• Journal of Genetic Medicine
• /
• 제5권2호
• /
• pp.89-93
• /
• 2008

"Personalized medicine," the goal of which is to provide better clinical care by applying patient's own genomic information to their health care is a global challenge for the $21^{st}$ century "genomic era." This is especially true in Korea, where provisions for clinical genetic services are inadequate for the existing demand, let alone future demands. Genomics-based knowledge and tools make it possible to approach each patient as a unique biological individual, which has led to a paradigm-shift in medical practice, giving it more of a predictive focus as compared with current treatment oriented approach. With recent advancements in genomics, many genetic tests, such as susceptibility genetic tests, have been developed for both rare single gene diseases and more common multifactorial diseases. Indeed, genetic tests for presymtomatic individuals and genetic tests for drug response have become widely available, and personalized medicine will face the challenge of assisting patients who use such tests to make appropriate and wise use of genetic risk assessment. A major challenge of genomic medicine lies in understanding and communicating disease risk in order to facilitate and support patients and their families in making informed decisions. Establishment of a health care system with provisions for genetic counseling as an integral part of health care service, in addition to genomic literacy of health care providers, is vital to meet this growing challenge. Realization of the promise of personalized medicine in the era of genomics for improvement of health care is dependent on further development of next generation sequencing technology and affordable sequencing test costs. Also necessary will be policy development concerning the ethical, legal and social issues of genomic medicine and an educated and ready medical community with clinical practice guidelines for genetic counseling and genetic testing.

• 한국초전도ㆍ저온공학회논문지
• /
• 제21권4호
• /
• pp.39-43
• /
• 2019

The breaking of a circuit in DC grid could pose a challenge because of the absence of zero-crossing instant for both current and voltage when a fault occurs. An additional fault current limiting function will be very helpful for reducing the burden of the DC circuit breaker by limiting the fault current to a reasonable value. In this paper, we studied the overcurrent characteristics of several HTS conductors so that we could use the selected conductors for the basic design work of a resistive type fault current limiting module as a part of the circuit breaking system. According to the short-circuit test results, we suggested and compared two different basic design parameters of the HTS fault current limiting module, which will be connected in series to the DC circuit breaker.

• 생물정신의학
• /
• 제8권1호
• /
• pp.71-78
• /
• 2001

The current understanding of the neurobiology of anxiety is generally based on experimental animal model, empirical effective psychopharmacological agents, chemical and naturalistic challenge paradigms, and psychoendocinological assessment. This article focuses on reviewing neuroanantomical, neuroendocinological and neurofunctional research of anxiety disorder. In the decade ahead, we anticipate that extension of current research and the new integrated approach promise novel insight into mechanism of anxiety.

• EDISON SW 활용 경진대회 논문집
• /
• 제3회(2014년)
• /
• pp.457-458
• /
• 2014

In this paper, quantum mechanical simulations of the double-gate ultra-thin body (DG-UTB) MOSFETs are performed according to the International Technology Roadmap of Semiconductors (ITRS) specifications planned for 2020, to devise the way for on-current ($I_{on}$) improvement. We have employed non-equilibrium Green's function (NEGF) approach and solved the self-consistent equations based on the parabolic effective mass theory [1]. Our study shows that the [100]/<001> Ge and GaSb channel devices have higher $I_{on}$ than Si channel devices under the body thickness ($T_{bd}$) <5nm condition.

• 한국막학회:학술대회논문집
• /
• 한국막학회 1991년도 추계 총회 및 학술발표회
• /
• pp.17-26
• /
• 1991

It can be said that the current ULSI technology has been supported and/or accomplished by a major challenge to the clean room environment and the ultrapure water equipment manufacturers as to contamination control. The required improvement in ultrapure water quality, which is shown in Figure 1, would not have been possible without significant improvements in membrane performance and enhancements in analytical capabilities.

