• 제목/요약/키워드: D-Race

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Association of Lower Socioeconomic Status and SARS-CoV-2 Positivity in Los Angeles, California

  • Allan-Blitz, Lao-Tzu;Goldbeck, Cameron;Hertlein, Fred;Turner, Isaac;Klausner, Jeffrey D.
    • Journal of Preventive Medicine and Public Health
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    • 제54권3호
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    • pp.161-165
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    • 2021
  • Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads heterogeneously, disproportionately impacting poor and minority communities. The relationship between poverty and race is complex, with a diverse set of structural and systemic factors driving higher rates of poverty among minority populations. The factors that specifically contribute to the disproportionate rates of SARS-CoV-2 infection, however, are not clearly understood. Methods: We evaluated SARS-CoV-2 test results from community-based testing sites in Los Angeles, California, between June and December, 2020. We used tester zip code data to link those results with United States Census report data on average annual household income, rates of healthcare coverage, and employment status by zip code. Results: We analyzed 2 141 127 SARS-CoV-2 test results, of which 245 154 (11.4%) were positive. Multivariable modeling showed a higher likelihood of SARS-CoV-2 test positivity among Hispanic communities than among other races. We found an increased risk for SARS-CoV-2 positivity among individuals from zip codes with an average annual household income

Necrotrophic Fungus Pyrenophora tritici-repentis Triggers Expression of Multiple Resistance Components in Resistant and Susceptible Wheat Cultivars

  • Andersen, Ethan J.;Nepal, Madhav P.;Ali, Shaukat
    • The Plant Pathology Journal
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    • 제37권2호
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    • pp.99-114
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    • 2021
  • Tan spot of wheat, caused by Pyrenophora tritici-repentis (Ptr), results in a yield loss through chlorosis and necrosis of healthy leaf tissue. The major objective of this study was to compare gene expression in resistant and susceptible wheat cultivars after infection with Ptr ToxA-producing race 2 and direct infiltration with Ptr ToxA proteins. Greenhouse experiments included exposure of the wheat cultivars to pathogen inoculum or direct infiltration of leaf tissue with Ptr-ToxA protein isolate. Samples from the experiments were subjected to RNA sequencing. Results showed that ToxA RNA sequences were first detected in samples collected eight hours after treatments indicating that upon Ptr contact with wheat tissue, Ptr started expressing ToxA. The resistant wheat cultivar, in response to Ptr inoculum, expressed genes associated with plant resistance responses that were not expressed in the susceptible cultivar; genes of interest included five chitinases, eight transporters, five pathogen-detecting receptors, and multiple classes of signaling factors. Resistant and susceptible wheat cultivars therefore differed in their response in the expression of genes that encode chitinases, transporters, wall-associated kinases, permeases, and wound-induced proteins, among others. Plants exposed to Ptr inoculum expressed transcription factors, kinases, receptors, and peroxidases, which are not expressed as highly in the control samples or samples infiltrated with ToxA. Several of the differentially expressed genes between cultivars were found in the Ptr resistance QTLs on chromosomes 1A, 2D, 3B, and 5A. Future studies should elucidate the specific roles these genes play in the wheat response to Ptr.

삼국시대(三國時代) 병기체제(兵器體制)의 연구(硏究) (This Study of the Arms Used in the Three Kingdoms)

