• Advances in pediatric surgery
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• v.8 no.1
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• pp.41-47
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• 2002

Abnormal distribution of the enteric nerves such as adrenergic, cholinergic and peptidergic nerves may cause the functional obstruction in Hirschsprung's disease (HD). Although the sustained contraction of the aganglionic segment is the main pathophysiology of HD, the etiology and pathogenesis is not thoroughly understood, With the recent progress of molecular biology and genetics,a more detailed approach to the pathogenesis of the HD can be undertaken. In this review, the roles of the nitric oxide, nitric oxide synthase and interstitial cells of Cajal on smooth muscle relaxation, the effects of extracellular matrix, cell adhesion molecules, neurotrophic factors on the migration and maturation of the neural crest cells are described. In the section of genetic factors, familial occurrences, association of chromosomal abnormalities, RET gene, glial cell line-derived neurotrophic factor gene, endothelin-3 gene and endothelin-B receptor gene and their r elationships to HD is briefly reviewed.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.524-528
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• 2009

An influence factors for soundness evaluation of river levee include resistibility and embankment for piping of ground consisting embankment in case piping, permeability coefficient of ground, height of embankment, the width of crest, material characteristics of embankment and foundation ground, shape of embankment slope, an influence for penetration of rainfall or river water in case slope stability. In this study, it was operated a feasibility investigation of existing design result, stability evaluation for permeability coefficient use and permeability coefficient change of foundation ground to investigate an influence in line with permeability coefficient change for result of river levee penetration analysis. The evaluation results of influence factors, the permeability coefficient used in design and it was evaluated influence in safety factor of piping. After the evaluation of influence factors, the permeability coefficient used in the design appears with the fact that differs in a design report about same soil, Accordingly, the stability investigation of embankment by application of literature data can affect stability evaluation results by change factors like a permeability coefficient, void ratio. It should be certainly used material properties by a test in soundness evaluation of river levee.

• Journal of the Korean GEO-environmental Society
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• v.11 no.11
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• pp.19-26
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• 2010

An influence factors for soundness evaluation of river levee include consisting embankment in case piping, permeability coefficient of ground, height of embankment, the width of crest, material characteristics of embankment and foundation ground, shape of embankment slope, an influence for penetration of rainfall or river water in case slope stability. In this study, it was operated a feasibility investigation of existing design result, stability evaluation for permeability coefficient use and permeability coefficient change of foundation ground to investigate an influence in line with permeability coefficient change for result of river levee penetration analysis. The evaluation results of influence factors, the permeability coefficient was used in design and it was evaluated influence in safety factor of piping. After the evaluation of influence factors, the permeability coefficient used in the design appears with the fact that differs in a design report about same soil.

• Annals of Rehabilitation Medicine
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• v.42 no.6
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• pp.863-871
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• 2018

Objective To evaluate the association between progression of curvature of scoliosis, and correction for functional component in patients with juvenile idiopathic scoliosis (JIS). Methods We retrospectively reviewed medical data of patients prescribed custom molded foot orthosis (FO) to correct inequality of RCSPA (resting calcaneal stance position angle), and chose 52 patients (26 females, 26 males) with Cobb angle ${\geq}10^{\circ}$ in radiology and uneven pelvic level at iliac crest by different RCSPA (${\geq}3^{\circ}$) as a factor of functional scoliosis. They had different hump angle ${\geq}5^{\circ}$ in forward bending test, for idiopathic scoliosis component. Their mean age and mean period of wearing FO were $79.5{\pm}10.6months$ and $18.6{\pm}0.70months$. Results Cobb angle was reduced from $22.03^{\circ}{\pm}4.39^{\circ}$ initially to $18.86^{\circ}{\pm}7.53^{\circ}$ after wearing FO. Pelvis height difference and RCSPA difference, were reduced from $1.07{\pm}0.25cm$ initially to $0.60{\pm}0.36$, and from $4.25^{\circ}{\pm}0.71^{\circ}$ initially to $1.71^{\circ}{\pm}0.75^{\circ}$ (p<0.01). Cobb angle improved most in 9 months. However, there was no significant improvement for those with more than $25^{\circ}$ of Cobb angle initially. Mean Cobb angle improved in all age groups, but patients less than 6 years had clinically significant improvement of more than $5^{\circ}$. Conclusion JIS can have functional components, which should be identified and managed. Foot orthosis is useful in correcting functional factors, in the case of pelvic inequality caused by different RCSPA, for patients with juvenile idiopathic scoliosis.

