• Title/Summary/Keyword: Cycle Efficiency

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Enhanced Sensitivity and Long-Term G2/M Arrest in Adriamycin-treated DNA-PK-null Cells are Unrelated to DNA Repair Defects (DNA-PK-null 세포주의 adriamycin 처리에 의한 G2/M 세포주기 변화)

  • Kim, Chung-Hee;Kim, Jong-Soo;Van Cuong, Dang;Kim, Na-Ri;Kim, Eui-Yong;Han, Jin
    • Journal of Life Science
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    • v.13 no.3
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    • pp.241-247
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    • 2003
  • While the DNA-protein kinase (DNA-PK) complex, comprised of DNA-PKcs and Ku80, is primary involved in the repair of DNA double-strand breaks, it is also believed to participate in additional cellular processes. Here, treatment of embryo fibroblasts (MEFs) derived from either wild-type (Wt) or DNA-PKcs-null (DNA-$PKcs^{-/-}$) mice with various stress inducing agents revealed that adriamycin was markedly more cytotoxic for $Ku80^{-/-}MEFs$ and led to their long-term accumulation in the $G_2$/M phase. This differential response was not due to differences in DNA repair, since adrimycin-triggered DNA damage was repaired with comparable efficiency in both Wt and $Ku80^{-/-}MEFs$, but was associated with differences in the expression of important cell cycle regulatory genes. Our results support the notion that Ku80-mediated cytoprotection and $G_2$/M-progression are not only dependent on the cell's DNA repair but also may reflect Ku80's influence on additional cellular processes such as gene expression.

Nonlinear Time Series Prediction Modeling by Weighted Average Defuzzification Based on NEWFM (NEWFM 기반 가중평균 역퍼지화에 의한 비선형 시계열 예측 모델링)

  • Chai, Soo-Han;Lim, Joon-Shik
    • Journal of the Korean Institute of Intelligent Systems
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    • v.17 no.4
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    • pp.563-568
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    • 2007
  • This paper presents a methodology for predicting nonlinear time series based on the neural network with weighted fuzzy membership functions (NEWFM). The degree of classification intensity is obtained by bounded sum of weighted fuzzy membership functions extracted by NEWFM, then weighted average defuzzification is used for predicting nonlinear time series. The experimental results demonstrate that NEWFM has the classification capability of 92.22% against the target class of GDP. The time series created by NEWFM model has a relatively close approximation to the GDP which is a typical business cycle indicator, and has been proved to be a useful indicator which has the turning point forecasting capability of average 12 months in the peak point and average 6 months in the trough point during 5th to 8th cyclical period. In addition, NEWFM measures the efficiency of the economic indexes by the feature selection and enables the users to forecast with reduced numbers of 7 among 10 leading indexes while improving the classification rate from 90% to 92.22%.

A Survey on the Persons in Charge for Economic Estimation Analysis and Improvement of BTL Projects (BTL사업의 경제성 평가 현황조사 및 개선을 위한 실무자 설문조사연구)

  • Lee, Chun-Kyong;Cho, Bong-Ho;Park, Tae-Keun
    • Korean Journal of Construction Engineering and Management
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    • v.8 no.4
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    • pp.73-80
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    • 2007
  • As BTL(Build-Transfer-Lease) private investment business benchmarking PHI(Private Finance Initiative) of USA and Japan is introduces to Korea since 2005, as a part of supplying high leveled public service and early expanding required facilities for SOC, Value for Money on private investment business from treasury investment business at the beginning gets to be needed. Accordingly, this survey has been conducted in order to analyse BTL projects status, propriety of economic analysis method(VFM analysis, calculation of estimated business expenses, valuation of bidding price, etc.) by business advance phases from the viewpoint of person in charge, necessity of improvement and alternative plants. As the result of conducting cross tabulation analysis and correlation analysis by occupational group, BTL project advance phases and alternative plans for improvement, it is necessary ye prepare standardized service level against business expense and basis for calculating and evaluation operation expenses. Based on the necessity of quantitative analysis (LCC analysis) of VFM, standard for calculating management, maintenance and administration expenses is required. In addition, reliable economic valuation system considering domestic BTL environment should be setup, for business efficiency.

