• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• 전기의세계
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• v.18 no.3
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• pp.15-23
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• 1969

A combinational circuit is one of the fundamental elements in digital circuits, containing electronic computers. W.A. Davis presented a new approach to the problem of assigning binary input codes so that the combinational circuits necessary to realize the given output functions may be minimized. This paper has derived an algorithm for determining the actual cost of a given assignment scheme in Davis method. First, the combinations of partitions realizing the output functions are obtained and then those among them implementing all of the output functions are found by using a table. In consequence it has been proved that by this algorithm the process of the assignment in a schcme with 16 states and 3 determined partitions can be reduced to 1/10$^{6}$ .

• The Korean Journal of Ceramics
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• v.6 no.3
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• pp.245-249
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• 2000

Consolidation of amorphous powders is emerging as a route for synthesis of high strength composite materials. Diffusion processes necessary for consolidation are expected to be more rapid in amorphous state(SRO) than in the crystalline state(LRO). A new synthesis technique of exploiting polymeric ceramic precursors(polysilazane and polyborosilazane) is derived for Si$_3$N$_4$/SiC and boron-modified nanocomposites for extremely high temperature applications up to 200$0^{\circ}C$. The characterization methods include thermal analysis of DTA, and XRD, NMR, TEM, after pyrolysis, as a function of time and temperature.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2004.06a
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• pp.282-287
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• 2004

• Proceedings of the Korean Nutrition Society Conference
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• 1995.05c
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• pp.24-24
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• 1995

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09a
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• pp.28-29
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• 2005

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2004.05a
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• pp.103-104
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• 2004

• Proceedings of the Materials Research Society of Korea Conference
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• 2001.05a
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• pp.174-174
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• 2001

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.04b
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• pp.31-32
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• 2009

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.747-758
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• 2002

The skin displays a highly active metabolism of polyunsaturated fatty acids (PUFA). Dietary deficiency of linoleic acid (LA), an 18-carbon (n-6) PUFA, results in characteristic scaly skin disorder and excessive epidermal water loss. Although arachidonic acid (AA), a 20-carbon (n6) PUFA, is metabolized via cyclooxygenase pathway into predominantly prostaglandin $E_2(PGE_2)$ and $PGF_{2{\alpha}}$, the metabolism of AA via the 15-lipoxygenase (15-LOX) pathway, which is very active in skin epidermis and catalyzes the transformation of M into predominantly 15S-hydroxyeicosatetraenoic acid (15S-HETE). Additionally, the 15-LOX also metabolizes the 18-carbon LA into 13S-hydroxyoctadecadienoic acid (13S-HODE), respectively. Interestingly, 15-LOX catalyzes the transformation of $dihomo-{\gamma}-linolenic$ acid (DGLA), derived from dietary gamma-linolenic acid, to 15S-hydroxyeicosatrienoic acid (15S-HETrE). These monohydroxy fatty acids are incorporated into the membrane inositol phospholipids which undergo hydrolytic cleavage to yield substituted-diacylglycerols such as 13S-HODE-DAG from 13S-HODE and 15S-HETrE-DAG from 15S-HETrE. These substituted-monohydroxy fatty acids seemingly exert anti-inflammatory/antiproliferative effects via the modulation of selective protein kinase C as well as on the upstream/down-stream nuclear MAP-kinase/AP-1/apoptotic signaling events.