• Asian-Australasian Journal of Animal Sciences
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• 제33권1호
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• pp.166-176
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• 2020

Objective: An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits. Methods: Eighteen normal-grade male weanling Japanese White rabbits (JWR) were selected and randomly divided into 6 groups with or without L-Arg and NCG supplementation. The whole feeding process was divided into weanling stage (day 37 to 65) and young stage (day 66 to 85). The effects of L-Arg and NCG on the growth, metabolism, immunity and development of the ileum and jejunum were compared via nutrient metabolism experiments and histological assessment. The different communities of cecal bacterial flora affected by L-Arg and NCG were assessed using high-throughput sequencing technology and bioinformatics analysis. Results: The addition of L-Arg and NCG enhanced the growth of weanling and young rabbit by increasing the nitrogen metabolism, protein efficiency ratio, and biological value, as well as feed intake and daily weight gain. Both L-Arg and NCG increased the concentration of immunoglobulin A (IgA), IgM, and IgG. NCG was superior to L-Arg in promoting intestinal villus development by increasing villus height, villus height/crypt depth index, and reducing the crypt depth. The effects of L-Arg and NCG on the cecal bacterial flora were mainly concentrated in different genera, including Parabacteroides, Roseburia, dgA-11_gut_group, Alistipes, Bacteroides, and Ruminococcaceae_UCG-005. These bacteria function mainly in amino acid transport and metabolism, energy production and conversion, lipid transport and metabolism, recombination and repair, cell cycle control, cell division, and cell motility. Conclusion: L-Arg and NCG can promote the growth and immunity of weanling and young JWR, as well as effecting the jejunum and ileum villi. L-Arg and NCG have different effects in the promotion of nutrient utilization, relieving inflammation and enhancing adaptability through regulating microbial community.

• 한국정보시스템학회지:정보시스템연구
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• 제27권1호
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• pp.171-191
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• 2018

Purpose Corporate technology leakage is not only monetary loss, but also has a negative impact on the corporate image and further deteriorates sustainable growth. In particular, since SMEs are highly dependent on core technologies compared to large corporations, loss of technology leakage threatens corporate survival. Therefore, it is important for SMEs to "prevent and protect technology leakage". With the recent development of data analysis technology and the opening of public data, it has become possible to discover and proactively detect companies with a high probability of technology leakage based on actual company data. In this study, we try to construct profiles of enterprises with and without technology leakage experience through profiling analysis using data mining techniques. Furthermore, based on this, we propose a classification model that distinguishes companies that are likely to leak technology. Design/methodology/approach This study tries to develop the empirical model for prevention and protection of technology leakage through profiling method which analyzes each SME from the viewpoint of individual. Based on the previous research, we tried to classify many characteristics of SMEs into six categories and to identify the factors influencing the technology leakage of SMEs from the enterprise point of view. Specifically, we divided the 29 SME characteristics into the following six categories: 'firm characteristics', 'organizational characteristics', 'technical characteristics', 'relational characteristics', 'financial characteristics', and 'enterprise core competencies'. Each characteristic was extracted from the questionnaire data of 'Survey of Small and Medium Enterprises Technology' carried out annually by the Government of the Republic of Korea. Since the number of SMEs with experience of technology leakage in questionnaire data was significantly smaller than the other, we made a 1: 1 correspondence with each sample through mixed sampling. We conducted profiling of companies with and without technology leakage experience using decision-tree technique for research data, and derived meaningful variables that can distinguish the two. Then, empirical model for prevention and protection of technology leakage was developed through discriminant analysis and logistic regression analysis. Findings Profiling analysis shows that technology novelty, enterprise technology group, number of intellectual property registrations, product life cycle, technology development infrastructure level(absence of dedicated organization), enterprise core competency(design) and enterprise core competency(process design) help us find SME's technology leakage. We developed the two empirical model for prevention and protection of technology leakage in SMEs using discriminant analysis and logistic regression analysis, and each hit ratio is 65%(discriminant analysis) and 67%(logistic regression analysis).

