• 농약과학회지
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• 제4권1호
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• pp.64-70
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• 2000

아인산의 고추 토마토 역병 및 노균병에 대한 방제 효과를 성체 식물체를 이용하여 온실에서 검정한 결과, 고추 역병의 경우 $1,408{\mu}g$ a.i./mL ($H_{3}PO_{3}$) 농도 처리에서 91%와 80%의 예방 및 치료효과를 보였다. 토마토 역병의 경우는 $1,408{\mu}g$ a. i./mL 처리에서 각각 63.4%와 13.0%의 예방 및 치료효과를 보여 고추 역병에 비해 효과가 저조하였다. 토마토 역병균의 유주자낭의 밀도가 $1{\times}10^{3}{\sim}1{\times}10^{4}/mL$일 경우 방제 효과가 높았다. 고추역병균에 대한 약제지속효과에 있어서 아인산은 경엽처리 4일 후에도 94%의 높은 방제 효과를 보여 대조약제인 포롬 수화제에 비해 효과가 지속됨을 알 수 있었다. 오이 노균병에 대해서는 $1,408{\mu}g$ a.i./mL 처리는 82와 62%의 예방 및 치료효과를 보였다. 아인산의 경엽처리는 식물의 생육을 촉진시키는 것으로 나타났다.

• 한방안이비인후피부과학회지
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• 제15권1호
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• pp.291-300
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• 2002

I experienced one case of Dermatitis Rhus from the 12th to the 18th in July 2001 in Dongshin University Gwangju Oriental Medical Hospital Dennatology. Administration of herbal medicine "Cheongyangsamul-Tang", external use of "Sambakyihwang-Guo" and "Kumeunhwa-Tang", acupunture, and venesection therapy, as a curative means of clearing away Heat and Toxic Materiale, expelling Pathogenic Wind, and stoping pruritus achieved desirable effect.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2016년도 춘계 종합학술대회 논문집
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• pp.379-380
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• 2016

본 연구는 빠르게 진행되고 있는 노인 인구의 증가에 따라 노인들의 사회적, 경제적, 건강상의 복잡한 문제로 발생되는 정신병 문제가 대두되고 있고. 그중 우울증은 노인들의 자살로 이끄는 중대한 질병이므로 본 연구에서는 간단한 자가 치료가 가능한 귀자극 요법을 활용하여 노인들의 우울증에 대한 치료 효과를 알아보고 이에 대한 활용 방법을 제시하고 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6565-6570
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• 2014

Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rh-endostatin+DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin+DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.

• Journal of Microbiology and Biotechnology
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• 제23권6호
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• pp.771-778
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• 2013

Essential oils are increasingly of interest for use as novel drugs acting as antimicrobial and antiviral agents. In the present study, we report the in vitro antiviral activities of 29 essential oils, extracted from Chinese indigenous aromatic plants, against the tobacco mosaic virus (TMV). Of these essential oils, those oils from ginger, lemon, tea tree, tangerine peel, artemisia, and lemongrass effected a more than 50% inhibition of TMV at 100 ${\mu}g/ml$. In addition, the mode of antiviral action of the active essential oils was also determined. Essential oils isolated from artemisia and lemongrass possessed potent inactivation and curative effects in vivo and had a directly passivating effect on TMV infection in a dose-dependent manner. However, all other active essential oils exhibited a moderate protective effect in vivo. The chemical constitutions of the essential oils from ginger, lemon, tea tree, tangerine peel, artemisia, and lemongrass were identified by gas chromatography and gas chromatography-mass spectrometry. The major components of these essential oils were ${\alpha}$-zingiberene (35.21%), limonene (76.25%), terpinen-4-ol (41.20%), limonene (80.95%), 1,8-cineole (27.45%), and terpinolene (10.67%). The curative effects of 10 individual compounds from the active essential oils on TMV infection were also examined in vivo. The compounds from citronellal, limonene, 1,8-cineole, and ${\alpha}$-zingiberene effected a more than 40% inhibition rate for TMV infection, and the other compounds demonstrated moderate activities at 320 ${\mu}g/ml$ in vivo. There results indicate that the essential oils isolated from artemisia and lemongrass, and the individual compound citronellal, have the potential to be used as an effective alternative for the treatment of tobacco plants infected with TMV under greenhouse conditions.

• BMB Reports
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• 제38권3호
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• pp.300-306
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• 2005

Tamoxifen citrate is an anti-estrogenic drug used for the treatment of breast cancer. It showed a degree of hepatic carcinogenesis, when it used for long term as it can decrease the hexose monophosphate shunt and thereby increasing the incidence of oxidative stress in liver rat cells leading to liver injury. In this study, a model of liver injury in female rats was done by intraperitoneal injection of tamoxifen in a dose of 45 mg/kg body weight for 7 successive days. This model produced a state of oxidative stress accompanied with liver injury as noticed by significant declines in the antioxidant enzymes (glutathione-S-transferase, glutathione peroxidase and catalase) and reduced glutathione concomitant with significant elevations in TBARS (thiobarbituric acid reactive substance) and liver transaminases; sGPT (serum glutamate pyruvate transaminase) and sGOT (serum glutamate oxaloacetate transaminase) levels. The oral administration of dimethyl dimethoxy biphenyl dicarboxylate (DDB) in a dose of 200 mg/kg body weight daily for 10 successive days, resulted in alleviation of the oxidative stress status of tamoxifen-intoxicated liver injury in rats as observed by significant increments in the antioxidant enzymes (glutathione-S-transferase, glutathione peroxidase and catalase) and reduced glutathione concomitant with significant decrements in TBARS and liver transaminases; sGPT and sGOT levels. The administration of DDB before tamoxifen intoxication (as protection) is more little effective than its curative effect against tamoxifen-induced liver injury. The data obtained from this study speculated that DDB can mediate its biochemical effects through the enhancement of the antioxidant enzyme activities and reduced glutathione level as well as decreasing lipid peroxides.

