• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3109-3116
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• 2013

The majority of hepatocellular carcinoma (HCC) patients have a poor prognosis with current therapies, and new approaches are urgently needed. We have developed a novel therapeutic cancer vaccine platform based on tumor cell derived autophagosomes (DRibbles) for cancer immunotherapy. We here evaluated the effectiveness of DRibbles-pulsed dendritic cell (DC) immunization to induce anti-tumor immunity in BALB/c mouse HCC and humanized HCC mouse models generated by transplantation of human HCC cells (HepG2) into BALB/c-nu mice. DRibbles were enriched from H22 or BNL cells, BALB/c-derived HCC cell lines, by inducing autophagy and blocking protein degradation. DRibbles-pulsed DC immunization induced a specific T cell response against HCC and resulted in significant inhibition of tumor growth compared to mice treated with DCs alone. Antitumor efficacy of the DCs-DRibbles vaccine was also demonstrated in a humanized HCC mouse model. The results indicated that HCC/DRibbles-pulsed DCs immunotherapy might be useful for suppressing the growth of residual tumors after primary therapy of human HCC.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.2
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• pp.328-338
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• 2017

In this paper, a zero torque control scheme adopting current sharing function (CSF) used in integrated Switched Reluctance Motor (SRM) drive with DC battery charger is proposed. The proposed control scheme is able to achieve the keeping position (KP), zero torque (ZT) and power factor correction (PFC) at the same time with a simple novel current sharing function algorithm. The proposed CSF makes the proper reference for each phase windings of SRM to satisfy the total charging current of the battery with zero torque output to hold still position with power factor correction, and the copper loss minimization during of battery charging is also achieved during this process. Based on these, CSFs can be used without any recalculation of the optimal current at every sampling time. In this proposed integrated battery charger system, the cost effective, volume and weight reduction and power enlargement is realized by function multiplexing of the motor winding and asymmetric SR converter. By using the phase winding as large inductors for charging process, and taking the asymmetric SR converter as an interleaved converter with boost mode operation, the EV can be charged effectively and successfully with minimum integral system. In this integral system, there is a position sliding mode controller used to overcome any uncertainty such as mutual inductance or DC offset current sensor. Power factor correction and voltage adaption are obtained with three-phase buck type converter (or current source rectifier) that is cascaded with conventional SRM, one for wide input and output voltage range. The practicability is validated by the simulation and experimental results by using a laboratory 3-hp SRM setup based on TI TMS320F28335 platform.

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.151-160
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• 2017

This paper presents a new technique of reference current generator based on Kalman filter (KF) estimator for three-phase shunt active power filter (APF). The stationary reference frame (d-q algorithm) is used to transform the load currents into DC component. The harmonics of load currents are extracted and the three-phase reference currents are generated using KF estimator. The work is simulated using Matlab/Simulink platform. To validate the simulation results, an experimental test-rig have been perform using real-time control dSPACE DS1104. In addition, hysteresis current control was used to generate the switching signal for the correction of the harmonics in the system. The non-linear load were constructed with three-phase rectifier which connected in series with inductor and parallel with resistor and capacitor. The results shows that the new technique of shunt APF embedded with KF is proven to eliminate the harmonics created by the non-linear load with some improvement on the total harmonics distortion (THD).

• Journal of electromagnetic engineering and science
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• v.16 no.4
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• pp.199-205
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• 2016

We present a novel schematic using a 3-dB coupler to transmit radiofrequency (RF) power to two receivers selectively. Whereas previous multiple receiver supporting schemes used hardware-switched methods, our scheme uses a soft power-allocating method, which has the advantage of variable power allocation in real time to each receiver. Using our scheme, we can split the charging area and focus the RF power on the targeted areas. We present our soft power-allocating method in three main points. First, we propose a new power distribution hardware structure using a FPGA (field-programmable gate array) and a 3-dB coupler. It can reconfigure the transmitting power to two receivers selectively using accurate FPGA-controlled signals with the aid of software. Second, we propose a power control method in our platform. We can variably control the total power of transmitter using the DC bias of the drain input of the amplifier. Third, we provide the possibility of expansion in multiple systems by extending these two wireless power transfer systems. We believe that this method is a new approach to controlling power amplifier output softly to support multiple receivers.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.301-304
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• 2003

Recently, the development of internet remote control system has been studied lively along with fast growth of internet. In this paper, we proposed the internet-based remote control and monitoring system using java platform. The apache web server that is now used worldwide was constructed for monitoring and controlling of an machine in administrator's web browser. We solved the limitation on security which is the biggest problem of internet control system due to strong security setting in web server. As a result of experiment which is used in the proposed remote internet control system, several time-delay occurred in internet. However, correct control result could be achieved without an error. And this system monitored informations of a RPM, temperature and the other condition in almost real time.

