• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.62-63
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• 1998

In this paper, a new method to find the corpus callosum from sagittal brain MR images is proposed, which uses the statistical characteristics and shape information of corpus callosum. First, we extract regions satisfying the statistical characteristics of the corpus callosum and then find a region matching the shape information. In order to match the shape information, a new directed window region growing algorithm is proposed instead of using conventional contour matching algorithms. Using the proposed algorithm, we adaptively relax the statistical requirement until we find a region matching the shape information. Experiments show very promising results.

• 대한의용생체공학회:의공학회지
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• 제20권1호
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• pp.59-68
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• 1999

본 논문에서는 뇌량의 형태정보와 통계적 특성을 이용한 중앙시상 두뇌자기공명영상의 뇌량자동인식 알고리즘을 제안한다. 제안된 알고리즘에서는 우선 뇌량의 통계적 특성에 일치하는 영역들을 추출하고 형태정보와 일치하는 영역을 검출한다. 이러한 형태정합을 위해 기존의 윤곽정합알고리즘 대신에 통계적인 특성을 적응적으로 변화시켜 형태정보와 일치하는 영역을 검출하는 방향성 창영역확장 알고리즘을 제안하였다. 실험결과 제안된 알고리즘의 우수성을 확인할 수 있었다.

• Journal of Trauma and Injury
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• 제37권1호
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• pp.79-82
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• 2024

The potential for traumatic brain injury resulting from falling coconuts is frequently overlooked. These incidents can cause focal lesions in the form of brain hemorrhage. Corpus callosum hemorrhage due to blunt trauma from a falling object is rare and typically associated with poor prognosis. The purpose of this report is to detail a case of corpus callosum hemorrhage caused by a coconut fall and to discuss the conservative management approach employed. We report the case of a 54-year-old woman who was admitted to the hospital with symptoms of unconsciousness, headache, and expressive aphasia after being struck by a falling coconut. Notably, hemorrhage was detected within the body of the corpus callosum, as revealed by imaging findings. The patient received intensive monitoring and treatment in the intensive care unit, including oxygen therapy, saline infusion, an osmotic diuretic, analgesics, and medication to prevent stress ulcers. The patient demonstrated marked clinical improvement while undergoing conservative treatment. Despite the typically unfavorable prognosis of these rare injuries, our patient exhibited meaningful clinical improvement with conservative treatment. Timely diagnosis and appropriate interventions were crucial in managing the patient's condition. This report emphasizes the importance of considering traumatic brain injury caused by falling coconuts and highlights the need for further research and awareness in this area.

• Clinical and Experimental Pediatrics
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• 제51권11호
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• pp.1205-1210
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• 2008

목 적: 뇌자기공명영상에서 정상소견을 보인 신생아와 뇌실주위 백질연화증을 보인 보인 미숙아와 저산소성 뇌손상 소견이 보이는 만삭아의 뇌량 크기를 비교하고 양적으로 분석하여 뇌량의 크기가 신생아시기에 신경학적 경과에 유용한 지표가 될 수 있는가에 대한 평가를 하고자 하였다. 방 법: 2002년 9월부터 2005년 2월까지 원광대학교병원에서 출생한 신생아에서 경련, 주산기 가사, 소두증, 늘어지는 영아증후군(floppy infant syndrome) 등 신경학적인 이상이 의심되어 뇌자기공명영상을 시행 후 정상소견을 보인 15명의 신생아와 이상소견을 보인 27명의 환아 등 총 42명 신생아의 뇌량 크기를 비교하였다. 선천적인 뇌 기형이 동반된 경우와 염색체 이상, 대사 이상, 신경계 감염이 동반된 예는 연구대상에서 제외 하였다. 각 군의 뇌자기공명 영상에서 시상의 정중면에서 보이는 뇌량 전후의 최장 길이와 뇌량슬부의 수평 최장 두께, 체부의 수직 최장 두께, 팽대부의 수평 최장 두께를 원광대학교병원 영상 분석 시스템의 자동 측량 방법으로 기록하였고 이렇게 얻어진 각 부위의 두께를 다시 뇌량 전후의 최장 길이로 나누어서 뇌량 전후 길이에 대한 뇌량슬, 체부, 팽대부의 두께에 대한 비율을 계산하여 얻어진 측정치를 정상소견을 보인 신생아의 수치와 저산소성 허혈성 뇌증 소견이 보이는 만삭아 19명과 뇌실주위 백질연화증이 있는 미숙아 8명의 뇌량 전후 길이에 대한 뇌량 각 부위 두께의 비를 비교 분석하였다. 결 과: 뇌량 전후의 길이에 대한 뇌량슬부와 팽대부 두께의 비는 정상 소견을 보인 대조군과의 비교에서 저산소성 허혈성 뇌증 소견이 보이는 만삭아와 뇌실주위 백질연화증 소견이 보이는 미숙아에서 각각 통계학적인 의의가 있는 차이는 보이지 않았다. 그러나 뇌량 전후의 길이에 대한 뇌량체부 두께의 비는 P value가 저산소성 허혈성 뇌증 소견이 보이는 만삭아의 경우에서는 0.042, 뇌실주위 백질연화증 소견이 보이는 미숙아의 경우에서는 0.017로 정상소견을 보인 대조군과는 통계적으로 의의 있는 차이를 보였다. 결 론: 뇌량의 크기나 모양은 대뇌백질의 부피나 백질의 수초화 정도를 나타내는 좋은 지표이므로 뇌자기공명영상에서 뇌량의 크기를 양적으로 측정하는 것은 뇌발달의 평가 및 출생 전후의 뇌손상의 정도와 범위를 평가하는데 유용할 뿐만 아니라 뇌성마비나 정신발달지체 등 향후 신경학적인 예후를 추정하는 데에도 큰 도움이 될 수 있을 것으로 생각된다.

