• Title/Summary/Keyword: Cure Process

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Natural radioprotectors and their impact on cancer drug discovery

  • Kuruba, Vinutha;Gollapalli, Pavan
    • Radiation Oncology Journal
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    • v.36 no.4
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    • pp.265-275
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    • 2018
  • Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use of cytostatic drugs to cure cancer. Cytostatic agents not only affect cancer cells but also affect the growth of normal cells; leading to side effects. Because of this, radiotherapy gained importance in treating cancer. Slaughtering of cancerous cells by radiotherapy depends on the radiosensitivity of the tumor cells. Efforts to improve the therapeutic ratio have resulted in the development of compounds that increase the radiosensitivity of tumor cells or protect the normal cells from the effects of radiation. Amifostine is the only chemical radioprotector approved by the US Food and Drug Administration (FDA), but due to its side effect and toxicity, use of this compound was also failed. Hence the use of herbal radioprotectors bearing pharmacological properties is concentrated due to their low toxicity and efficacy. Notably, in silico methods can expedite drug discovery process, to lessen the compounds with unfavorable pharmacological properties at an early stage of drug development. Hence a detailed perspective of these properties, in accordance with their prediction and measurement, are pivotal for a successful identification of radioprotectors by drug discovery process.

Expanding the MCS of Refinery Process Compressor through Operating-Speed Balancing at 10,500 rpm (정유공정 압축기의 10,500 rpm 운전속도 밸런싱을 통한 MCS의 확장)

  • Lee, An-Sung;Kim, Byung-Ok
    • The KSFM Journal of Fluid Machinery
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    • v.12 no.6
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    • pp.41-46
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    • 2009
  • This paper deals with the operating-speed (high-speed) balancing of a refinery gasoline HDS (hydrodesulfurization) process recycle-gas 8-stages compressor rotor. A low-speed balancing condition of the rotor was measured as maintaining the G2.5 level. But an inspection run of operating-speed balancing condition, using tilting-pad journal bearings of actual use, showed that while it could be continuously-operated safely at a rated speed of 10,500 rpm, the rotor would not be able to run over 11,000 rpm as the vibration increased very sharply, approaching 11,000 rpm. In order to cure that a series of operating-speed balancing, which first calculated balance correction-weights by applying the influence coefficient measured and calculated at 10,500 rpm and then implemented correction works, was carried-out. The final operating-speed balancing results showed that the vibrations at the bearing pedestals represented very good levels of 0.2 mm/s by decreasing to as much as the 1/10 of the original vibrations and particularly, even at a targeted maximum continuous operating speed, MCS, of 11,500 rpm the vibrations represented about 1 mm/s, which is the operating-speed balancing vibration specification of API. Therefore, the expansion of MCS was successfully accomplished through the operating-speed balancing.

A Study on Thermal Simulation for Adhesive Curing of Cylindrical Cigarettes (원통형 궐련의 접착제 경화를 위한 열전달 시뮬레이션에 관한 연구)

  • Park, Yong-Woo;Moon, Seong-Min;Zhang, Qi;Lyu, Sung-Ki
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.20 no.11
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    • pp.115-120
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    • 2021
  • In this study, cigarettes, which are an essential element in the production of tobacco, are generally not cylindrical. The main materials used for cigarettes are generally hemp and pulp. For the production of cylindrical cigarettes, the cigarettes or cylinders are mounted via gluing. This adhesive is a vinyl acetate emulsion, a high-temperature melt adhesive, and is adhered in a cylindrical shape immediately after being linearly applied to the inner surface of the paper roll or a local part. These adhesives are greatly affected by the atmospheric temperature of the manufacturing space in summer and winter. In the summer, even if the adhesive is temporarily adhered, the coagulation time of the adhesive is long, and problems such as deterioration of the adhesive state occur. in the winter, there is a problem that the temperature of the manufacturing space is low and the adhesive force of the adhesive is poor, resulting in defective adhesive products. In order to solve these problems, another heat transfer device is utilized to cure the remaining adhesive to ensure higher adhesiveness.

An Experimental Study on the Strengthening Effect of RC Beam subjected to Repeated Loading during CFS Strengthening Process (탄소섬유 보강 중에 반복하중을 받은 RC보의 보강효과에 관한 실험적 연구)

  • Jang, Hee-Suk;Kim, Hee-Sung
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.10 no.1
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    • pp.183-189
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    • 2006
  • When RC structures are repaired or strengthened using FRP, it is required to cure for some Period under certain air temperature and then it is hopeful to avoid detrimental action caused by external vibration sources during that period. Therefore, an effect of repeated loading during Carbon Fiber Sheet(CFS) strengthening Process on the strengthening efficiency is studied through an experiment for a number of RC beams. Experimental results showed that the curing time of 24 hours without any repeated loading after CFS attachment were recommended for 1 ply strengthening, and 12 hours for 2 plies strengthening.

