이용한 MVIC 및 ROM과 같은 신경근 기능 지표 및 VM을 제외한 모든 QG 근육 반향세기는 운동 직후 극적으로 감소 또는 증가 후 72시간까지 점진적 회복 양상을 나타내었다. 그러나 신경근 기능 지표에서 운동 강도에 따른 통계적 차이는 없었으나 RF 및 VL 반향세기에서 세션 내 및 세션 간 유의한 차이(p<.01)를 나타내었다. 본 연구의 결과로 ECC를 함유한 DR 운동 시 운동 강도는 DOMS 및 신경근 기능 지표에 부분적으로 영향을 미칠 가능성이 있으며, 특히 혈청 CK 수준과 함께 RF 및 VL의 근육 반향세기는 운동 강도의 영향을 직접적으로 반영한다는 사실을 알 수 있다. 또한, 현재 연구결과는 DR 동안 ECC를 겪는 QG 내 국소 근육 간 근손상 정도가 다를 수 있으며 초음파 근육 반향세기가 국소 근육의 EIMD 심각성을 차별화할 수 있는 유용한 평가기법임을 뒷받침하고 있다.

• 전자공학회논문지C
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• 제35C권4호
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• pp.21-29
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• 1998

As silicon geometry shrinks into deep submicron and the operating speed icreases, higher accuracy is required in the analysis of the propagation delays of the gates and interconnects in an ASIC. In this paper, the driving characteristics of a CMOS gate is represented by a gatedriver model, consisting of a linear resistor $R_{dr}$ and an independent ramp voltage source $V_{dr}$ . We drivered $R_{dr}$ and $V_{dr}$ as the functions of the timing data representing gate driving capability and an effective capacitance $C_{eff}$ reflecting resistance shielding effect by interconnet circuits. Through iterative applications of these equations and AWE algorithm, $R_{dr}$ , $V_{dr}$ and $C_{eff}$ are comuted simulataneously. then, the gate delay is decided by $C_{eff}$ and the interconnect circuit delay is determined by $R_{dr}$ and $V_{dr}$ . this process has been implemented as an ASIC timing analysis program written in C language and four real circuits were analyzed. In all cases, we found less than 5% of errors for both of gate andinterconnect circuit delays with a speedup factor ranging from a few tens to a few hundreds, compared to SPICE.SPICE.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7817-7819
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• 2014

Childhood cancers are relatively uncommon in comparison to adult cancers. There is no literature available to shed light on clinic-pathological types and patterns of care for childhood cancers in our population in North-East India. In this analysis we therefore tried to determine the common childhood cancers diagnosed in our institute, clinical profile of the patients, types of treatment and compliance, and median survival estimates. Leukemia was most common, followed by retinoblastoma, central nervous system tumours and lymphomas. Ascertaining the clinic-pathological profile of childhood cancers in our population is essential for allocation and management of resources for this small but important group of patients.

• Journal of Acupuncture Research
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• 제30권1호
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• pp.43-55
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• 2013

I investigated whether snake venom toxin(SVT) from Vipera lebetina turanica enhances the apoptosis ability of tumor necrosis factor(TNF)-related apoptosis-inducing ligand(TRAIL) in cancer cells. TRAIL inhibited HCT116 cell growth in a dose-dependent manner. Consistent with cell growth inhibition, the expression of TRAIL receptors; DR4 and DR5 was significantly increased as well as apoptosis related proteins such as cleaved caspase-3, 8, 9 and Bax. However, the expression of survival proteins(eg, cFLIP, survivin, XIAP and Bcl2) was suppressed by the combination treatment of SVT and TRAIL. Pretreatment with the reactive oxygen species(ROS) scavenger N-acetylcysteine reduced the SVT and TRAIL-induced upregulation of DR4 and DR5 expression and expression of the apoptosis related protein such as caspase-3 and-9 as well as cell growth inhibitory effects. The collective results suggest that SVT facilitates TRAIL-induced apoptosis in human colorectal cancer HCT116 cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS pathway signals.

