• 국제지역연구
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• 제13권1호
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• pp.445-464
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• 2009

현재 세계 여러 나라는 GATS의 통신에 관한 예외규정에 입각하여 기간통신서비스의 국경간 공급을 반경쟁행위 통제, 국내 소비자 보호, 조세부과, 국가안보 등을 이유로 규제하고 있다. 우리나라의 경우 통신서비스의 국경간 공급을 WTO 및 국내법의 규정을 통하여 부분적으로 규제를 시행하고 있으나, WTO 및 FTA 협상시 국경간 공급에 대한 규제완화를 요구받고 있다. 그러므로 규제에 대하여 실효성 파악하고 이에 대한 대응이 절실히 요구되고 있다. 따라서 본고에서는 주요국의 통신서비스의 국경간 공급 정책을 살펴보았다. 또한 주요국의 실제 규제 사례를 살펴봄으로써 우리나라의 국경간 공급 규제정책에 대한 시사점을 모색해 보았다.

• 한국재난정보학회 논문집
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• 제15권1호
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• pp.49-66
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• 2019

연구목적: 본 연구는 드론의 테러위협으로부터 민간 다중이용시설이 안전하고 유익하게 사용될 수 있도록, 민간시설의 드론테러 방어를 위한 법제도의 개선방안을 제시하고자 한다. 연구방법:연구를 위해 국가가 민간시설에 대해 시행하고 있는 대테러활동 운영실태를 조사 분석하였으며, 국외의 모범사례를 기술하고 비교하여 국내에 필요한 드론테러에 대한 국가 대테러정책의 방향을 제시하고 있다. 연구 결과: 국내 드론테러에 대한 법제도 한계점에 대하여 연구한 결과, 국내 적용 가능한 안티드론 기술을 구축 활용하기 어려워짐에 따라 드론테러에 대한 위협 뿐만 아니라, 사생활 침해, 스토킹 등의 범죄에도 취약점이 드러났다. "전파법과" 정보보호관련 법률 등 국민의 안전에 관한 법률은 안티드론기술의 도입을 방해하는 장애요인이 되고 있으므로 본 논문에서 제시하고 있는 법제도의 개선이 요구된다. 결론: 본 연구를 통해 민간시설 드론테러 취약요인과 피해경감대책의 법제도적 한계점과 개선방안을 하였다. 따라서 본 연구의 개선방안을 검토하여 드론테러의 대책방안이 마련되어야 한다.

• BMB Reports
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• 제35권6호
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• pp.623-628
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• 2002

The Th1 vs. Th2 balance is critical for the maintenance of immune homeostasis. Therefore, the genes that are selectively-regulated by the Th1 and Th2 cytokines are likely to play an important role in the Th1 and Th2 immune responses. In order to search for and identify the novel target genes that are differentially regulated by the Th1/Th2 cytokines, the human PBMC mRNAs differentially expressed upon the stimulation with IL-4 or IL-12, were screened by employing the differential display-polymerase chain reaction. Among a number of clones selected, DC21 was identified as a novel target gene that is regulated by IL-4 and IL-12. The DC21 gene expression was up-regulated either by IL-4 or IL-12, yet counter-regulated by co-treatment with IL-4 and IL-12. DC21 is a dendritic cell protein with an unknown function. The sequence analysis and conserved-domain search revealed that it has two AU-rich motifs in the 3'UTR, which is a target site for the regulation of mRNA stability by cytokines, and that it belongs to the N-acetyltransferase family. The induction of DC21 by IL-12 peaked around 8-12 h, and lasted until 24 h. LY294002 and SB203580 significantly suppressed the IL-12-induced DC21 gene expression, which implies that PI3K and p38/JNK are involved in the IL-12 signal transduction pathway that leads to the DC21 expression. Furthermore, tissue blot data indicated that DC21 is highly expressed in tissues with specialized-resident macrophages, such as the lung, liver, kidney, and placenta. Together, these data suggest a possible role for DC21 in the differentiation and maturation of dendritic cells regulated by IL-4 and IL-12.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2006년도 추계공동학술대회
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• pp.361-365
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• 2006

Air pollution problem has been one of the most urgent global environmental problems since UN Framework Convention on Climate Change accepted in Rio Conference, 1992. International environmental regulations of global community to reduce the green house gases have Influenced the domestic environmental policies. Recently, various policy have been made to cope with foreign environment restrction and active supports for development of related technology have been carried out in our government confrontation strategy still leaves much to be desired. In this paper, government confrontation program to climate agreement, counter strategies in motor and also electrics, electronics industries are investigated and discussed.