• Journal of international Conference on Electrical Machines and Systems
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• v.2 no.1
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• pp.120-126
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• 2013

The main aim of this paper is to expound high-efficiency operation of Switched Reluctance Generator (SRG) based on the current waveform. For this purpose, theoretical analysis of the copper loss and iron loss of the system is done first. Then, necessary simulation is done to find the variation trend of the copper loss and iron loss with the variation of the current waveform at the same output power. Finally, the best current waveform which can make the system operate with high efficiency is obtained by considering the influence of these two kinds of loss. In order to verity the simulation results, the experimental platform of DC motor-SRG is built and the modified angle position control (APC) method which can specify the current shape optionally is presented. By comparing the system efficiency at the three kinds of typical current waveform, the correctness and feasibility of the theory is verified. The proposed method is simple, reliable, and easy to achieve.

• Journal of Nutrition and Health
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• v.19 no.5
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• pp.333-341
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• 1986

Several aspects including physical development, reflex acquistion, neuromotor development and learning behavior at Y water maze were compared at the progeny of rats fed low 91.2mg/kg diet) or adequate leves(22mg/kg diet 0 of pyridoxine during growth, gestation, lactation, and adult period. Physical development and development of reflexes (righting reflex, cliff avoidance, negative geotaxis, palmar grasp, and startle reflex to sound) appeared different between control and deficient groups but not significantly. At the 2nd week, rats spent more time in supported standing during 6 minute period was longer in the control then the deficient groups. In the Y-water maze position reversal test, learning ability as judged by the number of errors was not different among three groups, but the rats in supplemented group(DC) reached the escape platform in significantly shorter time than the other two groups, which may suggest their emotional instability. In the visual discrimination test, the performance of rats from the supplemented group had the lower errors than the other groups on the early test days. but as the testing period progressed, the performance of rats in the supplemented group became inferior to those of the control and deficient groups. The performance of control group became superior to that of the deficient group.

• Journal of Power Electronics
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• v.11 no.1
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• pp.37-44
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• 2011

In this paper, a four-phase 8/6-pole 4-kW SR motor drive model is presented. Based on experimental data, the model allows an accurate simulation of a drive in dynamic operation. Simulations are performed and a laboratory type set-up is built based on a TI TMS320F2812 platform to experimentally verify the theoretical results obtained for a SR motor. To reduce acoustic noise and to correct the power factor of this drive, a two-stage power converter is proposed that uses a current source rectifier (CSR) as the input stage for the asymmetrical converter of the studied SRM. Employing the space-vector modulation (SVM) method in matrix converters, the CSR switching allows the dc link's capacitors to be eliminated and the power factor of the SRM drive to be improved. As the electrical motive force (emf) is directly proportional to the rotor speed, the input voltage to the machine can be programmed to be a function of the speed with the modulation index of the CSR, leading to a reduction in the acoustic noise of the SRM drive. Simulation of the whole SRM drive system is performed using MATLAB-Simulink. The results fully comply with the required conditions such as power factor correction with an improvement in the THD.

• Journal of Power Electronics
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• v.17 no.5
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• pp.1244-1255
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• 2017

The space vector pulse width modulation (SVPWM) technique is a popular PWM method for medium voltage drive applications. Conventional SVPWM (CSVPWM) and bus clamped SVPWM (BCSVPWM) are the most common SVPWM techniques. This paper evaluates the performance of various advanced BCSVPWM strategies in terms of their harmonic distortion and switching loss based on a uniform frame work. A uniform frame work, pulse number captures the performance parameter variations of different SVPWM strategies for various number of samples with heterogeneous pulse numbers. This work compares different advanced BCSVPWM techniques based on the modulation index and location of the clamping position (zero vector changing angle ) of a phase in a line cycle. The frame work provides a fixed fundamental frequency of 50Hz. The different BCSVPWM switching strategies are implemented and compared experimentally on a 415V, 2.2kW, 50Hz, 3-phase induction motor drive which is fed from an IGBT based 2 KVA voltage source inverter (VSI) with a DC bus voltage of 400 V. A low cost PIC microcontroller (PIC18F452) is used as the controller platform.

• Journal of Aerospace System Engineering
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• v.3 no.1
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• pp.36-41
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• 2009

Quad-rotor is one kind of a rotorcraft in Unmanned Aerial Vehicle (UAV), which consists of four rotors in total and fixed-pitch blades located at the four corners. This vehicle is emerging as popular platform for UAV research due to the simplicity of its construction, the ability of hovering and the vertical take-off and landing (VTOL) capability, etc. Because of those specific capabilities, this vehicle can be applied to many fields: search and rescue, mobile sensor networks, fire observation, etc. However a quad-rotor is much affected by the disturbance due to the characteristics of structure. So this vehicle needs attitude control for stabilizing. In this paper, we design the control law for automatic stabilization. The PID controller is used to control a brushless DC motor. And an accelerometer is used to measure the roll and pitch angles of a quad-rotor.