• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.418-438
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• 2023

Objective: This study was conducted to review the effects of herbal medicine on respiratory diseases induced by the treatment of particulate matter in in vivo animal models. Methods: Literature searches were performed in seven databases (Pubmed, Embase, Cochrane Library, KISS, KTKP, OASIS, and ScienceON). After the searched studies were screened based on the inclusion/exclusion criteria, the publication date, origin, used animals, induction of particulate matter models, herbal medicine used for intervention, study design, outcome measure, and results of studies were analyzed. Results: Among a total of 972 studies primarily searched, 34 studies were finally included in our study. Of this number, 29 studies induced animal models by using only particulate matter, and 5 studies induced animal models with respiratory diseases, such as asthma and chronic obstructive pulmonary disease, by using particulate matter and other materials. In the selected studies, the treatments of herbal medicine in particulate matter models suppressed oxidative stress and inflammation in lung tissue, bronchoalveolar lavage fluid, and blood as well as lung injury in histological analysis. Conclusion: The results of this study suggest that herbal medicine is effective in treating respiratory diseases induced by particulate matter. These results are also expected to be useful data for designing further studies. However, more systematically designed in vivo studies related to particulate matter are needed.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.4
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• pp.497-505
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• 2015

Traditional herbs, such as Lonicera japonica, Arctii Fructus, and Scutellariae Radix have been used as traditional drug due to their anti-inflammatory and anti-oxidant activities. The aim of this study was to investigate the anti-inflammatory effects of extract mixture (YG-1) in a model of lipopolysaccharide (LPS)-induced acute inflammation in both macrophage (RAW 264.7) cells and Sprague-Dawley rats. YG-1 did not show specific cellular toxicity in RAW 264.7 cells until a concentration of $100{\mu}g/mL$. YG-1 reduced various markers related to inflammation such as IL-$1{\beta}$, COX-2, and iNOS caused by LPS in RAW 264.7 cells. Consistent with these results, YG-1 exerted significant anti-inflammatory effects in an acute inflammation rat model. Acute fever and high concentration of IL-$1{\beta}$ in serum induced by LPS were significantly reduced by YG-1. These results were similar to flubiprofen, a commercial anti-inflammatory and anti-febrile drug. Therefore, these results indicate that YG-1 has beneficial effects on LPS-induced acute inflammation and suggest that YG-1 can serve as an effective anti-inflammatory and anti-febrile drug.

• Journal of Life Science
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• v.20 no.11
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• pp.1738-1741
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• 2010

Caliper measurements of tumor volume have been widely used in the assessment of tumors in animal models. However, experiments based on caliper data have resulted in unreliable estimates of tumor growth, due to necrotic areas of tumor mass. To overcome this systematic bias, we engineered a new luciferase-expressing rat prostate cancer cell line (MLL-Luc) that produces bioluminescence from viable cancer cells. MLL-Luc cells showed a strong correlation between bioluminescence intensity and cell number ($R^2$=0.99) and also accurately quantified tumor growth, with reduced bioluminescence signals caused by necrotic cells in a subcutaneous MLL-Luc xenograft model. The accurate quantification of tumor growth with bioluminescence imaging (BLI) was confirmed by a better antitumor effect of combination chemotherapy, compared to that based on caliper measurements with a correlation between the bioluminescence signal and tumor volume ($R^2$=0.84). These data suggest that bioluminescent MLL xenografts are a powerful and quantitative tool for monitoring tumor growth and are useful in evaluating the efficacy of anticancer drugs, with less systematic bias.

• The Journal of Internal Korean Medicine
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• v.38 no.3
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• pp.353-366
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• 2017

Objective: This study aimed to use a mouse model to evaluate the effects of Gwaruhaengryeon-hwan (GHH) on chronic obstructive pulmonary disease (COPD) and particulate matter induced lung injury. Materials and Methods: The study was carried out in two ways (in vitro, in vivo). In vitro RAW 264.7 cells (mouse macrophage) were used and analyzed by flow cytometry, ELISA. In vivo lipopolysaccharide (LPS) and cigarette smoke solution (CSS), or coal, fly ash, diesel exhaust particle (CFD) challenged mice were used and its BALF was analyzed by ELISA, lung tissue by real-time PCR. Results: In vitro, GHH maintained an 80-100% rate of viability. So cytotoxicity was not shown. In the ELISA analysis with RAW 264.7 cells, GHH significantly decreased NO over $30{\mu}g/ml$. In the ELISA analysis, GHH significantly decreased $TNF-{\alpha}$, IL-6 over $300{\mu}g/ml$. In the COPD model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increasing of neutrophils, $TNF-{\alpha}$, IL-17A, MIP2, CXCL-1 in BALF, $TNF-{\alpha}$, $IL-1{\beta}$ mRNA expression in lung tissue and histological lung injury. In the CFD induced lung injury model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increase of neutrophils, $TNF-{\alpha}$, IL-17A, MIP2, CXCL-1 in BALF, MUC5AC, $TGF-{\beta}$ mRNA expression in lung tissue and histological lung injury. Conclusion: This study suggests the usability of GHH for COPD patients by controlling lung tissue injury.