  • 김성태
    • 헤리티지:역사와 과학
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    • 제34권
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    • pp.20-58
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    • 2001
  • In order to unravel the characteristics of arms used in the 'Three Kingdoms,' Kokuryo, Silla and Paikje. the classification and the developing procedures of the arms should be first discussed. At first, the basic arms of the soldiers of Three Kingdoms were iron swords, iron spearheads, and bows. During that period, swords attached a ring pommel were commonly used. But after 5A. D. a sword with a decoration pommel appeared. Infantry generally used iron spearheads. From the late 4A. D. the long spearheads were broadly used in cavalry battles. In the late 6A. D. infantry mainly used long spearheads, and this resulted in the foundation of long spearheads units. There were two kinds of bows: Short Bow whose arch is small and Long Bow whose arch is long. It is known that the Short Bow was widely used in Kokuryo and Paikje up to 5A. D. In the early era, infantry used Long Bow, yet it was vastly used after 6A. D. when a castle's strategical value was great and defending a castle was. significant. Above mentioned, as basic combat weapons, iron spearhead and bow were fundamental. In particular, the spearhead was the essential weapon to a soldier. Yet, arrow gun and hook-shape cutters were important weapons. Especially, after 6A.D., when a castle became strategically pivotal in military, the arrow gun became the important weapon. This resulted in the foundation of arrow gun units. Hook-shape cutters were used to snatch horsemen or to climb up to fall the castle. Yet, the cutter was not the Three Kingodoms' basic weapon. In addition, the three stages of arms development in the Three Kingdoms are formation stage, development stage, and settlement stage. The formation stage was the period when premitive military unit appeared in the Three Kingdoms. It ranged from 1B. C. to the mid 3A. D. At that time according to regions. there were two weapon systems operating: North area including Kokuryo and the northern part of Paikje and South area including Silla, Kaya and the southern part of Paikje. ln North area a sword with a ring attached at the end of the holder, iron spear with neck and mid-size flat holder and iron arrowhead with an extension to fix, were used. In this period, during a war calvary units were mostly used and their weapon systems seemed possibly to succeed in that of Kochosun. In the development stage, when LoLang's influence on surroundings became weak, Koguryo, Paikjae and Silla had directly contacted each other. In the late 3A.D. to the early 6A.D., Silla achieved a drastic improvement in weapon system. This was the period when Kokuryo played a leading role in arms race. Kokuryo's arms manufacturing techniques passed onto Silla, Kaya and Paikje. In combat strategy a joint operation between infantry and calvary prevailed even if their military tactics were different. In a calvary battle heavily armed horsemen played import roles at this period. The horsemen and even horses were heavily guarded with iron armors. After all, the appearance of fully armed horsemen implies the very need of powerful destructive forces in weapon system. At that time, basic weapons were a big sword with a ring attached at the end of the holder, swallow's tail-shape spear with neck, and iron spearhead with neck and an extension. The settlement stage began at the mid 6A.D., when it was the revolutionary period in the arms development history. Of course, actual proofs and picture documents were not sufficient enough to penetrate full scale of the weapon system. But, according to historical circumstances and historic records, it is very certain that this period was the peak in arms development. In this period special military units, such as infantry-calvary companies, Archery units and Long spear units, that executed particular duties with special weapons, were founded. This became the characteristics of the settlement stage.

Molecular Cloning and Characterization of a New cDNA Encoding Hyoscyamine 6β-hydroxylase from Roots of Anisodus acutangulus

  • Kai, Guoyin;Chen, Junfeng;Li, Li;Zhou, Genyu;Zhou, Limin;Zhang, Lei;Chen, Yuhui;Zhao, Linxia
    • BMB Reports
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    • 제40권5호
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    • pp.715-722
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    • 2007
  • A new full-length cDNA encoding hyoscyamine $6\beta$-hydroxylase (designated as aah6h, GenBank Accession No. EF187826), which catalyzes the last committed step in the scopolamine biosynthetic pathway, was isolated from young roots of Anisodus acutangulus by rapid amplification of cDNA ends (RACE) for the first time. The full-length cDNA of aah6h was 1380 bp and contained a 1035 bp open reading frame (ORF) encoding a deduced protein of 344 amino acid residues. The deduced protein had an isoelectric point (pI) of 5.09 and a calculated molecular mass of about 38.7 kDa. Sequence analyses showed that AaH6H had high homology with other H6Hs isolated from some scopolamine-producing plants such as Hyoscyamus niger, Datura metel and Atropa belladonna etc. Bioinformatics analyses results indicated AaH6H belongs to 2-oxoglutarate-dependent dioxygenase superfamily. Phylogenetic tree analysis showed that AaH6H had closest relationship with H6H from A. tanguticus. Southern hybridization analysis of the genomic DNA revealed that aah6h belonged to a multi-copy gene family. Tissue expression pattern analysis firstly founded that aah6h expressed in all the tested tissues including roots, stems and leaves and indicated that aah6h was a constitutive-expression gene, which was the first reported tissue-independent h6h gene compared to other known h6h genes.

