• 한국정보통신학회논문지
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• 제15권10호
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• pp.2217-2222
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• 2011

본 연구에서는 이중게이트(Double Gate; DG)MOSFET의 채널내 전위와 전하분포의 관계를 가우스 함수를 이용한 포아송방정식으로부터 유도하고자 한다. 즉, 도핑분포는 가우스 함수를 이용하였으며 변수인 이온주입범위 및 분포편차에 대하여 문턱전압이하 스윙과 산화막 두께의 관계를 관찰하고자 한다. 포아송방정식으로부터 해석학적 전위분포 모델을 구하였으며 이를 이용하여 산화막 두께에 대한 문턱전압이하 스윙값의 변화를 구하였다. 문턱전압이하 스윙은 게이트전압에 대한 드레인전류의 변화를 나타내고 이론적으론 최소값 60 mV/dec을 나타내며 디지털소자응용에 매우 중요한 요소이다. 본 연구의 모델이 타당하다는 것을 입증하기 위하여 포텐셜 분포값을 수치해석학적 값과 비교하였다. 결과적으로 본 연구에서 제시한 포텐셜모델이 수치해석학적 시뮬레이션모델과 매우 잘 일치하였으며 도핑분포에 따라 문턱전압이하 스윙과 산화막두께의 관계를 분석하였다.

• 한국컴퓨터정보학회논문지
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• 제13권4호
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• pp.1-9
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• 2008

대부분의 전자제품은 날로 다양한 소비자의 니즈로 인해 수많은 라인업을 보유하고 있다. 이에 대응하기 위해 보통 '베이스 모델'이라 불리는 초기 개발모델에서 각 상품화 과제의 특정 요구사항을 반영하여 파생개발을 한다. 제품 라인업에 기반한 소프트웨어 라인 업이 형성되는 개발환경에서 '베이스 코드'의 구조와 그 구성요소의 품질은 향후 파생되는 여러 많은 제품의 생산성과 품질의 근간이 된다. '베이스코드'는 최초 개발 후 여러 상품화를 거치면서 그 구조와 코드 자체에 수많은 변경이 가해진다. 상품화 과제의 요구사양에 따라 변경되거나 추가되는 기능의 구현은 필수적 활동이며, 성능 개선 및 문제점 해결을 위한 구조 및 코드의 변경 역시 상품화를 통해 지속적으로 발생하는 유지관리 활동이다. 하지만 위와 같은 변경은 최초 설계 시 의도된 구조가 깨지거나 코드의 복잡도가 증가하는 등의 노쇠화 징후(Ageing symptom)로 나타나 유지관리에 어려움을 준다. 본 논문은 노쇠화 된 베이스 코드의 상품화 적용 효율을 높이기 위해 재사용성, 유지보수성, 확장성 등의 비기능적 요소(quality attribute)의 개선을 위한 절차와 기법으로 리엔지니어링 프레임워크를 제안한다.

• International Journal of Oral Biology
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• 제38권3호
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• pp.93-100
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• 2013

Bile acids and synthetic bile acid derivatives induce apoptosis in various kinds of cancer cells and thus have anticancer properties. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, few data are available regarding the role of autophagy in oral cancers and there have been no reports of autophagic cell death in OSCCs (oral squamous cell carcinoma cells) induced by HS-1200, a synthetic bile acid derivative. We thus examine whether HS-1200 modulates autophagy in OSCCs. Our findings indicate that HS-1200 has anticancer effects in OSCCs, and we observed in these cells that autophagic vacuoles were visible by monodansylcadaverine (MDC)and acridine orange staining. When we analyzed HS-1200-treated OSCC cells for the presence of biochemical markers, we observed that this treatment directly affects the conversion of LC-3II, degradation of p62/SQSTM1 and full-length beclin-1, cleavage of ATG5-12 and the activation of caspase. An autophagy inhibitor suppressed HS-1200-induced cell death in OSCCs, confirming that autophagy acts as a pro-death signal in these cells. Furthermore, HS-1200 shows anticancer activity against OSCCs via both autophagy and apoptosis. Our current findings suggest that HS-1200 may potentially contribute to oral cancer treatment and thus provide useful information for the future development of a new therapeutic agent.

