Current Optics and Photonics

Optical Society of Korea (한국광학회)
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Biphasic Tumor Oxygenation during Respiratory Challenge may Predict Tumor Response during Chemotherapy

  • Lee, Songhyun (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST)) ;
  • Jeong, Hyeryun (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST)) ;
  • Anguluan, Eloise (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST)) ;
  • Kim, Jae Gwan (Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST))
  • Received : 2017.11.14
  • Accepted : 2017.11.28
  • Published : 2018.02.25
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Abstract

Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.

Keywords

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FIG. 1. Experimental setup of the CWNIRS system used for monitoring tumor hemodynamics.

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FIG. 2. Protocol of inhaled-gas intervention.

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FIG. 3. (a) Representative set of data showing oxyhemoglobin (OHb), deoxyhemoglobin (RHb), pulmonary oxygen saturation (SpO2), and heart rate (HR) during the inhaled-gas interventions. (b) A double-exponential equation (Eq. (1)) was fitted to the change of OHb concentration during hyperoxia. Amplitude 1 (A1) corresponds mainly to hemodynamics in the well-perfused region of the tumor, while Amplitude 2 (A2) corresponds to the poorly perfused region.

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FIG. 4. The changes of A1 and A2 values and tumor-volume change from (a) the control group (n = 6), (b) chemo group (n = 6), and (c) early chemo group (n = 6). A1(t) and A2(t) represent amplitude values from the tumor breast, while A1(c) and 2(c) represent amplitude values from the contralateral normal breast.

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