• International journal of advanced smart convergence
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• 제12권4호
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• pp.434-442
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• 2023

The relationship between acute kidney injury (AKI) prediction and nephrotoxic drugs, or drugs that adversely affect kidney function, is one that has yet to be explored in the critical care setting. One contributing factor to this gap in research is the limited investigation of drug modalities in the intensive care unit (ICU) context, due to the challenges of processing prescription data into the corresponding drug representations and a lack in the comprehensive understanding of these drug representations. This study addresses this gap by proposing a novel approach that leverages patient prescription data as a modality to improve existing models for AKI prediction. We base our research on Electronic Health Record (EHR) data, extracting the relevant patient prescription information and converting it into the selected drug representation for our research, the extended-connectivity fingerprint (ECFP). Furthermore, we adopt a unique multimodal approach, developing machine learning models and 1D Convolutional Neural Networks (CNN) applied to clinical drug representations, establishing a procedure which has not been used by any previous studies predicting AKI. The findings showcase a notable improvement in AKI prediction through the integration of drug embeddings and other patient cohort features. By using drug features represented as ECFP molecular fingerprints along with common cohort features such as demographics and lab test values, we achieved a considerable improvement in model performance for the AKI prediction task over the baseline model which does not include the drug representations as features, indicating that our distinct approach enhances existing baseline techniques and highlights the relevance of drug data in predicting AKI in the ICU setting.

• KSBB Journal
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• 제30권6호
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• pp.307-312
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• 2015

Transgenic rice cells using RAmy3D promoter can provide high productivity, and the production of recombinant protein is induced by sugar starvation. In this system, productivity was reduced during the scale-up processes. To ensure the influences of shear stress and oxygen transfer rate, working volume and mixing performances were investigated under various agitation speeds and working volumes. In addition, inoculation methods including suspended cells and filtered cells were compared. Working volumes and shaking speeds were 300, 450 mL and 80, 120 rpm, respectively. Hydrodynamic environment of each condition was measured numerically like mixing time and $k_La$. Good mixing performance and high shear stress were measured at high agitation speed and low volume. The highest level of hCTLA4Ig was 30.7 mg/L at 120 rpm, 300 mL. When conditioned medium was used for inoculation, increased cell growth was noticed during the day 0~4 and decreased slower than filtered cells. Compared with filtered cells, the maximum hCTLA4Ig level reached 37.8 mg/L at 120 rpm, 300 mL and lower protease activity level was observed. In conclusion mixing performance is critical factor for productivity and conditioned medium can have a positive effect on damaged cells caused by hydrodynamic shear stress.

• 한국산업정보학회논문지
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• 제12권4호
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• pp.74-88
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• 2007

우편물을 배달순서대로 정렬하는 순로구분의 자동화를 위해서는 우편물에 표기된 주소를 인식해야 하며, 이 과정에서 표준화된 우편주소 데이터베이스는 필수적이다. 우편주소 데이터베이스는 주소인식뿐만 아니라 우편물 정보처리 등 다양한 측면에서 사용 가능하여 우편물 처리의 자동화와 정보화에 매우 중요하다. 본 연구는 우편주소 데이터베이스에서의 정보체계 표준을 위한 스키마 및 이에 따른 우편주소파일의 설계 방법과 설계된 스키마에 따른 주소해석 과정 및 방법에 관한 것이다. 주소를 표준화된 형태로 변환하는 데에 필요한 정보를 분석하여 이를 우편주소파일 설계과정에 포함시킴으로써 향후 순로구분 자동화를 위한 한글 주소인식 시스템과 고객 바코드 인증을 위한 주소 데이터베이스 매칭 및 주소검색 시스템에 활용할 수 있도록 하기 위해 우편주소파일을 설계하였다.

• PNF and Movement
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• 제17권3호
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• pp.487-497
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• 2019

Purpose: This tutorial review investigated the effect of prior fatigue and passive stretches on eccentric contraction-induced muscle injuries, as well as the underlying mechanisms of eccentric contraction-related injuries. Methods: Contraction-induced muscle damage is the most common disabling problem in sports and routines. The mechanisms underlying the pathology and prevention of muscle damage lessened by prior fatigue or stretches are critical in assessing musculoskeletal injuries. Even though there are treatments to reduce eccentric contraction-induced muscle injuries, fatigue negatively influences them. Therefore, we reviewed previous studies on eccentric contraction-induced muscle injuries with prior treatments using the MEDLINE and PubMed databases. Results: Prior passive stretching had a preventative and therapeutic effect, but prior lengthening contractions did not. On the other hand, prior isometric contractions involving relatively small forces may not provide a sufficient stimulus to induce protection. As a result, high force isometric contractions may be necessary. The studies supported the positive effects of prior fatigue, concluding that it was a factor in determining the amount of damage caused by eccentric exercise. This was due to a reduction in force and increased temperature. Studies that did not support the positive effects of prior fatigue concluded that a shift in optimal length to a longer length and reduced energy absorption during lengthening are evidence that fatigue is not related to muscle injuries induced by lengthening. Conclusion: The variability of the experiment models, conditions, muscles, and treatment methods make it necessary to interpret the conditions of previous studies carefully and draw conclusions without making direct comparisons. Thus, additional studies should be carefully conducted to investigate the positive effect of fatigue on lengthening.