• 한국정보통신학회논문지
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• 제13권2호
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• pp.207-214
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• 2009

본 연구에서는 결합상품 서비스 제공에 대한 경제적 이론을 분석한다. 먼저, 번들링의 부정 적 측면을 강조한 연구에 대해 분석한다. 그 다음에는 번들링의 경쟁중립적 효과에 대한 연구를 분석한다. 이는 번들링의 부정적 측면에 대한 반박이라 할 수 있다. 그 다음에는 번들링에 영향을 주는 주요 상환들을 정리하고 각 상황하에서 번들링의 제반 효과에 대해 분석한다. 번들링은 경쟁기업을 저지함으로써, 사회 전체의 효율을 떨어뜨리기는 하지만, 어떠한 경우에는 경쟁을 저지하는 역할을 수행하지 않고 오히려 후생을 증대시키는 역할도 한다. 마지막으로 순수번들링에 대한 허가기준, 동등접속의 요건 설정, 결합요금규제로서 할인율 제도, 사전규제와 사후규제, 그리고 요금적 정성 규제에서 약탈적 가격에 대한 기준 등 번들링에 대한 정책적 접근방안을 제시한다.

• Clinical and Experimental Pediatrics
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• 제48권3호
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• pp.251-259
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• 2005

Atopy is a highly prevalent and serious health problem. The prevalence and severity of asthma and allergic diseases have increased over recent decades, particularly in industrialized nations. Early life infections may protect against the development of atopy and allergic diseases like asthma. The inverse relationship between the incidence of atopy and childhood infections has led to the 'hygiene hypothesis', which suggests that diminished exposure to childhood infections in modern society has led to decreased Th1-type responses. Th1 and Th2 responses are counter-regulatory. Reduced Th1 may lead to enhanced Th2-type inflammation, which is important in promoting asthma and allergic disease via up-regulation of IL-4, IL-5, and IL-13. It is now widely accepted that altered regulation of Th2 responses(and possibly the balance between Th1 and Th2 responses) is an important factor in the development of atopy. CpG DNA represent a novel class of drugs with substantial immunomodulatory properties. CpG DNA contain unmethylated motifs centered on the CpG dinucleotides, like bacterial DNA. These CpG DNA promote Th1 and regulatory type immune responses and suppress Th2 responses. In murine studies, CpG DNA are effective in prevention and treatment of asthma and allergic diseases. CpG DNA are just beginning to be tested in human asthma. While its precise mechanisms continue to be fully studied, CpG DNA offers considerable promise as a novel treatment for atopic inflammation. It may prove to be an important disease modifying therapy, or even curative therapeutic agent for asthma and allergic diseases.

• 한국분무공학회지
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• 제17권4호
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• pp.185-191
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• 2012

Particulate matters (PM) that is generated by most diesel engine is regulated by the mass concentration measured by the conventional method it had been. Recently, Europe PMP (Particle Measurement Program) decided to start the regulation of vehicle's nano-sized particle number (PN) from the year of 2011 because of nano-particle's higher degree of harm to the human body. So firstly, the standard level of PN emission is introduced in the Euro 5/6 emissions regulation with a limit of $6{\times}10^{11}$ per km for light duty vehicle. Also KPMP(Korea Particle Measurement Program) was organized to copy quickly international technical trend. In this paper, it was investigated the nano-sized PN measurement characteristics for different particle generators between spray type and soot type. And the difference ratio between particle generators, the characteristic of PN concentration, counting efficiency and linearity was analyzed. Then, we make conclusions as followed. When particle diameter is increased, counting efficiency of two generators is decreased. Also Secondary calibration method is more higher 3% than Primary calibration method. Finally, SOF which is included in soot particles is not totally removed so it have great influence on test result of counting efficiency and linearity.

