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Effect of prehydration solution on hearing threshold after chemotherapy in patients with head and neck cancers: a retrospective study

  • Dongbin Ahn;Kyu-Yup Lee;Eunjung Oh;Minji Oh;Boseung Jung;Da Jung Jung
    • Journal of Yeungnam Medical Science
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    • v.40 no.2
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    • pp.164-171
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    • 2023
  • Background: The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. Methods: In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE). Results: Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis. Conclusion: Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers.

Actor-Critic Algorithm with Transition Cost Estimation

  • Sergey, Denisov;Lee, Jee-Hyong
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • v.16 no.4
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    • pp.270-275
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    • 2016
  • We present an approach for acceleration actor-critic algorithm for reinforcement learning with continuous action space. Actor-critic algorithm has already proved its robustness to the infinitely large action spaces in various high dimensional environments. Despite that success, the main problem of the actor-critic algorithm remains the same-speed of convergence to the optimal policy. In high dimensional state and action space, a searching for the correct action in each state takes enormously long time. Therefore, in this paper we suggest a search accelerating function that allows to leverage speed of algorithm convergence and reach optimal policy faster. In our method, we assume that actions may have their own distribution of preference, that independent on the state. Since in the beginning of learning agent act randomly in the environment, it would be more efficient if actions were taken according to the some heuristic function. We demonstrate that heuristically-accelerated actor-critic algorithm learns optimal policy faster, using Educational Process Mining dataset with records of students' course learning process and their grades.

The Development and Implementation of Problem-Based Learning Package in Physical Therapy (물리치료학에서의 PBL 학습교재 개발 및 적용)

  • Hwang, Hyun-Sook;Chung, Jin-Woo;Lim, Jong-Soo
    • Journal of Korean Physical Therapy Science
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    • v.9 no.4
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    • pp.83-94
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    • 2002
  • Within physical therapy education, there has been increased attention to curricula and course that emphasize problem solving, clinical reasoning, and synthesis of information across traditional discipline-specific boundaries. This article describes the development implementation, and outcomes of a problem-based learning course in Physical therapy. The course was designed to help students to integrate the various elements of a physical therapy curriculum and to enhance their abilities to respond to an ever-changing health care environment. An evaluation of the course by the first 50 students who completed it revealed both strengths and weaknesses. Students responded that the course enhanced their professional behavior, including interpersonal communication skills, team work, and follow-through with professional responsibilities. The learning package was developed by the authors and implemented to a college students during three weeks of the first semester of 2001. Most studies which conducted PBL module development were short period or temporary PBL package application and evaluation rather than a whole semester's. While, this study carried on partial integrated PBL curriculum development and application with recomposing content of the two subjects to one subject Physical therapy which includes four PBL packages. This package was developed from a simple concept to complex and partial integrated PBL curriculum application systematically variable learning methods such as discussion, practice, lecture, video. There are 2 classes, each class has 25 students, in the college. Each class has 5 small groups consisting 5 students. Two tutors proceeded discussion charging each class also, they used multiple methods and materials like tutorials, self-directed learning, lecture, and video. The package is 5 grades and 5 hours per week and the rate of discussion, lecture is 4, 1 respectively. One of the most change is the increase of interaction between students and tutors. Whenever students need information and suggestion, they can visit tutors who provide reading materials and guide for the direction of self learning. Therefore, this study describes the PBL package development process and application during one semester recomposing contents of two subjects to Physical therapy concepts. Besides, it will contribute to active application of existing each subject to tutors who intend to convert as PBL methods. The study has significant meaning to show potentiality of partially integrated PBL application, using systematic PBL package development from two subjects contents. However, when students' need of yearning is over the extent of Introduction of Physical therapy and Rehabilitation medicine, tutors should set learning extent. So, there is limitation to attain completely integrated PBL education within one subject, therefore, it is high lighted to proceed development of integrated curriculum to maximize learning effects of PBL. It is exected that partial integrated PBL package development and application will distribute to prosper excellent physiotherapist in practice.

