• Journal of Korean Neurosurgical Society
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• v.63 no.6
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• pp.673-680
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• 2020

The demineralized bone matrix (DBM) as the bone graft material to increase the fusion rate was widely used in spinal fusion. The current study aimed to compare the fusion rate of DBM to the fusion rate of autograft in lumbar spine fusion via meta-analysis of published literature. After systematic search, comparative studies were selected according to eligibility criteria. Checklist (risk of bias assessment tool for non-randomized study) was used to evaluate the risk of bias of the included nonrandomized controlled studies. The corresponding 95% confidence interval (95% CI) were calculated. We also used subgroup analysis to analyze the fusion rate of posterolateral lumbar fusion and lumbar interbody fusion. Eight studies were finally included in this meta-analysis. These eight studies included 581 patients. Among them, 337 patients underwent spinal fusion surgery using DBM (DBM group) and 204 patients underwent spinal fusion surgery with mainly autologous bone and without using DBM (control group). There was no significant differences of fusion rate between the two groups in posterolateral fusion analysis (risk ratio [RR], 1.03; 95% CI, 0.90-1.17; p=0.66) and interbody fusion analysis (RR, 1.13; 95% CI, 0.91-1.39; p=0.27). Based on the available evidence, the use of DBM with autograft in posterolateral lumbar spine fusion and lumbar interbody fusion showed a slightly higher fusion rate than that of autograft alone; however, there was no statistically different between two groups.

• Journal of KIISE:Computing Practices and Letters
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• v.12 no.1
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• pp.21-30
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• 2006

As the amount of information to be processed by computers has recently been increased, there has been cluster computing systems developed by connecting PCs and workstations using high-speed networks. hs a result, the studies on a cluster-based DBMS have been done with a wide range and it is necessary to develop a cluster manager for monitoring and managing cluster-based DBMSs. But, a cluster manager for efficiently managing cluster-based DBMSs has been studied in a first step. In this paper, we design and implement a high-availability cluster manager for a cluster-based DBMS. It monitors the status of nodes in cluster systems as well as the status of DBMS instances in a node, by using a graphic user interface (GUI). Our cluster manager supports the high-availability for a cluster-based DBMS by perceiving errors and recovering them, based on the monitored information on the status of a server.

• Journal of Digital Contents Society
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• v.15 no.5
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• pp.631-642
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• 2014

The main memory DBMS is operated which the contents of the table that resides on a disk at the same time as the drive is in the memory. However, because the main memory DBMS stores the data and transaction log file using the disk file system, there are a limit to the speed at which the CPU accesses the memory. In this paper, I evaluated the performance through analysis of the application side difference the technology that has been implemented in Altibase system of main memory DBMS and Sybase of disk-based DBMS. When the application performance of main memory DBMS is in comparison with the disk-based DBMS, the performance of main memory DBMS was outperformed 1.24~3.36 times in the single soccer game, and was outperformed 1.29~7.9 times in the soccer game / special soccer. The result of sale transaction response time showed a fast response time of 1.78 ~ 6.09 times.

• The Journal of the Korean bone and joint tumor society
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• v.19 no.2
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• pp.56-63
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• 2013

Purpose: This study was performed to evaluate the efficiency of demineralized bone matrix (DBM, Genesis$^{(R)}$) used for bone defect after operative traetment of benign bone tumors by clinical and radiological methods. Materials and Methods: DBM was used to treat bone defect after operative treatment of benign tumor from February 2012 to May 2013. Total 25 benign bone tumor cases (15 males, and 10 females) with mean age of 30.3 were studied. The diagnoses were solitary bone cyst in 9 cases, non ossifying fibroma in 5, fibrous dysplasia in 5, aneurysmal bone cyst in 3 and enchondroma in 3. In categorization by location of tumor, there were 5 cases of distal femur, 4 of proximal tibia, 3 of proximal femur, 3 of proximal humerus, 3 of phalanx, 2 of distal radius, 2 of hip bone, 2 of calcaneus, and 1 of scapula. Autogenous bone was used with DBM in 6 cases, and only DBM used in 19 cases. Mean periods of follow up were 8.7 months (range: 6 to 14 months). Amount of graft resorption and bone formation was observed with compare of post operation radiograph and the difference was shown by percentage. Resorption level was measured by DBM level which could be observed from simple x-ray, and bone formation level by bone trabecular formation level at impaired site. Results: Twenty three cases of total 25 cases showed bone union. In the 23 cases, more than 98% DBM resorption was observed after mean 4.3 months, and more than 98% bone formation was observed after mean 6.9 months. Lesser bone defect sizes showed faster bone formation and it was statistically significant (p=0.036). But other comparative studies on other factors such as, sex, age of patients and combination of autogenous bone were no statistically significant differences in graft resorption and bone formation. And there was no significant complication in periods of follow-up. Conclusion: Demineralized Bone Matrix (Genesis$^{(R)}$) is thought to be useful treatment for bone defect after operative treatment of benign bone tumor, however longer follow-up periods appears to be needed.