INFLUENCE OF TUNGSTEN CARBIDE/CARBON COATING ON THE PRELOAD OF IMPLANT ABUTMENT SCREWS (임플랜트 지대주 나사의 텅스텐 카바이드/탄소 코팅이 전하중에 미치는 영향에 관한 연구)

  • Choi Jin-Uk;Jeong Chang-Mo;Jeon Young-Chan;Lim Jang-Seop;Jeong Hee-Chan;Eom Tae-Gwan
    • The Journal of Korean Academy of Prosthodontics
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    • v.44 no.2
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    • pp.229-242
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    • 2006
  • Statement of problem: In order to increase preload with reducing the friction coefficient, abutment screws coated with pure gold and Teflon as dry lubricant coatings have been introduced. But the reported data indicate that if screw repeated tightening and loosening cycle, an efficiency of increasing preload was decreased by screw surface wearing off. Purpose: This study was to evaluate the influence of tungsten carbide/carbon coating, which has superior hardness and frictional wear resistance, on the preload of abutment screws and the stability of coating surface after repeated closures. Material and method: The rotational values of abutment screws and the compressive forces between abutment and fixture were measured in implant systems with three different joint connections, one external butt joint and two internal cones. Moreover the stability and the alteration of coating surface were examined by comparison of the compressive force and the removable torque values during 10 consecutive trials, observation with scanning electron microscope and analyzed the elemental composition with energy dispersive x-ray spectroscopy Results and conclusion: 1. Application of coating resulted in significant increase of compressive force in all implant systems(P<.05). The increasing rate of compressive force by coating in external butt joint was gloater than those in internal cones (P<.05). 2. Coated screw showed the significant additional rotation compared to non-coated screw in all implant systems (P<.05). There were no significant differences in the increasing rate of rotation among implant systems (P>.05). 3. Removable torque values were greater with non-coated screw than that with coated screw (P<.05). 4. Coated screw showed insignificant variations in the compressive forces during 10 consecutive trials(P>.05) 5. After repeated trials, the surface layer of coated screw was maintained relatively well. However surface wearing and irregular titanium fragments were found in non-coated screw.

Decontamination Characteristics of 304 Stainless Steel Surfaces by a Q-switched Nd:YAG Laser at 532 nm (532 nm 파장의 큐스위치 Nd:YAG 레이저를 이용한 스테인리스 스틸 표면 제염특성)

  • Moon, Jei-Kwon;Baigalmaa, Byambatseren;Won, Hui-Jun;Lee, Kune-Woo
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.8 no.3
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    • pp.181-188
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    • 2010
  • Metal surface decontamination characteristics were investigated by using a laser ablation method. A second harmonic generation of a Q-switched Nd:YAG laser with a wave length of 532 nm, a pulse energy of 150 mJ and a pulse width of 5 ns was employed to assess the decontamination performance for metal surfaces contaminated with $CsNO_3$, $Co(NH_4)_2(SO_4)_2$, $Eu_2O_3$ and $CeO_2$. The ablation behavior was investigated for the decontamination variables such as a number of laser shots, laser fluence and an irradiation angle. Their optimum values were found to be 8, 13.3 J/$cm^2$ and $30^{\circ}$, respectively. The decontamination efficiency was different depending on the kinds of the contaminated ions, due to their different melting and boiling points and was in the order: $CsNO_3>Co(NH_4)_2(SO_4)_2>Eu_2O_3>CeO_2$. We also evaluated a correlation between the metal ablation thickness and the number of laser shots for the different laser fluences.

U.S. Policy and Current Practices for Blending Low-Level Radioactive Waste for Disposal (저준위 방사성폐기물의 혼합 관련 미국의 정책과 실제 적용)

  • Kessel, David S.;Kim, Chang-Lak
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.3
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    • pp.235-243
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    • 2016
  • In the near future, many countries, including the Republic of Korea, will face a significant increase in low level radioactive waste (LLW) from nuclear power plant decommissioning. The purpose of this paper is to look at blending as a method for enhancing disposal options for low-level radioactive waste from the decommissioning of nuclear reactors. The 2007 U.S. Nuclear Regulatory Commission strategic assessment of the status of the U.S. LLW program identified the need to move to a risk-informed and performance-based regulatory approach for managing LLW. The strategic assessment identified blending waste of varying radionuclide concentrations as a potential means of enhancing options for LLW disposal. The NRC's position is that concentration averaging or blending can be performed in a way that does not diminish the overall safety of LLW disposal. The revised regulatory requirements for blending LLW are presented in the revised NRC Branch Technical Position for Concentration Averaging and Encapsulation (CA BTP 2015). The changes to the CA BTP that are the most significant for NPP operation, maintenance and decommissioning are reviewed in this paper and a potential application is identified for decommissioning waste in Korea. By far the largest volume of LLW from NPPs will come from decommissioning rather than operation. The large volumes in decommissioning present an opportunity for significant gains in disposal efficiency from blending and concentration averaging. The application of concentration averaging waste from a reactor bio-shield is also presented.

