• Biomolecules & Therapeutics
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• v.21 no.3
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• pp.190-195
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• 2013

Cisplatin is a member of platinum-containing anti-cancer drugs that causes cross-linking of DNA and ultimately cancer cell apoptosis. The therapeutic function of cisplatin on various types of cancers has been widely reported but the side effects have been discovered together and nephrotoxicity has been regarded as major side effect of cisplatin. To select candidates for new sensitive nephrotoxicity biomarker, we performed proteomic analysis using 2-DE/MALDI-TOF-MS followed by cisplatin treatment in human kidney cell line, HK-2 cells, and compared the results to the gene profile from microarray composed of genes changed in expression by cisplatin from formerly reported article. Annexin A5 has been selected to be the most potential candidate and it has been identified using Western blot, RT-PCR and cell viability assay whether annexin A5 is available to be a sensitive nephrotoxic biomarker. Treatment with cisplatin on HK-2 cells caused the increase of annexin A5 expression in protein and mRNA levels. Over-expression of annexin A5 blocked HK-2 cell proliferation, indicating correlation between annexin A5 and renal cell toxicity. Taken together, these results suggest the possibility of annexin A5 as a new biomarker for cisplatin-mediated nephrotoxicity.

• Health Policy and Management
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• v.21 no.4
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• pp.617-642
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• 2011

The purpose of our study is to analyze the determinants of the benefits of the long-term care insurance in Korea using 2008 and 2009 cross-sectional data. Per capita long-term care insurance benefits can be divided into home care services utilization rate, institutional care services utilization rate, per capita home care services benefits, and per capita institutional care services benefits, which are used as the dependent variables in our regression analysis. Admission rate and the ratio of the admitted to the applicant also used as the dependent variables. The results of our analysis show that the explanatory variables such as income level, needs for care, family type, access to the services, and regional characteristics are statistically significant to explain the dependent variables, the long-term care insurance benefits. The higher is the regional income and the more of the female residents, the more are the long-term care insurance benefits. The easier is the access to the services, the more are the insurance benefits. In the rural area, the level of the insurance benefits is relatively high. We propose that copayment rates of the long-term care insurance should be examined and monitoring on the over-use of the services should be done. Also preventive services and care by the family member should be expanded.

• Journal of Korean society of Dental Hygiene
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• v.15 no.1
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• pp.137-146
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• 2015

Objectives: This study was obtained to identify current education status of the community dental hygiene practice. Methods: It was designed cross section and self-reported on-line questionnaire(Survey monkey). It was performed probability sampling by targeting 82 dental hygiene schools(each one faculty member) in charge of community dental hygiene curriculum and 254 community health centers's community dental hygienists whom was working at oral health section. The response rate was 60% and 53%, respectively. The questionnaire consisted of time, duration, practice group, evaluation method, and practice contents including 63 learning objectives of dental hygiene. Results: Nearly half of these schools conduct such community field work practice in the spring semester of the junior year. This practice was mainly progressed based on average 4 students as one team per each one school for 7-8 hours a day during the period of more than 5 weeks(p<0.05). However, in case of both school and community health center, almost half of feedback after practice was not achieved and there was a difference in needs for practice education between schools and community health center. Conclusions: We should be considered that a sufficient consultation for the practice environment and its contents between schools and community health centers. It was considered that development of a standardized practice manual reflecting such requirement.

• The Journal of the Korea Contents Association
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• v.10 no.10
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• pp.304-317
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• 2010

The purpose of this study is to research on attitudes toward legalization of death with dignity. The respondents are 561 adults aged 20 years old and over, living in Seoul and Kyunggi Province. Research questionnaire consist of 28 questions concerning general background, personal experiences of death, attitudes toward death, pros and cons on death with dignity and legalization. Statistical analyses employ frequency, mean, cross tab, and t-test. 87.3% of respondents agree the legalization of death with dignity. The persons who are older, self-employed, and production employees, get married, live with spouse, believe buddhism, experience care for the death, believe life after death, recognize the necessity of testament agree more on death with dignity. The first requisite for legalization of death with dignity is the standard of judgement concerning self decision on death with dignity. The decision makers are prioritized by self, family member in order. The necessary services for decisions on death with dignity are the mediation role between medical team and family, medical information about illness prognosis and prolongation, psychological counselling on depression.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.70
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• pp.135-157
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• 2016

Globalization of consumption, expansion of cross border e-trade, increase use of internet and mobile have led to rapid growth of world e-commerce particularly in Asia and emerging markets. Impacted by Korean wave, online export is continuously increasing, yet Korea is experiencing severe e-commerce trade imbalance. Export growth rate and ratio of Korean small companies are relatively low from OECD member countries. Therefore, Korean government is currently emphasizing on vitalization of online export to China to resolve trade imbalance and to increase export of small companies. To propose detail measures to vitalize online export to China, this study is focused on export customs clearance procedure of Korea and import customs clearance procedure of China in view of online export company. Also suggested countermeasure plan and analysis for the new tax revision plan related to e-commerce which implemented on April 8th 2016. This study have grouped countermeasure plan by short term plan of firms and long term plan of the government. As for the short-term countermeasure plan for firms, first, comparison analysis of tax rate on products is need to decide type of e-commerce strategy; second, if planning to start e-commerce business to China, sales possibility and certification check is necessary; third, through preparation of customs clearance document is needed; last in order to obtain price competitiveness, new logistics strategy and packing development is required. As for the long-term countermeasure plan for the government, I have suggested cooperated bonded logistics service for small businesses and operation plan of show room for promising Korean products.