Molecular Cloning and mRNA Expression of the Porcine Insulin-responsive Glucose Transporter (GLUT4)

  • Zuo, Jianjun;Dai, Fawen;Feng, Dingyuan;Cao, Qingyun;Ye, Hui;Dong, Zemin;Xia, Weiguang
    • Asian-Australasian Journal of Animal Sciences
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    • 제23권5호
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    • pp.640-648
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    • 2010
  • Insulin-responsive glucose transporter 4 (GLUT4) is a member of the glucose transporter family and mainly presents in skeletal muscle and adipose tissue. To clarify the molecular structure of porcine GLUT4, RACE was used to clone its cDNA. Several cDNA clones corresponding to different regions of GLUT4 were obtained by amplifying reverse-transcriptase products of total RNA extracted from Landrace porcine skeletal muscles. Nucleotide sequence analysis of the cDNA clones revealed that porcine GLUT4 cDNA was composed of 2,491 base pairs with a coding region of 509 amino acids. The deduced amino acid sequence was over 90% identical to human, rabbit and cattle GLUT4. The tissue distribution of GLUT4 was also examined by Real-time RT-PCR. The mRNA expression abundance of GLUT4 was heart>liver, skeletal muscle and brain>lung, kidney and intestine. The developmental expression of GLUT4 and insulin receptor (IR) was also examined by Real-time RT-PCR using total RNA extracted from longissimus dorsi (LM), semimembranosus (SM), and semitendinosus (SD) muscle of Landrace at the age of 1, 7, 30, 60 and 90 d. It was shown that there was significant difference in the mRNA expression level of GLUT4 in skeletal muscles of Landrace at different ages (p<0.05). The mRNA expression level of IR also showed significant difference at different ages (p<0.05). The developmental change in the mRNA expression abundance of GLUT4 was similar to that in IR, and both showed a higher level at birth and 30 d than at other ages. However, there was no significant tissue difference in the mRNA expression of GLUT4 or IR (p>0.05). These results showed that the nucleotide sequence of the cDNA clones was highly identical with human, rabbit and cattle GLUT4 and the developmental change of GLUT4 mRNA in skeletal muscles was similar to that of IR, suggesting that porcine GLUT4 might be an insulin-responsive glucose transporter. Moreover, the tissue distribution of GLUT4 mRNA showed that GLUT4 might be an important nutritional transporter in porcine skeletal muscles.

수도품종(水稻品種)의 생태형(生態型) 차이(差異)가 잡초(雜草)와의 경쟁력(競爭力)에 미치는 영향(影響) (Competition between Transplanted Lowland Rice and Weeds as Affected by Plant Spacing and Rice Cultivar Having Different Eco-geographic Race)

  • 김순철;이수관;김동수
    • 한국잡초학회지
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    • 제2권1호
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    • pp.1-6
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    • 1982
  • 수도(水稻)의 품종형(品種型) 차이(差異)가 잡초(雜草)와의 경쟁(競爭)에 미치는 영향력(影響力)을 알기 위해 통일형(統一型) 품종(品種)(Japonica${\times}$Indica)인 서광(曙光)벼와 일본형(日本型) 품종(品種)인 낙동(洛東)벼를 공시(供試)하여 30${\times}$15 cm, 40${\times}$(10${\times}$10 cm), 10${\times}$10 cm 재식거리(裁植距離)로 1980년(年) 포장시험(圃場試驗)으로 실시(實施)하였던 결과(結果_를 요약(要約)하면 다음과 같다. 1. 잡초발생량(雜草發生量)은 대체로 서광(曙光)벼보다 낙동(洛東)벼 재배구(栽培區)에서 많은 발생량(發生量을) 보였고 재식거리(裁植距離) 간(間)에는 밀식(密植)인 10${\times}$10 cm구(區)에서 잡초발생량(雜草發生量)이 가장 적었고, 30${\times}$15 cm구(區)와 40${\times}$(10${\times}$10cm) 구(區) 간(間)에는 차이(差異)가 없었다. 그리고 제초방법(除草方法) 간(間)에는 서광(曙光)벼 10${\times}$10 cm 구(區)를 제외(除外)한 모든 처리구(處理區)에서 무제초구(無除草區)의 잡초발생량(잡초발생량)이 월등히 많았다. 2. 잡초발생(雜草發生)에 의한 벼 수량감소(收量減少)는 서광(曙光)벼의 경우 40${\times}$(10${\times}$10 cm)> 30${\times}$15 cm 구(區) > 10${\times}$10 cm 구(區) 순(順)이었고 낙동(落東)벼의 경우는 30${\times}$15 cm구(區) > 40${\times}$(10${\times}$10 cm)> 10${\times}$10 cm 구(區) 순(順)이었으나 10${\times}$10 cm 구(區)에서는 제초방법간(除草方法間)의 수량차(收量差)가 없었다. 3. 잡초건물중(雜草乾物重)과 벼 수량(收量)과는 두 품종(品種) 다 같이 높은 부(負)의 상관관계(相關關係)가 인정(認定)되었으며 벼 수량감소율(收量減少率)이 50% 예상(豫想)되는 잡초발생량(雜草發生量)은 서광(曙光)벼 213 $g/m^2$, 낙동(洛東)벼 241 $g/m^2$였다. 4. 이상(以上)의 결과(結果)를 종합(綜合)하여 보면 잡초(雜草)와의 경쟁력(競爭力)은 통일형(統一型) 품종(品種)인 서광(曙光)벼보다 일본형(日本型) 품종(品種)인 낙동(洛東)벼가 약간 높은 것으로 추정(推定)되었다.