• 동의생리병리학회지
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• 제20권4호
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• pp.1073-1077
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• 2006

The purpose of this study is to find out oriental medical management and treatment of uterus myoma patients by investigating and analyzing them. We analyzed the results of medical records for 132 patients who were diagnosed as uterus myoma and visited Dong-Eui University Oriental Medical Center from March 2001 to December 2004. We investigated the frequency of symptom, the company frequency of symptom, the variety of treatment method. The frequency of symptom was dysmenorrhea 79 persons 59.85%, menorrhagia 61 persons 46.21%, subjective symptom of mass 12 persons 9.09%, infertility 4 persons 3.03%, lumbago 24 persons 18.18%, dysuria 10 persons 7.58%, dyschezia 22 persons 16.67'/), and the average number was 2.33. We investigated the company frequency of symptom, silent patients were 16 persons 12.12%, 116 persons 87.88(/) had myoma symptom. The treatment method; The frequency of taking herb medicine was 115 persons 87.12% and the average period was $50.65{\pm}5757$. The frequency of taking pill medicine was 56 persons 42.42% and the average period was $54.34{\pm}74.02$. The frequency of taking acupuncture treatment was 83 persons 62.88% and auricular acupuncture treatment was 30 persons 22.73%. We could find out the possibility of oriental medical management and treatment of uterus myoma.

• 대한한방부인과학회지
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• 제34권3호
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• pp.137-156
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• 2021

Objectives: The purpose of this study is to assess the effect of taking herbal medicine for the postpartum lactation. Methods: We searched 9 databases for recent three years, that contained four english, two chinese, one japanese and two korean database from September 17, 2016 to December 31, 2020. Randomized controlled trials (RCTs) were eligible. Measurement of outcome included total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Total 725 of studies was screened, 11 RCTs were finally selected. Number of participants per study ranged from 60 to 257. The treatment group of taking a herbal medicine is effective for improving total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration compared with control group. Because most of the studies had considerable heterogeneity in terms of type of intervention and comparison for outcome measurement, meta analysis for quantitative analysis was impossible. Conclusions: This studies showed that taking a herbal medicine is effective on increasing volume of lactation and speeding up the start of the first breastfeeding. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for breastfeeding and reduce the risk of bias.

• 대한약침학회지
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• 제10권1호통권22호
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• pp.23-36
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• 2007

Objective : We performed this study in order to investigate the effects of Paljeongsan-gamibang(八正散加味方) on the renal failure. Methods : We injected 8ml/kg of 50% glycerol on the rats. And then administered Paljeongsan-gamibang extract ; 209mg/200g/day to sample group during 3 days and observed the body temperature, urine volume, stool volume and the levels of creatinine, glucose, inorganic phosphorus, Na+, K+, Cl-, threonine, tyrosine in blood and creatinine, glucose, threonine, tyrosine in urine. Results : 1, The sample group administered Paljeongsan-gamibang showed a suppressive effect of body temperature, an improving effect in capability of concentrating urine at convoluted tubule and showed an increasing effect of stool volume. 2. The sample group administered Paljeongsan-gamibang showed a lowering effect in creatinine level in blood and showed an increasing effect in the levels of inorganic phosphorus, Na+, K+, Cl-, threonine and tyrosine in blood. 3. The sample group administered Paljeongsan-gamibang showed an increasing effect in creatinine level in urine and showed a lowering effect in the levels of glucose, inorganic phosphorus, threonine and tyrosine in urine. Conclusions : Conclusively, Paljeongsan-gamibang was recognized to have a curative effect against the damage of rat kidney induced by 50% glycerol, especially to improve the capability of reabsorption in proximal convoluted tubule.

• 동의생리병리학회지
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• 제16권4호
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• pp.774-781
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• 2002

This study was carried out to test the recuperative effect of 2 types of sample drugs for 3 degree burn. The burn injury was made by iron plate heated in the boiling water. The Sprague Dawley rats were shaven with a razor preliminarily and burned by direct contact method for 10 seconds. The experimental groups were classified with 5 each-normal, control, MEBO ointment, sample A, sample B. The effect of the sample drugs were decided by histological results after 3 week application. The results were as following. The 3 treatment groups recovered the burn injury faster than control group. The recuperative effect precedes about 4-5 days at the time of 15th day and 1 week at the time of 3rd week. The therapeutical procedure of 3 treatment groups was similar with naked eye and with microscopic histology in the 1 st, 2nd and 3rd specimens. So there weren't significant differences in curative effect in 3 treatment groups of this experiment. But a regeneration of hair follicle was noted in Sample B uniquely. These results suggested that 3 burn remedies have similar effect of therpy, but sample B containing yolk sac oil has slightly better effect in part of hair regeneration.