• 한국재료학회지
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• 제20권12호
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• pp.669-675
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• 2010

One of the greatest challenges for our society is providing powerful electrochemical energy conversion and storage devices. Rechargeable lithium-ion batteries and fuel cells are among the most promising candidates in terms of energy and power density. As the starting material, $TiCl_4{\cdot}YCl_3$ solution and dispersing agent (HCP) were mixed and synthesized using ammonia as the precipitation agent, in order to prepare the nano size Y doped spherical $TiO_2$ precursor. Then, the $Li_4Ti_5O_{12}$ was synthesized using solid state reaction method through the stoichiometric mixture of Y doped spherical $TiO_2$ precursor and LiOH. The Ti mole increased the concentration of the spherical particle size due to the addition of HPC with a similar particle size distribution in a well in which $Li_4Ti_5O_{12}$ spherical particles could be obtained. The optimal synthesis conditions and the molar ratio of the Ti 0.05 mol reaction at $50^{\circ}C$ for 30 minutes and at $850^{\circ}C$ for 6 hours heat treatment time were optimized. $Li_4Ti_5O_{12}$ was prepared by the above conditions as a working electrode after generating the Coin cell; then, electrochemical properties were evaluated when the voltage range of 1.5V was flat, the initial capacity was 141 mAh/g, and cycle retention rate was 86%; also, redox reactions between 1.5 and 1.7V, which arose from the insertion and deintercalation of 0.005 mole of Y doping is not a case of doping because the C-rate characteristics were significantly better.

• 대한한의학회지
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• 제31권1호
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• pp.138-152
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• 2010

Objective: Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) is one of the representative prescriptions for invigoration of vitality and nourishing of the blood. This study was carried out to investigate the effects of Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) on hair regrowth and cytokine changes in a shaving model of C57BL6 mice. Method: Five-week-old mice were acclimated for 1 week at a temperature between $21-23^{\circ}C{\acute{E}}$, 40-60% relative humidity, and 12h of a light/dark cycle before beginning of the experiment. There were two groups including normal saline (control) and a positive control of oral intake of Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) extract (sample) in 18 female mice. The test compounds were topically treated once a day over 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-${\beta}1$ and EGF were also determined using immunohistochemistry. In addition to that, IFN-$\gamma$, IL-4 and IL-10 were determined in serum. Results: Hair regrowth in the sample group was promoted earlier and faster than the control group, as shown by concentrations of hairs and thick-hair ratio in the sample group. TGF-${\beta}1$ was not revealed in either control or sample group. EGF was strongly positive in out root sheath of some thick hair of the sample group. Serum IFN-$\gamma$ was significantly decreased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-4 was significantly increased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-10 was decreased in the sample group compared with the control group, but with no real statistical significance. Conclusion: These results suggest that Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) has hair growth promoting activity and it can be used for treatment of alopecia. Also, these effects relate to EGF revelation of hair roots, a decrease in serum IFN-$\gamma$, and an increase of serum IL-4.

• 한국지능시스템학회논문지
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• 제23권6호
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• pp.519-526
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• 2013

심전도 신호는 P, Q, R, S, T파를 한 주기로 하여 반복되는 특징을 가지고 있으며 일반적으로 높은 표본화 주파수로 샘플링 된다. 이러한 심전도 신호의 주기적인 특징을 이용하여 진단에 중요한 정보의 손실을 최소화하면서 압축 효율을 극대화시키는 방법이 필요하다. 그러나 이러한 주기적인 특징은 심검자와 측정 시기에 따라 진폭과 주기가 일정하지가 않다. 또한 환자의 경우, 같은 시기에 측정하더라도 주기적 특징이 다르게 나타나는 구간이 존재한다. 본 논문에서는 적응적 멀티 레벨 코드를 이용하여 주도적인 신호 구간과 비주도적인 신호 구간의 심전도 신호를 적응적으로 코드화하는 방법을 제안한다. 제안하는 방식은 주도적인 신호 구간과 비주도적인 신호 구간에 따른 손실 대비 압축률을 차등 적용함으로써 반복적인 신호를 멀티 레벨 코드를 이용하여 압축의 효율성을 극대화하는 것이다. 이는 심전도 신호의 주기성을 이용하지 않은 기존의 압축 방식에 비해 장시간 측정 데이터의 압축률을 극대화시키고 비주도적인 신호를 코드화하여 무손실 압축을 함으로써 진단에 중요한 정보를 손실 없이 보존할 수 있는 장점이 있다. MIT-BIH 부정맥 데이터베이스에 있는 심전도 신호에 대한 실험을 통하여 압축의 효용성을 검증하였다.