• Journal of Korean Neurosurgical Society
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• 제41권3호
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• pp.177-179
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• 2007

Most of intradural epidermoid cyst arise as slowly growing extraaxial lesions but purely intracerebral epidermoid cysts are rare. A 39-year-old female presented with a headache during several months. Brain computed tomography [CT] scan showed a mass lesion in the both frontal lobe with heterogenous density approximately $5{\times}5cm$ in size. Magnetic resonance imaging [MRI] revealed a mass of heterogenous signal intensity on T1, T2-weighted image and faint enhancement with gadolinium [Gd]. Through the both interhemispheric approach, mass was removed subtotally except the calcified portion tightly attached to the corpus callosum. The patient discharged without neurological deficit. The authors report a case of epidermoid cyst in the corpus callosum and discuss the pathogenesis of the intraparenchymal epidermoid cyst.

• 한국멀티미디어학회논문지
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• 제17권12호
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• pp.1412-1417
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• 2014

The corpus callosum is the largest part of the brain, which is related to many neurological diseases. Snake model or active contour model is widely used in medical image processing field, especially image segmentation they look into the nearby edge, localizing them accurately. In this paper, corpus callosum segmentation using the snake model, is proposed. We tested a snake model on brain MRI. Then we compared the result with an active shape approach and found that snake model had better segmentation accuracy also faster than active shape approach.

• 한국멀티미디어학회논문지
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• 제16권9호
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• pp.1018-1030
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• 2013

The corpus callosum is the largest connective structure in the brain, and its shape and size are correlated to sex, age, brain growth and degeneration, handedness, musical ability, and neurological diseases. Manually segmenting the corpus callosum from brain magnetic resonance (MR) image is time consuming, error prone, and operator dependent. In this paper, two semi-automatic segmentation methods are present: the active contour model-based approach and the active shape model-based approach. We tested these methods on an MR image of the human brain and found that the active contour approach had better segmentation accuracy but was slower than the active shape approach.

• Annals of Clinical Neurophysiology
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• 제22권2호
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• pp.121-124
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• 2020

The most common form of autosomal recessive hereditary spastic paraplegia (HSP) is caused by mutations in SPG11/KIAA1840 gene, which encodes for spatacsin. The clinical presentation of SPG11 is characterized by cognitive impairment, peripheral neuropathy and a thin corpus callosum in brain magnetic resonance imaging. We identified a novel homozygous nonsense mutation (c.6082C>T [p.Q2028]) in exon 32 of SPG11 in Korean siblings. Our findings suggest that this novel homozygous mutation in SPG11 is associated with HSP and with dysgenesis of the corpus callosum.

• Journal of Korean Neurosurgical Society
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• 제47권2호
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• pp.148-150
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• 2010

Osteolipoma is an ossified lipoma with distinct components of fat and bone. We present a case of interhemispheric osteolipoma associated with total agenesis of the corpus callosum. A 20-year-old man complained of severe headache, nausea and vomiting. Brain computed tomography showed a low-density mass in an interhemispheric fissure, with high T1 and T2 magnetic resonance signals compatible with fat. The mass measured $4.9\;{\times}\;2.9\;cm$ in size and showed peripheral calcifications. There was another small piece of same signal mass within the lateral ventricular choroid plexus. The interhemispheric lesion was removed by an interhemispheric approach. Osteolipoma is rare in interhemispheric region, however, it should be a differential diagnosis of lesions with fat intensity mass and calcifications.

• Clinical and Experimental Pediatrics
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• 제53권9호
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• pp.859-862
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• 2010

Transient magnetic resonance (MR) signal changes in the splenium of the corpus callosum (SCC) arise from many different conditions, including encephalopathy or encephalitis caused by infection, seizures, metabolic derangements, and asphyxia. Few case reports exist on reversible SCC lesions associated with rotavirus infection. A benign convulsion with mild gastroenteritis (CwG) is frequently associated with rotaviral infections. This entity is characterized by normal laboratory findings, electroencephalogram, neuroimaging, and good prognosis. We report a case of a 2.5-year-old Korean girl with rotavirus-associated CwG demonstrating a reversible SCC lesion on diffusion-weighted MR images. She developed 2 episodes of brief generalized tonic-clonic seizure with mild acute gastroenteritis without any other neurologic abnormality. Stool test for rotavirus antigen was positive. Brain MRI done on the day of admission showed a linear high signal intensity and decreased apparent diffusion coefficient values on the SCC. The lesion completely disappeared on follow-up MRI 6 days later. The patient fully recovered without any sequelae.