• 전기학회논문지P
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• 제63권4호
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• pp.290-294
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• 2014

PID(Proportional, Integral, Derivative) controller is the most popular process controllers in nuclear power plants. The optimized parameter setting of the process controller contributes to the stable operation and the efficiency of the operating nuclear power plants. PID parameter setting is tuned when new process control systems are installed or current process control systems are changed. When the nuclear plant is shut down, a lot of PID tuning methods such as the Trial and Error method, Ultimate Oscillation method operation, Ziegler-Nichols method, frequency method are used to tune the PID values. But inadequate PID parameter setting can be the cause of the unstable process of the operating nuclear power plant. Therefore the results of PID parameter setting should be simulated, optimized and finally verified. This paper introduces the simulation method of PID tuning to optimize the PID parameter setting and confirms them of the actual PID controller in the operating nuclear power plants. The simulation method provides the accurate process modeling and optimized PID parameter setting of the multi-loop control process in particular.

• 대한조선학회논문집
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• 제54권2호
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• pp.102-112
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• 2017

Many studies on dynamic positioning control algorithms using fixed feedback gains have been carried out to improve station keeping performance of dynamically positioned vessels. However, the control algorithms have disadvantages in that it can not cope with changes in environmental disturbances and response characteristics of vessels motion in real time. In this paper, the Fuzzy Gain Scheduling - PID(FGS - PID) control algorithm that can tune PID gains in real time was proposed. The FGS - PID controller that consists of fuzzy system and a PID controller uses weighted values of PID gains from fuzzy system and fixed PID gains from Ziegler - Nichols method to tune final PID gains in real time. Firstly, FGS - PID controller, control allocation algorithm, FPSO and environmental disturbances were modeled using Matlab/Simulink to evaluate station keeping performance of the proposed control algorithm. In addition, simulations that keep positions and a heading angle of vessel with wind, wave, current disturbances were carried out. From simulation results, the FGS - PID controller was confirmed to have better performances of keeping positions and a heading angle and consuming power than those of the PID controller. As a consequence, the proposed FGS - PID controller in this paper was validated to have more effectiveness to keep position and heading angle than that of PID controller.

• Restorative Dentistry and Endodontics
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• 제24권2호
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• pp.286-298
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• 1999

The endodontic-periodontic combined lesions have been difficult to get correct diagnosis and predictable treatment. This study was to make the experimental endodontic-periodontic combined defects in dogs for the study of the periodontal regeneration and to evaluate the efficacy of the enamel matrix protein and e-PTFE membrane in the experimental endodontic-periodontic combined defects. 5 mongrel dogs were used. The pulp chambers were opened and the plaque was inserted into the chambers to induce the periapical lesions on the mandibular second, third and fourth premolars of the dogs. 1 month later, the root canal treatments were done with gutta perch a and ZOE sealer. On the day of surgery, the periapical defects were standardized by trephine bur. The buccal dehiscence defects were made by the dental bur and bone chisels. The apicoectomy with retrofilling was done. The prepared roots were randomly selected for test and control groups. In the experimental groups, the enamel matrix derivative and e-PTFE membrane were used. Nothing was placed on the control group. Fluroscent labelling was used to evaluate the bone formation. After 4 and 12 weeks, the dogs were sacrificed and undecalcified sections were prepared and stained with toluidine blue. Those histologic sections were examined by fluorescent microscopy and light microscopy. The results were as follows. 1. In the control group, new bone was formed in the periapical defects and scarcely in the buccal dehiscence defects. New cementum was not detected at 4 and 12 weeks. 2. In the experimental groups, new bone, new cementum and periodontal ligament were found in the periapical and buccal dehiscence defects. The relative amount and the quality of the new bone, new cementum and periodontal ligament tissue that had formed on the experimental groups were superior to those of the control group. 3. The current observation implicated that e-PTFE membrane and enamel matrix protein could be the effective tools for the guided tissue regeneration of the endo-perio combined defects.

• Biomolecules & Therapeutics
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• 제23권4호
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• pp.313-319
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• 2015

P7C3 and its derivatives, 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(p-tolylamino)propan-2-ol (1) and N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide (2), were previously reported to increase neurogenesis in rat neural stem cells (NSCs). Although P7C3 is known to increase neurogenesis by protecting newborn neurons, it is not known whether its derivatives also have protective effects to increase neurogenesis. In the current study, we examined how 1 induces neurogenesis. The treatment of 1 in NSCs increased numbers of cells in the absence of epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2), while not affecting those in the presence of growth factors. Compound 1 did not induce astrocytogenesis during NSC differentiation. 5-Bromo-2'-deoxyuridine (BrdU) pulsing experiments showed that 1 significantly enhanced BrdU-positive neurons. Taken together, our data suggest that 1 promotes neurogenesis by the induction of final cell division during NSC differentiation.