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Analysis of Factors Affecting Major Satisfaction

  • Kim, Jungae;Cho, Euiyoung
    • International Journal of Advanced Culture Technology
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    • v.6 no.2
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    • pp.72-79
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    • 2018
  • The purpose of this study was to analyze general characteristics and empathy factors of nursing student's major satisfaction. Participants in this study were 235 students from both located in J do and C do Universities. The research method was a cross-sectional survey and the survey period was from September 1 to 10, 2017. The questionnaire was used to investigate general characteristics, empathy, and major satisfaction. The analysis was based on frequency analysis, p value of t or F value, Pearson correlation, regression analysis, and hierarchical regression analysis using SPSS 18.0. The result of this study were as follows: (1) The C University showed higher satisfaction than J University(3.44), (2) the factors affecting major satisfaction were school location, grade, religion, cognitive empathy, and emotional empathy correlated, Regression analysis was used to examine factors that correlated with major satisfaction, followed by hierarchical regression analysis to identify the most influential factors. (3) The result of the analysis showed that the greatest influence factors on major satisfaction were the University location(${\beta}=.325$, p<.01), the cognitive empathy (${\beta}=.287$, p<.01), and the next order was negative grade(${\beta}=-.230$, p<.01). Based on the results of this stud, the following conclusions can be drawn. The most influential factor in the major satisfaction was the school location, but this was an irreversible factor. Therefore, if the cognitive empathy factor and grades are corrected, it can be said that it can increase the satisfaction of major in nursing University students. In this study, it was emphasized that cognitive empathy contained in the course of nursing education program and suggested guidance on major satisfaction in lower grades.

An Analysis of Preferences for Science and the Role Gender Differences Plays in Determining Preferences for It Amongst Elementary School Students (성별에 따른 초등학생의 과학 선호도 차이와 과학 선호도에 영향을 주는 요인 분석)

  • Park, Chan-Ju;Dong, Hyo-Kwan;Shin, Young-Joon
    • Journal of Korean Elementary Science Education
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    • v.26 no.2
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    • pp.216-225
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    • 2007
  • The purpose of this study is to find out the differences (if any) and the causes of preferences for science between elementary school boys and girls. Another purpose of this study is to find out when such differences in preference begin and what their causes we. Fourth, fifth and sixth grades from elementary school A in Gyeongg-gi Province participated twice in research surveys on preference levels in science with education, career course and personal experience taken into account. A total of 997 survey responses, (excluding no responses or half-hearted ones) were selected for comparative analysis. The analysis methods used were frequency analysis, cross stabs and one-way ANOVA Analysis which depended on survey items. The results of this study show that preference levels in science are 61.7% and the difference of preference levels in science between boys and girls are 31.2% and 30.5% with boys showing higher percentages in science preference levels than girls(p<.01). Moreover, the results also show that the point in which changes in preference level in science emerges is from fifth and sixth grades. Therefore, the gender difference in preference levels in science begins with fifth grade students, with science being slightly more favored by boys. finally, the main causes in gender differences seems to be the experiment participants' levels, scientific education textbook preference level, interests in science class, and plans for the future that are related to field of science. Among these causes, interests level in science class and preference levels in science are closely related.

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A Comparative Study on the Curriculum on Electricity and Magnetism between in Korean and in (캐나다 Ontario주와 우리나라 초등학교의 전기, 자기 관련 교육 과정의 비교 연구)

