• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.6
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• pp.809-813
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• 2009

We want to show that the construct of best fuzzy tests for certain fuzzy situations of Poisson distribution. Due to Neyman and Pearson theorem, if we have ${\theta}_0$ and ${\theta}_1$ be distinct fuzzy values of ${\Omega}=\{{\theta}\;:\;{\theta}\;=\;{\theta}_0,\;{\theta}_1\}$ such that $L({\theta}_0\;:\;X)/L({\theta}_1\;:\;X)$ < k, then k is a fuzzy number. For each fuzzy random samples point $X\;{\subset}\;C$, we have most power test for fuzzy critical region C by agreement index.

• Journal of the Korea Institute of Military Science and Technology
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• v.8 no.1 s.20
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• pp.81-91
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• 2005

It is well known that the natural frequencies of the pipe come to be lower as internal fluid velocity and pressure increase, and the pipe will be unstable if the fluid velocity is higher than critical velocity. But even if the velocity of the fluid below the critical velocity, resonance will be caused by pulsation of the fluid. So the effects of pulsating fluid in pipe should be also taken into consideration for better analysis. The research of the vibration of piping system due to a fluid pulsation has been studied by many people. But most of them are dealt with determining the boundary between stable and unstable region without analyzing forced response in the stable region. In this study, not only stability analysis but also forced response analysis, which is caused by harmonically excited fluid especially, is conducted. In order to analyze the system numerically, the descretized equation is formulated by using FEM(Finite Element Method). And the results of this method are compared with those of AMM(Assumed Mode Method) which were used by many researcher earlier.

• Journal of the Korean Geographical Society
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• v.39 no.1
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• pp.13-26
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• 2004

This paper examined the possibility of NET application for a relative weather stress index in Korea. The characteristic of NET distribution used temperature, relative humidity, wind speed which forecasting at Korean Meteorological Administration were analyzed. Regional critical values of daily maximum NET of stress index for summer resembled the distribution of daily maximum temperature because were not impacted wind and humidity but temperature. Regional critical values of daily minimum NET of stress index for winter distributed variously compared with summer. The highland region and the northern region of Seoul were impacted of low temperature and coastal region which strong wind. The occurrences of stressful days did not vary in summer, but obviously increased in winter after mid-1990s.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2001.10a
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• pp.14-17
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• 2001

Positional clonging (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in-vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. A deletion in the cdf critical region on chromosome 6 that removes approximately 150 kb of DNA selection. cdf mutant mice with the transgenic copy of the identified gene restored the brain abnormalities of the mutant mice. The positional cloning of cdf gene provides a good example showing the identification of a gene could lead to finding a new component of important molecular pathways.

• Journal of Sericultural and Entomological Science
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• v.39 no.2
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• pp.186-196
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• 1997

The IR crystallinity index of Calcium nitrate treated silk fiber decreased proportionally to the concentration of calcium nitrate. A partial change of conformation was observed in the concentration of over 46.4-47.6% changing from $\beta$-sheet or to random coil in the crystalline region. This is in coincidence with the result of crystallinity index, which was started to be reduced in the concentration range of 46.4-47.6%. A same trend was observed for the X-ray order factor, birefringence, degree of orientation and surface structure. These structural parameters were remarkably changed on the treatment of silk fibers with concentration of 46.4-17, 6% calcium nitrate. Therefore, it seems that there exists a critical concentration of calcium nitrate in affection the structure and morphology of silk fibers. According to the examination of surface morphology, the fine stripe was observed in the direction of fiber axis at 46.4% concentration. However, the treated concentration was exceeded by 47.6%, the cracks were appeared severely on the fiber surface in the transverse direction as well as fiber axis direction. This result might be related to the tensile properties, specially a tenacity of silk fibers. As a result of quantitative analysis of a dilute acid hydrolysis, three different regions, which are known as a amorphous, semi-crystalline and crystalline region, could be obtained. The hydrolysis rate curves were different with various concentrations of treatment and the relative contents of each region could be calculated.

