• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• Journal of Information Technology and Architecture
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• v.9 no.4
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• pp.401-411
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• 2012

There has been increased interest for cloud computing services that can promote cost savings while increasing investment in information resources. Cloud computing, however, has a disadvantage physically located in the external information resources to take advantage of the economic benefits, the advantages and increase the vulnerability of information protection and control of information assets. In this study, due to the unique properties of the new services, including vulnerability, the vulnerability of cloud computing derive the vulnerability of cloud computing and control items were derived through the mapping between vulnerability and control items, that are not being managed to identify vulnerabilities Cloud computing risk factors are presented.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2000.06a
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• pp.34-39
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• 2000

Today's size of production operations in the packaging paper sector I sconstantly increasing , featuring integral processing systems, high-speed paper machines, and the increased marketing of lower basis weight products. The risk factors involved in these large investments lie more than ever in the available furnish potential and ongoing requirements for further closure of water loops and lower operating costs. A comparison is drawn between recovered paper furnish mixtures used in European mills with regard to fibre properties, strength potential and contaminant content, Both the furnish situation and development trends in modern fluting and testliner machines are instigating concept changes in stock preparation, the approach flow as well as in process water and rejects technology. Developments are currently focussed for example on more efficient debris separation using fine slotted screening, optimized refining , more systematic process water management with loop separation and integral water clarification as well as more efficient removal of microstickies, fillers and fines through appropriate combination of rejects handling and water clarification processes. Product quality differentiation depends decisively on strength characteristics as a function of refining , fines removal , paper machine technology, and sizing . Maximum availability of today's high speed paper machines and , as a result, cost effective production can be ensured by optimum balancing of all subsystems with in the overall concept and by reliable control of problems with contaminants and deposits.

• Advances in environmental research
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• v.11 no.1
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• pp.17-30
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• 2022

Road transport allows all forms of land conditions to be met at less cost. Because of this function, despite numerous disadvantages, it becomes the most frequently used method of transport, especially in underdeveloped or developing countries. One of the most significant factors used in evaluating the atmosphere's air quality is the amount of CO₂, increasing people's density in indoor spaces. The amount of CO₂ indoors is, therefore, vital to determine. In this study, CO₂ and temperature measurements made on nine different bus journey was made in Turkey. The minimum and maximum values were recorded as 555 ppm and 3000 ppm CO₂, respectively, in the measurements. On all journeys, the average concentration is 1088.72 ppm. The minimum and maximum values were measured as 17.4℃ and 32.7℃ in the temperature measurements, and the average of all trips was calculated to be 25.76℃. In this study conducted before the Covid-19 pandemic, it was determined that the amount of CO₂ increased with the density and insufficient ventilation in the buses. The risk of infection increases in places with high human density and low clean air. For situations such as pandemics, CO₂ measurement is a rapid indicator of determining human density.

• Clinical Nutrition Research
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• v.12 no.2
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• pp.138-153
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• 2023

The prevalence of metabolic syndrome (MetS) and its cost are increasing due to lifestyle changes and aging. This study aimed to develop a deep neural network model for prediction and classification of MetS according to nutrient intake and other MetS-related factors. This study included 17,848 individuals aged 40-69 years from the Korea National Health and Nutrition Examination Survey (2013-2018). We set MetS (3-5 risk factors present) as the dependent variable and 52 MetS-related factors and nutrient intake variables as independent variables in a regression analysis. The analysis compared and analyzed model accuracy, precision and recall by conventional logistic regression, machine learning-based logistic regression and deep learning. The accuracy of train data was 81.2089, and the accuracy of test data was 81.1485 in a MetS classification and prediction model developed in this study. These accuracies were higher than those obtained by conventional logistic regression or machine learning-based logistic regression. Precision, recall, and F1-score also showed the high accuracy in the deep learning model. Blood alanine aminotransferase (β = 12.2035) level showed the highest regression coefficient followed by blood aspartate aminotransferase (β = 11.771) level, waist circumference (β = 10.8555), body mass index (β = 10.3842), and blood glycated hemoglobin (β = 10.1802) level. Fats (cholesterol [β = -2.0545] and saturated fatty acid [β = -2.0483]) showed high regression coefficients among nutrient intakes. The deep learning model for classification and prediction on MetS showed a higher accuracy than conventional logistic regression or machine learning-based logistic regression.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.15-23
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• 2016

Polycyclic aromatic hydrocarbons (PAHs) are primarily formed as a result of thermal treatment of food, especially barbecuing or grilling. Contamination by PAHs is due to generation by direct pyrolysis of food nutrients and deposition from smoke produced through incomplete combustion of thermal agents. PAHs are ubiquitous compounds, well-known to be carcinogenic, which can reach the food in different ways. As an important human exposure pathway of contaminants, dietary intake of PAHs is of increasing concern for assessing cancer risk in the human body. In addition, the risks associated with consumption of barbecued meat may increase if consumers use cooking practices that enhance the concentrations of contaminants and their bioaccessibility. Since total PAHs always overestimate the actual amount that is available for absorption by the body, bioaccessibility of PAHs is to be preferred. Bioaccessibility of PAHs in food is the fraction of PAHs mobilized from food matrices during gastrointestinal digestion. An in vitro human digestion model was chosen for assessing the bioaccessibility of PAHs in food as it offers a simple, rapid, low cost alternative to human and animal studies; providing insights which may not be achievable in in vivo studies. Thus, this review aimed not only to provide an overview of general aspects of PAHs such as the formation, carcinogenicity, sources, occurrence, and factors affecting PAH concentrations, but also to enhance understanding of bioaccessibility assessment using an in vitro digestion model.