• 유통과학연구
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• 제14권3호
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• pp.63-71
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• 2016

Purpose - A variety of indicators are used for the diagnosis of economic situation. However, most indicators explain the past economic situation because of the time difference between the measurement and announcement. This study aims to argue for the resurrection of an idea: electricity demand can be used as an indicator of economic activity. In addition, this study made an endeavor to develop a new Real Business Index(RBI) which could quickly represent the real economic condition based on the sales statistics of industrial and public electricity. Research design, data, and methodology - In this study monthly sales of industrial and public electricity from 2000 to 2015 was investigated to analyze the relationship between the economic condition and the amount of electricity consumption and to develop a new Real Business Index. To formulate the Index, this study followed next three steps. First, we decided the explanatory variables, period, and collected data. Second, after calculating the monthly changes for each variable, standardization and estimating the weighted value were conducted. Third, the computation of RBI finalized the development of empirical model. The principal component analysis was used to evaluate the weighted contribution ratio among 3 sectors and 17 data. Hodrick-Prescott filter analysis was used to verify the robustness of out model. Results - The empirical results are as follows. First, compatibility of the predictability between the new RBI and the existing monthly cycle of coincident composite index was extremely high. Second, two indexes had a high correlation of 0.7156. In addition, Hodrick-Prescott filter analysis demonstrated that two indexed also had accompany relationship. Third, when the changes of two indexes were compared, they were found that the times when the highest and the lowest point happened were similar, which suggested that it is possible to use the new RBI index as a complementing indicator in a sense that the RBI can explain the economic condition almost in real time. Conclusion - A new economic index which can explain the economic condition needs to be developed well and rapidly in a sense that it is useful to determine accurately the current economic condition to establish economic policy and corporate strategy. The salse of electricity has a close relationship with economic conditions because electricity is utilized as a main resource of industrial production. Furthermore, the result of the sales of electricity can be gathered almost in real time. This study applied the econometrics model to the statistics of the sales of industrial and public electricity. In conclusion, the new RBI index was highly related with the existing monthly economic indexes. In addition, the comparison between the RBI index and other indexes demonstrated that the direction of the economic change and the times when the highest and lowest points had happened were almost the same. Therefore, this RBI index can become the supplementary indicator of the official indicators published by Korean Bank or the statistics Korea.

• Journal of Biosystems Engineering
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• 제35권2호
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• pp.100-107
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• 2010

This study was conducted to investigate the effects of electric current stimuli and high-voltage electric field treatments on brown rice germination. The brown rice stimulated by electrical current stimuli, functional electrical stimuli of a pulse type, and high-voltage electric field treatments were observed (Type I, II and III). Treatment Type I was a method of semi-soaking brown rice with electric current stimuli of 0.13 V/cm, 0.19 V/cm, and 0.25 V/cm into Petri-dishes for 72 hours. Type II was a method of semi-soaking brown rice with functional electrical stimuli of a pulse type(DC 1 V, 1 Hz, 5%, and duty cycles of 5%, 20%, and 35%) into Petri-dishes for 72 hours. Type III was a method of water-soaking with high-voltage electric field treatments for 60 hours. High-voltage electric field treatments at 15 kV/cm were also conducted for 2.5 min, 7.5 min, and 10 min, respectively. The germination rate and the sprout growth of brown rice germinated by electric current stimuli with 0.13 V/cm, 0.19 V/cm, and 0.25 V/cm were increased by about 10-15% compared with those of the control group. The germination rate and the sprout growth of brown rice germinated by functional electrical stimuli of pulse type(DC 1 V, 1 Hz, 5% duty cycle) were increased by about 10∼15% compared to those of the control group. Also, the best effective treatment among high-voltage electric field treatments was the 10 min group at 15 kV/cm. The germination rate and the sprout growth of brown rice germinated by this treatment of 10 min at 15 kV/cm were increased by about 10∼20% compared to those of the control group. The treatments of electric current stimuli and high-voltage electric field accelerated the germination rate and sprout growth of brown rice by about 10∼15% compared to those of the control group.

