• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.1
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• pp.45-49
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• 2022

With the development of monoclonal antibodies, therapeutic or diagnostic radioisotope has been successfully delivered at tumor sites with high selectivity for antigens. Different approaches have been applied to improve the tumor-to-normal ratio by considering the in vivo stability of radioimmunoconjugates as a prerequisite. Various stable and inert antibody radiolabeling techniques for radioimmunoconjugate preparation have been extensively evaluated to enhance in vivo stability. Antibody radiolabeling techniques should be rapid and easy; they should not disrupt the immunoreactivity and in vivo behavior of antibodies, which are coupled with a bifunctional chelator (BFC) to stably coordinate with a radiometal. For the design of BFCs, radiometal coordination properties must be considered. However, various diagnostic radionuclides, such as ⁸⁹Zr, ⁶⁴Cu, ⁶⁸Ga, ¹¹¹ln, and ^99mTc, or therapeutic radionuclides, such as ¹⁷⁷Lu, ⁶⁷Cu, ⁹⁰Y, and ²²⁵Ac, have been increasingly used for antibody radiolabeling. In addition to useful radionuclides, ⁶⁴Cu and ¹⁷⁷Lu with the most accessible or the highest production rates in many countries should be considered. In this review, we mainly discussed antibody radiolabeling techniques and conditions that involve ⁶⁴Cu and ¹⁷⁷Lu radiometals.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3133-3139
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• 2023

Neutron imaging technology as a means of non-destructive detection of materials is complementary to X-ray imaging. Silicon photomultiplier (SiPM), a new type of optical readout device, has overcome some shortcomings of traditional photomultiplier tube (PMT), such as high-power consumption, large volume, high price, uneven gain response, and inability to work in strong magnetic fields. Its application in the field of neutron detection will be an irresistible general trend. In this paper, a thermal neutron imaging detector based on ⁶LiF/ZnS scintillation screen and SiPM array readout was developed. The design of the detector geometry was optimized by geant4 Monte Carlo simulation software. The optimized detector was evaluated with a step wedge sample. The results show that the detector prototype with a 48 mm × 48 mm sensitive area can achieve about 38% detection efficiency and 0.26 mm position resolution when using a 300 ㎛ thick ⁶LiF/ZnS scintillation screen and a 2 mm thick Bk7 optical guide coupled with SiPM array, and has good neutron imaging capability. It provides effective data support for developing high-performance imaging detectors applied to the China Spallation Neutron Source (CSNS).

• Journal of the Korean Geotechnical Society
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• v.22 no.4
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• pp.61-71
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• 2006

A numerical procedure is presented fur evaluating seismic liquefaction on sloping ground sites. The procedure uses a fully coupled dynamic effective stress analysis with a plastic constitutive model called UBCSAND. The model was first calibrated against laboratory element behavior. This involved cyclic simple shear tests performed on loose sand with and without initial static shear stress. The numerical procedure is then verified by predicting a centrifuge test with a slope performed on loose Fraser River sand. The predicted excess pore pressures, accelerations and displacements are compared with the measurements. The results are shown to be in good agreement. The shear stress reversal patterns depend on static and cyclic shear stress levels and are shown to play a key role in evaluating liquefaction response in sloping ground sites. The sand near the slope has low effective confining stress and dilates more. When no stress reversals occur, the sand behaves in a stiffer manner that curtails the accumulated downslope displacements. The numerical procedure using UBCSAND can serve as a guide for design of new soil structures or retrofit of existing ones.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.4B
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• pp.389-397
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• 2010

This study introduced a Bayesian based frequency analysis in which the statistical trend analysis for hydrologic extreme series is incorporated. The proposed model employed Gumbel extreme distribution to characterize extreme events and a fully coupled bayesian frequency model was finally utilized to estimate design rainfalls in Seoul. Posterior distributions of the model parameters in both Gumbel distribution and trend analysis were updated through Markov Chain Monte Carlo Simulation mainly utilizing Gibbs sampler. This study proposed a way to make use of nonstationary frequency model for dynamic risk analysis, and showed an increase of hydrologic risk with time varying probability density functions. The proposed study showed advantage in assessing statistical significance of parameters associated with trend analysis through statistical inference utilizing derived posterior distributions.