• Survey Research
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• v.10 no.2
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• pp.97-114
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• 2009

Even the importance and necessity of a basic national statistical survey, the population and housing census is facing with some practical difficulties such as higher survey cost, decrease of survey information and much longer survey period. As an alternative to the traditional census for tackling such difficulties, a rolling census has been introduced. The rolling census has some advantages such as improved timeliness with much more frequent data and evenly distributed survey cost over several years. On the contrary, the rolling census has also some disadvantages such as the lost of snapshot feature of the population and increasing risk of outside influence on field work. In this paper we reviewed the French rolling census and the American community survey as roiling surveys, and then investigated some factors like balanced sample selection, population update, synthetic estimation, and the operation of rolling survey, which are to be checked carefully in case of introducing a rolling census as an alternative to the current census.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.1 no.2
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• pp.117-121
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• 2008

Prolotherapy can be defined as the injection of growth factors or growth factor production stimulants to grow normal cells or tissue. Even though it has been a controversal procedure for decades, it is currently gaining in popularity among many physicians. The term prolotherapy was coined by Hacket in the 1950s to imply proliferation of normal tissue at ligamentous and tendinous entheses. The procedure has been described by other terms, such as sclerotherapy, regenerative injection therapy, and stimulated ligament repair. Incomplete healing from sprains or strains is common and can lead to chronic pain, joint instability and laxity, and is a risk factor for the development of osteoarthritis. Prolotherapy is commonly used for these musculoskeletal conditions which are refractory to usual care therapies. The proliferant solution and technique varies according to physicial training and preferance. Commonly reported proliferants include 10% to 25% dextrose, P2G and sodium morrhuate. High resolution ultrasound imaging of musculoskeletal tissue is increasing in popularity because of patient tolerability, low cost, ability to visualize tissue in real time motion and superior resolution of highly organized tissue such as a tendon. This procedure can be introduced by ultrasound imaging and tissue growth and repair after this procedure in a tendon or a ligament can be documented with ultrasound.

• Journal of the Korea Institute of Building Construction
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• v.22 no.3
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• pp.269-280
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• 2022

With property values of buildings rising, interior construction works are also increasing globally. Interior construction technology has developed into building information modeling(BIM) that can estimate and integrate material quantities. Two-dimensional(2D) drawings and three-dimensional (3D) modeling are becoming a trend owing to the demanding on-site cost and process. 2D drawings and 3D modeling have both advantages and disadvantages that give rise to defects during interior construction work. The field problems, 2D drawings, 3D modeling, and preliminary risk factors of interior construction work were analyzed to identify real problems. Based on the problem analysis, various problems were derived, such as (1) communication with purchasers, (2) communication with workers, and (3) comprehension of the drawings. In this study, a checklist for quality improvement of interior construction was proposed to address the aforementioned issues.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.29-38
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• 2023

Recent studies have highlighted the link between diseases and inflammation across our lifespan. Our sedentary lifestyle, high-calorie diet, chronic stress, chronic infections, and exposure to pollutants and xenobiotics, collectively intensify the course and recurrence of infections and inflammation in our bodies, promoting the prevalence of chronic diseases and aging. Given such phenomena and considering additional factors such as the frequency of prescription, and easy access to over-the-counter drugs, the need for anti-inflammatory therapeutics is ever-increasing. However, the readily available anti-inflammatory treatment option comes with a greater risk of side effects or high cost (biologics). Therefore in this growing competition of discovering and developing new potent anti-inflammatory drugs, we focused on utilizing the established knowledge of traditional medicine to find lead compounds. Since lead optimization is an indispensable step toward drug development, we applied this concept for the production of potent anti-inflammatory compounds achieved by structural modification of flavonoids. The derivative obtained through acetylation of myricetin, 3,3',4',5,5',7-hexaacetate myricetin, showed a greater inhibitory effect in the production of pro-inflammatory mediators such as nitric oxide, Prostaglandin E₂, and pro-inflammatory cytokines like interleukin-6, interleukin1β, in lipopolysaccharide-stimulated RAW264.7 mouse macrophage cells compared to myricetin. The increased potency of inhibition was in conjunction with an increased inhibitory effect on inducible nitric oxide synthase and cyclooxygenase-2 proteins. Through such measures, this study supports lead optimization for well-established lead compounds from traditional medicine using a simpler and greener chemistry approach for the purpose of designing and developing potent anti-inflammatory therapeutics with possibly fewer side effects and increased bioavailability.