• 폴리머
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• 제27권1호
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• pp.33-39
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• 2003

본 논문에서는 비스페놀계 2관능성 에폭시 수지 DGEBA/DGEBS 블렌드 시스템의 경화거동, 열안정성, 그리고 파괴인성 특성을 고찰하였다. DGEBA/DGEBS 블렌드 시스템의 함량비율을 100 : 0, 90 : 10, 80 : 20, 70 : 30, 그리고 60 : 40 wt%까지 변화시켰으며, DSC에 의한 열분석을 통하여 Ozawa식으로 경화 활성화 에너지 ($E_a$)를 계산하였으며, TGA 열분석을 사용하여 열분해 개시 온도(IDT), 최대 무게 감량시 온도($T_{max}$), 그리고 적분 열분해 진행 온도(IPDT) 등 열안정성 인자를 고찰하였다. 경화된 시편의 파괴인성 특성은 크랙성장 저항을 나타내는 임계응력세기 인자 ($K_{IC}$) 실험을 통하여 알아보았으며, 주사전자현미경 (SEM)을 사용하여 시편의 파단 특성을 조사하였다. 실험 결과 DGEBA/DGEBS 블렌드 시스템의 $E_a$, IPDT, 그리고 $K_{IC}$는 DGEBS 함량이 20 wt%인 경우 최대값을 나타내었는데, 이는 설폰기의 도입으로인한 치밀한 네트워크 구조의 형성때문이라 사료된다.

• 품질경영학회지
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• 제46권4호
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• pp.877-898
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• 2018

Purpose: This study empirically examines the effect of Communication Privacy Management(CPM) factors and Privacy Calculus factors to the intention to disclose Personal Health Information(PHI) in the context of healthcare ecosystem. Also, it investigates the moderating effects of CPM factors in the relationship between privacy calculus variables and the intention to disclose PHI. Methods: We conducted scenario-based repeated-measures quasiexperiment and used total 364 samples for analysis. Confirmatory factor analysis and repeated-measure ANOVA were employed using SPSS 24.0. Results: All CPM factors, such as type of information, requesting purpose, and requesting stakeholder, directly influence to the intention to disclose PHI, whereas only the medium trust out of the Privacy Calculus factors has direct influence on the intention to disclose PHI. With regard to the moderating effects, the requesting stakeholder is the most influential and the information type is the least influential construct. Conclusion: The findings suggest that healthcare system should be designed to provide more definite and personalized benefits to customers to enhance social and individual benefits by getting more participation from customers. Also, it is desirable that the requesting stakeholder of PHI would be non-profit organizations such as hospital, government or public agencies to secure more willingness of PHI from people. Furthermore, it is implied that extensive information gathering and utilization, instead of excluding sensitive information or critical patients' records, is recommended which is substantial to invigorate the healthcare industry.

• KEPCO Journal on Electric Power and Energy
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• 제7권1호
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• pp.129-135
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• 2021

Recently, additive manufacturing (AM) technology such as powder bed fusion (PBF) and directed energy deposition (DED) are actively attempted as consumers' needs for parts with complex shapes and expensive materials. In the present work, the effect of processing parameters on the mechanical properties of 316L stainless steel coupons fabricated by PBF and DED AM technology was investigated. Three major mechanical tests, including tension, impact, and fatigue, were performed on coupons extracted from the standard components at angles of 0, 45, 90 degrees for the build layers, and compared with those of investment casting and commercial wrought products. Austenitic 316L stainless steel additively manufactured have been well known to be generally stronger but highly vulnerable to impact and lack in elongation compared to casting and wrought materials. The process-induced pore density has been proved the most critical factor in determining the mechanical properties of AM-built metal parts. Therefore, it was strongly recommended to reduce those lack of fusion defects as much as possible by carefully control the energy density of the laser. For example, under the high energy density conditions, PBF-built parts showed 46% higher tensile strength but more than 75% lower impact strength than the wrought products. However, by optimizing the energy density of the laser of the metal AM system, it has been confirmed that it is possible to manufacture metal parts that can satisfy both strength and ductility, and thus it is expected to be actively applied in the field of electric power section soon.