• 한국물환경학회지
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• 제22권5호
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• pp.807-814
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• 2006

Sapkyo Lake Watershed occupies about 19.3% of total area of Chungnam Province, and it is necessary to make a plan of counter-measure for the maintenance of public waterbody sound as well as to ensure water resources due to urbanization and industrialization in this area so densely populated and excessively developed. Conventionally water quality management has been enforced by concentration-based system which is not considered the carrying capacity of receptors, hence there are no proper measures for the prevention of an excessive pollutant load over a waterbody. So even though emission sources abide by the conventional permission regulation, then the quantity of wastewater is increased continuously and encountered water shortage to use finally. Therefore this research focused on the review of introduction of total water quality management system in Sapkyo Lake watershed to maintain public waterbody sound and to ensure water resources. By doing this research in introduction of the system in advance, it can contribute to establish the methodology on systematic water quality management. Also the application of this system in Sapkyo Lake watershed can promote the sustainable development of the area by harmonizing the environment and regional economy ultimately.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 춘계학술대회
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• pp.103-112
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• 2001

Bone homeostasis is maintained by a balance between activities of osteoblasts(bone forming cells) and osteoclasts (bone resorbing cells). The activities of these cells are closely regulated by multiple factors including hormones and cytokines. The cessation of estrogen at menopause disrupts the balanced regulation and is the main cause of osteoporosis in postmenopausal women. Recent molecular biological studies led to a discovery of tumor necrosis factor(TNF) and TNF receptor families genes that play critical roles in the regulation of osteoclast formation and function. RANKL (receptor activator of nuclear factor kappa B ligand; also called ODF, TRANCE, and OPGL) expressed on cells supporting osteoclast is essential for osteoclast differentiation, activation, and survival. RANK, the counter-receptor for RANKL, is expressed on progenitor and mature osteoclasts. The interaction between RANKL and RANK is requlated by a soluble decoy receptor OPG (osteoprotegerin). Gene knock out studies of these molecules showed profound effects on bone. These results prompted development of new strategies for treatment of bone diseases. Inhibition of osteoclast activity by blocking the RANKL-RANK interaction using OPG is being attempted. Research on the signaling pathways of RANK is also actively carried out. Screening natural products that inhibit the RANKL-RANK interaction or the activity of obteoclasts would be another effective means to a new drug target for bone resorbing diseases.

• Journal of Microbiology and Biotechnology
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• 제32권11호
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• pp.1447-1453
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• 2022

Prohibitin 1 (Phb1) is a pleiotropic protein, located mainly in the mitochondrial inner membrane and involved in the regulation of cell proliferation and the stabilization of mitochondrial protein. Acetaminophen (APAP) is one of the most commonly used over-the-counter analgesics worldwide. However, at high dose, the accumulation of N-acetyl-p-benzoquinone imine (NAPQI) can lead to APAP-induced hepatotoxicity. In this study, we sought to understand the regulation of mRNA expression in relation to APAP and GSH metabolism by Phb1 in normal mouse AML12 hepatocytes. We used two different Phb1 silencing levels: high-efficiency (HE, >90%) and low-efficiency (LE, 50-60%). In addition, the siRNA-transfected cells were further pretreated with 0.5 mM of Sadenosylmethionine (SAMe) for 24 h before treatment with APAP at different doses (1-2 mM) for 24 h. The expression of APAP metabolism-related and antioxidant genes such as Cyp2e1 and Ugt1a1 were increased during SAMe pretreatment. Moreover, SAMe increased intracellular GSH concentration and it was maintained after APAP treatment. To sum up, Phb1 silencing and APAP treatment impaired the metabolism of APAP in hepatocytes, and SAMe exerted a protective effect against hepatotoxicity by upregulating antioxidant genes.