• Korean Journal of Materials Research
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• v.10 no.6
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• pp.450-455
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• 2000

For further scaling down of the silicon devices, the application of low dielectric constant materials instead of silicon oxide has been considered to reduce power consumption, crosstalk, and interconnection delay. In this paper, the effect of $O_2/SF_6$ plasma chemistry on the etching characteristics of polyimide-one of the promising low-k interlayer dielectrics-has been studied. The etch rate of polyimide decreases with the addition of $SF_6$ gas due to formation of nonvolatile fluorine compounds inhibiting reaction between oxygen and hydrocarbon polymer, while applying substrate bias enhances etching process through physical attack. However, addition of small amount of $SF_6$ is desirable for etching topography. $SiO_2$ hard mask for polyimide etching is effective under $O_2$plasma etching(selectivity~30), while $O_2/SF_6$ chemistry degrades etching selectivity down to 4. Based on the above results, $1-2\mu\textrm{m}$ L&S PI2610 patterns were successfully etched.

• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.342-351
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• 2021

Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE2 secretion. To elucidate the role of the LSEC intercellular adhesion molecule-1 (ICAM-1) in the prometastatic response exerted by tumor and stromal COX-2, we utilized celecoxib (CLX) as a COX-2 inhibitory agent. We analyzed the in vitro proliferative and secretory responses of murine C26 colorectal cancer (CRC) cells to soluble ICAM-1 (sICAM-1), cultured alone or with LSECs, and their effect on LSEC and hepatic stellate cell (HSC) migration and in vivo liver metastasis. CLX reduced sICAM-1-stimulated COX-2 activation and PGE2 secretion in C26 cells cultured alone or cocultured with LSECs. Moreover, CLX abrogated sICAM-1-induced C26 cell proliferation and C26 secretion of promigratory factors for LSECs and HSCs. Interestingly, CLX reduced the protumoral response of HSC, reducing their migratory potential when stimulated with C26 secretomes and impairing their secretion of chemotactic factors for LSECs and C26 cells and proliferative factors for C26 cells. In vivo, CLX abrogated the prometastatic ability of sICAM-1-activated C26 cells while reducing liver metastasis. COX-2 inhibition blocked the creation of a favorable tumor microenvironment (TME) by hindering the intratumoral recruitment of activated HSCs and macrophages in addition to the accumulation of fibrillar collagen. These results point to COX-2 being a key modulator of processes initiated by host ICAM-1 during tumor cell/LSEC/HSC crosstalk, leading to the creation of a prometastatic TME in the liver.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.05a
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• pp.353-358
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• 2002

Human's vision is mostly confined to the area in the front and we, humans heavily depend on the sense of hearing to gather information in areas out of our sight. Thus, the virtual reality system consisting of the 3D sound effect gives the user a much better sense of reality than the system without the sound effect. Virtual 3D sound technology has mainly been researched with binaural system. The conventional binaural sound systems reproduce the desired sound at two arbitrary points using two channels in 3-D space. Head movement of listener might be change the nominal acoustic transfer function and deteriorate the performance of 3D sound system based on loudspeakers that needs a crosstalk canceller. In this paper, low kinds of sensitivity functions of sphere HRTF are derived to investigate the effect of head movement on HRTF in 3D sound system. Changes of HRTF caused by rotational and translational motion of head are obtained as we calculate the derivatives of HRTF with respect to angle and distance.

• IMMUNE NETWORK
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• v.12 no.5
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• pp.217-221
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• 2012

Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS, but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6 production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis.

• The KIPS Transactions:PartC
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• v.8C no.4
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• pp.415-420
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• 2001

VLSI 기술의 빠른 발전으로 디지털 시스템의 동작주파수가 높아짐에 따라 고속 통신시스템 의 하드웨어 설계 시 신호 무결성을 고려한 설계가 필수적이다. 디지털시스템에서의 잡음원 은 전송선에서의 전원장치, 접지 바운스, 실장 재료 등에 관련된다. 본 연구에서는 고속네트 워크/통신시스템의 기가비트 연결 설계기술에 필요한 요소들을 언급하였고, 실제 설계 신호 불연속에 영향을 미치는 커넥터의 누화 및 전송선의 표피 효과, 유전손실 등을 고려한 백플 레인보드를 시뮬레이션 하였다.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.11 no.5
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• pp.407-412
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• 1998

In this paper, we design PHASAR(Phased Array) WDM(Wavelength Dvision Division Multi- and Demultiplexing) filters and evaluate their performance. The PHASAR WDM filter is designed to have flat-passband characteristics by inserting the multimode waveguides between input waveguides and a first star coupler. BPM simulation results show that the excess loss is smaller than 6.5 dB, the crosstalk is less than -22 dB and the 1 dB passband is about 50 GHz. The effect of the path difference error is also investigated.

