• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3847-3850
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• 2013

The three homologous members of the p160 SRC family (SRC-1, SRC-2 and SRC-3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRC-3 gene is subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRC-3 promotes breast and prostate cancer cell proliferation and survival, have been identified. However, the function of SRC-3 in bladder cancer remains poorly understood. In the present study, our results indicate that overexpression of SRC-3 promotes bladder cancer cell proliferation whereas knockdown of SRC-3 results in inhibition. At the molecular level, we further established that CXCR4 is a transcriptional target of SRC-3. Therefore, our study first identified that SRC-3 plays a critical role in the bladder cancer, which may be a target beneficial for its prevention and treatment.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.8
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• pp.660-667
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• 2008

During the last two decades, lots of efforts have been devoted to resolve thermal stratification phenomenon and primary water environment issues. While several effective methods were proposed especially in related to thermally stratified flow analyses and corrosive material resistance experiments, however, lack of details on specific stress and fatigue evaluation make it difficult to quantify structural behaviors. In the present work, effects of the thermal stratification and primary water are numerically examined from a structural integrity point of view. First, a representative austenitic nuclear piping is selected and its stress components at critical locations are calculated in use of four stratified temperature inputs and eight transient conditions. Subsequently, both metal and environmental fatigue usage factors of the piping are determined by manipulating the stress components in accordance with NUREG/CR-5704 as well as ASME B&PV Codes. Key findings from the fatigue evaluation with applicability of pipe and three-dimensional solid finite elements are fully discussed and a recommendation for realistic evaluation is suggested.

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1317-1322
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• 2005

This work describes neo-fructooligosaccharides (neo-FOSs) production using the immobilized mycelia of Penicillium citrinum. Some critical factors were evaluated to optimize maximal production of neo-FOS. Optimal alginate and cell concentrations were determined to be $1.96\%$ alginate and $7.17\%$ cell, respectively, by statistical analysis. The optimal concentration of $CaCl_{2}$, which is related to bead stability, was determined to be 2 M. It was possible to increase the neo-FOS production by adding 15 units of glucose oxidase to the batch reaction. By co-immobilizing cells and glucose oxidase, neoFOS productivity increased $123\%$ compared with the whole-cell immobilization process. Based on the results above, a co-immobilization technique was developed and it can be utilized for large-scale production.

• Journal of the Korean Society of Systems Engineering
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• v.7 no.1
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• pp.1-7
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• 2011

This work describes a study on the Analysis of Alternatives (AoA) based defense decision making. Future battle-space is transformed into a System of Systems (SoS) concept which is accomplished missions and their functions through network based battle management systems under forming their grids of various sensors and shooters in a single theater. The acquisition process is, therefore, changing over from single system requirements to capabilities based acquisition of SoS. AoA help to justify the need for starting, stopping, or continuing an acquisition program. AoA identify potentially viable solutions and provide comparative cost, effectiveness, and risk assessments of each solution to a baseline. The decision making must consider not only cost-effectiveness, risk, and military worth, but also domestic policy, foreign policy, technological maturity of the solution, the environment, the budget, treaties, and a host of additional factors. In this point of view, this paper analyzes AoA template which are critical elements of the defense decision making. From results of this analysis of AoA template for Korean acquisition environment are presented.

• The Journal of Industrial Distribution & Business
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• v.7 no.3
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• pp.13-18
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• 2016

Purpose - Usage of E-services is critical for businesses to maximize work efficiency and gain competitive advantage. The aim of the study is to explore how awareness of technology and e-services usage in an emerging economy in Pakistan. The studies aimed to explore as to what extent these factors can potentially motivate transport employees towards e-services; who are generally not aware about technology and hence also not confident in using it also. Research design, data, and methodology - Employees from the three transport subsidiary units from a large private company in Pakistan were sampled for the study. Through using self-administered technique, the questionnaires were distributed during the month of April, 2016 to 189 employees. A total of 150 responses were taken further for analysis where the study found a positive link between awareness of technology and e-services usage. Results - This study found positive relationship between intention to use and e-service usage among the employees of three subsidiary units. The paper has reported 30 percent variance explained by the predicting variables in relation with e-services usage. Conclusions - Employees could be motivated to use e-services and latest technology through enhancing their awareness about their respective importance and viability. Accordingly, organizations can foster employees' intentions to use to enhance e-service usage.