• 식물분류학회지
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• 제48권4호
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• pp.278-288
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• 2018

Polyploidization plays an important role in generating the current high diversity of plants. Studies of the distributional patterns of diploid and derivative polyploid races have provided important insights into the evolutionary process and cryptic speciation by polyploidization within and between closely related taxa defined on the basis of their morphology. Allium thunbergii and A. sacculiferum, occurring throughout eastern Russia, eastern China, Korea, and Japan, are examples of closely related species with unsolved taxonomic relationships. A total of 97 and 65 individuals from 26 and 13 populations of A. thunbergii (including var. thunbergii, var. deltoids, and var. teretifolium) and A. sacculiferum, respectively, were studied to determine their ploidy. The geographic structure and habitat differentiation of the cytotypes were also analyzed. The main cytotype of A. thunbergii was diploid (92.3% in total; the rest were tetraploids). In contrast, the majority of A. sacculiferum plants were tetraploids (69.2% of the total; the rest were diploids). No populations of the studied taxa harbored both cytotypes. Allium thunbergii was more often found at higher elevations than A. sacculiferum, and it tended to occur more frequently on rocky slopes and below forests in mountainous areas. On the other hand, A. sacculiferum occurred at forest margins and in lowland pastures. The cytotypes differed with respect to the elevation; diploids were found more frequently at higher elevations than tetraploids. The results of this study and additional biosystematics data indicate that the morphological characteristics of A. thunbergii and A. sacculiferum may be influenced by polyploidization and by their adaptation to various habitat conditions and that A. thunbergii and A. sacculiferum do not clearly fulfill the requirements of any species concept. Consequently, we propose that A. sacculiferum be considered as an additional synonym of A. thunbergii. Additionally, Allium thunbergii var. deltoides is unified into A. thunbergii var. thunbergii.

• Journal of Ginseng Research
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• 제43권4호
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• pp.625-634
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• 2019

Background: Ginsenoside Rg3, a derivative of steroidal saponins abundant in ginseng, has a range of effects on cancer cells, including anti-cell proliferation and anti-inflammation activity. Here, we investigate two long noncoding RNAs (lncRNAs), STXBP5-AS1 and RFX3-AS1, which are hypomethylated and hypermethylated in the promoter region by Rg3 in MCF-7 cancer cells. Methods: The lncRNAs epigenetically regulated by Rg3 were mined using methylation array analysis. The effect of the lncRNAs on the apoptosis and proliferation of MCF-7 cells was monitored in the presence of Rg3 or Korean Red Ginseng (KRG) extract after deregulating the lncRNAs. The expression of the lncRNAs and their target genes was examined using qPCR and Western blot analysis. The association between the expression of the target genes and the survival rate of breast cancer patients was analyzed using the Kaplan-Meier Plotter platform. Results: STXBP5-AS1 and RFX3-AS1 exhibited anti- and pro-proliferation effects, respectively, in the cancer cells, and the effects of Rg3 and KRG extract on apoptosis and cell proliferation were weakened after deregulating the lncRNAs. Of the genes located close to STXBP5-AS1 and RFX3-AS1 on the chromosome, STXBP5, GRM1, RFX3, and SLC1A1 were regulated by the lncRNAs on the RNA and protein level. Breast cancer patients that exhibited a higher expression of the target genes of the lncRNAs had a higher metastasis-free survival rate. Conclusion: The current study is the first to identify lncRNAs that are regulated by the presence of Rg3 and KRG extract and that subsequently contribute to inhibiting the proliferation of cancer cells.

• Earthquakes and Structures
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• 제20권3호
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• pp.353-364
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• 2021

Natural hazards like earthquakes, high winds, and tsunami are a threat all the time for multi-story structures. The environmental forces cannot be clogged but the structures can be prevented from these natural hazards by using protective systems. The structural control can be achieved by using protective systems like the passive, active, semi-active, and hybrid protective systems; but the semi-active protective system has gained importance because of its adaptability to the active systems and reliability of the passive systems. Therefore, a semi-active protective system for the earthquake forces has been adopted in this work. Magneto-Rheological (MR) damper is used in the structure as a semi-active protective system; which is connected to the current driver and proposed controller. The Proportional Integral Derivative (PID) controller and reliable PID controller are two proposed controllers, which will actuate the MR damper and the desired force is generated to mitigate the vibration of the structural response subjected to the earthquake. PID controller and reliable PID controller are designed and tuned using Ziegler-Nichols tuning technique along with the MR damper simulated in Simulink toolbox and MATLAB to obtain the reduced vibration in a three-story benchmark structure. The earthquake is considered to be uncertain; where the proposed control algorithm works well during the presence of earthquake; this paper considers robustness to provide satisfactory resilience against this uncertainty. In this work, two different earthquakes are considered like El-Centro and Northridge earthquakes for simulation with different controllers. In this paper performances of the structure with and without two controllers are compared and results are discussed.