• 대한기계학회논문집A
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• 제30권5호
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• pp.602-608
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• 2006

Vehicle components such as lower control arm are usually affected by heat during the welding process. As a result, residual stress is generated, which has much effect on mechanical performances such as crashworthiness and durability. In this study, the residual stress in lower control arm has been measured by the x-ray diffraction method and been analyzed by finite element methods. Heat transfer during seam weld process has been calculated and used in calculating thermal deformation with temperature dependent material properties. High residual stress has been found at vertical wall both by measurement and simulation. The simulation also showed the residual stress re-distribution when the component is subjected to cyclic loading condition.

• Structural Engineering and Mechanics
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• 제70권2호
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• pp.133-141
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• 2019

The aim of the present paper is to present the cyclic behavior of strengthened reinforced concrete shear wall test specimen, which was reinforced with cold drawn welded wire mesh fabric. Two reinforced concrete shear wall specimens have been tested in the present study. The walls were tested under reversed cyclic loading with loading applied near the tip of the walls. The control wall is tested in its original state to serve as a baseline for the evaluation of the repair and strengthening techniques. The two test specimens include a control wall and a repaired wall. The control wall test specimen was designed and detailed to simulate non-ductile reinforced concrete shear walls that do not meet the modern seismic provisions. The response of the original wall was associated with the brittle failure. The control shear wall was repaired by addition of the reinforcements and the concrete and then it was reloaded. The effectiveness of the repair technique was investigated. Test results indicate that there can be a near full restoration of the walls' strength. The data from this test, augmenting other data available in the literature, will be useful in calibrating improved analytical methods as they are developed.

• 대한치과교정학회지
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• 제11권1호
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• pp.7-15
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• 1981

Tooth movement by orthodontic force is based upon alveolar bone resorption at compression site and bone formation at tension site of tooth. The function of cyclic AMP is to participate not only in initial action of bone cells by mechanical forces but also in the continuous cellular response leading to bone remodeling. This experiment was performed to clarify the role of cyclic AMP in bone remodeling by mechanical forces. The orthodontic forces of about 80 gm and 100 gm were applied to the right canines of maxillary and mandibular bone, respectively, in cats, treated for periods of time ranging from one hour to 28 days. Alveolar bones were obtained from compression and tension sites surrounding tipping maxillary and mandibular canines as well as from contralateral control sites. The samples were extracted, boiled and homogenized, and the supernatants were assayed for cyclic AMP by a radioimmunoassay method. The results were as follows: 1. The orthodontic movement of canines was increased to the end of experimental period and the action of orthodontic forces on tooth movement was more effective in maxillary canine. 2. The cyclic AMP levels of alveolar bones in compression and tension sites initially decreased, then increased and remained elevated to the end of experiment. The differences of the cyclic AMP levels between treated sites and non-treated sites were gradually increased. 3. The cyclic AMP levels in treated sites of mandibular alveolar bone was higher than that of maxillary alveolar bone.

• Journal of Korean Neurosurgical Society
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• 제37권3호
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• pp.217-222
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• 2005

Objective: To achieve optimal fit of implant, it is necessary to bend the implant during spine surgery. Bending procedure may decrease stiffness of plate especially made of titanium and stainless steel. Typically titanium suffers adverse effects including early crack propagation when it is bent. We investigate whether 6 degree bending of titanium plates would decrease the stiffness after full cyclic loading by comparing with non-bending titanium plates group. Methods: Authors experimented 40 titanium alloy plates of 57mm in length, manufactured by 5 different companies. Total 40 plates were divided into two groups (20 bent plates for experimental group and 20 non-bent plates for control group). Twenty plates of experimental group were bent to 6 degree with 3-point bending technique and verified with image analyzer. Using the electron microscope, we sought for a initial crack before and after 3-point bending. Mechanical testing by means of 6000 cyclic axial-compression loading of 35N in compression with moment arm of 35mm-1.1 Nm was conducted on each plate and followed by the electron microscopic examination to detect crack or fissure on plates. Results: The stiffness was decreased after 6000 cyclic loading, but there was no statistically significant difference in stiffness between experimental and control group. There was no evidence of change in grain structure on the electron microscopic magnification. Conclusion: The titanium cervical plates can be bent to 6 degree without any crack or weakness of plate. We also assume that minimal bending may increase the resistance to fatigue fracture in cervical flexion-extension movement.

• 대한약리학회지
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• 제22권2호
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• pp.128-134
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• 1986

hydrochlorothiazide의 이뇨작용과 cyclic nucleotides와의 관계를 알아보기 위해 신조직내cyclic nucleotides 함량과 adenylate cyclase 및 guanylate cyclase 활성에 대한 hydrochlorothiazide의 영향을 관찰하였다. hydrochlorothiazide를 정맥내 투여시 약물투여 후 10분과 20분 사이에서 이뇨작용이 가장 강하게 나타났으며 60분 경과시는 이뇨작용이 소실되었다. 신조직 내 CAMP 함량은 약물투여 후 5분과 15분에 유의하게 감소되었으며 60분 경과시는 대조군과 차이가 없었다. 신조직내 cGMP 함량은 hydrochlorothiazide에 의해 영향받지 않았다. 신조직의 adenylate cyclase는 hydrochlorothiazide에 의해 활성이 억제되었으며 guanylate cyclase는 영향받지 않았다. 이상의 결과는 hydrochlorothiazide의 이뇨작용에 cAMP가 어떤 관련성을 가질 것을 시사하며 cGMP는 관련성이 없는 것으로 사료된다.