• Journal of architectural history
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• v.7 no.1 s.14
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• pp.93-108
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• 1998

The threads of this thesis are several theoretical issues of modern urban ideals. Modern architects and urban designers conceived their individual artifacts, which assumed to be laid out on the new settings totally different from the existing urban fabrics derived from inherently medieval ones. In the discussion of modern ideal society, the Industrial Revolution and the Enlightenment was a pivotal point. Innovations in technology and expanded living territories since the double revolution have been critical factors in the evolution of new ideas of urbanism. The tremendous success in science and technology led a way to the 'science-fiction' environment as a destined apocalyptic world. The dream, whether it was socialist or in any other believes, to a pastoral utopia beyond the capitalist society was represented through the ideal cities, which were modern versions of arcadia in the other approaches. Two sides of revolutionary ideas are presented as a futurist city and a garden city, which are on the separate notions but co-existed or overlapped in a single urban project such as in Le Corbusier urban schemes or even Tchumi's recent work, Parc de la Villette. Urban ideas in the twentieth century are based on urban naturalism, the notion of which was consistant from abbe Laugier to Le Corbusier, as well as machine aesthetics interpreted in terms of archeological research and modern technology.

• Journal of Industrial Technology
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• v.38 no.1
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• pp.41-52
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• 2018

Recently, object detection is a critical function for any system that uses computer vision and is widely used in various fields such as video surveillance and self-driving cars. However, the conventional methods can not detect the objects clearly because of the dynamic background change in the beach. In this paper, we propose a new technique to detect humans correctly in the dynamic videos like shores. A new background modeling method that combines spatial GMM (Gaussian Mixture Model) and temporal GMM is proposed to make more correct background image. Also, the proposed method improve the accuracy of people detection by using SVM (Support Vector Machine) to classify people from the objects and KCF (Kernelized Correlation Filter) Tracker to track people continuously in the complicated environment. The experimental result shows that our method can work well for detection and tracking of objects in videos containing dynamic factors and situations.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.4
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• pp.189-197
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• 1993

The management of wastes within the urban landscape has become a critical concern to both local governments and inhabitants. With landfill capacities steadily decreasing, rapid growth of economy, population and urbanization, citizen awareness of the environment and public health problems occured by existing landfill sites make difficulties in selecting the landfill site. Therefore, this study has been performed to select the optimum waste landfill site using GSIS methodology to reduce the time, cost and effort. As the result of this study, we can investigate many factors synthetically which could not be handled by the former method using hands in the site selection for waste landfill, and we can carry out economically the work of selecting suitable site throughout the vast area.

• Journal of Korea Spatial Information System Society
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• v.8 no.2 s.17
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• pp.1-11
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• 2006

This paper addresses a GIS (Geographic Information System) based system in order to reduce the rate of public transportation accidents occurring in Iranian roads network. Over the years, the road accidents are a major issue throughout the world. Today, particular consideration is given to those technologies which can lead to diminish on the number of critical incidents. One of the main factors resulting in accidents and fatalities rates growth is the speed violation of buses in Iranian road network. The conventional speed controlling approach in Iran based on the Tachograph which records vehicle's speed, time, and stoppage in the mechanical processing has many problems. Hence, this research is intended to design and implement a GIS-based system to manage road accident of Bus transportation system using offline tracking system. This was accomplished using a GIS-based technique that encompasses three steps. The first step is developing a GIS-based accident system. The second step includes designing and applying a tracking system inside 90 buses for recording Bus information for speed controlling. Lastly, by using mentioned system in police center, the illegal drivers' punishment would be considered properly. Overall, this system has been successfully applied in this work. Therefore, the police and transportation office are able to control and make policy to diminish the number of accident. It is anticipated that online tracking system through the Web GIS would be utilized In this system in the near future.

• Molecules and Cells
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• v.42 no.12
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• pp.836-839
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• 2019

A tumor is an abnormal mass of tissue that arises when cells divide more than they should or do not die when they should. The cellular decision regarding whether to undergo division or death is made at the restriction (R)-point. Consistent with this, an increasingly large body of evidence indicates that deregulation of the R-point decision-making machinery accompanies the formation of most tumors. Although the R-point decision is literally a matter of life and death for the cell, and thus critical for the health of the organism, it remains unclear how a cell chooses its own fate. Recent work demonstrated that the R-point constitutes a novel oncogene surveillance mechanism operated by R-point-associated complexes of which RUNX3 and BRD2 are the core factors (Rpa-RX3 complexes). Here, we show that not only RUNX3 and BRD2, but also other members of the RUNX and BRD families (RUNX1, RUNX2, BRD3, and BRD4), are involved in R-point regulation.