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http://dx.doi.org/10.3746/jkfn.2015.44.4.497

Effects of Extract Mixture (Yg-1) of Anti-Inflammatory Herbs on LPS-Induced Acute Inflammation in Macrophages and Rats  

Song, In-Bong (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Na, Ji-Young (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Song, Kibbeum (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Kim, Sokho (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Lee, Ji-Hyun (Department of Immunology, Institute for Medical Science, Chonbuk National University)
Kwon, Young-Bae (Department of Pharmacology, Institute for Medical Science, Chonbuk National University)
Kim, Dae-Ki (Department of Immunology, Institute for Medical Science, Chonbuk National University)
Kim, Dae-Sung (Central Research and Development, Hanpoong Pharm & Foods)
Jo, Hyoung-Kwon (Central Research and Development, Hanpoong Pharm & Foods)
Kwon, Jungkee (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.4, 2015 , pp. 497-505 More about this Journal
Abstract
Traditional herbs, such as Lonicera japonica, Arctii Fructus, and Scutellariae Radix have been used as traditional drug due to their anti-inflammatory and anti-oxidant activities. The aim of this study was to investigate the anti-inflammatory effects of extract mixture (YG-1) in a model of lipopolysaccharide (LPS)-induced acute inflammation in both macrophage (RAW 264.7) cells and Sprague-Dawley rats. YG-1 did not show specific cellular toxicity in RAW 264.7 cells until a concentration of $100{\mu}g/mL$. YG-1 reduced various markers related to inflammation such as IL-$1{\beta}$, COX-2, and iNOS caused by LPS in RAW 264.7 cells. Consistent with these results, YG-1 exerted significant anti-inflammatory effects in an acute inflammation rat model. Acute fever and high concentration of IL-$1{\beta}$ in serum induced by LPS were significantly reduced by YG-1. These results were similar to flubiprofen, a commercial anti-inflammatory and anti-febrile drug. Therefore, these results indicate that YG-1 has beneficial effects on LPS-induced acute inflammation and suggest that YG-1 can serve as an effective anti-inflammatory and anti-febrile drug.
Keywords
extract mixture (YG-1); lipopolysaccharide (LPS); acute inflammation; fever;
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