• 한방비만학회지
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• 제22권1호
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• pp.77-85
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• 2022

While the Coronavirus disease 2019 (COVID-19) pandemic is gradually turning into an endemic disease, concerns about post COVID-19 conditions (Long COVID) are emerging. Obesity is a major risk factor for severe complications of COVID-19, and COVID-19 has a wide range of effects on obesity and metabolic function. This paper aims to examine the interaction between COVID-19 and obesity, the effects and mechanisms of long COVID on obesity, and the role of Korean medicine on long COVID-related obesity. Obesity may worsen with cardiometabolic damage and psychosocial insecurity during COVID-19 and long COVID-induced neuroinflammation, systemic inflammation, mitochondrial dysfunction, and hypoxia also may aggravate obesity. Korean Medicine treatments, which have been widely used to treat obesity, have the potential to improve obesity in the era of long COVID by intervening in these mechanisms.

• IMMUNE NETWORK
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• 제23권2호
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• pp.19.1-19.10
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• 2023

Endemic human coronaviruses (HCoVs) have been evidenced to be cross-reactive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a correlation exists between the immunological memory to HCoVs and coronavirus disease 2019 (COVID-19) severity, there is little experimental evidence for the effects of HCoV memory on the efficacy of COVID-19 vaccines. Here, we investigated the Ag-specific immune response to COVID-19 vaccines in the presence or absence of immunological memory against HCoV spike Ags in a mouse model. Pre-existing immunity against HCoV did not affect the COVID-19 vaccine-mediated humoral response with regard to Ag-specific total IgG and neutralizing Ab levels. The specific T cell response to the COVID-19 vaccine Ag was also unaltered, regardless of pre-exposure to HCoV spike Ags. Taken together, our data suggest that COVID-19 vaccines elicit comparable immunity regardless of immunological memory to spike of endemic HCoVs in a mouse model.

• 보건행정학회지
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• 제32권3호
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• pp.330-333
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• 2022

Korea's quarantine response to the novel coronavirus (coronavirus disease 2019 [COVID-19]) pandemic is based on the sacrifice of health professionals, especially public health doctors (PHDs) who were called out first and put in the first place in the country. PHDs performed major quarantine tasks, such as collecting samples from screening clinics and epidemiological investigations, in various parts of the country, including the Daegu area, where the first large-scale COVID-19 confirmed cases in Korea and explosively increased. Because of their position as fixed-term civil servants, however, PHDs' professionalism as doctors was ignored, and they were not properly compensated for their work. They were also exposed to problems such as a high risk of infection, mental suffering, and various human rights violations. We must prepare concrete measures to improve the fundamental treatment of PHDs and protect their human rights in order to prepare for a possible infectious disease pandemic in the future.

• Clinical and Experimental Pediatrics
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• 제63권4호
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• pp.119-124
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• 2020

A cluster of severe pneumonia of unknown etiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was isolated from lower respiratory tract sample as the causative agent. The current outbreak of infections with SARS-CoV-2 is termed Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO). COVID-19 rapidly spread into at least 114 countries and killed more than 4,000 people by March 11 2020. WHO officially declared COVID-19 a pandemic on March 11, 2020. There have been 2 novel coronavirus outbreaks in the past 2 decades. The outbreak of severe acute respiratory syndrome (SARS) in 2002-2003 caused by SARS-CoV had a case fatality rate of around 10% (8,098 confirmed cases and 774 deaths), while Middle East respiratory syndrome (MERS) caused by MERS-CoV killed 861 people out of a total 2,502 confirmed cases between 2012 and 2019. The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features.

• 한국비블리아학회지
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• 제34권3호
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• pp.135-161
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• 2023

본 연구는 국내 의학 학술지에 발행된 COVID-19(Coronavirus Disease 2019) 논문의 연구 동향을 분석하였다. 연구 대상은 MEDLINE에 등재된 의학 분야 학술지 25종으로 총 800건을 선정하였으며, 이를 대상으로 저자 분석, 빈도 분석, 주제 분석, 토픽모델링을 수행하였다. 연구 결과, 저자의 소속 기관은 국내 기관이 76.96%였으며, 국외 기관 저자의 비율은 소폭 감소하였다. 저자의 전공은 '내과학'(32.85%), '예방의학/직업환경의학'(16.23%), '방사선과학'(5.74%), '소아과학'(5.50%) 순이었으며, 공동 연구가 진행된 논문은 435건(54.38%)이었다. 저자 키워드는 'COVID19'(674번), 'SARSCoV2'(245번), 'Coronavirus'(81번), 'Vaccine'(80번) 등이 상위 키워드로 도출되었다. 전체 기간 등장한 단어는 'COVID19', 'SARSCoV2', 'Coronavirus', 'Korea', 'Pandemic', 'Mortality' 등 6개이다. MeSH 용어와 저자 키워드를 대상으로 동시 출현 네트워크 분석을 실시하였으며, 공통적으로 'covid-19', 'sars-cov-2', 'public health' 등의 중심 주제어가 도출되었다. 토픽모델링에서는 '백신 접종', 'COVID-19 발생 현황', '오미크론 변이 바이러스', '정신 건강, 방역 조치', '국내 감염의 전파 및 관리' 등 총 5가지의 토픽이 확인되었다. 이 연구를 통하여 '국제적 공중보건 비상사태'(Public Health Emergency of International Concern, PHEIC) 기간 동안 발행된 국내 COVID-19 논문의 연구 영역과 연도별 주요 키워드를 파악할 수 있었다.

