• 생체재료학회지
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• 제22권4호
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• pp.235-248
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• 2018

Background: Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded. Main body: In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. The various factors are as follows: several different non-covalent interactions resulting in physical crosslinking (the electrostatic interactions (e.g., the ionic and hydrogen bonds), hydrophobic interactions, ${\pi}$-interactions, and van der Waals forces), in-situ chemical reactions inducing chemical crosslinking (the Diels Alder click reactions, Michael reactions, Schiff base reactions, or enzyme-or photo-mediated reactions), and external stimuli (temperatures, pHs, lights, electric/magnetic fields, ultrasounds, or biomolecular species (e.g., enzyme)). Finally, their applications with accompanying therapeutic agents and notable properties used were reviewed as well. Conclusion: Injectable hydrogels, of which network morphology and properties could be tuned, have shown to control the load and release of therapeutic agents, consequently producing significant therapeutic efficacy. Accordingly, they are believed to be successful and promising biomaterials as scaffolds and carriers of therapeutic agents for disease and cancer therapy and tissue engineering.

• 한국염색가공학회지
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• 제35권1호
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• pp.8-19
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• 2023

Silicone rubber is widely used in most industries due to diverse advantages like heat stability, UV stability, durability, chemical resistance, environment friendliness, inertness and so on. But there is limitation to expand applications due to relatively weak rubber strengths such as tensile strength and tear strength, especially in fabric coating applications. The purpose of this study is to find influence of coating agent on performances of rubber and coated fabrics and their correlation according to different crosslinking densities of silicone rubbers. Addition cure type of silicones were formulated using crosslinked MQ-type silicone resin consisting of M (R₃SiO_1/2) and Q (SiO_4/2) and linear polymers. Raw materials used were; 1) linear vinyl endblocked polymers and vinyl functional MQ resin as main polymers, 2) linear silicone hydride polymers as crosslinkers, 3) platinum catalyst and 4) inhibitor to control curing speed. Rubber specimens were prepared to check mechanical strength using universal testing machine (UTM). Crosslinking density was calculated using Flory-Rhener equation using solvent swelling method. Differential scanning calorimetry (DSC) and scanning electron microscope (SEM-EDS) were used to characterize rubbers. Consequently, it was found that physical properties of silicone rubbers and coated fabrics can be expected by crosslinking density of rubbers. Silicone rubber formulations that contain 20 ~ 30 wt% of vinyl MQ resin showed strongest balanced performances.

• 공업화학
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• 제5권5호
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• pp.772-778
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• 1994

페놀-물 혼합 용액에 대하여 Type 1과 Type 2의 실리콘 막을 이용하여 30, 40, $50^{\circ}C$에서 투과 증발 분리 실험을 수행하였다. 이때 공급 원액의 페놀 농도는 500ppm부터 5wt%이었다. 실험 결과, Type 2막이 Type 1막보다 분리능력이 더 효율적이었다. 공급원액의 농도가 5wt%와 500ppm일 때, Type 2막을 이용하여 투과액의 페놀 농도가 각각 70wt%, 11wt%의 양호한 결과를 얻었다.

• Elastomers and Composites
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• 제46권4호
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• pp.318-323
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• 2011

폐타이어고무분말을 재활용하기 위하여 방수시트용 고무분말 복합체를 제조하였으며, 수지 종류와 가교제의 함량이 복합체의 기계적 특성에 미치는 영향을 고찰하였다. EPDM이 부가됨에 따라 고무분말 PE 복합체의 신장율이 3배 이상 증가하는 현상을 나타내었다. 고무분말 충전 복합체에 가교제의 농도가 증가함에 따라 복합체의 강도가 증가하였으며, 특히 재생 폴리프로필렌을 사용한 경우 3배 이상 인장강도가 현저하게 높게 나타났다. 따라서 폴리프로필렌 블렌드물로 고무분말 복합체를 제조하는 경우 신재 폴리프로필렌을 사용하는 것 보다 재생 폴리프로필렌을 사용하는 것이 기계적 특성면에서 효과적인 것으로 나타났다.

• 공업화학
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• 제7권4호
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• pp.777-786
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• 1996

Seed 중합 방법에 의하여 단분산성 다공의 폴리아크릴로니트릴-에틸렌글리콜 디메타크릴레이트 (PAN) 고분자 마이크로 겔이 제조되었다. PAN 마이크로 겔의 물리적인 특성을 모노머/seed와 희석제/모노머의 비율, 가교제의 농도 및 희석제의 종류에 따라 연구하였다. PAN 마이크로 겔의 입도 분포는 모노머/seed의 비율이 50 이하 일 때 단분산성을 나타냈으며, 가교제의 농도가 증가할수록 입자 내부의 미소 구체 (microsphere)의 크기가 작아져 더욱 밀집된 형태를 나타내기 때문에 입자의 비표면적이 증대되었다. 또한 희석제로 톨루엔을 사용하고 희석제/모노머의 비율이 1.0일 때 입자표면의 세공이 가장 발달되었다.