• BMB Reports
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• v.42 no.1
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• pp.6-15
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• 2009

The most common genetic disorder Down syndrome (DS) displays various developmental defects including mental retardation, learning and memory deficit, the early onset of Alzheimer's disease (AD), congenital heart disease, and craniofacial abnormalities. Those characteristics result from the extra-genes located in the specific region called 'Down syndrome critical region (DSCR)' in human chromosome 21. In this review, we summarized the recent findings of the DYRK1A and RCAN1 genes, which are located on DSCR and thought to be closely associated with the typical features of DS patients, and their implication to the pathogenesis of neural defects in DS. DYRK1A phosphorylates several transcriptional factors, such as CREB and NFAT, endocytic complex proteins, and AD-linked gene products. Meanwhile, RCAN1 is an endogenous inhibitor of calcineurin A, and its unbalanced activity is thought to cause major neuronal and/or non-neuronal malfunction in DS and AD. Interestingly, they both contribute to the learning and memory deficit, altered synaptic plasticity, impaired cell cycle regulation, and AD-like neuropathology in DS. By understanding their biochemical, functional and physiological roles, we hope to get important molecular basis of DS pathology, which would consequently lead to the basis to develop the possible therapeutic tools for the neural defects in DS.

• Steel and Composite Structures
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• v.25 no.5
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• pp.603-615
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• 2017

This experimental research presents the seismic performance of steel reinforced high-strength concrete (SRHC) short columns. Eleven SRHC column specimens were tested under simulated earthquake loading conditions, including six short column specimens and five normal column specimens. The parameters studied included the axial load level, stirrup details and shear span ratio. The failure modes, critical region length, energy dissipation capacity and deformation capacity, stiffness and strength degradation and shear displacement of SRHC short columns were analyzed in detail. The effects of the parameters on seismic performance were discussed. The test results showed that SRHC short columns exhibited shear-flexure failure characteristics. The critical region length of SRHC short columns could be taken as the whole column height, regardless of axial load level. In comparison to SRHC normal columns, SRHC short columns had weaker energy dissipation capacity and deformation capacity, and experienced faster stiffness degradation and strength degradation. The decrease in energy dissipation and deformation capacity due to the decreasing shear span ratio was more serious when the axial load level was higher. However, SRHC short columns confined by multiple stirrups might possess good seismic behavior with enough deformation capacity (ultimate drift ratio ${\geq}2.5%$), even though a relative large axial load ratio (= 0.38) and relative small structural steel ratio (= 3.58%) were used, and were suitable to be used in tall buildings in earthquake regions.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06d
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• pp.360-365
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• 2010

In this paper, we present a distributed algorithm for detecting dynamic event regions in wireless sensor network with the consideration on energy saving. Our model is that the sensing field is monitored by a large number of randomly distributed sensors with low-power battery and limited functionality, and that the event region is dynamic with motion or changing the shape. At any time that the event happens, we need some sensors awake to detect it and to wake up its k-hop neighbors to detect further events. Scheduling for the network to save the total power-cost or to maximize the monitoring time has been studied extensively. Our scheme is that some predetermined sensors, called critical sensors are awake all the time and when the event is detected by a critical sensor the sensor broadcasts to the neighbors to check their sensing area. Then the neighbors check their area and decide whether they wake up or remain in sleeping mode with certain criteria. Our algorithm uses only 2 bit of information in communication between sensors, thus the total communication cost is low, and the speed of detecting all event region is high. We adapt two kinds of measure for the wake-up decision. With suitable threshold values, our algorithm can be applied for many applications and for the trade-off between energy saving and the efficiency of event detection.

• Proceedings of the KSAR Conference
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• 2001.10a
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• pp.14-17
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• 2001

Positional cloning (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in-vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. A deletion in the cdf critical region on chromosome 6 that removes approximately 150kb of DNA was identified. A gene associated with this deletion was identified using cDNA selection. cdf mutant mice with the transgenic copy of the identified gene restored the brain abnormalities of the mutant mice. The positional cloning of cdf gene provides a good example showing the identification of a gene could lead to finding a new component of important molecular pathways.

• Molecules and Cells
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• v.43 no.8
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• pp.671-685
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• 2020

The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1, encoded in a region termed the Down syndrome critical region (DSCR) of human chromosome 21. Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1, RCAN2, and RCAN3, present in most jawed vertebrates, with one member observed in most invertebrates and fungi. RCAN is most highly expressed in brain and striated muscles, but expression has been reported in many other tissues, as well, including the heart and kidneys. Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca²⁺, amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. RCAN binding to calcineurin, a Ca²⁺/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides significant contributions to DS pathologies and calcineurin regulation, RCAN is an important participant across physiological systems, suggesting it as a favorable therapeutic target.