• Journal of Industrial Convergence
• /
• v.5 no.1
• /
• pp.45-59
• /
• 2007

This paper empirically examines the portfolio diversification effect using data from both KOSPI and KOSDAQ. In KOSPI market, portfolio diversification effect disappears when more than 18 stocks are added in the portfolio. About 63% of portfolio risk is eliminated. In KOSDAQ market, the maximum portfolio diversification effect is achieved when 17 stocks are at least included in a portfolio. The maximum cumulative risk reduction is 35%.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2001.11a
• /
• pp.859-864
• /
• 2001

An effective live load model for analyzing probable maximum live load effects such as moment and shear in transverse direction was developed. The main procedure of this live load model is composed of four parts, i.e., firstly, determination of the appropriate influence lines in longitudinal direction, secondly, application of the characteristics of vehicles and traffic patterns in longitudinal direction, thirdly, determination of the appropriate influence lines in transverse direction, and fourthly, application of the characteristics of vehicles and traffic patterns in transverse direction. Through this procedure, the probabilistic distributions of maximum probable load effects are deduced in the form of probability density function (PDF) and/or cumulative density function(CDF). This live load model is able to consider local or global deterioration of bridges in the structural analysis.

• Journal of Korean Society for Quality Management
• /
• v.34 no.4
• /
• pp.102-109
• /
• 2006

This paper investigates the effects of non-normality on the performance of univariate and multivariate cumulative sum(CUSUM) control charts for monitoring the process mean. In-control and out-of-control average run lengths of the charts are examined for the univariate/multivariate lognormal and t distributions. The effects of the reference value and the correlation coefficient under the non-normal distributions are also studied. Simulation results show that the CUSUM charts with small reference values are robust to non-normality but those with moderate or large reference values are sensitive to non-normal data especially to process data from skewed distributions. The performance of the chart to detect mean shift of a process is not invariant to the direction of the shift for skewed distributions.

• Biomolecules & Therapeutics
• /
• v.1 no.2
• /
• pp.160-165
• /
• 1993

The effects of Glycyrrhizae Radix (GR) on the metabolism of acetaminophen (AA) were examined in male Sprague-Dawley rats. The methanol extract of GR (500 mg/kg) was administered orally to rats for 6 days. AA and its metabolites excreted in bile, urine and blood within 120 min after dosing of AA (150 mg/kg, i.v.) were assayed by HPLC. Treatment of rats with the methanol extract of GR significantly increased the cumulative biliary excretion of AA-glucuronide (156% of the control) and decreased that of AA-sulfate (63% of the control). The cumulative urinary excretion of AA-glucuronide was also significantly increased to 132% of the control. GR treatment significantly increased total (biliary plus urinary) excretion of AA-glucuronide (172% of the control) without influencing thioether and sulfate conjugates of AA. The results clearly show that GR enhances UDP-glucuronosyl transferase-mediated detoxication of AA, but may not influence sulfotrans-ferase-mediated and cytochrome P-450-mediated metabolites formation.

• Journal of Nutrition and Health
• /
• v.29 no.1
• /
• pp.97-103
• /
• 1996

This study was performed to investigate the effects of lipid on cellular senescence, lipid peroxide production, and morphological changes. For this study we used primary skin fibroblasts from neonate rats grown in media various lipid contents. Fibroblasts were cultured until they lost their proliferation potential either in control medium (Dulbecco's modified Eagle's medium supplement with 10% fetal bovine serum) or in media supplemented with various concentrations of lipid-cholesterol rice component from bovine serum. Cumulative population doublings(CPD, as an index of cellular life span), and cellular thiobarbituric acid reactive substances (TBARS, as an index of lipid peroxide) concentrations were measured and morphological changes were observed. CPD were shortened with increasing lipid concentration in media ; 28.12 for cells grown in control medium and 13.42, 11.42, and 6.19 for those grown in 0.1%, 1% and 5% lipid rich components containing media, respectively. Cellular proliferation ratios were those grown in 5% lipid rich components containing media were delayed and they were degenerated soon. TBARS concentrations were increased with increasing concentration of lipid in media. Morphological changes were observed in cells grown in control medium by cellular senescence. Especially lipid droplets were observed in cells grown in 5% lipid rich components containing media. Therefore it seems that lipid contents in media had an effect on cellular proliferation and cellular life span, possibly via lipid peroxide production.

• Environmental Mutagens and Carcinogens
• /
• v.22 no.4
• /
• pp.296-302
• /
• 2002

In recent years, the safety of sunscreens have been challenged based on the reports of its adverse effects on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. In the toxicological aspect, the need to investigate the safety of sunscreens is steadily increasing. However, there were few studies on the correlation between sun protection factor (SPF) and the safety of sunscreens. The objective of this study was to assess whether there was a correlation between SPF and the skin irritation index of sunscreens. Octyl methoxycinnamate (OMC) was selected, which was the most frequently used (about 92% in korea and about 90% in the world) in sunscreens. In vitro SPF test was performed using the standard samples recommended by KFDA guideline. We examined primary and cumulative skin irritation and eye irritation of OMC standard sample as well as homosalate. As in vitro SPF was increased, skin irritation index was increased in primary skin irritation test ($r^2$=0.986) and cumulative skin irritation test ($r^2$=0.939). In addition, OMC was non-irritating and non-sensitizing. In this results, there was a good correlation between SPF index and skin irritation index.