• Journal of Periodontal and Implant Science
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• v.53 no.1
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• pp.20-37
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• 2023

Purpose: Our pilot study showed that a 3-dimensional dual drug delivery scaffold (DDDS) loaded with Chinese herbs significantly increased the regenerated bone volume fraction. This study aimed to confirm the synergistic anti-inflammatory and osteogenic preclinical effects of this system. Methods: The targets and pathways of parthenolide and naringin were predicted. Three cell models were used to assess the anti-inflammatory effects of parthenolide and the osteogenic effects of naringin. First, the distance between the cementoenamel junction and alveolar bone crest (CEJ-ABC) and the bone mineral density (BMD) of surgical defects were measured in a rat model of periodontitis with periodontal fenestration defects. Additionally, the mRNA expression levels of matrix metallopeptidase 9 (MMP9) and alkaline phosphatase (ALP) were measured. Furthermore, the number of inflammatory cells and osteoclasts, as well as the protein expression levels of tumor necrosis factor-alpha (TNF-α) and levels of ALP were determined. Results: Target prediction suggested prostaglandin peroxidase synthase (PTGS2) as a potential target of parthenolide, while cytochrome P450 family 19 subfamily A1 (CYP19A1) and taste 2 receptor member 31 (TAS2R31) were potential targets of naringin. Parthenolide mainly targeted inflammation-related pathways, while naringin participated in steroid hormone synthesis and taste transduction. In vitro experiments revealed significant antiinflammatory effects of parthenolide on RAW264.7 cells, and significant osteogenic effects of naringin on bone marrow mesenchymal stem cells and MC3T3-E1 cells. DDDS loaded with parthenolide and naringin decreased the CEJ-ABC distance and increased BMD and ALP levels in a time-dependent manner. Inflammation was significantly alleviated after 14 days of DDDS treatment. Additionally, after 56 days, the DDDS group exhibited the highest BMD and ALP levels. Conclusions: DDDS loaded with parthenolide and naringin in a rat model achieved significant synergistic anti-inflammatory and osteogenic effects, providing powerful preclinical evidence.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.2
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• pp.333-342
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• 2017

In order to understand the mechanism of the cross-shore evolution of storm (barred) and normal (nonbarred) profiles of a sandy beach, the vertically two-dimensional laboratory experiment was performed with a movable bed. The beach profiles and free surface motion were measured under monochromatic wave conditions evolving the storm and normal beach profiles. The observation was conducted in the surf zone during the alternation of the two wave conditions to reach its quasi-equilibrium state. The sandbar-crest and trough and the steep berm were evolved due to the plunging breakers in the storm case, and the bar-trough was decayed due to the spilling breakers in the normal case. From the measurements, it was found that the storm wave case was in an erosion state and the normal wave case was in an accretion state. The strong undertow, which is a dominant factor of the offshore migration mechanism, was developed in the storm wave case, and the weak undertow was developed in the normal wave case. The skewness and the asymmetry of the nonlinear wave motion, which is a dominant factor of the onshore migration mechanism, was measured similarly in both cases.

• Journal of Bio-Environment Control
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• v.15 no.4
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• pp.289-295
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• 2006

A computational fluid dynamics (CFD) numerical model has been developed to effectively study the ventilation efficiency of multi-span greenhouses with internal crops. As the first step of the study, the internal plants of the CFD model had to be designed as a porous media because of the complexity of its physical shapes. In this paper, the results of the wind tunnel tests were introduced to find the aerodynamic resistance of the plant canopy. The Seogun tomato was used for this study which made significant effects on thermal and mass exchanges with the adjacent air as well as internal airflow resistance. With the main factors of wind speed, static pressure, and density of plant canopy, the aerodynamic resistance factor was statically found. It was finally found to be 0.26 which will be used later as an input data of the CFD model. Moreover, the experimental procedure of how to find the aerodynamic resistance of various plants using, wind tunnel was established through this study.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.6
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• pp.335-343
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• 2019

Overtopping discharge for sea dike having low mound and high wave wall (LMHW sea dike) is investigated with hydraulic experiments in this study. Vertical, Flare and Bullnose type wave walls are selected and Tetrapods (double layer) and Accropode (one layer) are adopted for armour layers of the front slope. The results of the hydraulic experiments are compared to the overtopping formulas for armoured rubble slopes and vertical sea dikes suggested by EurOtop Manual. Predicted overtopping discharges are underestimated as the roughness efficiency factors (γ_f) of armour blocks suggested by EurOtop are adopted when the overtopping formula for armoured rubble slopes sea dike is used. Meanwhile the predicted overtopping discharges agree well with the hydraulic experiments when the modified roughness efficiency factors redefined by multiplying efficiency factor of the heights of armoured crest berm and wave wall (γ_AR) are adopted. Return wall effects on a vertical wall (Kortenhaus et al., 2003; Pearson et al., 2004a) and the effects on a smooth dike slope (Van Doorslaer et al., 2015) in EurOtop Manual are investigated for Flare and Bullnose type wave walls. As a results of the comparison between experimental results and 2 formulas, return wall effect on a smooth dike was more valid for LMHW sea dike.