• 한국건설관리학회논문집
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• 제9권2호
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• pp.190-198
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• 2008

최근 고층화, 대형화, 복잡화 된 건물의 신축이 증가하면서 장비의 사용이 증가하고 있다 특히 공동주택이나 주상복합빌딩의 신축에 따른 고소작업이 증가하면서 타워크레인의 장비가 증가하고 있는 실정이다. 이러한 장비사용의 증가로 장비의 선정, 운용과 더불어 장비의 안정성 확보는 공사프로젝트의 중요한 관리요소로 작용한다. 최근 공사 시 구조물의 높이가 증가함에 따라 크레인의 위치가 수직상승하는 상승식 타워크레인의 사용이 증가하고 있다. 이에 본 연구는 상승식 크레인의 안정성을 검토하는 모델을 제시하였다. 본 모델은 상승식 크레인의 주변 환경 및 조건에 적절한 선정 뿐 아니라 제시된 3가지 타입의 지지부재인 Collar의 설계 및 안정성 검토 및 고정부의 설계, 검토 또한 손쉽게 이루어 질 수 있도록 하였다. 이러한 모델을 통하여 장비의 적절한 선정 뿐 아니라 지지부재 및 고정부의 설계검토를 통한 안정성 확보를 통하여 공사프로젝트의 효율적 수행이 가능해 질 것으로 기대 된다.

• Journal of Ecology and Environment
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• 제40권1호
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• pp.75-83
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• 2016

Background: In order to evaluate the effect of pH, known as a critical factor for shaping the biogeographical microbial patterns in the studies by others, on the bacterial diversity, we selected two sites in a similar geographical location (site 1; north latitude 35.3, longitude 127.8, site 2; north latitude 35.2, longitude 129.2) and compared their soil bacterial diversity between them. The mountain soil at site 1 (Jiri National Park) represented naturally acidic but almost pollution free (pH 5.2) and that at site 2 was neutral but exposed to the pollutants due to the suburban location of a big city (pH 7.7). Methods: Metagenomic DNAs from soil bacteria were extracted and amplified by PCR with 27F/518R primers and pyrosequenced using Roche 454 GS FLX Titanium. Results: Bacterial phyla retrieved from the soil at site 1 were more diverse than those at site 2, and their bacterial compositions were quite different: Almost half of the phyla at site 1 were Proteobacteria (49 %), and the remaining phyla were attributed to 10 other phyla. By contrast, in the soil at site 2, four main phyla (Actinobacteria, Bacteroidetes, Proteobacteria, and Cyanobacteria) composed 94 %; the remainder was attributed to two other phyla. Furthermore, when bacterial composition was examined on the order level, only two Burkholderiales and Rhizobiales were found at both sites. So depending on pH, the bacterial community in soil at site 1 differed from that at site 2, and although the acidic soil of site 1 represented a non-optimal pH for bacterial growth, the bacterial diversity, evenness, and richness at this site were higher than those found in the neutral pH soil at site 2. Conclusions: These results and the indices regarding diversity, richness, and evenness examined in this study indicate that pH alone might not play a main role for bacterial diversity in soil.

• 한국정보통신학회논문지
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• 제21권7호
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• pp.1429-1434
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• 2017

기존의 안경 렌즈 흠집 검출 방법은 영상내의 미세 잡음이 제거되지 않아 렌즈 영역이 정확히 추출되지 않는 경우가 발생하여 흠집 영역을 검출할 수 없다는 문제점이 발생한다. 따라서 본 논문에서는 이러한 문제점을 개선하기 위해 적응적 이진화 기법과 Bresenham algorithm을 적용하여 흠집 영역을 검출한다. 제안된 방법은 안경 렌즈 영상에서 명암 대비를 적용하여 렌즈의 명암을 강조한다. 명암이 강조된 영상에서 렌즈 밖의 배경 영역은 흠집 검출에 불필요하므로 이진화 기법을 적용한 후에 Bresenham algorithm을 적용하여 렌즈의 윤곽선을 검출하고 렌즈 이외의 배경을 제거한다. 렌즈 이외의 배경이 제거된 렌즈 영상에서 렌즈 내부의 배경과 흠집의 명암 대비를 높인다. 명암이 강조된 렌즈 내부 영역에서 적응적 이진화 기법을 적용하여 흠집과 잡음을 검출한다. 잡음은 중간값 필터를 적용하여 제거한 후에 흠집 영역을 추출한다. 추출된 흠집 영역에서 렌즈의 중심으로부터의 거리와 흠집의 크기를 퍼지 추론 규칙에 적용하여 눈에 미치는 영향 정도를 분석한다. 제안된 방법의 성능을 분석하기 위해 CHEMI, MID, HL, HM과 같은 시력 보정용 렌즈 영상을 대상으로 실험한 결과, 12개의 시력 보정용 렌즈 영상 중에서 10개에서 결함을 성공적으로 추출하였다.