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http://dx.doi.org/10.3807/COPP.2018.2.1.001

Biphasic Tumor Oxygenation during Respiratory Challenge may Predict Tumor Response during Chemotherapy  

Lee, Songhyun (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST))
Jeong, Hyeryun (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST))
Anguluan, Eloise (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST))
Kim, Jae Gwan (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST))
Publication Information
Current Optics and Photonics / v.2, no.1, 2018 , pp. 1-6 More about this Journal
Abstract
Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.
Keywords
Vascular reactivity; Chemotherapeutic efficacy; Near-infrared spectroscopy; Hemodynamic changes;
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