• EDISON SW 활용 경진대회 논문집
• /
• 제2회(2013년)
• /
• pp.252-255
• /
• 2013

Nano MOS with $Er_2O_3/SiO_2$ double-layer gate dielectrics was demonstrated by EDISON Nanophysics software. Double-layer structure decreases the gate leakage current in two orders compared with $SiO_2$ single-layer gate dielectric.

• Current Optics and Photonics
• /
• 제2권1호
• /
• pp.1-6
• /
• 2018

Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.

• Journal of Power Electronics
• /
• 제16권5호
• /
• pp.1743-1751
• /
• 2016

The increasing demand for high voltage DC grids resulting from the continuous installation of offshore wind farms in the North Sea has led to the concept of multi-terminal direct current (MTDC) grids, which face some challenges. Power (current) flow control is a challenge that must be addressed to realize a reliable operation of MTDC grids. This paper presents a reduced switch count topology of a current flow controller (CFC) for power flow and current limiting applications in MTDC grids. A simple control system based on hysteresis band current control is proposed for the CFC. The theory of operation and control of the CFC are demonstrated. The key features of the proposed controller, including cable current balancing, cable current limiting, and current nulling, are illustrated. An MTDC grid is simulated using MATLAB/SIMULINK software to evaluate the steady state and dynamic performance of the proposed CFC topology. Furthermore, a low power prototype is built for a CFC to experimentally validate its performance using rapid control prototyping. Simulation and experimental studies indicate the fast dynamic response and precise results of the proposed topology. Furthermore, the proposed controller offers a real solution for power flow challenges in MTDC grids.

• Journal of Information Technology Applications and Management
• /
• 제27권5호
• /
• pp.49-68
• /
• 2020

The Push-Pull-Mooring (PPM) model employ to explore the factors that affect the switching intention of mobile game players by analyzing the online survey data of 240 mobile game players in China. From the perspective of PPM model, Dissatisfaction with the current mobile game can promote players to leave the current mobile game, and other more attractive mobile games can pull players out of the current mobile game. As a mooring factor, habit can affect players' switching decisions. Players who have formed strong habits in current mobile games are more likely to resist or ignore the attractiveness of other mobile games and stay in the current mobile games rather than migrate to other mobile games. Another result shows that the more dissatisfied with the current mobile game, the higher the quality of alternative (relative challenge) mobile game, and the lower the investment size in the current mobile game, the more reluctant the players are to continue to maintain the relationship with the current mobile game. The higher the player's commitment to the current mobile game, the more likely it is to maintain the relationship with the current mobile game. The empirical results show that the framework of this study is highly consistent with the results of PPM model, and confirming that they can well apply to mobile game situations.

• 한국통신학회논문지
• /
• 제42권2호
• /
• pp.349-357
• /
• 2017

많은 웹 사이트들이 사용자가 패스워드를 분실하거나 온라인 결제를 진행하는 등의 상황에서 SMS(Short Message Service) 기반의 사용자 인증을 채택하고 있다. SMS 기반 인증에서 인증 서버는 텍스트를 평문으로 전송하기 때문에 공격자가 그 텍스트를 도청하거나 가로채면 다른 사람(피해자)인 것처럼 인증을 받을 수 있다. 본 논문에서는 사용자가 스마트폰을 지금, 어느 위치에서 소유하고 있는지를 인증하는 챌린지-응답(challenge-response) 형태의 인증 방식을 제안한다. 제안 방식은 서버가 보낸 챌린지, 사용자의 현재 위치정보, 스마트폰에 저장된 비밀 값을 모두 사용하여 응답을 생성한다. 그 결과로, 단순히 사용자가 받은 SMS 메시지를 어떤 가공도 없이 그대로 서버로 되돌리는 SMS 기반 인증에 비해, 제안 방식은 훨씬 더 안전하다. 제안 방식은 기존 SMS 기반 인증의 텍스트에 해당하는 응답의 입력과 더불어, 인증 과정의 시작을 위해 추가로 패스프레이즈(passphrase)의 입력을 요구하나, 추가 입력의 부담은 향상되는 보안성을 고려할 때 대부분의 사용자들이 감내할 수 있는 수준이라 판단한다.