• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.265-270
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• 1996

The purpose of this study was to determine pharmacokinetic parameters and tissue distribution patters of urinary trypsin inhibitor(UTI) in Sprague-Dawley rats. $Na^{125}$I was conjugated to UTI to make $^{125}I-UTI$ and the concentrations were determined by $\gamma$-counter. With the aid of nonlinear least-square regression analysis for i.v bolus injection of 1,000 unit UTI including $^{125}I-UTI$, the temporal concentration curves were best fitted by 2-compartment open model. The distribution phase half-life was 0.39$\pm$0.02 hours whereas the elimination half-life was 12.99$\pm$1.05 hours in male rats. The volume of distribution and total body clearance in male rats were 0.28$\pm$0.01 1/kg and 83.16$\pm$1.15 ml/kg/h, respectively. We could not find any difference of pharmacokinetic parameters of UTI between male and female rats. UTI were distributed widely in rat organs. In both male and female rats, the kidney was the highest distributed organ. Amount of UTI in 24 hour cumulative urine in male rats was 36.22$\pm$8.74% and that in 48 hours was 43.32$\pm$10.55%. Excretion via feces was very scanty, with the 24 hours cumulative amount being only 2.76$\pm$0.97%. This data suggest the main excretion route of UTI is urine.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.12
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• pp.3892-3898
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• 1996

In this study, the prediction of the fatigue life as well as the extimation of the characteristics of fatigue cumulative damage on GFRP under random loading were performed. The constant amplitude tests and the ramdom loading test were carried on notched GFRP specimens with a circular hole. Random waves were generated with a micro-computer and had wide band spectra. Since it is useful that the prediction of fatigue life ot the given load sequences is based on S-N curves under constant amplitude loading, the estimation of equivalent stress is done on every random waves. The equivalent stress wasat first estimated by Miner's rule and then by the proposed model which was based on Hashin-Rotem's comulative damage theory regarding nonlinear fatigue cumulative damage behavior. The fatigue lives were predicted from each equivalent stress evaluated. And each predicted fatigue llife was compared with experimental results. The number of cycles of random loads were counted by mean-cross counting method. The reuslts showed that the fatigue life predicted by proposed model was correlated well with the experimental results in comparison with Miner's model.

• Journal of Korean Society for Quality Management
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• v.25 no.2
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• pp.1-14
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• 1997

This paper considers maximum likelihood (ML) estimation of lifetime distribution under stress bounded ramp tests in which the stress is increased linearly from used condition stress to the stress u, pp.r bound. The following assumptions are used: exponential lifetime distribution under a constant stress, an inverse power law relationship between stress and mean of exponential lifetime distribution, and a cumulative exposure model for the effect of changing stress. Likelihood equations for the parameters involved in the model and asymptotic distribution of the estimators are obtained, and a numerical example is given.

• Journal of Welding and Joining
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• v.9 no.1
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• pp.40-47
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• 1991

The most fatigue tests carried out under the either stress or strain control, but machines and structures had taken variable stress. This variable stress was treated as statistics based on p-type distributions. In this paper, the cumulative fatigue damage of SM45C round bar specimens having a center hole resulting from block loading with p-distributions in rotating bending conditions, is presented. The value of p was changed in the range from 0.25 to 1; 0.25, 0.5, 0.75, 1. The following conclusions were obtained through the constant stress amplitude experiments and the block loading experiments. (1) In constant loading test, fatigue life was affected by cyclic rate. From experimental data, N$_{f}$ (100cpm)/N$_{f}$(3000cpm)equal to 0.56. (2) In case of the cyclic rate 100cpm and 3000cpm, at the high stress amplitude level the crack propagation life N$_{*}$f is longer than the low stress amplitude level. (3) Miner's hypothesis may be valid for p=0.75 and prediction of fatigue life by Haibach's method agree with experimental data well for the case p=0.5, while the modified Miner's method agree with experimental data well for the case p=0.25.5.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.4
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• pp.1241-1250
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• 1996

The characteristics of fatigue cumulative damage and fatigue life of 8-harness satin woven CFRP composites with a circular hole under constant amplitude and 2-level block loading are estimated by Stochastic Makov chain model. It is found in this study that the fatigue damage accumulation behavior is very random and the fatigue damage is accumulated as two regions under constant amplitude fatigue loading. In constant amplitude fatigue loading the predicted mean number of cycles to a specified damage state by Markov chain model shows a good agreement with the test result. The predicted distribution of the fatigue cumulative damage by Markov chain model is similar to the test result. The fatigue life predictions under 2-level block loading by Markov chain model revised are good fitted to the test result more than by 2-parameter Weibull distribution function using percent failure rule.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5B
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• pp.519-528
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• 2006