• Journal of Korean Neurosurgical Society
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• v.65 no.6
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• pp.825-833
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• 2022

Objective : ABM/P-15 (anorganic bone matrix/15-amino acid peptide fragment) is a commercially available synthetically manufactured P-15 collagen peptide fragment, that is adsorbed on ABM. This study was done to investigate the efficacy of ABM/P-15 in achieving fusion in the lumbar spine and comparing it with that of recombinant bone morphogenic protein-2 (rhBMP-2) and demineralized bone matrix (DBM). Methods : A retrospective observational study of prospectively collected data of 140 patients who underwent lumbar spinal fusion surgeries in a single specialty spine hospital between 2016 and 2020, with a minimum 6-month follow-up was conducted. Based on the material used for the augmentation of the bone graft at the fusion site, the patients were divided into three categories namely ABM/P-15, rhBMP-2, and DBM group. Results : ABM/P-15, rhBMP-2, and DBM were used in 46, 44, and 50 patients, respectively. Patient characteristics like age, gender, bone mineral density, smoking history, and presence of diabetes mellitus were comparable amongst the three groups. Average follow-up was 16.0±5.2, 17.9±9.8, and 26.2±14.9 months, respectively in ABM/P-15, rhBMP-2, and DBM groups. The fusion was achieved in 97.9%, 93.2%, and 98% patients while the average time-to-union was 4.05±2.01, 10±4.28, and 9.44±3.49 months (p<0.001), respectively for ABM/P-15, rhBMP-2, and DBM groups. The average pre-operative Visual analogue scale score was 6.93±2.42, 7.14±1.97, 7.01±2.14 (p=0.900) for ABM/P-15, rhBMP-2 and DBM groups, respectively, which reduced to 1.02±0.80, 1.21±0.96, and 0.54±0.70 (p=0.112), respectively at the last follow up. Pre-operative Oswestry disability index scores were 52.7±18.02, 55.4±16.8, and 53.56±19.6 (p=0.751) in ABM/P-15, rhBMP-2, and DBM groups, which post-operatively reduced to 33.77±15.52, 39.42±16.47, and 38.3±15.89 (p=0.412) and further to 15.74±8.3, 17.41±10.45, and 16.76±9.81 (p=0.603), respectively at the last follow-up. Conclusion : ABM/P-15 appears to achieve union significantly earlier than rhBMP-2 and DBM in lumbar spinal fusion cases while maintaining a comparable clinical and complication profile.

• Journal of Korean Neurosurgical Society
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• v.67 no.3
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• pp.354-363
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• 2024

Objective : This study aims to determine the optimal dose of recombinant-human bone morphogenic protein-2 (rhBMP-2) for successful bone fusion in minimally invasive lateral lumbar interbody fusion (MIS LLIF). Previous studies show that rhBMP is an effective alternative to autologous iliac crest bone graft, but the optimal dose remains uncertain. The study analyzes the fusion rates associated with different rhBMP doses to provide a recommendation for the optimal dose in MIS LLIF. Methods : Ninety-three patients underwent MIS LLIF using demineralized bone matrix (DBM) or a mixture of rhBMP-2 and DBM as fusion material. The group was divided into the following three groups according to the rhBMP-2 usage : group A, only DBM was used (n=27); group B, 1 mg of rhBMP-2 per 5 mL of DBM paste (n=41); and group C, 2 mg of rhBMP-2 per 5 mL of DBM paste (n=25). Demographic data, clinical outcomes, postoperative complication and fusion were assessed. Results : At 12 months post-surgery, the overall fusion rate was 92.3% according to Bridwell fusion grading system. Groups B and C, who received rhBMP-2, had significantly higher fusion rates than group A, who received only DBM. However, there was no significant increase in fusion rate when the rhBMP-2 dosage was increased from group B to group C. The groups B and C showed significant improvement in back pain and Oswestry disability index compared to the group A. The incidence of screw loosening was decreased in groups B and C, but there was no significant difference in the occurrence of other complications. Conclusion : Usage of rhBMP-2 in LLIF surgery leads to early and increased final fusion rates, which can result in faster pain relief and return to daily activities for patients. The benefits of using rhBMP-2 were not significantly different between the groups that received 1 mg/5 mL and 2 mg/5 mL of rhBMP-2. Therefore, it is recommended to use 1 mg of rhBMP-2 with 5 mL of DBM, taking both economic and clinical aspects into consideration.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10c
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• pp.6-11
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• 2006