• BMB Reports
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• 제55권1호
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• pp.11-19
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• 2022

The coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe COVID-19 exhibit hyper-inflammatory responses characterized by excessive activation of myeloid cells, including monocytes, macrophages, and neutrophils, and a plethora of pro-inflammatory cytokines and chemokines. Accumulating evidence also indicates that hyper-inflammation is a driving factor for severe progression of the disease, which has prompted the development of anti-inflammatory therapies for the treatment of patients with COVID-19. Corticosteroids, IL-6R inhibitors, and JAK inhibitors have demonstrated promising results in treating patients with severe disease. In addition, diverse forms of exosomes that exert anti-inflammatory functions have been tested experimentally for the treatment of COVID-19. Here, we briefly describe the immunological mechanisms of the hyper-inflammatory responses in patients with severe COVID-19. We also summarize current anti-inflammatory therapies for the treatment of severe COVID-19 and novel exosome-based therapeutics that are in experimental stages.

• Pediatric Infection and Vaccine
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• 제29권1호
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• pp.1-15
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• 2022

소아청소년에서 코로나바이러스감염증-19 (coronavirus disease 2019 [COVID-19])은 대부분 경증이며 특별한 치료없이 호전될 수 있다. 하지만 일부 소아청소년 COVID-19 환자에서는 중증 또는 위중증으로 진행할 수 있다. 소아청소년 COVID-19 치료 약제에 대한 임상 데이터는 제한적이지만, 중증 및 위중증 COVID-19 소아청소년 환자에서 사용 가능한 약제들은 있다. 본 종설에서는 COVID-19 치료 약제 중 항바이러스제와 면역조절제에 중점을 두고 임상 데이터와 소아청소년에 대한 권고 사항들을 논의하였다.

• Asia pacific journal of information systems
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• 제30권4호
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• pp.785-807
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• 2020

The novel Coronavirus disease 2019 (COVID-19) is unprecedentedly changing the world since its outbreak in late 2019. Using the collected the data related to COVID-19 and the social media user data from a mobile application market research agency from January 25 to April 7, this study empirically examines the effect of the number of confirmed COVID-19 cases worldwide, the number news COVID-19, and the enforcement of social distancing measures on the daily active users (DAU) of two social media services - Twitter and Facebook - in South Korea. There are three important findings from the results of econometric analysis. First, the number of confirmed COVID-19 cases worldwide has a negative effect on the DAU of social media. Second, the number of COVID-19 news is negatively associated with the DAU of social media. Finally, the implementation of social distancing measures has no significant effect on the DAU of the social media. Theoretical implications and managerial guidelines are also discussed.

• Clinical and Experimental Pediatrics
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• 제63권4호
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• pp.125-132
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• 2020

Coronavirus disease-2019 (COVID-19), which started in Wuhan, China, in December 2019 and declared a worldwide pandemic on March 11, 2020, is a novel infectious disease that causes respiratory illness and death. Pediatric COVID-19 accounts for a small percentage of patients and is often milder than that in adults; however, it can progress to severe disease in some cases. Even neonates can suffer from COVID-19, and children may spread the disease in the community. This review summarizes what is currently known about COVID-19 in children and adolescents.

• Clinical and Experimental Pediatrics
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• 제65권4호
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• pp.167-171
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• 2022

In the era of the coronavirus disease 2019 (COVID-19) pandemic, countries worldwide have implemented several nonpharmaceutical interventions (NPIs) to contain its spread before vaccines and treatments were developed. NPIs included social distancing, mask wearing, intensive contact tracing and isolation, and sanitization. In addition to their effectiveness at preventing the rapid spread of COVID-19, NPIs have caused secondary changes in the epidemiology of other infectious diseases. In Korea, various NPI stages have been implemented since the first confirmed case of COVID-19 on January 20, 2020. This review, based on a PubMed database search, shows the impact of NPIs on several infectious diseases other than severe acute respiratory syndrome coronavirus 2 in the COVID-19 pandemic era in Korea.