• 기술혁신학회지
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• 제20권2호
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• pp.368-386
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• 2017

본 연구의 목적은 초연결 산업분야 자율주행차, 커넥티드카의 핵심기술인 차량內 이더넷 네트워크 기술을 대상으로 수익접근법과 IITP 실무가이드 기반 기술가치 모델을 제시하고 제품의 시장규모, 기술의 시장규모 및 시장가치를 평가하는 것이다. 기술평가를 위한 차량內 네트워크, 이더넷 기술, 이더넷 포트 수, 포트 가격, 그리고 어플리케이션 데이터는 글로벌 시장조사기관들이 출처이다. 기업의 매출원가, 판관비, 운전자금 소요율, 자본적지출 등 산정을 위한 재무상태표 및 손익계산서 데이터는 한국은행 기업경영분석보고서를 활용한다. 연구결과에 의하면 기술의 경제적 수명주기 7년 동안 제품시장 규모는 4,703억불, 기술시장 규모는 521억불로 산정되었다. 시장진입 가능성을 반영한 기술시장 가치는 2.6억불로 평가되었고, 기업경영분석보고서를 반영한 경우에는 한국은행 전체평균 및 IITP 하위 25% 수준에서 각각 -27.8백만불, -73.6백만불, IITP 전체평균 및 상위 25%에서는 각각 0.7백만불, 40.2백만불로 평가되었다. 이는 매출대비 원가 비중이 높은 기업 R&D 수행시 정부의 정책지원 뒷받침이 필요함을 함의한다. 본 연구결과는 4차 산업혁명 시대 산업인터넷 분야 시장수요 기반 ICT R&D 기술평가에 참고자료로 활용될 수 있을 것이다.

• 터널과지하공간
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• 제19권2호
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• pp.146-157
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• 2009

이 연구는 경상남도 함안군 일대에 분포하는 백악기 이암에 대하여 동결-융해 시험을 수행하고 동결-융해 반복 횟수의 증가에 따른 암석의 물리 역학적 특성변화를 고찰하였다. 동결-융해의 한 사이클은 24시간이며 진공 챔버에서 2시간 동안 포화시킨 시료를 $-16{\pm}1^{\circ}C$로 8시간 동결하고 상온에서 14시간 동안 융해하였다. 총 55 사이클의 동결-융해 시험 중에 물리적인 특성을 측정한 결과 비중, P파 속도는 지속적으로 감소하였으며 흡수율, 공극률은 지속적으로 증가하였다. 시험 전 풍화를 많이 받은 암석일수록 동결-융해에 따른 물성의 변화가 크며 풍화에 취약한 것으로 나타났다. 슬랩 시편에서 취득한 미세균열 트레이스의 크기 및 면적밀도는 30사이클 이후부터 급격히 증가하는 것으로 나타났다. 이는 30사이클 이후 급격히 감소하는 P파 속도의 특성과도 부합하며 암석 내부에 미세균열이 급격히 발현 확장하고 특히 층리면의 결합력이 약화되는 암석 풍화에 기인한 것으로 사료된다. 미세균열의 밀집도와 크기를 동시에 고려할 수 있는 박스 프랙탈 차원($D_B$)은 미세균열 트레이스의 변동성을 효과적으로 반영하며 중 장기적인 풍화 예측을 위한 새로운 풍화지수로 활용할 수 있을 것으로 기대된다.

• 생약학회지
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• 제49권1호
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• pp.55-64
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• 2018

Recently, it has been a big issue to distinguish the dried roots of Cynanchum wilfordii and C. auriculatum in health functional food market. The original plant species of Cynanchi Wilfordii Radix belong to the Asclepiadaceae family is differentially described in the national pharmacopoeia of Korea, China and Japan. Owing to the morphological similarities of the dried roots of this plant to those of C. auriculatum, which is often misidentified in Korean herbal medicine marketplace, distinguishing these two species is exceedingly difficult. The purpose of this study was to compare the conventional-PCR with the real-time PCR for detection of C. wilfordii and C. auriculatum DNA. We also tried to realize a quantitative real-time PCR assay using species-specific matK primers, which allowed us to estimate the ratio of C. willfordii and C. auriculatum using varying ratios of mixed genomic DNA template from the two species. The differentiation of intentional and unintentional mixture in this study would be applied to food safety management and can be helpful for protection of consumer's right and cultivators.