• Structural Engineering and Mechanics
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• v.88 no.2
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• pp.117-128
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• 2023

On February 6, 2023, Türkiye woke up with a strong ground motion felt in a wide geography. As a result of the Kahramanmaraş, Pazarcık and Elbistan earthquakes, which took place 9 hours apart, there was great destruction and loss of life. The 2023 Kahramanmaraş earthquakes occurred on active faults known to pose a high seismic hazard, but their effects were devastating. Seismic code spectra were investigated in Hatay, Adıyaman and Kahramanmaraş where destruction is high. The study mainly focuses on the investigation of ground motion parameters of 6 February Kahramanmaraş earthquakes and the correlation between ground motion parameters. In addition, earthquakes greater than Mw 5.0 that occurred in Türkiye were compared with certain seismic parameters. As in the strong ground motion studies, seismic energy parameters such as Arias intensity, characteristic intensity, cumulative absolute velocity and specific energy density were determined, especially considering the duration content of the earthquake. Based on the study, it was concluded that the structures were overloaded far beyond their normal design levels. This, coupled with significant vertical seismic components, is a contributing factor to the collapse of many buildings in the area. In the evaluation made on Arias intensity, much more energy (approximately ten times) emerged in Kahramanmaraş earthquakes compared to other Türkiye earthquakes. No good correlation was found between moment magnitude and peak ground accelerations, peak ground velocities, Arias intensities and ground motion durations in Türkiye earthquakes. Both high seismic components and long ground motion durations caused intense energy to be transferred to the structures. No strong correlation was found between ground motion durations and other seismic parameters. There is a strong positive correlation between PGA and seismic energy parameter AI. Kahramanmaraş earthquakes revealed that changes should be made in the Turkish seismic code to predict higher spectral acceleration values, especially in earthquake-prone regions in Türkiye.

• Journal of Korean Academy of Nursing
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• v.53 no.6
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• pp.666-677
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• 2023

Purpose: This study was intended to evaluate the effects of an Infant Health Promotion Program (IHPP) for mothers with their firstborn infants. Methods: This study employed a non-equivalent control group pretest-posttest design. The participants consisted of 17 mothers with their firstborn infants in the experimental group and 17 in the control group from two women's hospitals. The experimental group received eight sessions of the program for four weeks. The collected data were analyzed using the chi-square test and repeated-measures ANOVA using an SPSS/WIN ver. 22.0. Results: The experimental group receiving the program had statistically significant higher levels of infant health promotion knowledge (F = 22.91, p < .001), social support (F = 27.64, p < .001), maternal role confidence (F = 8.25, p = .005) and health promotion behavior for infants (F = 16.85, p < .001) than the control group. The experimental group had a statistically significant lower level of parenting stress than the control group (F = 29.93, p < .001). Conclusion: The study's findings indicate that the IHPP is effective in improving health promotion knowledge, social support, and maternal role confidence and decreasing parenting stress among mothers with their firstborn infants. A method of delivering intervention, focused on readily accessible online platforms, coupled with intervention strategies grounded in the theory of self-efficacy, proves to be an advantageous approach for this particular target group.

• Journal of the Korean GEO-environmental Society
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• v.25 no.7
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• pp.5-19
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• 2024

During the blasting process, a fracture zone is formed in the vicinity of the blast hole. Any damage that extends beyond the excavation boundary line necessitates the implementation of an additional support system to assure safety. Typically, fracture zone radius is estimated from blast hole pressure using theoretical methods due to its simplicity. However, linear charge concentration (kg/m) is used for tunnel blasting. This paper compiles Swedish experimental datasets to estimate the radius of fracture zones based on linear charge concentration. Further numerical analyses are performed in LS-DYNA for coupled single-hole blasting. The Riedel-Hiermaier-Thoma (RHT) model has been selected as the constitutive model for this investigation. The numerical model is validated against small-scale laboratory tests. Parametric studies are conducted to predict fracture zones in granite and sandstone rocks using two kinds of explosives, PETN and AFNO. The analyses evaluate ten types of blast hole sizes, ranging from 17 to 100 mm. The results indicate that granite has a larger fracture zone than sandstone, and the PETN explosive predicts more damage than ANFO. Smaller blast holes exhibit smaller fracture zones in comparison to larger blast holes. Wave propagation is more rapidly attenuated in granite than in sandstone. Subsequently, the predicted fracture zone outcomes are compared with the empirical dataset. Fracture zones of medium blast hole diameter align well with the experimental data set. A predictive equation is derived from the data set, which may be used to evaluate blast design to manage fracture zones beyond the excavation line.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.216-221
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• 2024