최근 휴대용 정보기기 사용이 보편화되어지고 있는 가운데 정보의 디지털화로 인해 휴대용 정보기기에서 처리되어야 하는 정보가 무수히 많아지고 있다. 이로 인해 휴대용 정보기기에서는 정보들을 효과적으로 관리하기 위해 임베디드 DBMS의 사용이 요구되고 있다. 또한 휴대용 정보기기에서 보편적으로 사용되는 저장장치는 NAND형 플래시 메모리로 단위 공간당 비용이 기존의 하드디스크에 비해 수십배 가량 높아 저장 공간의 효율적인 관리가 요구되고 있다. 따라서 본 논문에서는 플래시메모리를 저장매체로 사용하는 DBMS에서 압축기법을 사용한 효율적인 데이터 관리 시스템을 제안한다. 제안되는 압축 기반 시스템은 저장 공간과 데이터I/O를 줄이며, 데이터I/O를 줄임으로써 DBMS의 성능향상과 플래시 메모리의 수명을 연장시키는 효과를 기대할 수 있다.

• The Journal of the Korea Contents Association
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• v.8 no.1
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• pp.290-299
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• 2008

We propose the query optimization technique using query classification in hybrid spatial DBMS. In our approach, user queries should to be classified into three types: memory query, disk query, and hybrid query. Specialty, In the hybrid query processing, the query predicate is divided by comparison between materialized view creating conditions and user query conditions. Then, the deductions of the classified queries' cost formula are used for the query optimization. The optimization is mainly done by the selection algorithm of the smallest cost data access path. Our approach improves the performance of hybrid spatial DBMS than traditional disk-based DBMS by $20%{\sim}50%$.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.05a
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• pp.42-45
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• 2007

최근 사회는 정보의 디지털화로 인해 많은 디지털 정보들이 많아지고 있고, 또한 휴대용 정보기기의 발전으로 인해 휴대용 정보기기의 사용이 보편화 되었다. 이로 인해 휴대용 정보기기에서는 정보들을 효과적으로 관리하기 위해 임베디드 DBMS의 사용이 요구되고 있다. 또한 휴대용 정보기기에서 보편적으로 사용되는 저장장치는 NAND형 플래시 메모리로 단위 공간당 비용이 기존의 하드디스크에 비해 수십배 가량 높아 저장 공간의 효율적인 관리가 요구되고 있다. 따라서 본 논문에서는 플래시메모리를 저장매체로 사용하는 DBMS에서 압축기법을 사용한 효율적인 데이터 동적 관리 시스템을 제안한다. 제안되는 압축 기반 시스템은 저장 공간과 데이터I/O를 줄이며, 데이터I/O를 줄임으로써 DBMS의 성능향상과 플래시 메모리의 수명을 연장시키는 효과를 기대할 수 있다.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.155-160
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• 2002

A series of modified oligonucleotides containing a phosphorothioate (P=S) backbone and a six-membered azasugar (6-AZS) as a sugar substitute in a nucleotide were synthesized and tested for their ability to inhibit the human immunodeficiency virus type I(HIV-l) in vitro without the aid of any transfecting agents. While P=S oligonucleotides with natural nucleotides had little anti-HIV-l activity, the six-membered azasugar nucleotide (6-AZN)-containing P=S oligonucleotides (AZPSONs) potently inhibited the HIV-l/SHIV replication and syncytium formation (ECso = 0.02-0.2 /lM) without cytotoxicity up to 100 /lM. DBM-2198, the most effective in anti-HIV-l activity among the AZPSONs, consists of random sequence and five 6¬AZNs evenly distributed in 18 nucleotides. DBM-2198 showed strong antiviral activity against, not only laboratory strains, but also primary isolates and even drug-resistant strains of HIV-I. DBM-2198 was much more effective than ddI or ddC in its anti-HIV-l activity in vitro. Particularly noteworthy is that the anti-HIV-l activity of DBM-2198 was better than that of AZT with respect to its long-lasting efficacy after a single treatment. Nevertheless, the antiviral activity of the AZPSONs was very specific to HIV-I. Poliovirus, or even simian immunodeficiency virus (SIV), was not inhibited by the AZPSONs. Taken together, our results strongly suggest that AZPSON can be used as a safe and effective AIDS-therapeutic drug against a broad spectrum of HIV -1 strains.