• 한국조경학회지
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• 제23권2호
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• pp.213-222
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• 1995

To increase the night use level, this study was analyzed perception of users about the public safety, and extracted main variables which were influencing public safety. The public safety was evaluated by the actual (on site) and nonactual users (off site) and the Delphi method. The night users of female and the elders were relatively more than male and the young respectively as compared with day. Walking was predominant in approaching means. In public safety ratings, $\boxDr$vuknerability to violence$\boxUl$varied accoding to sex, income, education, marriage, job, age. $\boxDr$crowding, $\boxDr$noise$\boxUl$ were important variables in satisfying users at night. $\boxDr$Lack of surveillance, $\boxDr$harassment of other person$\boxUl$, $\boxDr$rowdy behavior in poorer visibility$\boxUl$, $\boxDr$fear in lower intensity of light$\boxUl$ and $\boxDr$vulnerability to violence$\boxUl$stood high , so it is required guarantee of security guard to enhance the park use at night Although the ratings between field and indoor evaluation were somewhat different the variables had so similiar rant.

• 한국항행학회논문지
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• 제7권1호
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• pp.1-5
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• 2003

본 논문에서는 9개의 전형적인 Push-Push FET DRO(Dielectric Resonator Oscillator: 유전체 공진기 발진기)의 드레인단에 게이트단에서 이용했던 동일한 DR을 첨가하여 출력전력과 위상 잡음특성변화를 실험적으로 조사하였다. 9개 발진기는 10 GHz의 기본주파수를 이용하여 20 GHz를 발생할 수 있도록 설계되었고, 출력단에는 3개의 다른 종류의 전력 결합기를 채택했는데, 이들 각각에 대해 측정하였다. 결과적으로 Push-Push FET DRO의 출력전력은 DR을 첨가함으로 향상되어질 수 있는 것과 위상잡음특성은 DR을 첨가하기 전과 대체로 같은 특성을 유지하는 것을 관찰할 수 있었다.

• BMB Reports
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• 제56권10호
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• pp.537-544
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• 2023

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

• 대한치과의사협회지
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• 제50권8호
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• pp.482-506
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• 2012

Dentists have been striving to find ways to relieve patients' pain and discomfort. The prestige of dentists is made up of dentists' self-sacrifice, academic research and pursuit of patients' well being. However, nowadays the dentists' prestige has been lost and practice on humanity has merely existed. At this time, it is meaningful to shed new light on life of a pioneer in Korean dentistry and take some time for self-examination. Today, we are going to look into life of Dr. Jong-Suh Ahn and his achievements in Korean dentistry. In 1925, Dr. Ahn Jong Suh graduated from KyungSung Dental school as a first graduating class. Then, he learned advanced dentistry at Severance Hospital and in April of 1932 as a young dentist with full of potentials, he opened his dental clinic in Tianjin, China. As an awakening Korean, in 1925 he organized an association of Korean dentists, called HanSung Dental Association and worked as a secretary to manage general affairs. Han Sung Dental Association later became today's Korean Dental Association. On December 9th, 1945, he founded ChoSun Dental Association. He accomplished great deals during his five consecutive terms as a chairman and held other important positions with prestige to lead and expand the scope Korean dental association. There were three other successors to Dr. Ahn as the presidents of Dental Association. Dr. Yong-Jin Kim had a great interest in internal affairs and dental materials. Dr. Myung-Jin Park was active in scientific affairs and Dr. Dong-Chan Han focused on smooth operation of the association. From 1945 to 1963, Dr. Ahn submitted important agendas such as dentist's qualification, scientific and academic affairs, general affairs, dental materials, public oral health, and dental administration to Dental Association's general meeting and central committee. Dr. Ahn overcame hardships of Japanese imperialism, celebrated independence of Korea, experienced 6.25 Korean War and lived through evolving Korean dentistry in 1960s. Dr. Jong-Suh Ahn, who showed the prestige of dentist and expanded the scope of dental association, is exemplary to all dentists.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2409-2412
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• 2015

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.