• Journal of Periodontal and Implant Science
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• v.31 no.4
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• pp.811-822
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• 2001

최근 임플란트를 원하고, 필요로 하는 환자가 증가하면서 술전의 정확한 진단이 보다 중요해졌고 다양한 진단방법이 소개되고 이용되어져 왔다. 그 중 보편적으로 가장 널리 사용되어지는 방법이 방사선 촬영법이고 그 중에서도 파노라마방사선사진이다. 하지만 파노라마방사선사진의 용이함과 간편성에도 불구하고 그 방법 자체가 가지고 있는 한계점 때문에 CT/MPR(Computer Tomography/Multiplanar Reformatting)이 일부 환자에서는 반드시 필요하다는 주장이 대다수이다. 본 연구의 목적은 하악 구치부에 임플란트 시술을 받은 환자를 대상으로 파노라마방사선사진의 확대율을 알아보고 파노라마방사선사진과 CT/MPR에서 치조정-하악관간 거리가 실제 어느 정도 차이를 보이는지, 그리고 CT/MPR에 대한 파노라마방사선사진의 확대율에 환자의 하악골의 경사도와 하악관의 해부학적 위치가 어떤 영향을 미치는지를 알아보는 것이다. 본 연구는 서울대학 치과병원 치주과를 내원하여 하악구치부에 Dental Implant 시술을 받은 15명의 환자, 32개 부위를 대상으로, 임플란트 시술을 위한 술전 파노라마방사선사진과 CT/MPR, 술후의 파노라마방사선사진, CT/MPR상을 자료로, 임플란트가 식립될 위치에서 치조정에서 하악관의 길이, 하악골의 협설폭경, 하악골의 설측면에서 하악관의 수평길이, 임플란트 매식체의 설측에서 하악관까지의 수평거리를 계측하였고 이 해부학적 계측치들이 CT/MPR에 대한 파노라마방사선사진의 확대율과 어떤 상관관계에 있는지 Pearson's correlation coefficient test를 이용해 살펴보았다. 1. CT/MPR에 대한 파노라마방사선사진의 확대율은 CT/MPR상에서 하악골 단면의 협설폭경(Pearson test에서의 상관관계 분석시, 상관계수 r=-0.604), 임플란트 매식체의 설측에서 하악관까지의 수평거리(r=-0.515), 하악골의 설측면에서 하악관까지의 수평거리(r=-0.640)와 뚜렷한 음적 선형관계가 있었다. 2. CT/MPR에 대한 파노라마방사선사진의 확대율은 CT/MPR상에서 하악골의 장축의 각도와는 뚜렷한 양적 선형관계(Pearson test에서의 상관관계 분석시, 상관계수 r=-0.446)가 있었다. 3. 여러 요소중 CT/MPR에 대한 파노라마방사선사진의 확대율과 가장 유의성있는 연관성을 보이는 것은 CT/MPR상에서 하악골의 설측면에서 하악관까지의 수평거리였다(r=-0.640) 4. CT/MPR에 대한 파노라마방사선사진의 확대율은 일반적으로 생각되어지는 파노라마방사선사진의 확대율 125%보다 큰, 약 135%로 나왔다. 이상의 결과로 볼 때, 하악골의 설측면에서 하악관까지의 수평거리가 CT/MPR에 대한 파노라마방사선사진의 확대율에 가장 영향을 미치는 요소로 추정되며 확대율은 125%보다 높은 것으로 나타났다.

• Journal of Gastric Cancer
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• v.6 no.4
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• pp.221-226
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• 2006

Purpose: Controversy still exists over in the prognostic significance of microscopic tumor cell dissemination in patients with cancer. This study evaluated the prognostic implication of isolated tumor cells in the bone marrow of patients with gastric cancer. Materials and Methods: Four hundred nineteen (419) patients who underwent surgery for gastric cancer between June 1998 and July 2000 were enrolled in the study. Bone marrow aspirate was obtained from the iliac crest before removal of the primary tumor. Mononuclear cells were isolated and stained with AE-1/AE-3 PAN-CYTOKERATIN. Results: Cytokeratin-positive cells were found in the bone marrow of 219 patients (52.3%). The incidence varied significantly with the depth of invasion (P=0.021) and the stage (P=0.026). The five-year survival rate of patients with cytokeratin-positive cells was 74.1% and that of patients without cytokeratin-positive cells was 81.1%(P=0.2481). There were no significant differences in the recurrence rate and the site of recurrence according to whether or not cytokeratin-positive cells were present in the bone marrow. Conclusion: The presence of cytokeratin-positive cells in the bone marrow of patients with gastric cancer did not predict outcome and recurrence. Therefore, it cannot be used as a prognostic factor.