• Title/Summary/Keyword: Crosstalk Effect

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Crosstalk of Zn in Combination with Other Fertilizers Underpins Interactive Effects and Induces Resistance in Tomato Plant against Early Blight Disease

  • Awan, Zoia Arshad;Shoaib, Amna;Khan, Kashif Ali
    • The Plant Pathology Journal
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    • v.35 no.4
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    • pp.330-340
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    • 2019
  • The present study was undertaken to evaluate the integrated effect of zinc (Zn) with other nutrients in managing early blight (EB) disease in tomato. A pot experiment was carried out with basal application of the recommended level of macronutrients [nitrogen, phosphorus and potassium (NPK)] and micronutrients [magnesium (Mg) and boron (B)] in bilateral combination with Zn (2.5 and 5.0 mg/kg) in a completely randomized deigned in replicates. Results revealed that interactive effect of Zn with Mg or B was often futile and in some cases synergistic. Zn with NPK yield synergistic outcome, therefore EB disease was managed significantly (disease incidence: 25% and percent severity index: 13%), which resulted in an efficient signaling network that reciprocally controls nutrient acquisition and uses with improved growth and development in a tomato plant. Thus, crosstalk and convergence of mechanisms in metabolic pathways resulted in induction of resistance in tomato plant against a pathogen which significantly improved photosynthetic pigment, total phenolics, total protein content and defense-related enzymes [superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), polyphenol oxidase (PPO) and phenylalanine ammonia-lyase (PAL)]. The tremendous increase in total phenolics and PAL activity suggesting their additive effect on salicylic acid which may help the plant to systemically induce resistance against pathogen attack. It was concluded that interactive effect of Zn (5.0 mg/kg) with NPK significantly managed EB disease and showed positive effect on growth, physiological and biochemical attributes therefor use of Zn + NPK is simple and credible efforts to combat Alternaria stress in tomato plants.

Low Voltage Swing BUS Driver and Interface Analysis for Low Power Consumption (전력소모 감소를 위한 저 전압 BUS 구동과 인터페이스 분석)

  • Lee Ho-Seok;Kim Lee-Sup
    • Journal of the Korean Institute of Telematics and Electronics C
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    • v.36C no.7
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    • pp.10-16
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    • 1999
  • This paper describes a low voltage swing bus driver using FCSR(Feedback Control Swing voltage Reduction) which can control bus swing voltage within a few hundred of mV. It is proposed to reduce power consumption in On-chip interface, especially for MDL(Merged DRAM Logic) architecture wihich has wide and large capacitance bus. FCSR operates on differential signal dual-line bus and on precharged bus with block controlling fuction. We modeled driver and bus to scale driver size automatically when bus environment is variant. We also modeled coupling capacitance noise(crosstalk) of neighborhood lines which operate on odd mode with parallel current source to analysis crosstalk effect in the victim-line according as voltage transition in the aggressor-line and environment in the victim-line. We built a test chip which was designed to swing 600mV in bus, shows 70Mhz operation at 3.3V, using Hyundai 0.8um CMOS technology. FCSR operate with 250Mhz at 3.3V by Hspice simulation.

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North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression

  • Garbett, Jaime;Wilson, Sarah A.F.;Ralston, Jessica C.;Boer, Anna A. De;Lui, Ed M.K.;Wright, David C.;Mutch, David M.
    • Journal of Ginseng Research
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    • v.40 no.2
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    • pp.141-150
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    • 2016
  • Background: Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest in understanding how exogenous compounds regulate the adipocyte-macrophage crosstalk. An aqueous (AQ) extract of North American (NA) ginseng (Panax quinquefolius) was previously shown to have strong inflammo-regulatory properties in adipocytes. This study examined whether different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression. Methods: The effects of AQ and ethanol (EtOH) ginseng extracts ($5{\mu}g/mL$) on adipocyte and macrophage inflammatory gene expression were studied in 3T3-L1 and RAW264.7 cells, respectively, using real-time reverse transcription polymerase chain reaction. Adipose tissue organ culture was also used to examine the effects of ginseng extracts on epididymal WAT (EWAT) and inguinal subcutaneous WAT (SWAT) inflammatory gene expression. Results: The AQ extract caused significant increases in the expression of common inflammatory genes (e.g., Mcp1, Ccl5, Tnf-${\alpha}$, Nos2) in both cell types. Culturing adipocytes in media from macrophages treated with the AQ extract, and vice versa, also induced inflammatory gene expression. Adipocyte Ppar-${\gamma}$ expression was reduced with the AQ extract. The AQ extract strongly induced inflammatory gene expression in EWAT, but not in SWAT. The EtOH extract had no effect on inflammatory gene expression in either both cell types or WAT. Conclusion: These findings provide important new insights into the inflammo-regulatory role of NA ginseng in WAT.