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비육후기 사료의 에너지 수준이 '고체중' 출하돈의 성장효율 및 도체특성에 미치는 영향 (Effects of the Energy Level of the Finisher Diet on Growth Efficiency and Carcass Traits of 'High'-Market Weight Pigs)

  • 이철영;김민호;하덕민;박재완;오관용;이제룡;하영주;박병철
    • Journal of Animal Science and Technology
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    • 제49권4호
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    • pp.471-480
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    • 2007
  • 본 연구의 목적은 저에너지 비육돈사료가 ‘고체중’ 출하돈의 사료효율, 성장효율 및 도체특성에 미치는 영향을 구명하여 고체중 출하돈용 사료의 적정 에너지 수준을 유추하고자 함이었다. 생체중 약 90kg의(Yorkshire × Land- race) × Duroc 교잡종 암퇘지와 거세돼지 총 160두를 16돈방에 임의로 배치하여 저에너지사료(3,200kcal DE/kg) 혹은 대조사료(3,400kcal)를 무제한으로 급여하고 성별로 각각 135 & 125kg에 도살하여 도체를 분석하였다[2(성) × 2(사료) ‘factorial’ 실험설계]. 일당증체량, 일당사료섭취량 및 사료효율은 두 성 혹은 사료 구간 차이가 없었다. 등지방두께는 암퇘지에서는 저에너지사료 구(22.4mm)가 대조사료 구(24.3mm)보다 낮았으나(P<0.05), 거세돼지(24.4±0.4mm)에서는 두 사료 구간 차이가 없었다. 암퇘지는 ‘과체중’ 문제로 인하여 90% 이상 C & D 도체등급 판정을 받은 반면 거세돼지는 A + B 등급과 C + D 등급을 각각 79% 및 21% 받았다. 총부분육 중량 대비 개별 부분육 비율은 두 성 혹은 사료 구간 차이가 없었다. 배최장근의 색깔(명도 및 적색도), pH, 육즙삼출율 및 화학적 조성을 포함한 이화학적 특성은 총괄적으로 정상도체의 범주에 속하였고 두 성 혹은 사료 구간 차이가 없었다. 이상을 종합하면 본 실험에 쓰인 저에너지사료와 대조사료는 모두 고체중 비육후기 돼지 사료로 적합할 것으로 판단된다. 만일 주어진 축군에서 사료를 통하여 지방침적을 억제할 필요가 있을 경우는 사료의 에너지 수준을 3,200kcal DE/kg 수준 이하로 낮춰야 할 것이다.

충남(忠南) 일부지역(一部地域)의 영양실태(營養實態) 및 임상조사(臨床調査) (청양군 운곡면을 중심으로) (A Nutritional and Clinical Survey on people in Chung Nam Area)