Effect of Target Material and the Neutron Spectrum on Nuclear Transmutation of 99Tc and 129I in Nuclear Reactors (표적물질 및 중성자 스펙트럼이 99Tc과 129I의 원자로 내부 핵변환에 미치는 영향)

  • Kang, Seung-gu;Lee, Hyun-chul
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.16 no.2
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    • pp.195-202
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    • 2018
  • As a rule, geological disposal is considered a safe method for final disposal of high-level radioactive waste. However, some long-lived fission products like $^{99}Tc$ and $^{129}I$ contained in spent nuclear fuel are highly mobile as less sorbing anionic species in the subsurface environment and can mainly cause exposure dose to the ecosystem by emission of beta rays in the hundreds of keV range. Therefore, if these two nuclides can be separated and converted with high efficiency into radioactively unharmful nuclides, this would have a positive effect on disposal safety. One candidate method is to transmute these two nuclides in nuclear reactors into short-lived nuclides or into stable nuclides. For this purpose, it is necessary to evaluate which reactor type is more efficient in burning these two nuclides. In this study, the simulation results of nuclear transmutation of $^{99}Tc$ and $^{129}I$ in light water reactor (PWR), heavy water reactor (CANDU) and fast neutron reactor (SFR, MET-1000) are compared and discussed.

Use of Accelerated Solvent Extraction Method for Determination of Residual Pesticides in Agricultural Products (농산물의 잔류농약분석을 위한 가속용매추출 (Accelerated Solvent Extraction) 방법의 이용)

  • Lee, Sung-Woo;Seo, Hye-Young;Han, Byung-Jae;Jeong, Yang-Mo;Kim, Jun-Hyoung;No, Ki-Mi;Kim, Kyong-Su
    • Applied Biological Chemistry
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    • v.47 no.2
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    • pp.228-237
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    • 2004
  • ASE (accelerated solvent extraction) was used to develop an analytical method for reducing the sample preparation time in pesticide residues analyses of agricultural produce. The conditions of ASE were as follows: preheat 1 min, heat 5 min, static 1 min, solvent flush% 60 vol., nitrogen purge 60 sec, 4 cycles, 1,500 psi pressure, and $100^{\circ}C$ temperature. When n-hexane:acetone (4 : l, v/v) was used as, an extraction solvent, the extraction and purification efficiency of ASE did not show the considerable difference compared with solvent extraction, and the reduction of extraction solvent did not affect the performance of extraction. It was proved that ASE method can reduce, sample preparation time as the extraction and purification steps were combined, and the extraction solvent was significantly reduced.

A Study of Optimal path Availability Clustering algorithm in Ad Hoc network (에드 혹 네트워크에서 최적 경로의 유효성 있는 클러스터링 알고리즘에 관한 연구)

  • Oh, Young-Jun;Lee, Kang-Whan
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.1
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    • pp.225-232
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    • 2013
  • In this paper, we introduce a method that can be used to select the position of head node for context-awareness information. The validity of the head node optimal location is saving the energy in the path according to the clustering. It is important how to elect one of the relay node for energy efficiency routing. Existing LEACH algorithm to elect the head node when the node's energy probability distribution function based on the management of the head node is optional cycle. However, in this case, the distance of the relay node status information including context-awareness parameters does not reflect. These factors are not suitable for the relay node or nodes are included in the probability distribution during the head node selects occurs. In particular, to solve the problems from the LEACH-based hierarchical clustering algorithms, this study defines location with the status context information and the residual energy factor in choosing topology of the structure adjacent nodes. The proposed ECOPS (Energy Conserving Optimal path Schedule) algorithm that contextual information is contributed for head node selection in topology protocols. This proposed algorithm has the head node replacement situations from the candidate head node in the optimal path and efficient energy conservation that is the path of the member nodes. The new head node election technique show improving the entire node lifetime and network in management the network from simulation results.

A Study on the Removal of harmful life from Ballast by Water Pretreatment (선박 밸러스트수의 유해생물 제거를 위한 전처리 연구)

  • Park Sang-Ho;Lim Jae-Dong;Park Sun-Jung;Kim In-Soo
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2006.06b
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    • pp.221-226
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    • 2006
  • This study is about backwash condition and membrane fouling at continuous filtration process in ballast water treatment. Displayed result that handle particle contaminant and hydrospace organism included a number of ballast that is happened in ship using automatic back washing filter. Reason that removes first contaminant that is included in number of ballast is that heighten processing effect of after processing process of the filter. Another advantage is to drop off the solids with controlling revolution of drum screen in pretreatment filtration process. The capacity of pilot plant was $10m^3/h$. The result of the test, Backwash cycle time and duration time and a signification effect on the efficiency of system and backwash Backwash duration time was determined to be fixed in 6 seconds of the system with more than 95% removal rate, It needed 1hour backwash frequency. Filtration system removal aquatic organism over $70{\mu}m$ in ballast water. This study shows that the filtration treatment system has a potential for the treatment of ballast water.

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