• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.5
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• pp.757-766
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• 1994

The survey was conducted to investigate several factors affecting the disease outcome with 116 infants aged 10 to 24 months residing in Kunsan city, Cheonbuk province . General characteristics, weaning practice , nutrient intake and the actual state for affecting disease were studied. Among many factors, mother's educational status was found to be the most influencing factor for affecting the disease outcome analyzed by oneway ANOVA. The exposure index disease, cold and diarrrhea, against mother's education were analyzed to find out the major factors for disease outcome. The education group up to middle school graduates, mother's job , nutrients supplements, feeding method, sex of baby were the factors, for the high school graduates, job , nutrients supplements were the causes, and the group graduated from the college the above grade mother's health state was the most important factor for the baby exposing to the disease. The disease outcome decreased when the bottle feeding was replaced by breast feeding, sufficient nutrients supplementation was recommended , and health care for mother during pregnancy was strongly advised.

• The Journal of Pediatrics of Korean Medicine
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• v.18 no.2
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• pp.225-232
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• 2004

Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

• Childhood Kidney Diseases
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• v.3 no.2
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• pp.221-226
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• 1999

Glomerulocystic kidney disease(GCKD) is a rare form of renal cystic disease defined histopathologically by containing dilated Bowman's space with variable atrophy of glomerular tufts, which may occur as sporadically or as familial cases and can be presented as a major component of heritable syndromes. It has not been recognized in Korean children but only one report of adult case has been reported having GCKD. We experienced a case of GCKD in a 10-year-10-month-old boy, who was admitted for hypertension. Abdominal ultrasonography and computed tomography revealed clustered numerous small cysts in left kidney and renal biopsy findings was consistent with the GCKD showing cystic dilatation of Bowman's space with intact glomerular structure.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.9
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• pp.1247-1253
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• 2003

Selection for increased milk production in dairy cows has often resulted in a higher incidence of disease and thus incurred a greater health costs. Considerable interests have been shown in breeding dairy cattle for disease resistance in recent years. This paper discusses the limitations of breeding dairy cattle for genetic resistance in six parts: 1) complexity of disease resistance, 2) difficulty in estimating genetic parameters for planning breeding programs against disease, 3) undesirable relationship between production traits and disease, 4) disease as affected by recessive genes, 5) new mutation of the pathogens, and 6) variable environmental factors. The hidden problems of estimating genetic and phenotypic parameters involving disease incidence were examined in terms of categorical nature, non-independence, heterogeneity of error variance, non-randomness, and automatic relationship between disease and production traits. In light of these limitations, the prospect for increasing genetic resistance by conventional breeding methods would not be so bright as we like. Since the phenomenon of disease is the result of a joint interaction among host genotype, pathogen genotype and environment, it becomes essential to adopt an integrated approach of increasing genetic resistance of the host animals, manipulating the pathogen genotypes, developing effective vaccines and drugs, and improving the environmental conditions. The advances in DNA-based technology show considerable promise in directly manipulating host and pathogen genomes for genetic resistance and producing vaccines and drugs for prevention and medication to promote the wellbeing of the animals.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.05a
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• pp.114-114
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• 2008

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.2
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• pp.97-107
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• 2016

Purpose : Cardiovascular disease is major factor of mortality in worldwide. Previous studies shown that the socioeconomic factors, nutrition factors, health behavior factors, biological factors and co-morbidity are increasing a prevalence of cardiovascular disease. Method : This study examined the risk factors for cardiovascular disease among adults aged 30 years and older using the data from the 2012 to 2014 Korean National Health and Nutrition Examination Survey (KNHANES). The study participants were 7,555 Cardiovascular disease includes hypertension, stroke, angina pactoris, and myocardial infarction. Descriptive statistic and multivariates logistic regression were calculated. Result : The overall prevalence of cardiovascular disease was 31.16% in the participants. Cardiovascular disease was significantly associated with gender, age, income, education, marital status as socioeconomic factors in unadjusted model. After adjusting socioeconomic status variables, past smoker (OR 1.27, 95% CI 1.05-1.55), obesity (OR 7.14, 95% CI 4.21-12.11), skipping a meal (OR 2.79, 95% CI 2.46-3.16), HDL-C (OR 0.99, 95% CI 0.98-0.99) and WC (OR 1.06, 95% CI 1.05-1.07) were associated with cardiovascular disease. Conclusion : The results marked the importance of finding high risk groups and an early management of cardiovascular disease.