  • Han, Moo-Hyun;Kim, Jong-Seong
    • Journal of Korean Elementary Science Education
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    • v.24 no.5
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    • pp.620-626
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    • 2005
  • In this study, we conducted a comparative study to investigate the curriculums on electricity and magnetism between in Korean and in Ontario elementary schools in Canada with respect to connectivity and difference among course materials with grades. We compared textbooks that contain the contents about electricity and magnetism, and connectivity in curriculums that were relevant to the science content system in each country. We report the following differences in the curriculums on electricity and magnetism in each country. First, it turns out that science is taught from the first grade in Ontario, while it is taught from the third grade in Korea. Second, Ontario covers electricity and magnetism only in science curriculum, while Korea covers the same topics both in the science and practical arts curriculum. Third, while the curriculum in Korea introduces 'a magnet' in the third grade, 'electricity' in the fourth and the fifth grade, and 'an electromagnet' in the sixth grade, while the curriculum in Ontario covers the concept of energy from the first grade. As the grades go up, the contents of electricity and magnetism tend to be more deepen. It also emphasizes enhancing students' ability that they can communicate what they learn about technology with others, and that they can apply their knowledge to other fields as well. Based on this study of the Ontario curriculum, we suggest that it is necessary for us to n Science curriculum from the first grade, so that the students can learn science from the early grade, without a need to run another subject, like practical arts. We also found that the Korean curriculum has an interesting structure for the young students to learn to apply their knowledge to the real life immediately, based on an idea that the topic of 'Manipulating the electric appliances' in practical arts curriculum moves to the Science.

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A Study on Global Nursing Practice Education Experience (글로벌 간호실습 교육 경험에 관한 연구)

  • Cho, Eun Sil;Seo, Myoung Hee;You, Soo Ok;Ahn, Ok Hee;Song, Myeoung Hi
    • Research in Community and Public Health Nursing
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    • v.32 no.4
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    • pp.485-496
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    • 2021
  • Purpose: This study attempted to obtain basic data for developing a global nursing practice education program. Methods: The data collection period was from July 2 to 11, 2020. The study participants were professors with experience in design, operation and management of global nursing practice education or experts with experience in international cooperation projects, and 8 people who agreed to participate in focus group interview (FGI). FGI was conducted twice in total and the directed content analysis method was applied. Results: The categories of 'practice design' are 'growing as a global nursing leader' and 'working together towards one goal'. The categories of 'practice operation' are 'watching, listening, and performing', 'self-directed organizing from preparation to finishing', and 'learning the value of participation rather than grades'. The category of 'practice management' is 'one's own weight to carry'. Conclusion: Global nursing practice education aims one goal - growing as a global nursing leader - and is self-directed course from preparation to an end with watching, listening and performing together. It is about learning the value of participation rather than grades. This can be used as basic data for the design, operation and management of global nursing practice education in the future.

Preoperative short course radiotherapy with concurrent and consolidation chemotherapies followed by delayed surgery in locally advanced rectal cancer: preliminary results

  • Aghili, Mahdi;Sotoudeh, Sarvazad;Ghalehtaki, Reza;Babaei, Mohammad;Farazmand, Borna;Fazeli, Mohammad-Sadegh;Keshvari, Amir;Haddad, Peiman;Farhan, Farshid
    • Radiation Oncology Journal
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    • v.36 no.1
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    • pp.17-24
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    • 2018
  • Purpose: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. Materials and Methods: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin. Total mesorectal excision was done at least 8 weeks after the last fraction of radiotherapy. Primary outcome was complete pathologic response and secondary outcomes were treatment related complications. Results: Thirty-three patients completed the planned preoperative chemoradiation and 26 of them underwent surgery (24 low anterior resection and 2 abdominoperineal resection). Acute proctitis grades 2 and 3 were seen in 11 (33.3%) and 7 (21.2%) patients, respectively. There were no grades 3 and 4 subacute hematologic and non-hematologic (genitourinary and peripheral neuropathy) toxicities and perioperative morbidities such as anastomose leakage. Grade 2 or higher late toxicities were observed among 29.6% of the patients. Complete pathologic response was achieved in 8 (30.8%) patients who underwent surgery. The 3-year overall survival and local control rates were 65% and 94%, respectively. Conclusion: This study showed that SRT combined with concurrent and consolidation chemotherapies followed by delayed surgery is not only feasible and tolerable without significant toxicity but also, associated with promising complete pathologic response rates.