• Korean Chemical Engineering Research
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• 제52권1호
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• pp.63-67
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• 2014

페놀-포름알데히드를 이용하여 레졸형 구형 페놀수지 입자를 합성함에 있어 반응물의 조성이 입도분포, 수율 및 밀도에 미치는 영향을 확인하였다. 분산매의 양을 감소시킴에 따라 현탁액의 점도가 증가하며 이로 인해 입도분포의 변화 및 응집 현상의 원인이 됨을 확인하였고, 안정제의 양을 증가시킴에 따라 현탁입자의 표면적을 증가시키기 위해 평균입도가 감소하는 것을 확인하였다. 적정량 이상의 경화제의 사용은 입도분포 및 수율에는 영향을 미치지 않으나 형성된 입자 내부의 격렬한 경화반응으로 인해 발생하는 물분자의 탈출이 원활하지 않게 되어 밀도가 감소하는 것을 SEM 사진을 통해 확인하였다.

• 대한치과기공학회지
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• 제35권4호
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• pp.313-320
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• 2013

Purpose: The purpose of this study was to know the physical properties of UDMA dental composite resins containing two photosensitizers, PD, DA, as a photosensitizer instead of CQ. We want to know Remaining Double Bond(RDB) of UDMA unfilled resin and diametral tensile strength and flexural strength of composite resin containing PD and DA were compared with those of CQ, most widely used photosensitizer for dental composite resins. Methods: The RDB of UDMA studied by FT-IR spectroscopy increased with irradiation time. The composite resins were tested for their physical properties. The dental composite resins were made with UDMA as a monomer, silanized silica as filler, N,N-dimethylaminoethyl methacrylate (DAEM) as amine initiator, and one of the two kinds of new photosensitizers. Results: The relative RDB of UDMA was in the order: DA > CQ > PD but the physical properties of the composite resins show PD and DA with higher results compared with that containing CQ. The reason for the results is that PD and DA serve not only as a photosensitizer but also as a photo-crosslinking agent. Conclusion: PD and DA show as effective photosensizers, suitable for UDMA dental composite resin compare with a higher efficiency than CQ.

• Macromolecular Research
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• 제17권8호
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• pp.580-584
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• 2009

The effects of crystallinity and radiation crosslinking on the physical properties of a microporous high density polyethylene (HDPE) film with Millad3988 as a nucleating agent were investigated. The pores of the HDPE film were affected by the crystallinity. The crystallinity of the HDPE films increased with increasing Millad3988 amount up to 0.1 wt% but decreased with further addition. The mechanical characteristics of the HDPE containing Millad3988 films improved with increasing irradiation dose up to 50 kGy, but decreased at 75 kGy due to severe degradation. The thermal shrinkage behavior of the HDPE films decreased with increasing radiation dose up to 50 kGy. The porosity of the stretched HDPEIMillad3988 films after ${\gamma}$-ray radiation increased with increasing y-ray radiation dose up to 50 kGy. The pores of the irradiated films were formed more easily by a stretching due to the formation of a crosslinked structure.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.853-858
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• 2001

Generally, mixed materials of LDPE, EVA and foaming agent are manufactured by crosslinking foaming or chemical foaming process. Above materials were used in a microcellular foaming injection molding process. Influence of each factor such as injection type, temperature of barrel, rate of mixed materials and contents of foaming agent was estimated by DOE(Design of Experiments). As a result of experiments, injection type and rate of LDPE, EVA have an influence on foaming rate. This data can be used in field of application of LDPE and EVA.

• Korean Chemical Engineering Research
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• 제49권1호
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• pp.69-74
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• 2011

본 연구에서는 전기방사를 이용하여 PS의 취성을 개선하고자 내충격성이 우수한 HIPS와 가교제 DVB를 혼합하여 방사한 후 가교와 술폰화 반응을 통해 HIPS 이온교환 나노섬유를 제조하였다. 또한, 이들을 FT-IR, XPS, 함수율, 이온교환 용량, SEM 및 접촉각으로 나노섬유의 기본특성을 확인하였다. FT-IR 및 XPS 구조분석 결과, HIPS 나노섬유는 술폰화 시간이 지남에 따라 $-SO_3H$기의 도입이 증가하는 것을 확인할 수 있었다. 또한 술폰화 시간이 지남에 따라 섬유의 친수성이 증가하여 DVB 함량이 7.5 wt%, 술폰화 시간이 200분일 때 함수율과 이온교환용량은 최대 75.6%, 2.67 meq/g으로 나타났다.