Performance Analysis of High-Speed Transmission Line for Terabit Per Second Switch Fabric Interface (테라급 스위치 패브릭 인터페이스를 위한 고속 신호 전송로의 성능 분석)

  • Choi, Chang-Ho;Kim, Whan-Woo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.12
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    • pp.46-55
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    • 2014
  • PCB design technology for high-speed transmission line has been developed continuously. Adapting to the high capacity of the communication system, switch fabric interface used for backplane is being standardized to accommodate more than 10Gbps serial interface. In this paper, various computer simulations are performed to compare the performance of each transmission line per length according to PCB material, and also to analyze the effect from via stub length and crosstalk, for the purpose of applying 11.5Gbps serial interface as a switch fabric interface in tera-bit switching system. As a result of the simulation, important design issues, such as PCB material of each board supporting 8dB improvement in transmission loss using low loss PCB, maximum available stub length on transmission line via, whether or not to apply the backdrill process to the via, and the clearance of the differential pair between transmission lines, are determined. The most efficient system architecture which could be applied 11.5Gbps serial interface in all switch fabric interfaces is defined from the simulation results.

The Poly-γ-ᴅ-Glutamic Acid Capsule of Bacillus licheniformis, a Surrogate of Bacillus anthracis Capsule Induces Interferon-Gamma Production in NK Cells through Interactions with Macrophages

  • Lee, Hae-Ri;Jeon, Jun Ho;Rhie, Gi-Eun
    • Journal of Microbiology and Biotechnology
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    • v.27 no.5
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    • pp.1032-1037
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    • 2017
  • The poly-${\gamma}$-$\small{D}$-glutamic acid (PGA) capsule, a major virulence factor of Bacillus anthracis, provides protection of the bacterium from phagocytosis and allows its unimpeded growth in the host. We investigated crosstalk between murine natural killer (NK) cells and macrophages stimulated with the PGA capsule of Bacillus licheniformis, a surrogate of the B. anthracis capsule. PGA induced interferon-gamma production from NK cells cultured with macrophages. This effect was dependent on macrophage-derived IL-12 and cell-cell contact interaction with macrophages through NK cell receptor NKG2D and its ligand RAE-1. The results showed that PGA could enhance NK cell activation by inducing IL-12 production in macrophages and a contact-dependent crosstalk with macrophages.

FDTD Analysis of Lossy Multiconductor Transmission Lines Terminated in Linear Loads (선형소자로 종단된 손실이 있는 다중 전송선의 FDTD 해석)

  • 박범준;주재철;이형영;박동철
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.11 no.3
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    • pp.419-428
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    • 2000
  • Multiconductor transmission line(MTL) equations are solved by FDTD(Finite-Difference Time-Domain) method to predict crosstalk and fields to transmission line coupling on lossy multiconductor transmission lines terminated in arbitrary linear loads. Skin effect losses as well as dc losses are included in the analysis. In order to increase computational efficiency, the convolution integral of internal impedance of conductors and the line currents is computed by using Prony method. For boundary conditions of MTLs terminated in linear loads, state-variable formulation is adopted. The simulated results by FDTD method are compared with the measured ones obtained by using TEM cell. The predictions are in good agreement with the measurements. In addition, it has been found that skin effect losses as well as dc losses of the conductors should be included for accurate predictions on relatively high loss transmission lines such as PCB. It has also been found that dc losses and skin-effect losses affect late-time responses and early-time responses, respectively.

