• 제목/요약/키워드: Crude drugs

검색결과 302건 처리시간 0.023초

항종양활성 Screening을 지표로 한 천연물의약품의 개발연구와 그 생약소재의 품질평가에 대하여(抗腫瘍活性スクリ-ニングを指標とした天然物醫藥品の開發硏究とその生約素材の品質評價について) (Development of New Antitumor Drugs from Natural Sources , with Guida)

  • Takeya, Koichi
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 1993년도 천연항암자원의 개발에 관한 국제학술회의
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    • pp.14-20
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    • 1993
  • We in anticancer drug development from natural resources have conceived and used a wide variety of experimental screening systems to support our efforts during the past 20 tears. Screens have been devided to address targets at the molecular, biochemical and cellular levels, both in vivo and in vitro. Screens have been essential for the experimental evaluation of the products from natural sources. In this congress, antitumor screening methods for deveol[ment of new drugs from natural sources and evaluation of their crude drugs are discussed.

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열약과 한약의 사기론적 평가기준에 대한 실험적 연구 (Experimental study on the standardization of the Hot and the Cold Natures)

  • 이한구;남봉현;이미영;김정숙
    • 한국한의학연구원논문집
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    • 제2권1호
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    • pp.506-513
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    • 1996
  • The odor theory(氣味論) has been defined as the Nature(氣) and the Taste(味) of traditional herbal medicine to find the logic in treatment of various diseases by them. There is a strong possibility these Natures of the drug can be categorized according to yin(陰) and yang(陽). To understand the Hot and the Cold Natures of traditional herbal drugs in scientific approaches, changes in skin, rectal temperature of rats have been measured at 0, 30, 60, 90 min after a 5, 10, 20g/Kg oral administration each of Coptidis Rizoma(Ranunculaceae, Coptis chinesis, $F_{RANCH}$), Aconiti Lateralis Preparata Radix(Ranunculaceae, Aconitum carmichaeli $D_{EBX}$). From this study, we obtained as follows. 1. We can categorize the four Natures of drug according to yin(陰) - Cool and Cold Natures and yang(陽) - Warm and Hot Natures. 2. The relation between the four Natures of drug and the changes of body temperature can be studied as the considertion of the dosage and the preparation of crude medicines. 3. Herbs containing toxicant should be studied carefully without the side effects.

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천연물로부터 사이클로옥시게나제-2 저해제 검색 (Screening of Cyclooxygenase-2 (COX-2) Inhibitors from Natural Products)

  • 문태철;정규찬;손건호;김현표;강삼식;장현욱
    • 약학회지
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    • 제42권2호
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    • pp.214-219
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    • 1998
  • Tissue distributions and association of cyclooxygenase-2 (COX-2) with inflammatory have led us to search for COX-2 selective inhibitors from natural products. Conceptually, COX- 2 selective inhibitors should be expected to retain anti-inflammatory efficacy by inhibition of PGs production while reducing or eliminating the gastric, renal and hemostatic side effects commonly associated with NSAIDs use. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of COX-2. To develop new COX-2 inhibitors from natural products, two hundred crude drugs were screened by inhibiting PGD2 generation in bone marrow derived mast cells (BMMC). Among them, 6 methanol extracts of crude drugs such as, Bletillae rhizoma, Aconiti kgreani rhizoma, Belamcandae rhizoma, Nelumbinis semen, Gleniae radix, Aurantii immatri pericarpium inhibited more than 85% of BMMC COX-2 activity at a concentration 2.5${\mu}$g/ml.

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시판(市販) 생약(生藥) 액제류중(液劑類中)의 보존제(保存劑) 함량(含量) (Liquid Chromatographic Determination of Preservatives in Commercial Herb Liquid Preparations)

  • 임종필
    • 생약학회지
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    • 제16권4호
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    • pp.214-220
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    • 1985
  • The preservatives in 32 commercial liquid preparations of crude drugs have been analyzed by using high performance liquid chromatography. Benzoic acid (BA) and p-hydroxybenzoates were separated with mobile phase of $MeOH-H_2O$ (70:30) (pH 7.0) at a flow rate of 0.9ml/min. BA, sorbic acid and dehydroacetic acid were separated with mobile phase of $MeOH-H_2O$ (40:60) (pH 4.5) at a same flow rate. In addition, the pH values of the preparations were investigated. It was found that BA was used in most of the preparations.

