Browse > Article
http://dx.doi.org/10.4046/trd.2014.77.2.85

A Case of IgG4-Related Lung Disease Presenting as Interstitial Lung Disease  

Ahn, Jee Hwan (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Hong, Sun In (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Cho, Dong Hui (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Chae, Eun Jin (Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center)
Song, Joon Seon (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center)
Song, Jin Woo (Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Publication Information
Tuberculosis and Respiratory Diseases / v.77, no.2, 2014 , pp. 85-89 More about this Journal
Abstract
Intrathoracic involvement of immunoglobulin G4 (IgG4)-related disease has recently been reported. However, a subset of the disease presenting as interstitial lung disease is rare. Here, we report a case of a 35-year-old man with IgG4-related lung disease with manifestations similar to those of interstitial lung disease. Chest computed tomography showed diffuse ground glass opacities and rapidly progressive pleural and subpleural fibrosis in both upper lobes. Histological findings showed diffuse interstitial lymphoplasmacytic infiltration with an increased number of IgG4-positive plasma cells. Serum levels of IgG and IgG4 were also increased. The patient was diagnosed with IgG4-related lung disease, treated with anti-inflammatory agents, and showed improvement. Lung involvement of IgG4-related disease can present as interstitial lung disease and, therefore, should be differentiated when evaluating interstitial lung disease.
Keywords
IgG4; Lung Diseases; Lung Diseases; Interstitial;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012;366:539-51.   DOI   ScienceOn
2 Shrestha B, Sekiguchi H, Colby TV, Graziano P, Aubry MC, Smyrk TC, et al. Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology. Am J Surg Pathol 2009;33:1450-62.   DOI   ScienceOn
3 Zen Y, Inoue D, Kitao A, Onodera M, Abo H, Miyayama S, et al. IgG4-related lung and pleural disease: a clinicopathologic study of 21 cases. Am J Surg Pathol 2009;33:1886-93.   DOI   ScienceOn
4 Fujinaga Y, Kadoya M, Kawa S, Hamano H, Ueda K, Momose M, et al. Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis. Eur J Radiol 2010;76:228-38.   DOI
5 Duvic C, Desrame J, Leveque C, Nedelec G. Retroperitoneal fibrosis, sclerosing pancreatitis and bronchiolitis obliterans with organizing pneumonia. Nephrol Dial Transplant 2004; 19:2397-9.   DOI   ScienceOn
6 Takato H, Yasui M, Ichikawa Y, Fujimura M, Nakao S, Zen Y, et al. Nonspecific interstitial pneumonia with abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune disease. Intern Med 2008;47:291-4.   DOI   ScienceOn
7 Tanaka K, Nagata K, Tomii K, Imai Y. A case of isolated IgG4-related interstitial pneumonia: a new consideration for the cause of idiopathic nonspecific interstitial pneumonia. Chest 2012;142:228-30.   DOI
8 Taniguchi T, Ko M, Seko S, Nishida O, Inoue F, Kobayashi H, et al. Interstitial pneumonia associated with autoimmune pancreatitis. Gut 2004;53:770.
9 Wibmer T, Kropf-Sanchen C, Rudiger S, Blanta I, Stoiber KM, Rottbauer W, et al. Isolated IgG4-related interstitial lung disease: unusual histological and radiological features of a pathologically proven case. Multidiscip Respir Med 2013;8:22.   DOI
10 Yoo JW, Roh JH, Lim CM, Lee SD, Kim WS, Kim DS, et al. Two cases of pulmonary involvement of immunoglobulin G4 related autoimmune disease. Tuberc Respir Dis 2009;67:359-63.   DOI   ScienceOn
11 Kwon SH, Lee YK, Shim MS, Lee HI. A case of immunoglobulin G4-related sclerosing disease mimicking lung cancer. J Korean Soc Radiol 2013;69:53-6.   DOI
12 Park HY, Han J, Kang G, Yi CA, Chung MP. IgG4-related lung disease presenting as a consolidative mass: a case report. J Lung Cancer 2010;9:103-5.   DOI
13 Choi IH, Jang SH, Lee S, Han J, Kim TS, Chung MP. A case report of IgG4-related disease clinically mimicking pleural mesothelioma. Tuberc Respir Dis 2014;76:42-5.   DOI
14 Kim DH, Koh KH, Oh HS, Kim SJ, Kang SH, Jung BW, et al. A case of immunoglobulin g4-related disease presenting as a pleural mass. Tuberc Respir Dis 2014;76:38-41.   DOI
15 Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012;25:1181-92.   DOI   ScienceOn