• Proceedings of the KIEE Conference
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• 2008.04a
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• pp.189-190
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• 2008

원자력발전소의 탈기기 계통(Gas Stripper System)은 약 $25^{\circ}C$의 순수를 1.2기압, $105^{\circ}C$ 상태를 거쳐서 가스가 없는 상태(탈기)로 만들어 주는 계통이다. 탈기 상태를 유지하면서 지속적으로 순수를 만들기 위해서 본 계통에는 수위와 압력 제어루프가 있다. 탈기 상태에서는 탈기기 탱크내의 유체 상태가 이상(Two Phase)이기 차가운 급수를 사용한 수위와 압력 제어가 어렵다. 본 논문에서는 모델 기반으로 제어 최적화를 하기 위하여 제어 구성 요소들에 대한 제어 모델링 및 검증 과정을 기술한다. 제어모델링은 일반적으로 Parameter Identification 기법을 적용하지만, 유체역학 수식 모델, 운전 데이터, 탱크와 배관의 설계 자료 등을 이용한 경험적 방법을 적용하였으며 운전 데이터를 사용하여 검증하였다.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.12
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• pp.1138-1145
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• 2011

The internal broadband noise of a centrifugal fan in a household refrigerator is predicted using hybrid CAA techniques based on stochastic turbulent synthetic model. First, the unsteady flow field around the centrifugal fan is predicted using computational fluid dynamics(CFD) method. Then, the turbulent flow field is synthesized by applying the stochastic turbulent synthetic technique to the predicted flow field. The aerodynamic noise sources of the centrifugal fan are modeled on a basis of the synthesized turbulent field. Finally, the internal broadband noise of the centrifugal fan is predicted using the boundary element method(BEM) and the modeled sources. The predicted noise spectrum is compared with the experimental data. It is found that the predicted result closely follows the experimental data. The proposed method can be used as an effective tool for designing low-noise fans without expensive computational cost required generally for the LES and DNS simulations to resolve the turbulence flow field responsible for the broadband noise.

• Journal of the Korean Society of Propulsion Engineers
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• v.16 no.2
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• pp.10-16
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• 2012

A computational analysis of nozzle flow characteristics and plume structure is conducted to examine performance of the supersonic nozzle employed in a thruster for ground firing test. At first, flow simulations in two-dimensional converging-diverging nozzle are performed for the verification of computational capability as well as turbulence model validity. Axisymmetric converging-diverging nozzles for ground firing test are analyzed with the k-${\omega}$ SST model. A performance penalty caused by flow separation in a diverging section is observed in initially-designed nozzle. The performance could be enhanced by the modification of the diverging section of nozzle contour.

• Journal of Digital Convergence
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• v.11 no.5
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• pp.31-39
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• 2013

Smart TV is a television set with internet capabilities, computing ability, and broadcasting service that increases user interactions. Usability has been regarded as one of the most important criteria for measuring and evaluating smart TV. To evaluate smart TV from the perspective of usability, we first need to develop a measurement model by determining the major factors affecting usability, which become a measurement the evaluation criteria of the model. The objective of this paper is to suggest an AHP(Analytic Hierarchy Process) model for measuring usability of smart TV. Factors affecting usability are described from the prior research. We show how the judgment data is acquired and the usability score is computed by an numerical example.

• Journal of the Korean Geotechnical Society
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• v.17 no.1
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• pp.119-129
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• 2001

연약지반 개량을 위한 시멘트의 사용은 깊은 심도의 점토 지반을 개량하는데 일반적으로 사용되는 기술이 되었다. 시멘트는 지반의 강도를 증가시키고 압축성을 감소시키는 역할을 한다. 시멘트-흙 혼합물의 강도 증가에는 여러 가지 요소가 있는데 이중 대표적인 것은 시멘트량, 흙의 종류, 함수비, 양생시간 등을 들 수 있다. 시멘트 첨가량이 적은 경우, 전단 강도증가는 기본적으로 시멘테이션 효과로 인한 점착력의 증가에 의한 입자들간의 마찰력으로부터 발생한다. 이러한 거동은 과압밀된 흙의 거동과 유사함을 볼 수 있다. 시멘트량이 많은 경우, 강도 증가의 주원인은 입자간의 물리적 결합에 기인하는데 이는 연약한 암석과 비슷한 거동을 한다. 시멘트 고화처리 흙의 응력-변형 거동을 분석하기 위해 한계상태 이론을 적용하였다. 그리고, 토립자간의 시멘테이션 효과를 반영하기 위해 새로운 한계상태 파라메타를 도입하였으며 시멘트 고화처리 점토의 거동을 분석하기 위한 새로운 한계상태 모델을 제시하였다.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2014.06a
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• pp.203-205
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• 2014

본 논문에서는 HEVC 기반 비디오 부호화에 있어 CTU 단위의 시각 민감도에 따라 CTU 별로 QP 를 조절하여 주관적 화질을 향상시키는 방법을 제안한다. 시각 민감도를 측정하는 방법으로서 화소 영역에서의 최소가지차(JND, just noticeable distortion)를 계산하여 이용하였고, 이를 HM 12.0 참조 소프트웨어에서 이용되는 $R-{\lambda}$ 모델 기반의 율 제어 모듈에 결합하여 시각 민감도에 따라 QP 를 제어할 수 있도록 하였다. 시각 민감도가 큰 영상의 영역에 대해서는 상대적으로 작은 QP 값을, 시각민감도가 작은 영역에 대해서는 큰 QP 값을 양자화 과정에 적용함으로써, 시각 민감도가 작은 영역에 대해서는 사용 비트양을 절약하고, 절약된 비트를 상대적으로 시각 민감도가 큰 영역을 위해 사용함으로써 비디오의 주관적 화질을 향상시킬 수 있었다. 뿐만 아니라 이를 하드웨어에 적용 가능하게 하기 위해 HM 12.0 기반 하드웨어 구현을 위한 소프트웨어 플랫폼에 구현하여 실험한 결과, $R-{\lambda}$ 모델 율 제어 알고리즘으로 율 제어 하여 부호화 한 경우 Y-PSPNR(peak signal to perceptual noise ratio)에 대한 BD-rate 는 평균 9.4%의 이득이 있었음을 확인하였다.