• Proceedings of the KIEE Conference
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• 1994.11a
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• pp.385-387
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• 1994

Optical interconnections are more attractive than electronic interconnections because of their higher speed, freedom from planar constraints, immunity to electromagnetic interference effects and higher interconnection capacity. Volume hologram is one of the best way to implement optical interconnections. Diffraction efficiency and crosstalk effect are very important things for ensuring independent interconnections. Recently, a general systematic method that can handle a large number of superposed volume gratings in anisotropic host material is presented. In this study for numerical analysis of diffraction, above method is programmed in general form near Bragg angle. Diffraction orders for variation of grating strength are determined by comparing with the coupled-mode method. The effects of parameter variation are considered. Parameters include vertical and azimuthal incident angle, wavelength and interaction length. Diffraction analyses are also performed for intra-mode and inter-mode diffractions.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1294-1302
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• 2008

Talk-Back systems comprised of master-equipment at the control room and slave-equipment at turnouts refer to the intercommunication facilities that optimize mutual communication between maintenance staff on trackside and the control room to facilitate quickness and accuracy of train operation control and its maintenance within depot and on mainlines with turnouts for direction switching of the trains in operation. The weakness lies in additional maintenance costs of cables since the Talk-Back system installed on line 1 along with line 2-4 has a profound effect on the voice quality leading to the attenuation and crosstalk of the system due to the deterioration of cables and environmental factors. This paper discusses the Talk-Back system in a radio communication environment with the application of RF(Radio Frequency) communication system from the wire communication system by cables to ameliorate these problems, and deals with the energy saving environmentally friendly facilities in consideration of replacing power section at salve-equipment with solar batteries benefitting the system in light of energy consumption.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.5
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• pp.649-657
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• 2014

In this study, the effects of the frequency-dependent characteristics of through-silicon vias (TSVs) on the performance of 3D ICs are examined by evaluating a typical interconnection structure, which is composed of 32-nm CMOS inverter drivers and receivers connected through TSVs. The frequency-domain model of TSVs is extracted in S-parameter from a 3D electromagnetic (EM) method, where the dimensional variation effect of TSVs can be accurately considered for a comprehensive parameter sweep simulation. A parametric analysis shows that the propagation delay increases with the diameter and height of the TSVs but decreases with the pitch and liner thickness. We also investigate the crosstalk effect between TSVs by testing different signaling conditions. From the simulations, the worst signal integrity is observed when the signal experiences a simultaneously coupled transition in the opposite direction from the aggressor lines. Simulation results for nine-TSV bundles having regular and staggered patterns reveal that the proposed method can characterize TSV-based 3D interconnections of any dimensions and patterns.

• Journal of the Korea Institute of Military Science and Technology
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• v.10 no.2
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• pp.90-99
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• 2007

We demonstrate an 80km-reach 64-channel DWDM-PON based on wavelength-locked F-P LDs by changing the position of the C-band BLS for upstream channels from the CO to the RN. It mitigates the necessity of the high power C-band BLS and its handling problems. It also reduces back scattering induced penalty. We obtained less than $10^{-6}$ PLRs in all 128channels through 80km SMF. We also demonstrate a 240km-reach DWDM-PON based on wavelength-locked F-P LDs by adding a bidirectional erbium-doped fiber amplifier(EDFA). We show packet-loss-free transmission in all 128channels at 125 Mb/s per channel over 240km SMF We report the detuning effect of arrayed waveguide gratings(AWGs) and crosstalk effect in the implemented system. We Propose an architecture of a next generation defense wire communication system with the demonstrated long-reach DWDM-PON.