Fabrication and Evaluation of Integrated Composite Part for Aircraft using OoA (Out-of-Autoclave) Prepreg (OoA (Out-of-Autoclave) 프리프레그를 이용한 항공기용 복합재 일체형 부품 제작 및 평가)

  • Hong, Sungjin;Song, Min-Hwan;Song, Keunil;Baik, Sang-Moon;Shin, Sang-Jun
    • Composites Research
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    • v.29 no.5
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    • pp.315-320
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    • 2016
  • Conventionally, composite aircraft structures are fabricated within autoclave at high pressure. However, autoclave process has several disadvantages including high curing costs and limitation of part size. Recently, out-of-autoclave (OoA) processes have been investigated in many studies to replace conventional autoclave process. A newly developed OoA prepreg, using conventional ovens, can significantly reduce the curing costs and produce autoclave-quality parts. Nevertheless, manufacture of void-free complex shape structure using OoA process presents significant challenges because of the low consolidation pressure. In this study, integrated skin-spar-rib composite part was fabricated using OoA prepreg. And cross-sectional macro- and micro-graphs of the part were examined in order to assess the possibility of replacing conventional autoclave process.

Refering to Sundry Records about Cause, Process and Treatment of Jungkijeung(Zhongqizheng) (중기(中氣)의 병인병기(病因病機) 및 치료(治療)에 관한 문헌고찰(文獻考察))

  • Hong, Suk;Lee, Dong-Won
    • Journal of Oriental Neuropsychiatry
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    • v.11 no.1
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    • pp.115-130
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    • 2000
  • Object: Show the treatment about Jungkijeung (Zhongqizheng) by distinguishing Apoplexy(Zhongfeng), yujungfung(Leizhongfeng), gualjung(Juezheng), and observation of cause, process, quality. Method: Researched definition, cause, process, treatment and herb med through chinese & korean medical publication refered to Jungkijeung(Zhongqizheng) Result: 1. Jungkijeung(Zhongqizheng) is simmilar to Apoplexy(Zhongfeng) that spiritual shock occurred to syncope, dysarthria, trismus, quadriplegia. But the symptom of Jungkijeung(Zhongqizheng) is coldness, no-sputum, sink-pluse; that of Apoplexy(Zhongfeng) is warmness, much secretion, float-pulse. 2. Jungkijeung(Zhongqizheng) is mainly caused by the serious anger and the reverse movement of spints by the seven emotional factor. The process of Jungkijeung(Zhongqizheng) are "Fire and Fever(huore)" "Weatness and sputum(shitan)", and most importantly "Weakness of vital-qi(qixi)" 3. The treatment of Jungkijeung(Zhongqizheng) is adjustment and circulation of jiao. In early stage, don't use of Apoplexial- Med. 4. As following herb-med are used for Jungkijeung (Zhongqizheng). Sohaphang-won(Suhexiangyan) is 18 times; Palmisungi-san(Baweishunqisan) is 13 times; Kang-tang(Jiangtang) is 8 times: Mokhyangsungi san(Muxiangshunqisan) is 6 times. 5. Atractylodes macrocephala KOIDZ(Baishu) is used for 40 times most frequently, Saussurea lappa CLARKE (Muxiang), Cyperus rotundus L (Xiangfuzi), Citrus unshiu MARCOR(Chenpi), Glycyrrhiza uralensis FISCH (Gancao), poria cocos WOLF (Furing), Panax ginseng NESS (Renshen) etc are orderly used. 6. Acupoints same as GV20(Baihui), LI4(Hegu), Liv2(Xingjian), 12 Junghyul(Jingxue) is used for acupunture. And CV8(Shenque), CV4(Guanyan) is used for moxibustion. Conclusion: As Jungkijeung(Zhangqizheng) is differed from Apoplexy(Zhongfeng), yujungfung(Leizhongfeng), gualjung(Juezheng), we must also cure Jungkijeung (Zhongqizheng) to the other disease. It is need to distinguishment Jungkijeung(Zhongqizheng) from neurotic, psychotic disease, though similar to conversation neurosis.

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Experimental and Numerical Validation of the Technique for Concrete Cure Monitoring Using Piezoelectric Admittance Measurements (어드미턴스 기반 콘크리트 경화 모니터링의 실험 및 수치적 검증)

  • Kim, Wan Cheol;Park, Gyuhae
    • Journal of the Korean Society for Nondestructive Testing
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    • v.36 no.3
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    • pp.217-224
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    • 2016
  • This paper presents a new technique for monitoring the concrete curing process using embedded piezoelectric transducers via admittance measurements. When a piezoelectric transducer is embedded in a structure, the electrical impedance (admittance) of the transducer is coupled with the mechanical impedance of the host structure, which allows monitoring of the structural condition. In this study, the admittance signatures are used for monitoring the concrete curing process. This new method is based on an admittance-based sensor diagnostic process, in which the capacitance values of the piezoelectric transducers are dependent on the strength of the host structure. We numerically and experimentally investigated the variations in capacitive value during the curing process. The results demonstrate that there is a clear relationship between the concrete curing status and the slope, this indicates that the proposed method could be efficiently used for monitoring the curing status of a concrete structure.