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Simultaneous Inhibition of CXCR4 and VLA-4 Exhibits Combinatorial Effect in Overcoming Stroma-Mediated Chemotherapy Resistance in Mantle Cell Lymphoma Cells

  • Kim, Yu-Ri;Eom, Ki-Seong
    • IMMUNE NETWORK
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    • v.14 no.6
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    • pp.296-306
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    • 2014
  • There is growing evidence that crosstalk between mantle cell lymphoma (MCL) cells and stromal microenvironments, such as bone marrow and secondary lymphoid tissues, promotes tumor progression by enhancing survival and growth as well as drug resistance of MCL cells. Recent advances in the understanding of lymphoma microenvironment have led to the identification of crucial factors involved in the crosstalk and subsequent generation of their targeted agents. In the present study, we evaluated the combinatory effect of blocking antibodies (Ab) targeting CXCR4 and VLA-4, both of which were known to play significant roles in the induction of environment-mediated drug resistance (EMDR) in MCL cell line, Jeko-1. Simultaneous treatment with anti-CXCR4 and anti-VLA-4 Ab not only reduced the migration of Jeko-1 cells into the protective stromal cells, but also enhanced sensitivity of Jeko-1 to a chemotherapeutic agent to a greater degree than with either Ab alone. These combinatorial effects were associated with decreased phosphorylation of ERK1/2, AKT and NF-${\kappa}B$. Importantly, drug resistance could not be overcome once the adhesion of Jeko-1 to the stromal occurred despite the combined use of Abs, suggesting that the efforts to mitigate migration of MCLs should be attempted as much as possible. Our results provide a basis for a future development of therapeutic strategies targeting both CXCR4 and VLA-4, such as Ab combinations or bispecific antibodies, to improve treatment outcomes of MCL with grave prognosis.

Polarization-Insensitive Design and Fabrication of Hybrid Sol-Gel Arrayed Waveguide Gratings (무편광 Hybrid Sol-Gel 배열도파로 격자 소자의 설계 및 제작)

  • Park, Soon-Ryong;Jeong, Ja-Wan;O, Beom-Hoan;Lee, Seung-Gol;Lee, El-Hang
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.04b
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    • pp.105-108
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    • 2002
  • We report on the polarization-insensitive design and fabrication of an arrayed waveguide gratings (AWG's) using sol-gel derived silica glass films formed on fused silica substrates to provide cheap and stable tools for better design. An arrayed-waveguide grating multiplexer with raised structure is fabricated in order to effect polarization sensitivity. Since polarization is usually not known after propagation in an optical fiber. passive WDM components such as monolithic wavelength demultiplexer have to be polarization insensitive. Here, we observed that polarization have effect on crosstalk of output spectrum in arrayed-waveguide grating

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Pattern Design and Driving of a Charged Particle Type Display (대전입자형 디스플레이의 패턴 설계 및 구동)

  • Kwon, Ki-Young;Kim, Sung-Woon;Hwang, In-Sung;Kim, Chul-Ju;Kim, Young-Cho
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2007.06a
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    • pp.53-54
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    • 2007
  • Charged particle type display using particles which have opposite charge and color is based on effect of reversible optical property due to electric field. we designed mask pattern for fabrication of the charged particle type display based on glass substrate and investigated cell gap dependent of driving voltage and selectively driving method. the panel driven by our selectively driving method, we could obtain image which had vary little crosstalk caused by electrical interference and conform the last image maintained by memory effect without additional voltage.

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Investigation of visible light communication transceiver applicable to both of illumination and wireless communication (조명 및 무선통신이 동시에 가능한 가시광 송수신기에 관한 연구)

  • Song, Seok-Su;Kong, Young-Sik;Park, Jin-Woo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.37 no.4A
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    • pp.219-226
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    • 2012
  • We investigated the performance of a visible light communication (VLC) transceiver applicable to both of illumination and wireless communication. we considered the visibility of VLC, the easy connection for wireless communication and high-speed transmission and implemented VLC transceiver based on edge-emitting laser diode and silicon photodiode. The proposed VLC transceiver is designated to operate in a full duplex mode at high speed of 120 Mbit/s. The shielding method that is employed as a means to reduce the light cross coupling effect inside the VLC transceiver is proposed and its performance is experimentally measured. We also applied optical antenna to have the larger angle of field of view (FOV) to novel structure of VLC transceiver and examined and analyzed their bit error rate performance, photometric result with respect to the transmission distance, the coverage range and the tilt degree as transmission link characteristic between two transceivers without optical antenna and with optical antenna.