In the construction of hydraulic structures deciding a design flood is one of the most important works. It should be especially noted that the time distribution of the design rainfall method makes a significant effect on the results of the design flood. Thus, choosing an appropriate time distribution method for the design rainfall is a very important process. In recent years, Huff's method is usually used in Korea. This method presents dimensionless rainfall-time cumulative curves, which are made through the analyses of storm data. In this study, the annual maximum rainfall data, from 1961 to 2004 were analyzed to make the dimensionless rainfall-time cumulative curves and hyetographs in Seoul. The results were compared with the "Regional Time Distribution of the Design Rainfall", (KICT, 1989 and MCT, 2000). As a result, the dimensionless rainfall-time cumulative curves are smoother than Huff's results when the duration of an annual maximum rainfall is short. In addition, the curves are similar with the Huff's results as the duration is longer.

• Computers and Concrete
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• v.8 no.2
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• pp.163-176
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• 2011

By virtue of chord-length density function from the field of statistical physics, this paper introduced a quantitative approach to estimate the distribution of cement paste thickness between aggregates in concrete. Dynamics mixing method based on molecular dynamics was employed to generate one model structure, then image analysis algorithm was used to obtain the distribution of thickness of cement paste in model structure for the purpose of verification. By comparison of probability density curves and cumulative probability curves of the cement paste thickness among neighboring aggregates, it is found that the theoretical results are consistent with the simulation. Furthermore, for the model mortar and concrete mixtures with practical volume fraction of Fuller-type aggregate, this analytical formula was employed to predict the influence of aggregate volume fraction and aggregate fineness. And evolution of its mean values were also investigated with the variation of volume fraction of aggregate as well as the fineness of aggregates in model mortars and concretes.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.445-450
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• 2003

This study was performed 10 develop the accelerated life test method using Weibull-IPL(Inverse Power Law) model for mechanical components. Weibull-IPL model is concerned with determining the assurance life with confidence level and the accelerated life test time From the relation of weibull distribution factors and confidence limit, the testing times on the no number of failure acceptance criteria arc determined. The mechanical components generally represent wear and fatigue characteristics as a failure mode. IPL based on the cumulative damage theory is applied effectively the mechanical components to reduce the testing time and to achieve the accelerating test conditions. As the actual application example, accelerated life test method of agricultural tractor transmission was described. Life distribution of agricultural tractor transmission was supposed to follow Weibull distribution and life test time was calculated under the conditions of average life (MTBF) 3,000 hours and 90% confidence level for one test sample. According to IPL, because test time call be shorten in case increase test load test time could be reduced by 482 hours when we put the load 1.1 times of rated load than 0.73 times of rated load that is equivalent load calculated by load spectrum of the agricultural tractor. This time, acceleration coefficient was 11.7.

• Journal of Advanced Navigation Technology
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• v.15 no.2
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• pp.234-240
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• 2011

In this paper, the performances of Cram$\acute{e}$r-Rao Lower Bound (CRLB) with Frequency Difference of Arrival (FDOA) measurements for Unmanned Aerial Vehicle (UAV) tracking are investigated. We focus on two cases: the influence on CRLB with FDOA measurements collected by time, and random distribution of Ground Stations (GSs). We derived the performance by gauging the size of CRLB through Complementary Cumulative Distribution Function (CCDF). From the simulation results, broader distribution of GSs and FDOA measurements by longer time bring about better performance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.2
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• pp.594-599
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• 2011

In this paper, the effect of the boundary conditions on the reliability and the cumulative distribution characteristics of the fatigue failure life is analyzed in a magnesium alloy AZ31. The boundary conditions are specimen thickness, stress ratio, and maximum fatigue load. The statistical data of the fatigue failure life are obtained by fatigue crack propagation tests under the detail conditions for each boundary condition. The 3-parameter Weibull distribution is used to analyze a statistical characteristics of the fatigue failure life in magnesium alloy AZ31. It is found that the statistical fatigue failure life is long in the case of a thicker specimen, a larger stress ratio, and a smaller maximum fatigue load. Under the opposite cases, the reliability on the fatigue failure life is rapidly dropped.