Current Oral Health Care of Elementary School in Chungnam Province, Korea (충남지역 초등학교의 구강보건관리 실태)

  • Bae, Jin-Soon;Chang, Seong-Sil
    • Journal of the Korean Society of School Health
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    • v.13 no.2
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    • pp.331-340
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    • 2000
  • Primary school is regarded as an important period when many health-related behaviors and life-styles begin to be formed. Acquiring them through school heath education has a strong influence on the health promotion of not only the family but also the community. The objectives of this study were to evaluate current oral health care of elementary schools in Chungnam province and to provide information for further development in elementary school oral health. We performed a questionnaire survey to 280 health teachers and among them, 155 teachers answered. The result of this study were as follows: 1. Sixty five percent of the health teachers had little interest in oral health. Major information sources for teaching oral health were books in 58.1% of the 155 teachers and 83.2% of teachers spent 30 minutes to 1hour per day in oral health care practice for the students. 2. Contents of the oral health education were composed of regular and special curriculums, and an average of education time during a semester was 2.6 hours in 3rd grade, and 1.3 hours in first and second grade. 60.6% of the teachers made the children practice the proper method of tooth brushing during the education time. 3. Major problems in oral health education were insufficient time, lack of equipment and difficulty in teaching method. The educational media were tooth models among 91.0% and OHP among 85.2% of the teachers. The tooth model was usually used in first to fourth grades and OHP in fifth to sixth grades. But 63.9% health teachers need to develop stronger educational methods using multimedia. 4. Meanwhile the most important strategy of oral health in urban schools was health education, that of rural schools was fluoride mouth-rinsing programme. Fluoride mouth-rinsing programmes were performed by 60.0% of the elementary school. Periodic dental examination was performed in all elementary schools. 98.2% of the schools sent the results home through school notification letters, but post-examination management was performed in only 67.1% of them 64.5% of the health teachers do follow-ups on the oral disease of the children after the examination. Only 0.7% of the schools have oral health education plans for the students' parents. Considering these major strategies for elementary school oral health care were health education, practicing proper methods of tooth brushing, periodic dental examinations, and fluoride mouth-rinsing programmes. But health teachers need more time for oral health education, practicing and management, and developing education materials. With regard to the high demand for oral health education and poor follow-up after periodic examination, the oral health education in elementary school should be considered as a formal educational course for more proper management of oral health, including application of major strategies to the children in earlier grades and efforts for increasing recognition and participation of the parents.

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An Investigation of Applications of 'Maths With Attitude' Manipulative Materials ('Maths With Attitude' 조작교구의 활용방안 탐색)

  • Kim, Mi-Hwa;Kim, Sung-Joon
    • Journal of the Korean School Mathematics Society
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    • v.12 no.4
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    • pp.523-544
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    • 2009
  • The object of this study is to analyze manipulative materials in the Pattern & Algebra field of Maths300-Maths with Attitude, Australian school mathematics program with manipulative materials to search meaningful ways for school mathematics. To accomplish these projects, 20 manipulative materials in the Pattern & Algebra field of the Maths with Attitude are introduced and each manipulative materials can be used are searched according to grades and fields of Korean educational course. And 4 mathematics classes for 3rd and 5th grades(two for each grades) with manipulative materials are performed and effect of these classes are examined by recorded data and students' opinions are inquired by questionnaire. First, We analyze Pattern & Algebra of the Maths with Attitude 20 manipulative materials such as 4ARM SHAPES, ADDITION TOTALS, ICE CREAM FLAVOURS, THE LAND OF ET, etc. In this analysis, plans for utilizing the manipulative materials are categorized in 9 types. Second, by students' handling these kinds of manipulative materials in classes, their interest in mathematics is increased and voluntary and creative classes out of the conventional ones can be made. Also, students' self-confidence in mathematics and active participation is animated. This kind of manipulative materials are introduced in the educational field of elementary schools, plans for utilizing the teaching aids in the field are analyzed, the teaching aids are practically applied to classes, and the effect and meanings for mathematics classes are examined. With this research, another researches about the introduction and utilization of other various manipulative materials for motivating students to efficiently understand what they learn in mathematics class of elementary schools are required.

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