• Journal of the Korea Concrete Institute
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• v.23 no.1
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• pp.57-65
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• 2011

Both shear and torsional moments apply shear stresses on cross-section of a member, which need to be considered in the design. But in the current Korean Building Code, the design equations for shear and torsional moments are expressed in terms of the sectional strength with different units, causing figures to be drawn separately in two axes. If the design equations are expressed in terms of stresses, then the stresses of shear and torsional moments can be added, allowing figures to be drawn in one axis for easy recognition of the design procedure and the final design results. Moreover, the current code's design equations for shear and torsional moments are considered separately with the intention of summing the area of stirrups with respect to unit length for shear moment ($A_{\upsilon}/s$) and torsional moment ($2A_t/s$). Since the size or type of vertical stirrups are predetermined in the design process, the design equations are expressed in terms of the spacing of stirrups rather than the $A_{\upsilon}/s$ and $2A_t/s$ terms, clarifying various design steps and a design process.

• International Journal of Concrete Structures and Materials
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• v.11 no.2
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• pp.327-341
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• 2017

Openings in slabs are usually required for many different applications such as aeriation ducts and air conditioning. Opening in concrete slabs due to cutouts significantly decrease the member stiffness. There are different techniques to strengthen slabs with opening cutouts. This study presents experimental and numerical investigations on the use of Carbon Fiber Reinforced Polymers (CFRP) as strengthening material to strengthen and restore the load carrying capacity of R.C. slabs after having cutout in the hogging moment region. The experimental program consisted of testing five (oneway spanning R.C. flat slabs) with overhang. All slabs were prismatic, rectangular in cross-section and nominally 2000 mm long, 1000 mm width, and 100 mm thickness with a clear span (distance between supports) of 1200 mm and the overhang length is 700 mm. All slabs were loaded up to 30 kN (45% of ultimate load for reference slab, before yielding of the longitudinal reinforcement), then the load was kept constant during cutting concrete and steel bars (producing cut out). After that operation, slabs were loaded till failure. An analytical study using finite element analysis (FEA) is performed using the commercial software ANSYS. The FEA has been validated and calibrated using the experimental results. The FE model was found to be in a good agreement with the experimental results. The investigated key parameters were slab aspect ratio for the opening ratios of [1:1, 2:1], CFRP layers and the laminates widths, positions for cutouts and the CFRP configurations around cutouts.

• Computational Structural Engineering
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• v.10 no.4
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• pp.205-216
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• 1997

In order to trace the lateral post-buckling behaviors of thin-wafled space frames, a geometrically nonlinear finite element formulation is presented by applying incremental equilibrium equations based on the updated Lagrangian formulation and introducing Vlasov's assumption. The improved displacement field for symmetric thin-walled cross sections is introduced based on inclusion of second order terms of finite rotations, and the potential energy corresponding to the semitangential rotations and moments is consistently derived. For finite element analysis, tangent stiffness matrices of the thinwalled space frame element with 7 degrees of freedom including the restrained warping for each node are derived by using the Hermition polynomials as shape functions. A co-rotational formulation in order to evaluate the unbalanced loads is presented by separating the rigid body rotations and pure deformations from incremental displacements and evaluating the updated direction cosines of the frame element due to rigid body rotations and incremental member forces from pure deformations. Finite element solutions for the spatial buckling and post-buckling analysis of thin-walled space frames are presented and compared with available solutions and other researcher's results.

• Computational Structural Engineering
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• v.10 no.1
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• pp.201-211
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• 1997

A clearly consistent finite element formulation for geometrically non-linear analysis of space frames is presented by applying incremental equilibrium equations based on the updated Lagrangian formulation and introducing Vlasov's assumption. The improved displacement field for symmetric cross sections is introduced based on inclusion of second order terms of finite rotations, and the potential energy corresponding to the semitangential rotations and moments is consistently derived. For finite element analysis, elastic and geometric stiffness matrices of the space frame element are derived by using the Hermitian polynomials as shape functions. A co-rotational formulation in order to evaluate the unbalanced loads is presented by separating the rigid body rotations and pure deformations from incremental displacements and evaluating the updated direction cosines of the frame element due to rigid body rotations and incremental member forces from pure deformaions. Finite element solutions for the spatial buckling and post-buckling analysis of space frames are compared with available solutions and other researcher's results.

• Wind and Structures
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• v.13 no.5
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• pp.413-431
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• 2010

The focus of this article is on the assessment of vertical wind vector components and their aerodynamic impact on lattice framework, specifically two distinct sections of a guyed transmission tower. Thunderstorm winds, notably very localized events such as convective downdrafts (including downbursts) and tornadoes, result in a different load on a tower's structural system in terms of magnitude and spatial distribution when compared to horizontal synoptic winds. Findings of previous model-scale experiments are outlined and their results considered for the development of a testing rig that allows for rotation about multiple body axes through a series of wind tunnel tests. Experimental results for the wind loads on two unique experimental models are presented and the difference in behaviour discussed. For a model cross arm with a solidity ratio of approximately 30%, the drag load was increased by 14% when at a pitch angle of $20^{\circ}$. Although the effects of rotation about the vertical body axis, or the traditional 'angle of attack', are recognized by design codes as being significant, provisions for vertical winds are absent from each set of wind loading specifications examined. The inclusion of a factor to relate winds with a vertical component to the horizontal speed is evaluated as a vertical wind factor applicable to load calculations. Member complexity and asymmetric geometry often complicate the use of lattice wind loading provisions, which is a challenge that extends to future studies and codification. Nevertheless, the present work is intended to establish a basis for such studies.