Ion cyclotron range of frequency (ICRF) heating system is an important auxiliary heating method in the experimental Advanced Superconducting Tokamak (EAST). In EAST, several megawatts of power are transmitted with coaxial transmission lines and coupled to the plasma. For the long pulse and high power operation of the ICRF waves heating system, it is very important to effectively control the power and initial phase of the ICRF signals. In this paper, a power and phase feedback control system is described based on field programmable gate array (FPGA) devices, which can realize complicated algorithms with the advantages of fast running and high reliability. The transmitted power and antenna phase are measured by a power and phase detector and digitized. The power and phase feedback control algorithms is designed to achieve the target power and antenna phase. The power feedback control system was tested on a dummy load and during plasma experiments. Test results confirm that the feedback control system can precisely control ICRF power and antenna phase and is robust during plasma variations.

• Structural Engineering and Mechanics
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• v.90 no.4
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• pp.325-343
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• 2024

Triple-tower double-cable suspension bridges have increased confinement stiffness imposed by the main cable on the middle tower, which has bright application prospects. However, vertical bending and torsional vibrations of the double-cable and the girder are coupled in such bridges due to the hangers. In particular, the bending vibration of the towers in the longitudinal direction and torsional vibrations about the vertical axis influence the vertical bending and torsional vibrations of the stiffening girders, respectively. The conventional analytical algorithm for assessing the dynamic features of the suspension bridge is not directly applicable to this type of bridge. This study attempts to mitigate this problem by introducing an analytical algorithm for solving the triple-tower double-cable suspension bridge's natural frequencies and mode shapes. D'Alembert's principle is employed to construct the differential equations of the vertical bending and torsional vibrations of the stiffening girder continuum in each span. Vibrations of stiffening girders in each span are interrelated via the vibrations of the main cables and the bridge towers. On this basis, the natural frequencies and mode shapes are derived by separating variables. The proposed algorithm is then applied to an engineering example. The natural frequencies and mode shapes of vertical bending and torsional vibrations derived by the analytical algorithm agreed well with calculations via the finite element method. The fundamental frequency of vertical bending and first- and second-order torsion frequencies of double-cable suspension bridges are much higher than those of single-cable suspension bridges. The analytical algorithm has high computational efficiency and calculation accuracy, which can provide a reference for selecting appropriate structural parameters to meet the requirements of dynamics during the preliminary design.

• Journal of Korean Society on Water Environment
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• v.39 no.6
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• pp.465-474
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• 2023

The chemical composition and molecular weight characteristics of dissolved organic matter (DOM) exert a profound influence on the efficiency of organic matter removal in water treatment systems, acting as efficiency predictive indicators. This research evaluated the primary chemical and molecular weight properties of DOM derived from diverse sources, including rivers, lakes, and biomasses, and assessed their relationship with the efficiency of coagulation/flocculation treatments. Dissolved organic carbon (DOC) removal efficiency through coagulation/flocculation exhibited significant correlations with DOM's hydrophobic distribution, the ratio of humic-like to protein-like fluorescence, and the molecular weight associated with humic substances (HS). These findings suggest that the DOC removal rate in coagulation/flocculation processes is enhanced by a higher presence of HS in DOM, an increased influence of externally sourced DOM, and more presence of high molecular weight compounds. The results of this study further posit that the efficacy of water treatment processes can be more accurately predicted when considering multiple DOM characteristics rather than relying on a singular trait. Based on major results from this study, a predictive model for DOC removal efficiency by coagulation/flocculation was formulated as: 24.3 - 7.83 × (fluorescence index) + 0.089 × (hydrophilic distribution) + 0.102 × (HS molecular weight). This proposed model, coupled with supplementary monitoring of influent organic matter, has the potential to enhance the design and predictive accuracy for coagulation/flocculation treatments targeting DOC removal in future applications.