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생약복합제(生藥複合劑)의 약효연구(藥效硏究) 제8보(第8報) -작약감초탕(芍藥甘草湯)이 중추신경(中樞神經)에 대(對)한 영향(影響)- (Studies on the Efficacy of Combined Preparations of Crude Drugs (VIII) -Effect of 'Jakyakgamcho-Tang' on the Central Nervous System-)

  • 홍남두;김종우;정규만;김남재
    • 생약학회지
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    • 제13권2호
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    • pp.79-86
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    • 1982
  • In order to investigate pharmacological actions of combined preparations of crude drugs, 'Jakyakgamcho-Tang' were studied. The 'Jakyakgamcho-Tang' using abdominal pain and convulsion of pediatric diseases are composed of Glycyrrhizae Radix and Paeoniae Radix alba. This study was undertaken to investigate the effect of 'Jakyakgamcho-Tang'(S-I) and parched 'Jakyakgamcho-Tang'(S-II) on anticonvulsive, analgesic, antipyretic and sedative actions. The results of this study were summarized as follows; Both 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' showed anticonvulsive effects against convulsions induced by strychnine, picrotoxine and caffeine. 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' also showed analgesic and antipyretic effects. Parched 'Jakyakgamcho-Tang' only prolonged the duration of hypnosis induced by sodium pentobarbital.

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생약의 소염활성에 관한 검색 (Screening on the Anti-inflammatory Activity of Crude Drugs)

  • 한병훈;지형준;한용남;류경수
    • 생약학회지
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    • 제3권4호
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    • pp.205-209
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    • 1972
  • Anti-inflammatory activity of crude drugs was evaluated by the albumin stabilizing activity test, according to the screening method of Mizushima et al., upon the randomly selected samples of 63 genus, 106 families, 123 species of plant. Almost every plant belonging to the families Araliaceae, Umbelliferae and Liliaceae showed strong stabilizing activity on the heat denaturation of bovine serum albumin, suggesting the presence of anti-inflammatory components in the plants.

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국내 생약자원으로부터의 항종양효과의 검색 (Screening of Antitumor Activity from the Crude Drugs in Korea)

  • 염곤;최병돈
    • 생약학회지
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    • 제31권1호
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    • pp.16-22
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    • 2000
  • These studies were designed to determine the potential cytotoxic activity of MeOH extracts of 65 crude drugs against leukemia L1210 and $P388D_1$, cell line in vitro, of which 25 samples were selected. The n-BuOH extracts of 25 samples were measured using the same method and nine were selected. These samples were measured for the potential antitumor activity against $P388D_1$, for life span in vivo, and against sarcoma 180 for tumor weight. On the basis of results, Notoginseng Radix, Anemarrhenae Rhizoma, Albizziae Cortex, Portulacae Herba, Bupleuri Radix were evaluated the effective plant on the antitumor activity. In addition, the mixture of Notoginseng Radix and Albizziae Cortex was evaluated to enhance the antitumor activity in vivo.

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생약복합제제의 약효연구(제38보). -가미인진오령산이 실험적 간장해에 미치는 영향- (Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXVIII) -Effect of Gamiinjinoryung-San on Hepatic Damage-)

  • 홍남두;김병운;김남재;심재옥
    • 생약학회지
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    • 제19권4호
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    • pp.270-277
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    • 1988
  • Gamiinjinoryung-San is composed of eight crude drugs including Artemisiae capillaris Herba which is widely used for the treatment of acute jaundice, acute and chronic hepatitis at the Oriental hospital of Kyung-Hee Medical Center. This study was conducted to investigate the effects of water extract of Gamiinjinoryung-San on the liver function. The results obtained were as follows; the extract markedly reduced LDH and ALP activities, but slightly decreased GOT and GPT activities elevated with D-galactosamine in rat serum. The liver protective activities were shown in $CCl_4-intoxicated\;rats$. The extract prevented the prolongation of sleeping time in $CCl_4-intoxicated\;rats$. The bile flow and the biliary bile acid secretion were significantly increased in normal rats.

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