A Study on the Fracture Behavior of CFRP in Tensile and Fracture Toughness Tests by Acoustic Emission (음향방출법에 의한 탄소 섬유 복합 재료의 인장 및 파괴 인성시험시의 파괴 거동에 관한 연구)

  • Lee, Sang-Guk;Oh, Sae-Kyoo;Nam, Ki-Woo;Kim, Og-Gyun
    • Journal of the Korean Society for Nondestructive Testing
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    • v.15 no.1
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    • pp.277-290
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    • 1995
  • The study was carried out to analyze the fracture behavior and the acoustic emission(AE) characteristics and to find the relationship among tensile strength, fracture toughness and cure pressure in owe process of the carbon fiber reinforced composites of two types, $[0^{\circ}/90^{\circ}]_{2S}$ and $[0^{\circ}\;_2/90^{\circ}\;_2]_S$. AE signals were detected during the curing process, tensile tests and fracture toughness tests by acoustic emission(AE) measurements, respectively. Tensile strengths showed that the less cure pressurizing steps and the side of $[0^{\circ}/90^{\circ}]_{2S}$ specimens had the higher strengths than those of the others. Fracture toughness by the change of test temperature showed nearly same values in the same temperature region, but the higher test temperature had the lower fracture toughness values. In order to examine the relationship between fracture behavior of CFRP in tensile and fracture toughness tests and AE signals, the post processing for AE parameters of AE data and the observations of microscope and SEM have been carried out respectively.

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Molding Quality Evaluation on Composite Laminate Panel for Railway Vehicle through Cure Monitoring using FBG Sensors (광섬유 FBG 센서기반 성형 모니터링을 통한 철도 차량용 복합재 내장재 패널의 성형 품질 평가)

  • Juyeop Park;Donghoon Kang
    • Composites Research
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    • v.36 no.3
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    • pp.186-192
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    • 2023
  • Recently, in the field of railway vehicles, interest in the use of composite materials for weight reduction and transportation efficiency is increasing. Accordingly, research and commercialization development to apply composite materials to various vehicle parts are being actively conducted, and evaluation is conducted centering on post-measurement such as mechanical performance evaluation of finished products to verify quality when composite materials are applied. However, the analysis of heat and stress generated during the molding process of composite materials, which are factors that greatly affect manufacturing quality, is insufficient. Therefore, in this study, in order to verify the molding quality of composite parts for railway vehicles, the molding quality analysis was conducted for the two types of composite interior panels (laminate panel and sandwich panel) that are most actively used. To this end, temperature and strain changes were monitored during the molding process by using an FBG fiber optic sensor, which is easy to apply to the inside of the composite, and the residual strain value generated after molding was completed was measured. As a result, it was confirmed that overheating and excessive residual stress did not occur, thereby verifying the excellent molding quality of the composite interior panel for railway vehicles.

Psychosocial Adjustment of Low-Income Koreans with Cancer (저소득층 암환자들의 심리사회적 적응 과정)

  • Yi, Myung-Sun;Park, Eun-Young;Kim, Dal-Sook;Tae, Young-Sook;Chung, Bok-Yae;So, Hyang-Sook
    • Journal of Korean Academy of Nursing
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    • v.41 no.2
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    • pp.225-235
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    • 2011
  • Purpose: To describe psychosocial adjustment of low-income Koreans who have cancer. Methods: Data were collected during 2008 using individual in-depth interviews with 18 Korean people with cancer. The income status of the participants was low, 11 were recipients of the National Basic Livelihood Protection program. Mean age was 58.3 yr and 11 were female. Five participants had stomach cancer, five, colorectal cancer, and four, breast cancer. Data were analyzed using grounded theory methodology. Results: The core category emerged as 'bearing up alone with double suffering'. 'Poverty and cancer: A double suffering' emerged as a causal condition. The adjustment process consisted of three stages: 'forming a treatment will to live', 'practicing for the cure', and 'restructuring self and repaying favors'. Each stage indicated action-interaction strategies which were employed to bear up alone with double suffering during the illness process. Self-reflection, parental responsibility, and support from the public sector played important roles in overcoming the double suffering. Two types of consequences were identified: Transcended life and strained life suppressed by poverty and cancer. Conclusion: The results provide insights into the psychosocial adjustment process for low income Korean with cancer and can be used in developing and implementing efficient home-care services for these people.