• Journal of Biomedical Engineering Research
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• v.23 no.6
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• pp.477-484
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• 2002

A pacemaker autosense algorithm with dual thresholds. one for noise or tachyarrhythmia detection (noise threshold, NT) and the other for intrinsic beat detection (sensing threshold. ST), was developed to improve the sensing performance in single pass VDD electrograms. unipolar electrograms, or atrial fibrillation detection. When a deflection in an electrogram exceeds the NT (defined as 50% of 57), the autosense algorithm with dual thresholds checks if the deflection also exceeds the ST. If it does, the autosense algorithm calculates the signal to noise ratio (SNR) of the deflection to the highest deflection detected by NT but lower than ST during the last cardiac cycle. If the SNR 2, the autosense algorithm declares an intrinsic beat detection and calculates the next ST based on the three most recent intrinsic peaks. If the SNR $\geq$2, the autosense algorithm checks the number of deflections detected by NT during the last cardiac cycle in order to determine if it is a noise detection or tachyarrhythmia detection. Usually the autosense algorithm tries to set the 57 at 37.5% of the average of the three intrinsic beats, although it changes the percentage according to event classifications. The autosense algorithm was tested through computer simulation of atrial electrograms from 5 patients obtained during EP study, to simulate a worst sensing situation. The result showed that the ST levels for autosense algorithm tracked the electrogram amplitudes properly, providing more noise immunity whenever necessary. Also, the autosense algorithm with dual thresholds achieved sensing performance as good as the conventional fixed sensitivity method that was optimized retrospectively.

• Journal of Korean Society for Quality Management
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• v.44 no.4
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• pp.935-949
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• 2016

Purpose: This study attempts to find out the optimum condition of the rotary cutter making pellet in the footwear outsole process. The pellets are used in the process of outsole rubber fabrication to reduce cycle time and save raw material. Methods: Computer simulations are used to analyze the maximum stress in the rotary cutter after designing a variety of cutter shapes. Taguchi method is used to identify the robust condition of the cutter. In $L_{18}$ orthogonal array, the control factors such as knife width, twisted angle, number of knives, diameter, knife depth and supported angle are considered and noise factors like assembly tolerance and amount of antifriction are allocated. Results: It is found that the most important factors to reduce maximum stress in the cutter are supported angle and diameter. Using Tacuchi's results, we can reduce 70% cycle time and 9% raw material compared to the traditional method using cutting die. Conclusion: When designing the rotary cutter, the best conditions are the diameter at its maximum allowable value and supported angle in the boundary of machine inner space.

• Development and Reproduction
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• v.24 no.2
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• pp.101-111
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• 2020

Coiled-coil domain containing 110 (CCDC110, KM-HN-1) is a protein containing C-terminal coiled-coil domain (CCD) which was previously discovered as a member of the human cancer/testis antigen (CTA). In addition, CCDC110 has both nuclear localization signal sequence and the leucine zipper motif. Although the functional role of CCDC110 has yet to be fully identified, the mRNA expression levels of CCDC110 are known to be highly elevated in various cancer types including testis, implying its relevance to cancer pathogenesis. In this study, we first developed several monoclonal antibody (mAb) hybridoma clones targeting CCDC110 and further isolated clone by characterizing for its specificity using immunoblotting and immunoprecipitation approaches with basal parenchymal sperm cells in testis tissue. Next, using these mAbs, we showed that the Tet-inducible overexpression of CCDC110 protein delayed the entry of G2/M phase in U2-OS osteosarcoma cells. Based on these results, we propose that CCDC110 plays a crucial role in cell cycle progression.

• Journal of Ocean Engineering and Technology
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• v.34 no.6
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• pp.442-453
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• 2020

Underwater color images suffer from low visibility and color cast effects caused by light attenuation by water and floating particles. This study applied single image enhancement techniques to enhance the quality of underwater images and compared their performance with real underwater images taken in Korean waters. Dark channel prior (DCP), gradient transform, image fusion, and generative adversarial networks (GAN), such as cycleGAN and underwater GAN (UGAN), were considered for single image enhancement. Their performance was evaluated in terms of underwater image quality measure, underwater color image quality evaluation, gray-world assumption, and blur metric. The DCP saturated the underwater images to a specific greenish or bluish color tone and reduced the brightness of the background signal. The gradient transform method with two transmission maps were sensitive to the light source and highlighted the region exposed to light. Although image fusion enabled reasonable color correction, the object details were lost due to the last fusion step. CycleGAN corrected overall color tone relatively well but generated artifacts in the background. UGAN showed good visual quality and obtained the highest scores against all figures of merit (FOMs) by compensating for the colors and visibility compared to the other single enhancement methods.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.9
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• pp.685-697
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• 2017

In this paper, it is presented the result of design and fabrication for C-band solid state high power amplifier unit and components using in search radar. The solid state power amplifier(SSPA) assembly was fabricated using GaN(Gallium Nitride), which is semiconductor device, and the transmit signal output power of the solid state high power amplifier unit is generated by combining the transmit signal power of the solid state power amplifier configured in parallel through a design and fabricated waveguide type transmit signal combine assembler. Designed solid state high power amplifier unit demonstrated C-band 500 MHz bandwidth, maximum 10.5% duty cycle, transmit pulse width from $0.0{\mu}s{\sim}000{\mu}s$, and transmit signal power is 44.98 kW(76.53 dBm).