• Restorative Dentistry and Endodontics
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• 제44권2호
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• pp.22.1-22.8
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• 2019

Objectives: The aim of this study was to investigate the effect of glide path preparation with PathFile and ProGlider nickel-titanium (NiTi) files on the cyclic fatigue resistance of WaveOne NiTi files. Materials and Methods: Forty-four WaveOne Primary files were used and divided into four groups (n = 11). In the first group (0 WaveOne), the WaveOne Primary files served as a control group and were not used on acrylic blocks. In the 1 WaveOne Group, acrylic blocks were prepared using only WaveOne Primary files, and in the PF+WaveOne group and PG+WaveOne groups, acrylic blocks were first prepared with PathFile or ProGlider NiTi files, respectively, followed by the use of WaveOne Primary files. All the WaveOne Primary files were then subjected to cyclic fatigue testing. The number of cycles to failure was calculated and the data were statistically analyzed using one-way analysis of variance (ANOVA) and the Tukey honest significant difference multiple-comparison test at a 5% significance level. Results: The highest number of cycles to failure was found in the control group, and the lowest numbers were found in the 1 WaveOne group and the PF+WaveOne group. Significant differences were found among the 1 WaveOne, PF+WaveOne, and control groups (p < 0.05). No statistically significant differences were found between the PG+WaveOne group and the other three groups (p > 0.05). Conclusion: Glide path preparation with NiTi rotary files did not affect the cyclic fatigue resistance of WaveOne Primary files used on acrylic blocks.

• Steel and Composite Structures
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• 제21권2호
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• pp.443-460
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• 2016

In this paper, the efficiency and effectiveness of two strengthening methods for upgrading behavior of the two external weak reinforced concrete (RC) beam-column joints were experimentally investigated under cyclic loading. Since two deficient external RC joints with reduced beam height and low strength concrete were strengthened using one-way steel prop and curbs with and without steel revival sheets on the beam. The cyclic performance of these strengthened specimens were compared with two another control external RC beam-column joints, one the standard RC joint that had not two mentioned deficiencies and another had both. Therefore, four half-scale RC joints were tested under cyclic loading.The experimental results showed that these innovative strengthening methods (RC joint with revival sheet specially) surmounted the deficiencies of weak RC joints and upgraded their performance and bearing capacity, stiffness degradation, energy absorption, up to those of standard RC joint. Also, results exhibited that the prop at joint acted as a fuse element due to adding steel revival sheets on the RC beam and showed better behavior than that of the specimen without steel revival sheets. In other words by stiffening of beam, the prop collected all damages due to cyclic loading at itself and acted as the first line of defense and prevented from sever damages at RC joint.

• Macromolecular Research
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• 제15권4호
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• pp.370-378
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• 2007

Mechanical stimulation is known to activate several cellular signal transduction pathways, leading to the induction of signaling molecules and extracellular matrix (ECM) proteins, thereby modulating cellular activities, such as proliferation and survival. In this study, primary human dermal fibroblasts (HDFs) were seeded onto chitosan-based scaffolds, and then cultured for 3 weeks in a bioreactor under a cyclic strain of 1 Hz frequency. Compared to control samples cultured under static conditions, the application of a cyclic strain stimulated the proliferation of HDFs in I week, and by week 3 the thickness of the cell/scaffold composites increased 1.56 fold. Moreover, immunohistochemical staining of the culture media obtained from the cell/scaffold samples subjected to the cyclic strain, revealed increases in the expression and secretion of ECM proteins, such as fibronectin and collagen. These results suggest that the preconditioning of cell/scaffold composites with a cyclic strain may enhance the proliferation of HDFs, and even facilitate integration of the engineered artificial dermal tissue into the host graft site.

• 생약학회지
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• 제52권1호
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• pp.26-33
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• 2021

During blood vessel damage, an essential step in the hemostatic process is platelet activation. However, it is important to properly control platelet activation, as various cardiovascular diseases, such as stroke, atherosclerosis, and myocardial infarction, are also caused by excessive platelet activation. Found primarily in the roots of plants of the genus Artemisia or Scopolia, isoscopoletin has been studied to demonstrate its potential pharmacological effects against Alzheimer's disease and anticancer, but the mechanisms and roles involved in thrombus formation and platelet aggregation are insufficient. This study investigated the effect of isoscopoletin on U46619-induced human platelet activation. As a result, isoscopoletin significantly increased the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) dose-dependently. In addition, isoscopoletin significantly phosphorylated inositol 1, 4, 5-triphosphate receptor (IP3R) and vasodilator-stimulated phosphprotein (VASP), which are known substrates for cAMP-dependent kinases and cGMP-dependent kinases. Phosphorylated IP3R by isoscopoletin inhibited Ca2+ mobilization from the dense tubular system Ca2+ channels to cytosol, and phosphorylated VASP was involved in the inhibition of fibrinogen binding through αIIb/β3 inactivation in the platelet membrane. Isoscopoletin finally reduced thrombin-induced fibrin clotting production. Therefore, this study suggests that isoscopoletin has a potent antiplatelet effect and may be helpful for platelet-related thrombotic diseases.

• International Journal of Automotive Technology
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• 제6권1호
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• pp.71-77
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• 2005

This paper presents a systematic approach which determines the optimal period to minimize performance measure subject to the schedulability constraints of a real-time control system by formulating the scheduling problem as an optimal problem. The performance measure is derived from the summation of end-to-end response times of processed I/Os scheduled by the static cyclic method. The schedulability constraint is specified in terms of allowable resource utilization. At first, a uniprocessor case is considered and then it is extended to a distributed system connected through a communication link, local-inter network, UN. This approach is applied to the design of an automotive body control system in order to validate the feasibility through a real example. By using the approach, a set of optimal periods can easily be obtained without complex and advanced methods such as branch and bound (B&B) or simulated annealing.