  • 하순용;김상보;신현성;하종철
    • Journal of Nutrition and Health
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    • 제11권4호
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    • pp.11-23
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    • 1978
  • This study is based on data from the nutritional and clinical survey in Chung Nam area, namely Myl-Yang-Ri, Yoon-Gok-Myon, Chyung Yang Koon. Under the direction of two Nutrition professors and two clinical pathology professors it was carried by 35 Dae Jeun medical Junior College students majoring in nutrition and clinical pathology from 18 July to 25 July 1978. The nutrition surveys were carried out with subjects in village from a total 67 households, 36 of them were randomly selected. The clinical surveys were carried out with subjects in village from a total 382 inhabitant, 154 inhabitant were randomly selected and 109 peoples were subjected to stool examination. The results obtained in this study are summarized as follows. 1) Nutritional survey a) Food Intake The average food intake per person per day in survey area was 929.9 grams (95.5% in vegetables and 4.5% in animal foods). The average consumption of the basicfood groups per person per day was 965g for meats and legumes (10.4% of the total food in take). 268.9g for fruits and vegetables (29% of the total food intake), 559.1g for cereals and potatoes(60.1% of the total food intake), 5.2g for milk and small fishes and 0.2g for fats and oils. b) Nutrient Intake The average daily consumption of calories and nutrients was 2054.1 kcal and 61.2g for total proteins, 223.2mg for calcium, 9.5mg for iron, 4914.4 IU for vitamin A, 1.5mg for thiamin, 1.2mg for riboflavin, 19.9mg for niacin and 54.7mg for ascorbic acid. When these figures are compared with the recommended allowances for Korean, the calories and nutrients intakes were insufficient. Especially the intakes of the calcium were lower than the recommended allowance which are 500 milligrams per day. c) Kinds of food stuffs consumed The kinds of food stuffs consumed by the subjects were 47 figures total. Generally these kinds of food were vegetables food. 2) Clinical Survey a) The mean value of hemoglobin from 72 males was 13.2g/dl, that of 82 females was 12.3g/dl. b) The proportion of low hemoglobin (<12.2g/dl for male and <11.3g/dl fo female) for male was 20.8%, females was 11.0% and from 24 male & female (both sexes) were 15.6% c) The mean value of Hematocrit of males was 39.6%, that of females was 37.4%. d) The mean value of MCHC of males was 33.9%, that of females was 33.6%. e) The ABO blood group was distributed as following; 30.5%, for group O, 29.2% for group A, 24.0% for group B, and 16.3% for AB group. Biochemical race index was 1.13. f) The over all prevalence rate of heminthic infectious by rate of each helminth was as following; Ascaris lumbricoides 33.9%, Thrichocephalus trichiurus 11.9%, Hookworm 0.9%, Hymenolepis diminuta 0.9%, Trichostromgylus orientalis 0.9% and the prevalence rate of two more helminthic infection was 7.2%.

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화랑곡나방(나비목: 명나방과)에 기생한 보리나방살이고치벌 (벌목: 고치벌과)의 발육과 온도와의 관계 (Effect of Temperature on the Development of Bracon hebetor (Hymenoptera: Braconidae) Parasitizing Indianmeal Moth (Lepidoptera: Pyralidae))

  • 김나경;나자현;류문일
    • 한국응용곤충학회지
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    • 제39권4호
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    • pp.275-279
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    • 2000
  • 화랑곡나방(Plodia interpunctella (Hubner)) 유충에 기생하는 보리나방살이고치벌 (Bra-con hebetor Say)의 발육을 장일조건(16시간 광)의 5가지 정온 조건(17, 20, 25, 28 and 32$\pm$0.5$^{\circ}C$)에서 조사하였다. 보리나방살이고치벌의 전발육기간은 온도가 17$^{\circ}C$에서 32$^{\circ}C$로 상승함에 따라 암컷과 수컷에서 각각 28.6$\pm$0.50일과 28.1$\pm$0.51일에서부터 9.3$\pm$0.09일과 9.2$\pm$0.09일로 감소하였다. 알의 발육은 32$^{\circ}C$에서 지연되었다. 고치벌의 발육과 온도와의 관계는 조합모형으로 잘 설명되었으며 ($R^2$>0.99), 각 충태별 저온발육임계온도는 알, 유충, 번데기에서 각각 14.0, 12.8, $15.1^{\circ}C$으로 추정되었다. 그러나 경계역을 제외한 정상발육이 예상되는 저온한계는 각각 14.0, 17.5, $15.1^{\circ}C$로 추정되었다. 타 충태에 비해 유충의 발육임계역이 넓은 것으로 추정됨으로써 유충이 타 충태에 비해 온도에 대한 감수도가 큰 것으로 판단되었다. 본 실험에서 나타난 고치벌의 발육과 온도와의 관계는 다른 지역에서 보고된 바와 부분적으로 차이를 보였으며 이로 미루어 이 고치벌이 다른 지역에 분포하는 개체군과는 상이한 생태형인 것으로 판단된다.

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Molecular analysis of alternative transcripts of equine AXL receptor tyrosine kinase gene

  • Park, Jeong-Woong;Song, Ki-Duk;Kim, Nam Young;Choi, Jae-Young;Hong, Seul A;Oh, Jin Hyeog;Kim, Si Won;Lee, Jeong Hyo;Park, Tae Sub;Kim, Jin-Kyoo;Kim, Jong Geun;Cho, Byung-Wook
    • Asian-Australasian Journal of Animal Sciences
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    • 제30권10호
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    • pp.1471-1477
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    • 2017
  • Objective: Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. Methods: We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Results: Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. Conclusion: It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an $NF-{\kappa}B$ signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.