• BMB Reports
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• v.36 no.1
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• pp.28-34
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• 2003

Breast cancer is the most prevalent cancer among women in Western countries, and its prevalence is also increasing in Asia. The major risk factor for breast cancer can be traced to reproductive events that influence the lifetime levels of hormones. However, a large percentage of breast cancer cases cannot, be explained by these risk factors. The identification of susceptibility factors that predispose individuals to breast cancer (for instance, if they are exposed to particular environmental agents) could possibly give further insight into the etiology of this malignancy and provide targets for the future development of therapeutics. The most interesting candidate genes include those that mediate a range of functions. These include carcinogen metabolism, DNA repair, steroid hormone metabolism, signal transduction, and cell cycle control. We conducted a hospital-based case-control study in South Korea to evaluate the potential modifying role of the genetic polymorphisms of selected low penetrance genes that are involved in carcinogen metabolisms (i.e., CYP1A1, CYP2E1, GSTM1/T1/P1, NAT1/2, etc.), estrogen synthesis and metabolism (i.e., CYP19, CYP17, CYP1B1, COMT, ER-$\alpha$, etc.), DNA repair (i.e., XRCC1/3, ERCC2/4, ATM, AGT, etc.), and signal transduction as well as others (i.e., TGF-$\beta$, IGF-1, TNF-$\beta$, IL-1B, IL-1RN, etc.). We also took into account the potential interaction between these and the known risk factors of breast cancer. The results of selected genes will be presented in this mini-review.

• Parasites, Hosts and Diseases
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• v.39 no.2
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• pp.151-160
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• 2001

Randomly selected 435 clones from Acanthamoeba healyi cDNA library were sequenced and a total of 387 expressed sequence tags (ESTs) had been generated. Based on the results of BLAST search, 130 clones (34.4%) were identified as the genes enconding surface Proteins , enzymes for DNA, energy Production or other metabolism, kinases and phosphatases, protease, proteins for signal transduction, structural and cytoskeletal proteins, cell cycle related proteins, transcription factors, transcription and translational machineries, and transporter proteins. Most of the genes (88.5%) are newly identified in the genus Acanthamoeba. Although 15 clones matched the genes of Acanthamoeba located in the public databases, twelve clones were actin gene which was the most frequently expressed gene in this study. These ESTs of Acanthamoeba would give valuable information to study the organism as a model system for biological investigations such as cytoskeleton or cell movement, signal transduction, transcriptional and translational regulations. These results would also provide clues to elucidate factors for pathogenesis in human granulomatous amoebic encephalitis or keratitis by Acanthamoeba.

• Journal of the Korean Institute of Intelligent Systems
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• v.13 no.1
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• pp.76-84
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• 2003

Now days, It is based on GIS and GPS, it can search for the shortest path and estimation of arrival time by using the internet and cell phone to driver. But, even though good car navigation system does not create which is the shortest path when there average vehicle speed is 10 -20 Km. Therefore In order to reduce vehicle waiting time and average vehicle speed, we suggest optimal green time algorithm using fuzzy adaptive control, where there are different traffic intersection length and lane. In this paper, it will be able to forecast the optimal traffic information, estimation of destination arrival time, under construction road, and dangerous road using internet.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.10
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• pp.1887-1894
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• 2016

In the RFID system, the reader transmits a query message to tags in order to identify a unique ID of tags within its detection range. The procedures for arbitrating a collision is essential because the multiple tags can response simultaneously in the same to the query of the Reader. This procedure is known as conflict resolution algorithm and it is a key technology in the RFID system. In this paper, we proposed a variable bits M-ary QT algorithm based on Manchester coding techniques. The proposed algorithm use the location information of the collision bits in the reader and tags. The proposed algorithm can reduce the number of the query-response cycle because it is capable of recognizing discontinuous bits and a variable number of bits. From computer simulation, the proposed method give better performance than the conventional M-ary QT techniques in terms of response, recognition efficiency, communication overhead.

• Journal of the Korean Magnetic Resonance Society
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• v.3 no.1
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• pp.44-51
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• 1999

An enzyme derived conformational changes of cobalamine is thought to be important in the homolytic cleavage of Co-C bond which is the first step of catalytic Cl-cycle of coenzyme B12-dependent enzymes. Modern 2D-NMR and NMR-based distance geometric studies were carried out to determine the 3D structure of corrin ring. Homonuclear and heteronuclear correlation NMR experiments were performed for complete 1H-NMR signal assignments. Distances between numerous proton pairs were deduced based on the NOE cross peak intensities and subsequently used as input into the distance geometry program for the 3D structure determination. The detailed 3D structure from the present NMR-based analysis was compared with the result from X-ray crystallographic study, which revealed greater conformational changes occur in benzimidazole group and sugar ring than in macrocyclic corrin and tetrapyrrole. In addition, the distance geometry used in this study was found to be quite useful for NMR-based structure determination of medium-sized molecules that give poor NOE effects arising from their intermediate tumbling rate ($\omega$$\tau$c 1.0).