• Journal of Sasang Constitutional Medicine
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• v.7 no.2
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• pp.129-134
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• 1995

Lee Je Ma (1837~1900) wrote the DongEuSuSeBoWon in 1894. Constitutional Medicine what is called Sasang Medicine has originated from him. In this book he refers to mild, serious, intractable, incurable and fatal disease. In the sight of his Medical theory each state of disease deserves to be researched. 1. In the case of Soumin exhaustion of Yang, Taeyang-Kwolum, noxious Yin, Yang is kept in the exterior by excessive Yin in the interior, middle diabetes and swelling belong to intractable disease and solid mass in the right epigastric zone belongs to fatal disease. 2. In the case of Soyangin exhaustion of Yin, lower diabetes, afternoon fever due to deficiency of Yin, spitting blood and swelling belong to intractable disease and distention of abdomen with gas or fluid belongs to fatal disease. 3. In the case of Taeumin syncope due to chills, dryness-heat, diabetes, pain of chest and abdomen and swelling belong to intractable disease and apoplexy with dosed eyes belongs to fatal disease. 4. In the case of Taeyangin vertebral disease makes flaccidity of lower limbs and dysphagia with vomiting of frothy fluid belongs to fatal disease.

• Tuberculosis and Respiratory Diseases
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• v.77 no.2
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• pp.85-89
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• 2014

Intrathoracic involvement of immunoglobulin G4 (IgG4)-related disease has recently been reported. However, a subset of the disease presenting as interstitial lung disease is rare. Here, we report a case of a 35-year-old man with IgG4-related lung disease with manifestations similar to those of interstitial lung disease. Chest computed tomography showed diffuse ground glass opacities and rapidly progressive pleural and subpleural fibrosis in both upper lobes. Histological findings showed diffuse interstitial lymphoplasmacytic infiltration with an increased number of IgG4-positive plasma cells. Serum levels of IgG and IgG4 were also increased. The patient was diagnosed with IgG4-related lung disease, treated with anti-inflammatory agents, and showed improvement. Lung involvement of IgG4-related disease can present as interstitial lung disease and, therefore, should be differentiated when evaluating interstitial lung disease.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.1
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• pp.19-23
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• 1995

The purpose of this project was to investigate alcohol consumption, cigarette smoking and family disease history in the family members of normal and hypertension disease, excluding patients themselves. Mean daily alcohol consumption in family members of hypertension disease patients was significantly higher, especially in the male with thirties, forties, and fifties, than those of normal subjects. Mean daily cigarette smoking in family members of hypertension disease patients was also significantly higher, especially in the male with forties and sixties than those of normal subjects. Cases of hereditary family disease was significantly higher in the family members of hypertension disease patients than those of normal subjects. Especially, a degree to be attacked with cerebrovascular disease was very higher in the family members of hypertension disease patients than normal family.

• Childhood Kidney Diseases
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• v.27 no.2
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• pp.70-75
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• 2023

Dent disease is a rare inherited kidney tubulopathy caused by mutations in either the CLCN5 (Dent disease 1) or OCRL1 (Dent disease 2) genes, and which is often underdiagnosed in practice. A diagnosis is clinically suspected in patients with low-molecular-weight proteinuria, hypercalciuria, and one of the following: hematuria, nephrolithiasis, nephrocalcinosis, hypophosphatemia, or chronic kidney disease. Inheritance is X-linked recessive, meaning, these symptoms are generally only found in males; female carriers may have mild phenotypes. Genetic testing is only a method to confirm the diagnosis, approximately 25% to 35% of patients have neither the CLCN5 nor OCRL1 pathogenic variants (Dent disease 3), making diagnosis more challenging. The genotype-phenotype correlations are not evident with the limited clinical data available. As with many other genetic diseases, the management of patients with Dent disease concentrates on symptom relief rather than any causative process. The current treatments are mainly supportive to reduce hypercalciuria and prevent nephrolithiasis. Chronic kidney disease progresses to end-stage between the ages of the third to fifth decades in 30% to 80% of affected males. In this review, we aimed to summarize the literature on Dent disease and reveal the clinical characteristics and molecular basis of Korean patients with Dent disease.