• 한국환경과학회지
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• 제23권6호
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• pp.1021-1027
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• 2014

This study was designed in order to determine the influences of haw (Crataegus pinnatifida $B_{UNGE}$) on the lipid metabolism syndrome. Sprague Dawley rats, 7 weeks old, were given four different types of diets for 5 weeks: ND group (noncholesterolemic diet), HE group (non cholesterolemic diet+haw extract), CD group (cholesterolemic diet), CH group (cholesterolemic diet+haw extract). Concentrations of LDL-cholesterol, triglyceride, phospholipid, free cholesterol, cholesteryl ester, blood glucose were remarkably higher in the CD group than the other groups. But by treatment of haw extract group with cholesterolemic diet (CH group) were significantly decreased compared with CD group. Cholesteryl ester ratio was no difference between CD group and CH group. These results indicate that Crataegus pinnatifida $B_{UNGE}$ would be effective in lipid metabolism syndrome.

• 한국환경과학회지
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• 제23권5호
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• pp.787-792
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• 2014

The objective of this study was to investigate the effects of the Crataegus pinnatifida BUNGE extract supplementation of non esterified fatty acid (NEFA), concentrations of serum protein and electrolyte in sera on the hyperlipidemic rats. Concentrations of NEFA and globulin were remarkably lower in the Crataegus pinnatifida BUNGE extract group (HW group) than in the hyperlipidemic group (HD group), but no difference between control group (CO group) and extract of Crataegus pinnatifida BUNGE supplement in control group (NW group). However, concentrations of electrolyte K and A/G were higher in the HW group than HD group. Concentrations of total protein, albumin, electrolyte of total Ca, Pi, Na and Cl were no difference between HW group than HD group. The results indicate that Crataegus pinnatifida BUNGE extract was in the improvement of hyperlipidemic rats.

• 한국환경과학회지
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• 제23권5호
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• pp.793-800
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• 2014

This study was conducted to observe the influences of Crataegus pinnatifida BUNGE extract on lipid concentration in hypercholesterolemic rats (Sprague Dawley, male) fed the experimental diets for 5 weeks. Body weight gain was remarkably lower in the Crataegus pinnatifida BUNGE extract intake group than in the hypercholesterolemic rats. Total cholesterol concentration was remarkably lower in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. Whereas, concentrations of HDL-cholesterol, ratio of HDL-cholesterol concentration to total cholesterol were remarkably higher in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. Atherosclerotic index (AI), cardiac risk factor (CRF) were remarkably lower in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. From the above research, Crataegus pinnatifida BUNGE extract was effective on the lipid concentrations in sera of dietary hypercholesterolemic rats.

• 한국환경과학회지
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• 제23권11호
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• pp.1791-1799
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• 2014

This study was conducted to evaluate the contents of antioxidative components from pulpy and seed in wild haw (Crataegus pinnatifida $B_{UNGE}$). Pulpy and seed of haw were smashed, then measured for color properties, antioxidative components of ascorbic acid, phytic acid, proanthocyanidin, anthocyanin, total carotene, ${\beta}$-carotene, lycopene, chlorophyll a, b and tannin. The $a^*$, $b^*$ and $C^*$ values of seed were significantly lower than pulpy, but $L^*$ and $H^{\circ}$ values were higher than that of pulpy. Ascorbic acid contents of pulpy and seed were found to be $10.89{\pm}1.69mg/100g$ and $1.45{\pm}0.16mg/100g$, respectively. Phytic acid, proanthocyanidin, total carotene and tannin contents of pulpy and seed were $689.17{\pm}3.63mg/g$, $597.78{\pm}2.93mg/g$; $355.61{\pm}19.39mg/g$, $49.12{\pm}4.97mg/g$; $8.32{\pm}0.42mg%$, $0.80{\pm}0.01mg%$; $7.53{\pm}0.09mg/g$, $1.02{\pm}0.03mg/g$, respectively. Similarly, ${\beta}$-carotene, lycopene, chlorophyll a and chlorophyll b contents of pulpy also displayed higher values than that of seed. On the contrary, anthocyanin content of seed ($4.24{\pm}0.33mg/L$) was remarkably higher than pulpy ($0.99{\pm}0.62mg/L$). The results showed that pulpy could be severed as great natural antioxidant and biohealth functional food.

• 한국환경과학회지
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• 제23권6호
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• pp.1029-1035
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• 2014

This study was investigate the influences of wild haw (Crataegus pinnatifida $B_{UNGE}$) on lowering blood urea nitrogen (BUN) and creatinine concentrations in dyslipidemic rats. Four groups of rats were fed different diets for 5 weeks: basal diet (BD group), nondyslipidemic diet+feral haw extract (NDF group), dyslipidemic diet (DLD group), dyslipidemic diet+feral haw extract (DFH group). BUN, creatinine and uric acid concentrations were significantly higher in the DLD group than in the BD group. However, DFH group significantly lowered BUN, creatinine and uric acid concentrations compared to the DLD group. Amylase activity was significantly lower in the DLD group than in the BD group, while DFH group significantly higher compared to the DLD group. Lipase activity was also also significantly lower in the DLD group than the other group. Accordingly, these results suggest that haw extract could be effective for improving kidney function in dyslipidemic rats.

• 생명과학회지
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• 제24권4호
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• pp.386-392
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• 2014

본 연구에서는 야생산사씨의 항산화 활성을 알아보고자 70% methanol, 70% ethanol, chloroform:methanol (CM, 2:1, v / v), n-butanol, ethyl acetate (EA) 용매로 추출하여, 시료 농도 0.2 mg/ml, 0.5 mg/ml, 0.8 mg/ml에서 측정 비교 하였다. DPPH, reducing power, FRAP 및 ABTS radical 소거활성은 70% methanol, 70% ethanol, EA, CM, n-butanol 추출물 순으로 높게 측정되어 모두 같은 경향을 나타내었다. 특히, DPPH에서 70% methanol 추출물은 18.22%~65.42%, 70% ethanol 추출물은 15.97%~60.25%의 우수한 radical 소거 활성을 보였다. NO radical 소거 활성은 n-butanol, EA, CM, 70% methanol, 70% ethanol 추출물 순으로 나타났으며, $OH^-$ radical 소거 활성은 n-butanol, 70% methanol, 70% ethanol, CM, EA 추출물 순으로 측정되었다. 모든 용매 추출물은 대조군으로 사용한 표준물질에 비해서는 유의적으로 항산화 활성이 낮은 것으로 나타났다. 산사씨 용매 추출물 중 70% methanol 및 70% ethanol 추출물의 항산화 활성이 대부분 높은 경향이었다. 따라서 산사씨는 우수한 천연 항산화제로 활용이 가능할 것으로 사료된다.