• Nuclear Engineering and Technology
• /
• v.43 no.5
• /
• pp.413-420
• /
• 2011

In Korea, although the concept of dry storage system for PWR spent fuels first emerged in the early 1990s, wet storage inside nuclear reactor buildings remains the dominant storage paradigm. Furthermore, as the amount of discharged fuel from nuclear power plants increases, nuclear power plants are confronted with the problem of meeting storage capacity demand. Various measures have been taken to resolve this problem. Dry storage systems along with transportation of spent fuel either on-site or off-site are regarded as the most feasible measure. In order to develop dry storage and transportation system safety analyses, development of design techniques, full scale performance tests, and research on key material degradation should be conducted. This paper deals with two topics, structural analysis methodology to assess cumulative damage to transportation packages and the effects of an aircraft engine crash on a dual purpose cask. These newly emerging issues are selected from among the many technical issues related to the development of transportation and storage systems of spent fuels. In the design process, appropriate analytical methods, procedures, and tools are used in conjunction with a suitably selected test procedure and assumptions such as jet engine simulation for postulated design events and a beyond design basis accident.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.35 no.3
• /
• pp.52-61
• /
• 2012

The design method for cumulative sum (CUSUM) control charts, which can be robust to autoregressive moving average (ARMA) modeling errors, has not been frequently proposed so far. This is because the CUSUM statistic involves a maximum function, which is intractable in mathematical derivations, and thus any modification on the statistic can not be favorably made. We propose residual-based robust CUSUM control charts for monitoring autocorrelated processes. In order to incorporate the effects of ARMA modeling errors into the design method, we modify parameters (reference value and decision interval) of CUSUM control charts using the approximate expected variance of residuals generated in model uncertainty, rather than directly modify the form of the CUSUM statistic. The expected variance of residuals is derived using a second-order Taylor approximation and the general form is represented using the order of ARMA models with the sample size for ARMA modeling. Based on the Monte carlo simulation, we demonstrate that the proposed method can be effectively used for statistical process control (SPC) charts, which are robust to ARMA modeling errors.

• Development and Reproduction
• /
• v.24 no.4
• /
• pp.277-285
• /
• 2020

The disease-causing koi herpes virus (KHV), also known as cyprinid herpesvirus-3 (CyHV3), causes mass mortality of koi and carp. Koi (Cyprinus carpio) is a host for KHV, one of 12 virus species in the Alloherpesviridae family. We examined the effects of KHV disease koi (KK), and on koi×red common carp (KR) and red common carp×koi (RK) cross, using a virus challenge test. The infected fish had clinical signs that included gill necrosis and skin lesions. The RK and KR were highly more resistant (cumulative mortality: RK; 6% and KR; 8%) to KHV infection than KK fish (cumulative mortality: 28%). KHV DNA was confirmed in the tissues of all dead fish in groups by use of polymerase chain reaction (PCR), and the presence of the KHV protein in kidney was confirmed by immunohistochemistry. Histological analysis showed severe gill lesions and fusion of the lamellae in KK fish, but less severe damage in RK fish. In immunohistochemistry analysis, the KHV protein localized in the cytoplasm of infected kidney cells of KK, but the cross groups had lower levels of KHV antigen. Our data indicate that the cross groups had increased resistance to KHV disease.

• Journal of Korea Society of Waste Management
• /
• v.34 no.5
• /
• pp.474-481
• /
• 2017

This study was conducted to investigate the effects of inoculum and carbon sources on anaerobic digestion characteristics. The treatments were combinations of inoculum (digestate of cattle manure and rumen fluid) with carbon sources (starch, cellulose, and xylan). Anaerobic digestion was performed in triplicate at $37^{\circ}C$ for 18 days at 100 rpm. Sampling was performed at 0, 1, 2, 3, 4, 5, 7, 9, 12, 15, and 18 days to measure pH, ammonia-N, volatile solids reduction, the cumulative methane content, and the cumulative methane production. There was a significant difference in methane content depending on the carbon source and there was a significant difference in pH, ammonia-N, methane production, and methane content depending on the inoculum (P < 0.05). The results of methane production were higher in the digestate of cattle manure treatment than in the rumen fluid treatment (P < 0.05). In this study, different digestive patterns depending on the type of carbon source could be used as basic research data to set the hydraulic residence time of anaerobic digestion facilities. In addition, the use of ruminal fluid as an inoculum may help accelerate the hydrolysis and acid production steps.